MX2011007647A - Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes. - Google Patents
Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes.Info
- Publication number
- MX2011007647A MX2011007647A MX2011007647A MX2011007647A MX2011007647A MX 2011007647 A MX2011007647 A MX 2011007647A MX 2011007647 A MX2011007647 A MX 2011007647A MX 2011007647 A MX2011007647 A MX 2011007647A MX 2011007647 A MX2011007647 A MX 2011007647A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- methods
- autoimmune diseases
- treating inflammatory
- molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14611109P | 2009-01-21 | 2009-01-21 | |
| PCT/US2010/021519 WO2010085495A1 (en) | 2009-01-21 | 2010-01-20 | Compositions and methods of treating inflammatory and autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011007647A true MX2011007647A (es) | 2011-09-01 |
Family
ID=42356180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011007647A MX2011007647A (es) | 2009-01-21 | 2010-01-20 | Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes. |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US20110274650A1 (https=) |
| EP (1) | EP2382228B2 (https=) |
| JP (7) | JP5766124B2 (https=) |
| AU (1) | AU2010206840B2 (https=) |
| CA (1) | CA2749539C (https=) |
| ES (1) | ES2825173T3 (https=) |
| MX (1) | MX2011007647A (https=) |
| WO (1) | WO2010085495A1 (https=) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011007647A (es) | 2009-01-21 | 2011-09-01 | Amgen Inc | Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes. |
| CU23923B1 (es) * | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| US9428567B2 (en) | 2010-12-22 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Antagonists of interleukin-2 receptor |
| HUE029139T2 (hu) * | 2011-02-10 | 2017-02-28 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
| ES2811624T3 (es) * | 2011-03-11 | 2021-03-12 | Hopitaux Paris Assist Publique | Régimen de dosificación de IL-2 para tratar lupus eritematoso sistémico |
| KR102220006B1 (ko) | 2011-03-11 | 2021-02-24 | 아시스땅스 퍼블리끄-오삐또 드 빠리 | 자가면역 - 관련 또는 염증성 장애를 치료하기 위한 저용량 il2 의 용도 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US9481866B2 (en) * | 2011-12-16 | 2016-11-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing T cell populations enriched for stable regulatory T-cells |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
| KR102042246B1 (ko) | 2014-02-06 | 2019-11-28 | 에프. 호프만-라 로슈 아게 | 인터류킨-2 융합 단백질 및 이의 용도 |
| WO2015164815A1 (en) * | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| GB2538666A (en) * | 2014-07-21 | 2016-11-23 | Delinia Inc | Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases |
| WO2016025385A1 (en) * | 2014-08-11 | 2016-02-18 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| PH12017501856B1 (en) * | 2015-04-10 | 2022-08-10 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
| MY188430A (en) * | 2015-04-10 | 2021-12-08 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
| US20170204154A1 (en) * | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| KR102687530B1 (ko) * | 2016-05-04 | 2024-07-25 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| CA3019005A1 (en) | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| US11077172B2 (en) | 2016-11-08 | 2021-08-03 | Delinia, Inc. | IL-2 variants for the treatment of psoriasis |
| CN116970059A (zh) | 2016-12-22 | 2023-10-31 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| IL269000B2 (en) | 2017-03-15 | 2024-06-01 | Cue Biopharma Inc | Methods for modulating an immune response |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| AU2018287317B2 (en) | 2017-06-19 | 2024-06-20 | Medicenna Therapeutics Inc. | Uses and methods for IL-2 superagonists, agonists, and fusions thereof |
| AU2018300069C1 (en) | 2017-07-11 | 2025-11-20 | Synthorx, Inc. | Incorporation of unnatural nucleotides and methods thereof |
| WO2019028419A1 (en) * | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES |
| EP3678677A4 (en) * | 2017-09-07 | 2021-06-16 | Cue Biopharma, Inc. | Antigen-presenting polypeptides and methods of use thereof |
| US20200299349A1 (en) | 2017-11-21 | 2020-09-24 | The Board Of Trustees Of The Leland Stanford Junior University | Partial agonists of interleukin-2 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US11319355B2 (en) | 2017-12-19 | 2022-05-03 | Xencor, Inc. | Engineered IL-2 Fc fusion proteins |
| WO2019131964A1 (ja) | 2017-12-27 | 2019-07-04 | 協和発酵キリン株式会社 | Il-2改変体 |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| WO2019158764A1 (en) | 2018-02-16 | 2019-08-22 | Iltoo Pharma | Use of interleukin 2 for treating sjögren's syndrome |
| WO2019173832A2 (en) | 2018-03-09 | 2019-09-12 | AskGene Pharma, Inc. | Novel cytokine prodrugs |
| JP7464530B2 (ja) | 2018-03-28 | 2024-04-09 | ブリストル-マイヤーズ スクイブ カンパニー | インターロイキン-2/インターロイキン-2受容体アルファ融合タンパク質および使用方法 |
| WO2019185705A1 (en) | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Il-2 conjugates |
| WO2020007937A1 (en) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
| US12459980B2 (en) | 2018-07-25 | 2025-11-04 | AskGene Pharma, Inc. | IL-21 prodrugs and methods of use thereof |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| ES3059360T3 (en) | 2018-11-08 | 2026-03-19 | Synthorx Inc | Interleukin 10 conjugates and uses thereof |
| BR112021010983A2 (pt) | 2018-12-21 | 2021-08-31 | Jiangsu Hengrui Medicine Co., Ltd. | Variante de interleucina-2 humana ou seu derivado |
| KR20260039812A (ko) | 2019-02-06 | 2026-03-20 | 신톡스, 인크. | Il-2 콘쥬게이트 및 이의 사용 방법 |
| CN113661175A (zh) | 2019-02-15 | 2021-11-16 | 整体分子公司 | 包含共同轻链的抗体及其用途 |
| EP3924389A4 (en) | 2019-02-15 | 2023-06-14 | Integral Molecular, Inc. | CLAUDIN-6 ANTIBODIES AND THEIR USES |
| AU2020252119B2 (en) * | 2019-03-29 | 2025-09-04 | Centre National De La Recherche Scientifique - Cnrs | Interleukin-2 variants with modified biological activity |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| AU2020287373B2 (en) * | 2019-06-05 | 2026-01-29 | Asher Biotherapeutics, Inc. | Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function |
| KR20220020879A (ko) | 2019-06-12 | 2022-02-21 | 에스크진 파마, 아이엔씨. | 새로운 il-15 프로드럭 및 이를 사용하는 방법 |
| CA3147757A1 (en) | 2019-07-26 | 2021-02-04 | Visterra, Inc. | Interleukin-2 agents and uses thereof |
| AU2020328038B2 (en) | 2019-08-13 | 2025-10-09 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| EP4013777A4 (en) * | 2019-08-15 | 2024-01-17 | Cytimm Therapeutics, Inc. | MODIFIED INTERLEUKIN 2 (IL-2) POLYPEPTIDES, CONJUGATES AND USES THEREOF |
| CN114555632A (zh) | 2019-08-23 | 2022-05-27 | 新索思股份有限公司 | Il-15缀合物及其用途 |
| MX2022002740A (es) | 2019-09-10 | 2022-03-25 | Synthorx Inc | Conjugados de il-2 y metodos de uso para tratar enfermedades autoinmunes. |
| TW202128961A (zh) | 2019-11-20 | 2021-08-01 | 美商安維塔生物科學股份有限公司 | 細胞激素融合蛋白及其醫藥組合物及治療應用 |
| EP4073094A1 (en) | 2019-12-12 | 2022-10-19 | Iltoo Pharma | Interleukin 2 chimeric constructs |
| MX2022007712A (es) | 2019-12-17 | 2022-09-26 | Amgen Inc | Agonista doble de interleucina-2/receptor de tnf para uso en terapia. |
| BR112022012112A2 (pt) | 2019-12-20 | 2022-09-06 | Regeneron Pharma | Agonistas de il2 e métodos de uso dos mesmos |
| US11633488B2 (en) | 2020-01-10 | 2023-04-25 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
| WO2021142471A1 (en) | 2020-01-11 | 2021-07-15 | AskGene Pharma, Inc. | Novel masked cytokines and methods of use thereof |
| EP4090674A4 (en) | 2020-01-14 | 2024-01-24 | Synthekine, Inc. | Biased il2 muteins methods and compositions |
| CN121319219A (zh) * | 2020-01-14 | 2026-01-13 | 辛德凯因股份有限公司 | Il2突变蛋白 |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| AR121891A1 (es) | 2020-04-22 | 2022-07-20 | Merck Sharp & Dohme | CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DÍMERO DEL RECEPTOR DE INTERLEUCINA 2 bgᶜ Y CONJUGADOS CON UN POLÍMERO HIDROSOLUBLE NO PEPTÍDICO |
| US11897930B2 (en) | 2020-04-28 | 2024-02-13 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| TW202208395A (zh) | 2020-05-12 | 2022-03-01 | 美商信號生物製藥公司 | 多聚體t細胞調節多肽及其使用方法 |
| MX2022014082A (es) | 2020-06-03 | 2022-12-07 | Ascendis Pharma Oncology Div A/S | Secuencias de interleucina (il-2) y usos de las mismas. |
| MX2023000734A (es) * | 2020-07-14 | 2023-02-13 | Pfizer | Virus vaccinia recombinante. |
| JP2023540701A (ja) * | 2020-08-28 | 2023-09-26 | アセンディス ファーマ オンコロジー ディヴィジョン エー/エス | グリコシル化il-2タンパク質及びその使用 |
| EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
| EP4232071A4 (en) | 2020-10-23 | 2024-08-28 | Asher Biotherapeutics, Inc. | FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION |
| MX2023005030A (es) | 2020-10-29 | 2023-05-16 | Bristol Myers Squibb Co | Proteinas de fusion para el tratamiento de enfermedades. |
| CN112279906B (zh) * | 2020-10-30 | 2022-09-20 | 浙江新码生物医药有限公司 | 人白细胞介素2-聚乙二醇偶联物及其制备方法与应用 |
| CN116234912A (zh) | 2020-11-13 | 2023-06-06 | 江苏恒瑞医药股份有限公司 | 一种包含人白细胞介素2变体或其衍生物的药物组合物及其用途 |
| EP4255466A1 (en) * | 2020-12-04 | 2023-10-11 | Visterra, Inc. | Methods of using interleukin-2 agents |
| CN116854802A (zh) * | 2021-04-13 | 2023-10-10 | 苏州复融生物技术有限公司 | 白介素2突变体及其应用 |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| WO2023281485A1 (en) * | 2021-07-09 | 2023-01-12 | Bright Peak Therapeutics Ag | Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases |
| US20230201364A1 (en) | 2021-07-09 | 2023-06-29 | Bright Peak Therapeutics Ag | Antibody conjugates and manufacture thereof |
| WO2023005680A1 (zh) | 2021-07-30 | 2023-02-02 | 西安龙腾景云生物科技有限公司 | 一种人白细胞介素2变体及其用途 |
| US20240376172A1 (en) | 2021-10-06 | 2024-11-14 | Iltoo Pharma | Interleukin 2 chimeric constructs with targeting specificy to inflamed tissues |
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| US20250222027A1 (en) | 2022-04-01 | 2025-07-10 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| WO2024056154A1 (en) | 2022-09-12 | 2024-03-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interleukin-2 for use in treating autism spectrum disorder |
| EP4626933A1 (en) | 2022-11-30 | 2025-10-08 | Integral Molecular, Inc. | Antibodies directed to claudin 6, including bispecific formats thereof |
| CN120529914A (zh) | 2023-01-09 | 2025-08-22 | 奥德赛治疗股份有限公司 | 抗tnfr2抗原结合蛋白及其用途 |
| WO2025217240A1 (en) | 2024-04-10 | 2025-10-16 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
| WO2025221954A1 (en) | 2024-04-17 | 2025-10-23 | Visterra, Inc. | Use of il-2 variant for treating kidney transplant rejection |
| WO2026006809A1 (en) | 2024-06-27 | 2026-01-02 | Odyssey Therapeutics, Inc. | Multispecific molecules binding tnfr2 and cd25 and uses thereof |
| EP4707296A1 (en) | 2024-09-05 | 2026-03-11 | Egle Therapeutics | Interleukin-2 variants with modified biological activity |
| EP4707295A1 (en) | 2024-09-05 | 2026-03-11 | Egle Therapeutics | Interleukin-2 variants with modified biological activity |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4470461A (en) | 1982-09-30 | 1984-09-11 | Phillips Petroleum Company | Organic nitro compounds as cosurfactants in enhanced oil recovery processes |
| US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| EP0262802A3 (en) | 1986-09-01 | 1990-01-31 | Takeda Chemical Industries, Ltd. | Medicament for the treatment or improvement of rheumatoid arthritis or systemic lupus erythematosus |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| US5466447A (en) | 1988-06-29 | 1995-11-14 | Amgen Inc. | Method for treating psoriasis |
| AU627477B2 (en) | 1988-07-05 | 1992-08-27 | Amgen, Inc. | Interleukin ii analogs |
| CA2062582C (en) | 1991-03-27 | 1996-03-26 | Tse-Wen Chang | Methods and substances for recruiting therapeutic agents to solid tissues |
| US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6348192B1 (en) | 1999-05-11 | 2002-02-19 | Bayer Corporation | Interleukin-2 mutein expressed from mammalian cells |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| US7371371B2 (en) | 2001-08-13 | 2008-05-13 | University Of Southern California | Interleukin-2 mutants with reduced toxicity |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| AR043504A1 (es) * | 2003-03-17 | 2005-08-03 | Novartis Ag | Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias |
| WO2005007121A2 (en) † | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
| BRPI0508470A (pt) | 2004-03-05 | 2007-07-31 | Chiron Corp | sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos |
| AU2006232374B2 (en) * | 2005-04-01 | 2011-08-25 | University Of Southern California | Preventing rejection of transplanted tissue using regulatory T cells |
| WO2007095643A2 (en) | 2006-02-16 | 2007-08-23 | Nascent Biologics, Inc. | Methods for improving immune function and methods for prevention or treatment of disease in a mammalian subject |
| ES2752137T3 (es) | 2006-02-28 | 2020-04-03 | Biogen Ma Inc | Métodos para tratar enfermedades inflamatorias y autoinmunes con natalizumab |
| CA2656700A1 (en) | 2006-07-06 | 2008-01-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
| JPWO2008004373A1 (ja) | 2006-07-06 | 2009-12-03 | 三菱電機株式会社 | ナビゲーション装置 |
| GB0623539D0 (en) | 2006-11-24 | 2007-01-03 | Avidex Ltd | Polypeptides |
| US20100136030A1 (en) | 2007-02-27 | 2010-06-03 | Lamhamedi-Cherradi Salah-Eddine | Antagonist ox40 antibodies and their use in the treatment of inflammatory and autoimmune diseases |
| JP5431171B2 (ja) | 2007-03-15 | 2014-03-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 自己免疫障害の処置 |
| WO2009061853A2 (en) | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Mutant interleukin-2 (il-2) polypeptides |
| ES2563027T3 (es) | 2008-01-07 | 2016-03-10 | Amgen Inc. | Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática |
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| WO2010017220A1 (en) | 2008-08-04 | 2010-02-11 | The Trustees Of The University Of Pennsylvania | Methods for expanding regulatory t-cells |
| US20110200534A1 (en) | 2008-08-21 | 2011-08-18 | Industry-Academic Cooperation Foundation, Yonsei U | T1-T2 Dual Modal MRI Contrast Agents |
| MX2011007647A (es) | 2009-01-21 | 2011-09-01 | Amgen Inc | Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes. |
| KR102220006B1 (ko) | 2011-03-11 | 2021-02-24 | 아시스땅스 퍼블리끄-오삐또 드 빠리 | 자가면역 - 관련 또는 염증성 장애를 치료하기 위한 저용량 il2 의 용도 |
| EP2686345B1 (en) | 2011-03-16 | 2018-04-25 | Amgen Inc. | Fc variants |
-
2010
- 2010-01-20 MX MX2011007647A patent/MX2011007647A/es active IP Right Grant
- 2010-01-20 US US13/145,537 patent/US20110274650A1/en not_active Abandoned
- 2010-01-20 WO PCT/US2010/021519 patent/WO2010085495A1/en not_active Ceased
- 2010-01-20 AU AU2010206840A patent/AU2010206840B2/en active Active
- 2010-01-20 CA CA2749539A patent/CA2749539C/en active Active
- 2010-01-20 JP JP2011548074A patent/JP5766124B2/ja active Active
- 2010-01-20 ES ES10733814T patent/ES2825173T3/es active Active
- 2010-01-20 EP EP10733814.7A patent/EP2382228B2/en active Active
-
2012
- 2012-11-08 US US13/672,417 patent/US9732134B2/en active Active
-
2014
- 2014-04-15 JP JP2014083388A patent/JP2014133756A/ja not_active Withdrawn
-
2016
- 2016-05-06 JP JP2016092985A patent/JP2016138140A/ja not_active Withdrawn
-
2017
- 2017-07-13 US US15/649,520 patent/US11560415B2/en active Active
-
2018
- 2018-02-26 JP JP2018031926A patent/JP2018087244A/ja not_active Withdrawn
-
2019
- 2019-10-18 JP JP2019191112A patent/JP2020023550A/ja not_active Withdrawn
-
2021
- 2021-09-03 JP JP2021143804A patent/JP2021185191A/ja not_active Withdrawn
-
2022
- 2022-12-20 US US18/068,970 patent/US12297248B2/en active Active
-
2024
- 2024-05-27 JP JP2024085664A patent/JP2024105721A/ja active Pending
-
2025
- 2025-01-17 US US19/028,861 patent/US20250270271A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010085495A1 (en) | 2010-07-29 |
| US9732134B2 (en) | 2017-08-15 |
| EP2382228B2 (en) | 2026-01-07 |
| US11560415B2 (en) | 2023-01-24 |
| AU2010206840B2 (en) | 2015-02-05 |
| JP5766124B2 (ja) | 2015-08-19 |
| AU2010206840A1 (en) | 2011-07-21 |
| JP2014133756A (ja) | 2014-07-24 |
| JP2018087244A (ja) | 2018-06-07 |
| US20250270271A1 (en) | 2025-08-28 |
| US12297248B2 (en) | 2025-05-13 |
| US20110274650A1 (en) | 2011-11-10 |
| US20230139534A1 (en) | 2023-05-04 |
| CA2749539C (en) | 2022-07-19 |
| JP2016138140A (ja) | 2016-08-04 |
| JP2024105721A (ja) | 2024-08-06 |
| CA2749539A1 (en) | 2010-07-29 |
| EP2382228A4 (en) | 2013-01-09 |
| EP2382228B1 (en) | 2020-08-26 |
| JP2021185191A (ja) | 2021-12-09 |
| ES2825173T3 (es) | 2021-05-14 |
| US20130195795A1 (en) | 2013-08-01 |
| EP2382228A1 (en) | 2011-11-02 |
| US20170313753A1 (en) | 2017-11-02 |
| JP2020023550A (ja) | 2020-02-13 |
| JP2012515778A (ja) | 2012-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2011007647A (es) | Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes. | |
| CY1124311T1 (el) | Παρεμποδιστες dna-pk | |
| GT201300209A (es) | Compuestos y composiciones como inhibidores de la trk | |
| ECSP10010475A (es) | Derivados de azetidina y ciclobutano como inhibidores de jak | |
| GT201300128A (es) | Variantes de fc silenciosas de los anticuerpos anti-cd40 | |
| MX2015003140A (es) | Formulaciones de enzalutamida. | |
| UY33597A (es) | Compuestos y composiciones como inhibidores de la trk | |
| MX2011009690A (es) | Métodos y composiciones para trastornos relacionados con la proliferación celurar. | |
| ECSP12012218A (es) | Derivados de piperidin-4-il azetidina como inhibidores de jak1 | |
| CL2010001637A1 (es) | Compuestos derivados de isoindolonas; composición farmacéutica que los comprende; y su uso como inhibidores de la quinasa mek para tratar enfermedades hiperproliferativas y/o inflamatorias tales como cáncer, artritis reumatoidea entre otras. | |
| UY35787A (es) | Composiciones útiles para tratar trastornos relacionados con kit | |
| BR112018000691A2 (pt) | inibidores peptídicos do receptor de interleucina-23 e seu uso para tratar doenças inflamatórias | |
| UY32937A (es) | Compuestos y composiciones como moduladores de la actividad de gpr119 | |
| MX365294B (es) | Inhibidores de proteína cinasa dependiente de adn. | |
| EA201300730A1 (ru) | Производные индазолилтриазола | |
| UY34545A (es) | Novedosas dihidropirimidinoisoquinolinonas y composiciones farmacéuticas de las mismas para el tratamiento de trastornos inflamatorios. | |
| EA201590850A1 (ru) | Трициклические конденсированные производные тиофена как ингибиторы jak | |
| EA201270100A1 (ru) | Пиримидиноны в качестве ингибиторов pi3k | |
| CR11818A (es) | Derivados de triazol utiles para el tratamiento de enfermedades | |
| EA201491215A1 (ru) | Несиалированные противовоспалительные полипептиды | |
| UY33616A (es) | Compuestos con estructura de imidazotriazinona | |
| EA201101686A1 (ru) | Новые композиции для лечения шмт и связанных с ней расстройств | |
| GT201200171A (es) | Derivados de fenilimidazol heteroaromáticos como inhibidores de enzima pde10a | |
| PT2501234T (pt) | Métodos e composições para o tratamento de sintomas associados com distúrbios de stress pós-traumático utilizando ciclobenzaprina | |
| EA201391440A1 (ru) | Производные пиразолопиримидина |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |