MX2011007759A - Analogos de bumetanida, furosemida, piretanida, azosemida y torsemida, composiciones y metodos de uso. - Google Patents
Analogos de bumetanida, furosemida, piretanida, azosemida y torsemida, composiciones y metodos de uso.Info
- Publication number
- MX2011007759A MX2011007759A MX2011007759A MX2011007759A MX2011007759A MX 2011007759 A MX2011007759 A MX 2011007759A MX 2011007759 A MX2011007759 A MX 2011007759A MX 2011007759 A MX2011007759 A MX 2011007759A MX 2011007759 A MX2011007759 A MX 2011007759A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- alkyl
- alkaryl
- heterocycloalkyl
- aryl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14633609P | 2009-01-22 | 2009-01-22 | |
US25723809P | 2009-11-02 | 2009-11-02 | |
PCT/US2010/000170 WO2010085352A2 (en) | 2009-01-22 | 2010-01-22 | Bumetanide, furosemide, piretanide, azosemide, and torsemide analogs, compositions and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011007759A true MX2011007759A (es) | 2011-10-11 |
Family
ID=42356370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011007759A MX2011007759A (es) | 2009-01-22 | 2010-01-22 | Analogos de bumetanida, furosemida, piretanida, azosemida y torsemida, composiciones y metodos de uso. |
Country Status (6)
Country | Link |
---|---|
US (6) | US20120004225A1 (zh) |
EP (1) | EP2389371A4 (zh) |
CN (1) | CN102341380A (zh) |
CA (1) | CA2750339A1 (zh) |
MX (1) | MX2011007759A (zh) |
WO (1) | WO2010085352A2 (zh) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2389371A4 (en) | 2009-01-22 | 2012-09-12 | Neurotherapeutics Pharma Inc | ANALOGUES OF BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE AND TORSEMID, AND RELATED COMPOSITIONS AND METHODS OF USE |
JP5886742B2 (ja) * | 2009-07-24 | 2016-03-16 | ウォルフガング・ミューラーWolfgang Mueller | 内側側頭葉てんかん(tle)の処置及び可能性を防止/減少させる方法 |
US9226898B1 (en) * | 2009-11-18 | 2016-01-05 | Richard C. K. Yen | Submicron particles for the treatment of radiation damage in patients |
WO2011086126A1 (en) * | 2010-01-15 | 2011-07-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compounds for the treatment of autism |
CN108057033A (zh) * | 2011-03-01 | 2018-05-22 | 法耐斯特公司 | 用于治疗肌萎缩性侧索硬化症的新组合物 |
US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
US9867837B2 (en) | 2011-03-01 | 2018-01-16 | Pharnext | Compositions for treating neurological disorders |
UA115968C2 (uk) * | 2011-03-01 | 2018-01-25 | Фарнекст | Нові композиції для лікування неврологічних захворювань |
US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
EP2705842A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
ES2564972T3 (es) | 2011-03-18 | 2016-03-30 | Bayer Intellectual Property Gmbh | Derivados de N-(3-carbamoilfenil)-1H-pirazol-5-carboxamida y su uso para combatir parásitos animales |
US9931326B2 (en) | 2011-03-29 | 2018-04-03 | Pharnext | Composition comprising torasemide and baclofen for treating neurological disorders |
WO2012154728A1 (en) | 2011-05-10 | 2012-11-15 | Concert Pharmaceuticals Inc. | Deuterated n-butyl bumetanide |
WO2013059648A1 (en) * | 2011-10-21 | 2013-04-25 | Neurotherapeutics Pharma, Inc. | 2,3,5 trisubstituted aryl and heteroaryl amino derivatives, compositions, and methods of use |
WO2013087090A1 (en) | 2011-12-12 | 2013-06-20 | Auris Medical Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
WO2013139861A1 (en) | 2012-03-20 | 2013-09-26 | Luc Montagnier | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
EP2887806B1 (en) | 2012-07-20 | 2019-11-13 | University Of Rochester | Method of treating and preventing brain impairment using na+-k+ -2ci- cotransporter isoform 1 inhibitors |
JP2015528470A (ja) * | 2012-09-04 | 2015-09-28 | ニューロプロ セラピューティクス, インコーポレイテッド | ブメタニド、フロセミド、およびピレタニドを含むループ利尿薬の類似体およびプロドラッグ、組成物、ならびに使用方法 |
EP2705843A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis |
CN105496995B (zh) * | 2014-09-22 | 2018-04-17 | 北京蛋白质组研究中心 | bumetanide在抑制肿瘤细胞增殖中的应用 |
LT6401B (lt) | 2015-07-28 | 2017-06-12 | Vilniaus Universitetas | Karboanhidrazės selektyvūs inhibitoriai |
JP2018536017A (ja) | 2015-09-22 | 2018-12-06 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための化合物及び組成物 |
US20170354669A1 (en) * | 2016-02-24 | 2017-12-14 | The Trustees Of Columbia University In The City Of New York | Disruption of the interaction between amyloid beta peptide and dietary lipids |
US20180052838A1 (en) * | 2016-08-22 | 2018-02-22 | International Business Machines Corporation | System, method and computer program for a cognitive media story extractor and video composer |
US10382558B2 (en) * | 2016-11-17 | 2019-08-13 | Nokia Of America Corporation | Edge resource sharing |
EP3600324A4 (en) | 2017-03-23 | 2020-12-09 | Graybug Vision, Inc. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISORDERS |
CN111201040A (zh) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | 用于医学疗法的缓释微粒及其悬浮液 |
JP7116792B2 (ja) | 2017-08-25 | 2022-08-10 | ザ ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュラル アンド メカニカル カレッジ | 疼痛を緩和するための組成物および方法 |
CA3023014C (en) * | 2017-11-06 | 2023-09-26 | Stalicla Sa | Pharmaceutical composition for treatment of autism |
CN117051096A (zh) * | 2017-12-08 | 2023-11-14 | 神经Gx有限责任公司 | 用于阿尔茨海默病的同步化细胞周期基因表达测试及相关治疗方法 |
WO2019193161A1 (en) | 2018-04-06 | 2019-10-10 | Universität Wien | Bumetanide derivatives for the therapy of stroke and other neurological diseases/disorders involving nkccs |
AU2019247641A1 (en) | 2018-04-06 | 2020-11-12 | Zilentin AG | Bumetanide derivatives for the therapy of hyperhidrosis |
US20210228519A1 (en) * | 2018-04-12 | 2021-07-29 | The Regents Of The University Of California | Methods for treating apoe4/4-associated disorders |
WO2019210215A1 (en) * | 2018-04-26 | 2019-10-31 | Graybug Vision, Inc. | Drugs to treat ocular disorders |
CN112752573A (zh) * | 2018-05-25 | 2021-05-04 | 儿童医疗中心有限公司 | 治疗脊髓损伤的方法 |
US11722778B2 (en) * | 2018-10-08 | 2023-08-08 | Florida Atlantic University Board Of Trustees | Underwater imaging system |
BR112021019935A2 (pt) * | 2019-04-02 | 2022-03-03 | Univ Bologna Alma Mater Studiorum | Composto, uso do composto e composição farmacêutica |
CN115023223A (zh) * | 2019-12-04 | 2022-09-06 | 雷斯乔制药有限责任公司 | 用于治疗口服利尿剂难治性水肿的方法和组合物 |
US20230293469A1 (en) * | 2020-07-01 | 2023-09-21 | Neuropro Therapeutics, Inc. | Novel pharmaceutical compositions |
US20230390230A1 (en) * | 2021-12-30 | 2023-12-07 | Neuropro Therapeutics, Inc. | Pharmaceutical composition |
CN116440079A (zh) * | 2022-02-22 | 2023-07-18 | 北京多纳医药科技有限公司 | 经鼻给药脑靶向主动载药的布美他尼脂质体 |
WO2023196614A1 (en) * | 2022-04-08 | 2023-10-12 | Axonis Therapeutics, Inc. | Methods and compounds for treating neurological disorders |
WO2024039653A1 (en) * | 2022-08-16 | 2024-02-22 | Neuropro Therapeutics, Inc. | Therapeutic composition, methods, and uses for the control of seizures |
WO2024079128A1 (en) * | 2022-10-11 | 2024-04-18 | B&A Oncomedical | New compounds, processes for preparing the same and their use as drugs |
CN116019799A (zh) * | 2022-11-09 | 2023-04-28 | 河南省精神病医院(新乡医学院第二附属医院) | 一种验证布美他尼能改善精神分裂症认知损伤的实验方法 |
CN115960059A (zh) * | 2022-12-30 | 2023-04-14 | 深圳市江川医药技术有限公司 | 一种高产率高纯度合成呋塞米杂质d的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3903146A (en) * | 1970-06-18 | 1975-09-02 | Leo Pharm Prod Ltd | Benzoic acid derivatives |
US8722668B2 (en) | 1998-12-23 | 2014-05-13 | Daryl W. Hochman | Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders |
US7214711B2 (en) | 1998-12-23 | 2007-05-08 | Neurotherapeutics Pharma Llc | Method of treating migraine headache without aura |
US20060025387A1 (en) * | 1998-12-23 | 2006-02-02 | Cytoscan Sciences Llc | Compositions and methods for the treatment of disorders of the central and peripheral nervous systems |
US6495601B1 (en) | 1998-12-23 | 2002-12-17 | Cytoscan Sciences Llc | Methods and compositions for treating conditions of the central and peripheral nervous systems using non-synaptic mechanisms |
US8008283B2 (en) * | 1998-12-23 | 2011-08-30 | Neurotherapeutics Pharma, Inc. | Methods and compositions for the treatment of neuropsychiatric disorders |
US20070149526A1 (en) * | 2005-10-17 | 2007-06-28 | Neurotherapeutics Pharma, L.L.C. | Diuretic and diuretic-like compound analogs |
EP2389371A4 (en) | 2009-01-22 | 2012-09-12 | Neurotherapeutics Pharma Inc | ANALOGUES OF BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE AND TORSEMID, AND RELATED COMPOSITIONS AND METHODS OF USE |
-
2010
- 2010-01-22 EP EP10733729A patent/EP2389371A4/en active Pending
- 2010-01-22 MX MX2011007759A patent/MX2011007759A/es not_active Application Discontinuation
- 2010-01-22 US US13/138,282 patent/US20120004225A1/en not_active Abandoned
- 2010-01-22 CN CN2010800101125A patent/CN102341380A/zh active Pending
- 2010-01-22 CA CA2750339A patent/CA2750339A1/en not_active Abandoned
- 2010-01-22 WO PCT/US2010/000170 patent/WO2010085352A2/en active Application Filing
-
2014
- 2014-08-28 US US14/472,181 patent/US9682928B2/en active Active
-
2017
- 2017-01-06 US US15/400,087 patent/US20170246131A1/en not_active Abandoned
-
2018
- 2018-08-22 US US16/108,463 patent/US20190151263A1/en not_active Abandoned
-
2021
- 2021-05-17 US US17/321,928 patent/US20220071935A1/en not_active Abandoned
-
2023
- 2023-09-13 US US18/367,900 patent/US20240009153A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20120004225A1 (en) | 2012-01-05 |
US20240009153A1 (en) | 2024-01-11 |
EP2389371A4 (en) | 2012-09-12 |
US20150080350A1 (en) | 2015-03-19 |
WO2010085352A3 (en) | 2010-11-04 |
CN102341380A (zh) | 2012-02-01 |
WO2010085352A2 (en) | 2010-07-29 |
EP2389371A2 (en) | 2011-11-30 |
US20220071935A1 (en) | 2022-03-10 |
US20170246131A1 (en) | 2017-08-31 |
CA2750339A1 (en) | 2010-07-29 |
US9682928B2 (en) | 2017-06-20 |
US20190151263A1 (en) | 2019-05-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20220071935A1 (en) | Bumetanide analogs, compositions and methods of use | |
JP2011231094A (ja) | ブメタニド、フロセミド、ピレタニド、アゾセミド、およびトルセミドのアナログ、組成物および使用方法 | |
WO2012018635A2 (en) | Arylsulfonamide derivatives, compositions, and methods of use | |
CA2595544C (en) | Compounds having analgesic and/or immunostimulant activity | |
EP3277276B1 (en) | Methods of administering glutaminase inhibitors | |
CA2888805C (en) | Methods and compositions for promoting axon regeneration and nerve function | |
KR20010086080A (ko) | N-헤테로고리 화합물의 카르복실산 및 카르복실산이소스테르 | |
US20070149526A1 (en) | Diuretic and diuretic-like compound analogs | |
KR20010014279A (ko) | 뮤 오피오이드 화합물의 호흡 저하 및 수반되는 부작용을감소시키기 위한 조성물 및 그 방법 | |
CA2828831C (en) | Compounds and methods for the treatment of pain and other disorders | |
MXPA02011160A (es) | Inhibidores del transporte de fosfato. | |
ES2672777T3 (es) | Métodos de tratamiento de estados con mediación alfa-adrenérgica | |
CA3144062A1 (en) | Compounds, compositions, and methods for protein degradation | |
EP3833354B1 (en) | Tissue transglutaminase modulators for medicinal use | |
KR101255578B1 (ko) | 뇌경색에 연관된 뇌혈관 장애를 치료하는데 유용한피라졸론 화합물 | |
JP5830983B2 (ja) | 抗癌剤の副作用軽減剤 | |
KR20210058586A (ko) | 실데나필 및 rock 저해제를 포함하는 뇌졸중 치료용 약학적 조성물 | |
MX2008004951A (en) | Methods and compositions for the treatment of neuropsychiatric and addictive disorders | |
JP2015166385A (ja) | 疼痛および他の障害の処置のための化合物および方法 | |
JP2017509617A (ja) | 抗異痛活性および抗痛覚過敏活性を有する新規化合物 | |
CZ20004471A3 (cs) | AZA-heterocyklické sloučeniny používané k léčbě neurologických poruch a ztráty vlasů |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |