MX2013000729A - Composiciones ciclopolisacárido anionico-catiónico y bendamustina. - Google Patents

Composiciones ciclopolisacárido anionico-catiónico y bendamustina.

Info

Publication number
MX2013000729A
MX2013000729A MX2013000729A MX2013000729A MX2013000729A MX 2013000729 A MX2013000729 A MX 2013000729A MX 2013000729 A MX2013000729 A MX 2013000729A MX 2013000729 A MX2013000729 A MX 2013000729A MX 2013000729 A MX2013000729 A MX 2013000729A
Authority
MX
Mexico
Prior art keywords
bendamustine
catioinic
anionic
cyclopolysaccharide
compositions
Prior art date
Application number
MX2013000729A
Other languages
English (en)
Other versions
MX341356B (es
Inventor
Valery Alakhov
Grzegorz Pietrzynski
Kishore Patel
Tomasz Popek
Original Assignee
Supratek Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supratek Pharma Inc filed Critical Supratek Pharma Inc
Publication of MX2013000729A publication Critical patent/MX2013000729A/es
Publication of MX341356B publication Critical patent/MX341356B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención esta dirigida a composiciones farmacéuticas incluyendo: (a) bendamustina, (b) u primer ciclopolisacarido cargado y (c) un agente estabilizante el cual es un segundo ciclopolisacárido cargado teniendo una carga opuesta aquella del primer ciclopolisacárido cargado. La composición proporciona una estabilidad inesperadamente deseable en ambientes reactivos tal como plasma acoplado con una actividad anticáncer inesperadamente deseable. Las composiciones son adecuadas para la inyección o infusión en pacientes en la necesidad para el tratamine5to con bendamustina.
MX2013000729A 2010-07-19 2011-02-23 Composiciones ciclopolisacárido anionico-catiónico y bendamustina. MX341356B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39985510P 2010-07-19 2010-07-19
US13/032,168 US8383663B2 (en) 2010-07-19 2011-02-22 Bendamustine anionic-catioinic cyclopolysaccharide compositions
PCT/IB2011/003367 WO2012127277A2 (en) 2010-07-19 2011-02-23 Bendamustine anionic-catioinic cyclopolysaccharide compositions

Publications (2)

Publication Number Publication Date
MX2013000729A true MX2013000729A (es) 2013-07-17
MX341356B MX341356B (es) 2016-07-07

Family

ID=45467434

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000729A MX341356B (es) 2010-07-19 2011-02-23 Composiciones ciclopolisacárido anionico-catiónico y bendamustina.

Country Status (11)

Country Link
US (1) US8383663B2 (es)
EP (1) EP2595660B1 (es)
JP (1) JP5788982B2 (es)
KR (2) KR101807903B1 (es)
CN (1) CN103228296B (es)
AU (3) AU2011363446B2 (es)
BR (1) BR112013001462B8 (es)
CA (1) CA2805805C (es)
MX (1) MX341356B (es)
RU (1) RU2647368C2 (es)
WO (1) WO2012127277A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108997514B (zh) * 2017-06-06 2021-06-08 首都医科大学 单-6-(苯达莫司汀酰胺基)-6-脱氧-β-环糊精的制备和应用
KR102450975B1 (ko) 2017-10-05 2022-10-07 튜브 파마수티칼스 게엠베하 경구 벤다무스틴 제형
WO2021203377A1 (zh) * 2020-04-09 2021-10-14 比卡生物科技（广州）有限公司 苯达莫司汀组合物及其用途
CN111557904A (zh) * 2020-04-09 2020-08-21 比卡生物科技（广州）有限公司 苯达莫司汀组合物及其用途
US11970977B2 (en) 2022-08-26 2024-04-30 Hamilton Sundstrand Corporation Variable restriction of a secondary circuit of a fuel injector
US20240148696A1 (en) 2022-10-25 2024-05-09 Softkemo Pharma Inc. Lyophilized bendamustine-cyclodextrin composition

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US6407079B1 (en) 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
US5068226A (en) 1987-12-07 1991-11-26 Cyclex, Inc. Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies
JPH04500229A (ja) * 1988-08-31 1992-01-16 オーストレイリアン・コマーシヤル・リサーチ・アンド・デイベロツプメント・リミテツド 薬剤分配用及びクロマトグラフィー用の組成物及び方法
MY106598A (en) 1988-08-31 1995-06-30 Australian Commercial Res & Development Ltd Compositions and methods for drug delivery and chromatography.
US5602112A (en) 1992-06-19 1997-02-11 Supergen, Inc. Pharmaceutical formulation
BR9808581A (pt) 1997-03-13 2000-05-30 Hexal Ag Estabilização de benzimidazóis sensìveis a ácido com combinações de aminoácido/ciclodextrina
US6624141B1 (en) 1999-03-17 2003-09-23 The Regents Of The University Of Michigan Protamine fragment compositions and methods of use
EP1165119B1 (en) 1999-04-08 2003-10-08 Genentech, Inc. Composition based on oppositely-charged polypeptides
GB9921958D0 (en) 1999-09-16 1999-11-17 Pharmacia & Upjohn Spa Formulations for parenteral use of estramustine phosphate and sulfoalkylether-cyclodextrins
US20030044356A1 (en) 2001-04-20 2003-03-06 Jin Auh Composition for nasal solution sprays having effective component of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one)
MXPA04008173A (es) 2002-02-22 2004-11-26 Pharmacia Corp Formulaciones de farmaco antibiotico oftalmico que contienen un compuesto de ciclodextrina y cloruro de cetil piridinio.
KR101121675B1 (ko) 2002-04-19 2012-03-13 노파르티스 아게 신규 생체적합물질, 그의 제조방법 및 용도
WO2004017897A2 (en) * 2002-08-20 2004-03-04 Bristol-Myers Squibb Company Aripiprazole complex formulation and method
US7834174B2 (en) * 2004-09-10 2010-11-16 Mavridis Irene M Per-6-guanidino-, alkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of DNA and intercellular delivery
CN101933923A (zh) * 2004-11-05 2011-01-05 赛福伦公司 癌症治疗
CN101052396A (zh) * 2004-11-05 2007-10-10 赛福伦公司 癌症治疗
US20060128653A1 (en) * 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of decitabine
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
JP5053101B2 (ja) 2005-01-28 2012-10-17 ブリガム ヤング ユニヴァーシティー ＣＤ１ｄ−拘束ＮＫＴ細胞の細菌糖脂質による活性化
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CN101897977A (zh) 2010-07-29 2010-12-01 浙江大学 离子型环糊精衍生物在制备用于离子导入透皮给药的药物制剂中的应用

Also Published As

Publication number Publication date
EP2595660B1 (en) 2015-07-22
KR101807903B1 (ko) 2017-12-12
AU2019219792A1 (en) 2019-09-12
JP2013531060A (ja) 2013-08-01
EP2595660A2 (en) 2013-05-29
WO2012127277A3 (en) 2013-03-14
MX341356B (es) 2016-07-07
KR20170102061A (ko) 2017-09-06
CN103228296B (zh) 2015-04-08
BR112013001462A2 (pt) 2016-05-31
CA2805805A1 (en) 2012-09-27
CA2805805C (en) 2018-10-23
AU2011363446B2 (en) 2017-05-18
BR112013001462B1 (pt) 2022-04-19
RU2647368C2 (ru) 2018-03-15
BR112013001462B8 (pt) 2022-08-02
AU2019219792B2 (en) 2023-03-02
AU2011363446A1 (en) 2013-02-21
WO2012127277A2 (en) 2012-09-27
AU2017216568A1 (en) 2017-09-14
KR101874764B1 (ko) 2018-07-04
US8383663B2 (en) 2013-02-26
JP5788982B2 (ja) 2015-10-07
CN103228296A (zh) 2013-07-31
RU2013107115A (ru) 2014-08-27
US20120015995A1 (en) 2012-01-19
EP2595660A4 (en) 2014-01-01
KR20130113428A (ko) 2013-10-15

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