MX2013007917A - Derivados fusionados de aminodihidrotiazina como inhibidores de beta secretasa. - Google Patents
Derivados fusionados de aminodihidrotiazina como inhibidores de beta secretasa.Info
- Publication number
- MX2013007917A MX2013007917A MX2013007917A MX2013007917A MX2013007917A MX 2013007917 A MX2013007917 A MX 2013007917A MX 2013007917 A MX2013007917 A MX 2013007917A MX 2013007917 A MX2013007917 A MX 2013007917A MX 2013007917 A MX2013007917 A MX 2013007917A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives useful
- fused aminodihydrothiazine
- bace inhibitors
- inhibitory effect
- aminodihydrothiazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invención se refiere a un derivado fusionado de aminodihidrotiazina de fórmula (I): (Ver Formula) En donde: X es hidrógeno o flúor; A es CH o N; Y es metilo, etilo, monofluorometilo, difluorometilo, trifluorometilo, difluoroetilo, metoxi, etoxi, metoximetilo o-C=N; y sales farmacéuticamente aceptables del mismo; compuesto que tiene un efecto inhibidor de la producción de A o un efecto inhibidor de la BACE1 y es útil como un agente profiláctico o terapéutico para una enfermedad neurodegenerativa causada por Aß y caracterizada por demencia tipo Alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1101140.0A GB201101140D0 (en) | 2011-01-21 | 2011-01-21 | Fused aminodihydrothiazine derivatives |
PCT/EP2012/050833 WO2012098213A1 (en) | 2011-01-21 | 2012-01-20 | Fused aminodihydrothiazine derivatives useful as bace inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013007917A true MX2013007917A (es) | 2013-08-29 |
Family
ID=43769479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013007917A MX2013007917A (es) | 2011-01-21 | 2012-01-20 | Derivados fusionados de aminodihidrotiazina como inhibidores de beta secretasa. |
Country Status (21)
Country | Link |
---|---|
US (3) | US8338407B2 (es) |
EP (1) | EP2665732B1 (es) |
JP (1) | JP5947815B2 (es) |
KR (1) | KR101906466B1 (es) |
CN (1) | CN103328486B (es) |
AR (1) | AR084903A1 (es) |
AU (1) | AU2012208526B2 (es) |
BR (1) | BR112013018602A2 (es) |
CA (1) | CA2828738A1 (es) |
CL (1) | CL2013002083A1 (es) |
ES (1) | ES2575914T3 (es) |
GB (1) | GB201101140D0 (es) |
IL (1) | IL226596A (es) |
MX (1) | MX2013007917A (es) |
PE (1) | PE20141182A1 (es) |
RU (1) | RU2593756C2 (es) |
SG (1) | SG190908A1 (es) |
TW (1) | TW201309710A (es) |
UA (1) | UA109927C2 (es) |
WO (1) | WO2012098213A1 (es) |
ZA (1) | ZA201303801B (es) |
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ES2537898T3 (es) | 2005-10-25 | 2015-06-15 | Shionogi & Co., Ltd. | Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1 |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
JP5383484B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | 環式基で置換されたアミノジヒドロチアジン誘導体 |
CA2711655C (en) | 2008-01-18 | 2013-03-05 | Eisai R&D Management Co., Ltd. | Condensed aminodihydrothiazine derivative |
US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
GB0912777D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydropyrimidone derivatives |
US8563543B2 (en) | 2009-10-08 | 2013-10-22 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
US8569310B2 (en) | 2009-10-08 | 2013-10-29 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use |
BR112012013854A2 (pt) | 2009-12-11 | 2019-09-24 | Shionogi & Co | derivados de oxazina. |
JP5816630B2 (ja) | 2010-10-29 | 2015-11-18 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
WO2012057247A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
BR112013016241A2 (pt) | 2011-01-21 | 2016-07-12 | Eisai R&D Man Co Ltd | composto, e, método para fabricar um composto |
GB201101140D0 (en) * | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
GB201101139D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
WO2013055386A2 (en) * | 2011-10-03 | 2013-04-18 | The University Of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
WO2014015125A1 (en) | 2012-07-19 | 2014-01-23 | Eisai R&D Management Co., Ltd. | Fused aminodihydrothiazine derivative salts and uses thereof |
GB201212816D0 (en) * | 2012-07-19 | 2012-09-05 | Eisai Ltd | Novel compounds |
EP2893042B1 (en) * | 2012-09-05 | 2018-02-14 | Emory University | Diagnostic testing in dementia and methods related thereto |
WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
TWI593692B (zh) * | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
JO3318B1 (ar) | 2013-06-18 | 2019-03-13 | Lilly Co Eli | مثبطات bace |
TWI599358B (zh) * | 2014-09-16 | 2017-09-21 | 美國禮來大藥廠 | 組合療法 |
AR103680A1 (es) * | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
US9938266B2 (en) * | 2015-03-19 | 2018-04-10 | Eli Lilly And Company | Selective BACE1 inhibitors |
AR104241A1 (es) * | 2015-04-29 | 2017-07-05 | Lilly Co Eli | Derivados de tetrahidrofuro tiazina como inhibidores de bace1 selectivos |
KR20170108203A (ko) * | 2016-03-16 | 2017-09-27 | 주식회사 피플바이오 | 응집형-형성 폴리펩타이드의 응집형을 검출하는 방법 |
TW201740954A (zh) * | 2016-03-16 | 2017-12-01 | 美國禮來大藥廠 | 組合療法 |
TWI675034B (zh) * | 2016-05-20 | 2019-10-21 | 美商美國禮來大藥廠 | 四氫呋喃并<img align="absmiddle" height="18px" width="27px" file="d10999.TIF" alt="其他非圖式 ed10999.png" img-content="tif" orientation="portrait" inline="yes" giffile="ed10999.png"></img>化合物及其作為選擇性BACE1抑制劑之用途 |
EP3500296A1 (en) * | 2016-08-18 | 2019-06-26 | Eli Lilly and Company | Combination therapy of bace-1 inhibitor and anti-n3pglu abeta antibody |
AR110470A1 (es) * | 2016-10-21 | 2019-04-03 | Lilly Co Eli | Terapia de combinación para tratar la enfermedad de alzheimer |
CA3047287A1 (en) | 2016-12-15 | 2018-06-21 | Amgen Inc. | Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use |
EP3555086B1 (en) | 2016-12-15 | 2021-09-01 | Amgen Inc. | 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use |
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MX2019007101A (es) | 2016-12-15 | 2019-12-16 | Amgen Inc | Derivados de oxazina como inhibidores de beta secretasa y metodos de uso. |
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GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
GB0912777D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydropyrimidone derivatives |
EP2588467A1 (en) | 2010-07-01 | 2013-05-08 | Amgen Inc. | Heterocyclic compounds and their use as inhibitors of pi3k activity |
GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
GB201101139D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
BR112013016241A2 (pt) | 2011-01-21 | 2016-07-12 | Eisai R&D Man Co Ltd | composto, e, método para fabricar um composto |
-
2011
- 2011-01-21 GB GBGB1101140.0A patent/GB201101140D0/en not_active Ceased
-
2012
- 2012-01-10 TW TW101100946A patent/TW201309710A/zh unknown
- 2012-01-20 EP EP12708716.1A patent/EP2665732B1/en not_active Revoked
- 2012-01-20 MX MX2013007917A patent/MX2013007917A/es active IP Right Grant
- 2012-01-20 AR ARP120100191A patent/AR084903A1/es unknown
- 2012-01-20 AU AU2012208526A patent/AU2012208526B2/en not_active Ceased
- 2012-01-20 RU RU2013138717/04A patent/RU2593756C2/ru not_active IP Right Cessation
- 2012-01-20 BR BR112013018602-0A patent/BR112013018602A2/pt not_active IP Right Cessation
- 2012-01-20 US US13/354,716 patent/US8338407B2/en not_active Expired - Fee Related
- 2012-01-20 SG SG2013041033A patent/SG190908A1/en unknown
- 2012-01-20 ES ES12708716.1T patent/ES2575914T3/es active Active
- 2012-01-20 UA UAA201310161A patent/UA109927C2/ru unknown
- 2012-01-20 PE PE2013001464A patent/PE20141182A1/es not_active Application Discontinuation
- 2012-01-20 JP JP2013549820A patent/JP5947815B2/ja not_active Expired - Fee Related
- 2012-01-20 KR KR1020137019966A patent/KR101906466B1/ko active IP Right Grant
- 2012-01-20 WO PCT/EP2012/050833 patent/WO2012098213A1/en active Application Filing
- 2012-01-20 CA CA2828738A patent/CA2828738A1/en not_active Abandoned
- 2012-01-20 CN CN201280004902.1A patent/CN103328486B/zh not_active Expired - Fee Related
- 2012-11-26 US US13/685,109 patent/US8592408B2/en not_active Expired - Fee Related
-
2013
- 2013-05-24 ZA ZA2013/03801A patent/ZA201303801B/en unknown
- 2013-05-27 IL IL226596A patent/IL226596A/en active IP Right Grant
- 2013-07-19 CL CL2013002083A patent/CL2013002083A1/es unknown
- 2013-10-18 US US14/057,403 patent/US8940734B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2012208526B2 (en) | 2015-09-24 |
CL2013002083A1 (es) | 2013-12-06 |
UA109927C2 (ru) | 2015-10-26 |
WO2012098213A1 (en) | 2012-07-26 |
KR20140002724A (ko) | 2014-01-08 |
BR112013018602A2 (pt) | 2020-09-01 |
JP2014502987A (ja) | 2014-02-06 |
NZ611365A (en) | 2015-04-24 |
ES2575914T3 (es) | 2016-07-04 |
US20140142091A1 (en) | 2014-05-22 |
US8940734B2 (en) | 2015-01-27 |
CN103328486B (zh) | 2016-08-17 |
JP5947815B2 (ja) | 2016-07-06 |
US20120190672A1 (en) | 2012-07-26 |
IL226596A (en) | 2016-04-21 |
CN103328486A (zh) | 2013-09-25 |
SG190908A1 (en) | 2013-07-31 |
EP2665732B1 (en) | 2016-03-30 |
AU2012208526A1 (en) | 2013-05-02 |
CA2828738A1 (en) | 2012-07-26 |
EP2665732A1 (en) | 2013-11-27 |
ZA201303801B (en) | 2014-07-30 |
TW201309710A (zh) | 2013-03-01 |
RU2013138717A (ru) | 2015-02-27 |
US8592408B2 (en) | 2013-11-26 |
PE20141182A1 (es) | 2014-09-14 |
RU2593756C2 (ru) | 2016-08-10 |
GB201101140D0 (en) | 2011-03-09 |
AR084903A1 (es) | 2013-07-10 |
KR101906466B1 (ko) | 2018-10-10 |
US20130203740A1 (en) | 2013-08-08 |
US8338407B2 (en) | 2012-12-25 |
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