MX2010008637A - Derivado de fenilpirrol novedoso. - Google Patents
Derivado de fenilpirrol novedoso.Info
- Publication number
- MX2010008637A MX2010008637A MX2010008637A MX2010008637A MX2010008637A MX 2010008637 A MX2010008637 A MX 2010008637A MX 2010008637 A MX2010008637 A MX 2010008637A MX 2010008637 A MX2010008637 A MX 2010008637A MX 2010008637 A MX2010008637 A MX 2010008637A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- groups
- mono
- alkyl
- substituted independently
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
La presente invención se refiere a un compuesto que tiene una actividad activadora de glucocinasa superior y está representado por la fórmula general (I), y las sales farmacológicamente aceptables del mismo: (ver fórmula (I)) [en donde: A representa, por ejemplo, un átomo de oxigeno o un átomo de azufre, R1 representa, por ejemplo, un grupo alquilo de C1-C6, un grupo alcoxi de C1-C6 o un grupo alquilo de C1-C6 halogenado, A y R1 junto con el átomo de carbono al que están unidos forman un grupo heterocíclico que puede estar sustituido con 1 a 3 grupos seleccionados independientemente del conjunto de sustituyentes a, R2 representa un grupo fenilo que puede estar sustituido con 1 a 5 grupos seleccionados independientemente del conjunto de sustituyentes a, o un grupo heterocíclico que puede estar sustituido con 1 a 3 grupos seleccionados independientemente del conjunto de sustituyentes a, R3 representa un grupo hidroxi o un grupo alcoxi de C1-C6, y el conjunto de sustituyentes a consiste, por ejemplo, en un átomo de halógeno, un grupo alquilo de C1-C6, un grupo alquilo de C1-C6 sustituido con 1 o 2 grupos hidroxi, un grupo alquilsulfonhlo de C1-C6 y un grupo representado por la fórmula -V-NR5R6 (en donde V representa un grupo carbonilo o un grupo sulfonilo, y R5 y R6 pueden ser iguales o diferentes entre sí y representan respectivamente un átomo de hidrógeno o un grupo alquilo de C1-C6, o R5 y R6, junto con el átomo de nitrógeno al que están unidos, forman un heterociclo saturado de 4 a 6 miembros que puede estar sustituido con 1 o 2 grupos seleccionados independientemente de un grupo alquilo de C1-C6 y un grupo hidroxi, y el heterociclo saturado de 4 a 6 miembros también puede contener un átomo de oxígeno o un átomo de nitrógeno)].
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008026519 | 2008-02-06 | ||
JP2008314479 | 2008-12-10 | ||
PCT/JP2009/051834 WO2009099080A1 (ja) | 2008-02-06 | 2009-02-04 | 新規フェニルピロール誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010008637A true MX2010008637A (es) | 2010-08-30 |
Family
ID=40952154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010008637A MX2010008637A (es) | 2008-02-06 | 2009-02-04 | Derivado de fenilpirrol novedoso. |
Country Status (21)
Country | Link |
---|---|
US (2) | US8017610B2 (es) |
EP (1) | EP2239253B1 (es) |
JP (2) | JP4503101B2 (es) |
KR (1) | KR20100118979A (es) |
CN (1) | CN102015637B (es) |
AU (1) | AU2009211718B2 (es) |
BR (1) | BRPI0908124A2 (es) |
CA (1) | CA2715143C (es) |
CO (1) | CO6331462A2 (es) |
DK (1) | DK2239253T3 (es) |
ES (1) | ES2425190T3 (es) |
HK (1) | HK1148740A1 (es) |
IL (1) | IL207372A0 (es) |
MX (1) | MX2010008637A (es) |
MY (1) | MY150269A (es) |
NZ (1) | NZ587126A (es) |
PL (1) | PL2239253T3 (es) |
PT (1) | PT2239253E (es) |
RU (1) | RU2470917C2 (es) |
TW (1) | TWI432429B (es) |
WO (1) | WO2009099080A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010082601A1 (ja) * | 2009-01-16 | 2010-07-22 | 第一三共株式会社 | 新規2,5-二置換ピロール誘導体 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011122458A1 (ja) * | 2010-03-29 | 2011-10-06 | 第一三共株式会社 | 含窒素芳香環化合物 |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201247659A (en) * | 2011-04-27 | 2012-12-01 | Daiichi Sankyo Co Ltd | Crystals of phenylpyrrole derivatives |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2018019758A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
WO2018019770A1 (en) | 2016-07-28 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
EP3275877A1 (en) | 2016-07-28 | 2018-01-31 | Basf Se | Herbicidal pyridine compounds |
TWI826531B (zh) | 2018-09-21 | 2023-12-21 | 南韓商愛思開生物製藥股份有限公司 | 具有㗁二唑之化合物及包含該化合物之醫藥組合物 |
CN112142716B (zh) * | 2020-10-29 | 2021-08-31 | 山东新时代药业有限公司 | 一种5元杂芳基取代的吡嗪衍生物及其应用 |
CN112707898A (zh) * | 2020-12-21 | 2021-04-27 | 徐新杰 | 一种杂芳基取代的吡嗪衍生物及其应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6320050B1 (en) | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
EP1169312B1 (en) | 1999-03-29 | 2004-10-06 | F. Hoffmann-La Roche Ag | Glucokinase activators |
JP4419571B2 (ja) | 2002-03-26 | 2010-02-24 | 萬有製薬株式会社 | 新規アミノベンズアミド誘導体 |
CA2516407C (en) | 2003-02-26 | 2013-07-09 | Banyu Pharmaceutical Co., Ltd. | Heteroarylcarbamoylbenzene derivatives |
GB0325402D0 (en) * | 2003-10-31 | 2003-12-03 | Astrazeneca Ab | Compounds |
JP4707560B2 (ja) * | 2003-12-29 | 2011-06-22 | Msd株式会社 | 新規2−ヘテロアリール置換ベンズイミダゾール誘導体 |
CA2551324C (en) | 2004-01-06 | 2012-11-27 | Novo Nordisk A/S | Heteroaryl-ureas and their use as glucokinase activators |
WO2005080359A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
GB0403593D0 (en) * | 2004-02-18 | 2004-03-24 | Astrazeneca Ab | Compounds |
EP1734040A4 (en) | 2004-03-23 | 2007-11-28 | Banyu Pharma Co Ltd | SUBSTITUTED CHINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE |
CN1950361A (zh) | 2004-05-10 | 2007-04-18 | 霍夫曼-拉罗奇有限公司 | 用于治疗肥胖的吡咯或咪唑酰胺化合物 |
US20090264650A1 (en) * | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
WO2006112549A1 (ja) | 2005-04-20 | 2006-10-26 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物 |
EP1889842A4 (en) * | 2005-06-08 | 2009-07-29 | Japan Tobacco Inc | HETEROCYCLIC CONNECTION |
CA2613303C (en) | 2005-07-11 | 2012-06-19 | Mitsubishi Tanabe Pharma Corporation | An oxime derivative for use as a glucokinase activator |
WO2007031739A1 (en) | 2005-09-16 | 2007-03-22 | Astrazeneca Ab | Heterobicyclic compounds as glucokinase activators |
CA2623958C (en) | 2005-09-30 | 2013-05-28 | Banyu Pharmaceutical Co., Ltd. | 2-heteroaryl-substituted indole derivative |
CN101321747A (zh) | 2005-11-01 | 2008-12-10 | 詹森药业有限公司 | 作为葡萄糖激酶变构调节剂的取代的环烷基吡咯酮类 |
CA2628259A1 (en) | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Dihydroisoindolones as allosteric modulators of glucokinase |
JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
MY148985A (en) | 2006-03-24 | 2013-06-28 | Array Biopharma Inc | 2-aminopyridine analogs as glucokinase activators |
EP2149550A4 (en) | 2007-04-27 | 2010-08-11 | Takeda Pharmaceutical | HETEROCYCLIC COMPOUND WITH FIVE NITROGEN CHAINS |
-
2009
- 2009-02-04 PL PL09708422T patent/PL2239253T3/pl unknown
- 2009-02-04 MY MYPI2010003478A patent/MY150269A/en unknown
- 2009-02-04 CA CA2715143A patent/CA2715143C/en not_active Expired - Fee Related
- 2009-02-04 AU AU2009211718A patent/AU2009211718B2/en not_active Ceased
- 2009-02-04 WO PCT/JP2009/051834 patent/WO2009099080A1/ja active Application Filing
- 2009-02-04 BR BRPI0908124-0A patent/BRPI0908124A2/pt not_active IP Right Cessation
- 2009-02-04 ES ES09708422T patent/ES2425190T3/es active Active
- 2009-02-04 PT PT97084222T patent/PT2239253E/pt unknown
- 2009-02-04 MX MX2010008637A patent/MX2010008637A/es active IP Right Grant
- 2009-02-04 NZ NZ587126A patent/NZ587126A/en not_active IP Right Cessation
- 2009-02-04 RU RU2010136953/04A patent/RU2470917C2/ru not_active IP Right Cessation
- 2009-02-04 JP JP2009552480A patent/JP4503101B2/ja not_active Expired - Fee Related
- 2009-02-04 EP EP09708422.2A patent/EP2239253B1/en not_active Not-in-force
- 2009-02-04 DK DK09708422.2T patent/DK2239253T3/da active
- 2009-02-04 KR KR1020107017370A patent/KR20100118979A/ko active IP Right Grant
- 2009-02-04 CN CN200980112177.8A patent/CN102015637B/zh not_active Expired - Fee Related
- 2009-02-05 TW TW098103602A patent/TWI432429B/zh not_active IP Right Cessation
-
2010
- 2010-03-11 JP JP2010053934A patent/JP5074545B2/ja not_active Expired - Fee Related
- 2010-07-26 US US12/843,348 patent/US8017610B2/en not_active Expired - Fee Related
- 2010-08-03 IL IL207372A patent/IL207372A0/en unknown
- 2010-09-03 CO CO10109309A patent/CO6331462A2/es active IP Right Grant
-
2011
- 2011-03-22 HK HK11102874.4A patent/HK1148740A1/xx not_active IP Right Cessation
- 2011-08-05 US US13/198,819 patent/US8415359B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20100118979A (ko) | 2010-11-08 |
AU2009211718A1 (en) | 2009-08-13 |
DK2239253T3 (da) | 2013-09-23 |
JPWO2009099080A1 (ja) | 2011-05-26 |
CA2715143A1 (en) | 2009-08-13 |
CO6331462A2 (es) | 2011-10-20 |
US20110003787A1 (en) | 2011-01-06 |
IL207372A0 (en) | 2010-12-30 |
CN102015637A (zh) | 2011-04-13 |
PL2239253T3 (pl) | 2013-11-29 |
AU2009211718B2 (en) | 2011-08-11 |
US20120022075A1 (en) | 2012-01-26 |
EP2239253B1 (en) | 2013-06-19 |
CN102015637B (zh) | 2014-05-21 |
EP2239253A1 (en) | 2010-10-13 |
HK1148740A1 (en) | 2011-09-16 |
US8415359B2 (en) | 2013-04-09 |
ES2425190T3 (es) | 2013-10-14 |
JP5074545B2 (ja) | 2012-11-14 |
TWI432429B (zh) | 2014-04-01 |
JP2010163449A (ja) | 2010-07-29 |
RU2470917C2 (ru) | 2012-12-27 |
NZ587126A (en) | 2011-12-22 |
CA2715143C (en) | 2013-04-02 |
BRPI0908124A2 (pt) | 2015-08-04 |
MY150269A (en) | 2013-12-31 |
WO2009099080A1 (ja) | 2009-08-13 |
EP2239253A4 (en) | 2011-02-23 |
PT2239253E (pt) | 2013-09-17 |
US8017610B2 (en) | 2011-09-13 |
TW200938539A (en) | 2009-09-16 |
RU2010136953A (ru) | 2012-03-20 |
JP4503101B2 (ja) | 2010-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2010008637A (es) | Derivado de fenilpirrol novedoso. | |
MX2009004920A (es) | Nuevos derivados de aminopirimidina como inhibidores de plk1. | |
MX2012015023A (es) | Derivado novedoso de nicotinamida o sal del mismo. | |
WO2008108378A3 (en) | Bicyclic oxomorpholine derivative | |
MX2011008305A (es) | Compuestos de piridazinona. | |
MY152972A (en) | Azabicyclo compound and salt thereof | |
MX2009010024A (es) | Nuevo compuesto de adenina. | |
MX2009002802A (es) | Derivados de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparacion y su aplicacion en terapeutica. | |
TNSN08372A1 (en) | Heterocyclic amides for use as pharmaceuticals | |
MX2010013275A (es) | Compuesto novedoso de uracilo o su sal que tiene actividad inhibidora de desoxiuridin trifosfatasa de humano. | |
WO2008108386A1 (ja) | 医薬組成物 | |
EA200870336A1 (ru) | Полициклические производные циннамида | |
TN2009000287A1 (en) | Cyclized derivatives as eg-5inhibitors | |
ATE404536T1 (de) | Substituierte chinolinderivate als inhibitoren von mitotischem kinesin | |
TN2011000422A1 (en) | Benzofuran derivatives | |
TW200716531A (en) | Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia | |
RS53679B1 (en) | FURAZANOBENZIMIDAZOLES AS PROGRAMS FOR THE TREATMENT OF NEOPLASTIC OR AUTOIMMUNE DISEASES | |
MY169179A (en) | Novel piperidine compound or salt thereof | |
WO2008126901A1 (ja) | 含窒素複素環化合物およびそれを含有する医薬組成物 | |
IN2012DN00770A (es) | ||
EA200900616A1 (ru) | Ингибиторы ikk-бета серин-треонин протеинкиназы | |
IN2012DN00768A (es) | ||
ES2439793T3 (es) | Compuestos de pirimidina, su uso como inhibidores de la mTOR quinasa y de la PI3 quinasa, y su síntesis | |
WO2007082262A3 (en) | Novel compounds | |
MX2010010471A (es) | Derivado de tetrahidroisoquinolina novedoso. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |