MX2010003333A - Sal de amina organica de 6-fluoro-3-hidroxi-2-pirazincarbonitrilo y metodo para su produccion. - Google Patents

Sal de amina organica de 6-fluoro-3-hidroxi-2-pirazincarbonitrilo y metodo para su produccion.

Info

Publication number
MX2010003333A
MX2010003333A MX2010003333A MX2010003333A MX2010003333A MX 2010003333 A MX2010003333 A MX 2010003333A MX 2010003333 A MX2010003333 A MX 2010003333A MX 2010003333 A MX2010003333 A MX 2010003333A MX 2010003333 A MX2010003333 A MX 2010003333A
Authority
MX
Mexico
Prior art keywords
fluoro
hydroxy
pyrazinecarbonitrile
organic amine
amine salt
Prior art date
Application number
MX2010003333A
Other languages
English (en)
Inventor
Kenji Yonezawa
Tamotsu Takamatsu
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of MX2010003333A publication Critical patent/MX2010003333A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se revela una sal de amina org?nica de 6-fluoro-3- hidroxi-2-pirazincarbonitrilo, que es excelente en cristalinidad y es ?til como un producto intermedio para la fabricaci?n de 6-fluoro-3-hidroxi-2- pirazincarboxamida.
MX2010003333A 2007-09-27 2008-09-25 Sal de amina organica de 6-fluoro-3-hidroxi-2-pirazincarbonitrilo y metodo para su produccion. MX2010003333A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007251191 2007-09-27
PCT/JP2008/067251 WO2009041473A1 (ja) 2007-09-27 2008-09-25 ６－フルオロ－３－ヒドロキシ－２－ピラジンカルボニトリルの有機アミン塩およびその製造法

Publications (1)

Publication Number Publication Date
MX2010003333A true MX2010003333A (es) 2010-04-09

Family

ID=40511356

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003333A MX2010003333A (es) 2007-09-27 2008-09-25 Sal de amina organica de 6-fluoro-3-hidroxi-2-pirazincarbonitrilo y metodo para su produccion.

Country Status (21)

Country Link
US (1) US8168789B2 (es)
EP (1) EP2192117B1 (es)
JP (1) JP5550347B2 (es)
KR (2) KR101686813B1 (es)
CN (2) CN104672153B (es)
AU (1) AU2008304956B2 (es)
BR (1) BRPI0817305B1 (es)
CA (1) CA2700490C (es)
CY (1) CY1115218T1 (es)
DK (1) DK2192117T3 (es)
ES (1) ES2470740T3 (es)
HR (1) HRP20140837T1 (es)
IL (1) IL204516A (es)
MX (1) MX2010003333A (es)
NZ (1) NZ584157A (es)
PL (1) PL2192117T3 (es)
PT (1) PT2192117E (es)
RU (1) RU2470924C2 (es)
SI (1) SI2192117T1 (es)
WO (1) WO2009041473A1 (es)
ZA (1) ZA201002001B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2623497B1 (en) * 2010-09-30 2016-01-20 Toyama Chemical Co., Ltd. Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
JPWO2012043700A1 (ja) * 2010-09-30 2014-02-24 富山化学工業株式会社 ６−フルオロ−３−ヒドロキシ−２−ピラジンカルボキサミドのナトリウム塩
WO2012063931A1 (ja) * 2010-11-12 2012-05-18 富士フイルム株式会社 ピラジノ〔２，３－ｄ〕イソオキサゾール誘導体
CN104496917B (zh) * 2014-12-15 2017-06-20 南京华威医药科技开发有限公司 一种法匹拉韦的合成方法
CN107635976A (zh) 2015-06-09 2018-01-26 富山化学工业株式会社 6‑溴‑3‑羟基‑2‑吡嗪甲酰胺的结晶及其制造方法
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
WO2021260516A1 (en) * 2020-06-22 2021-12-30 Pi Industries Ltd. An organic amine salt of favipiravir and a process for the purification of favipiravir
KR20230034848A (ko) * 2020-07-06 2023-03-10 옵티머스 드럭스 (피) 엘티디 파비피라비르의 합성
CN112645889A (zh) * 2020-12-24 2021-04-13 杭州煌森生物科技有限公司 一种法匹拉韦的精制方法
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB879259A (en) 1956-11-20 1961-10-11 Riker Laboratories Inc Acid addition salts of 2-dimethylaminoethanol and central nervous system stimulant compositions containing them
CZ282939B6 (cs) * 1992-03-04 1997-11-12 Lonza A.G. Mikrobiologický způsob hydroxylace dusíkatých heterocyklických karboxylových kyselin
ATE294185T1 (de) * 2000-02-16 2005-05-15 Toyama Chemical Co Ltd Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediäre zur herstellung der derivate
RU2297414C2 (ru) * 2001-02-14 2007-04-20 Тояма Кемикал Ко., Лтд. Производные пиразина или их соли, фармацевтическая композиция, содержащая данные соединения, и промежуточные соединения для их получения
JP4398631B2 (ja) * 2002-07-12 2010-01-13 富山化学工業株式会社 新規なピラジン誘導体またはその塩並びにそれらを含有する抗ウイルス剤
GB0407908D0 (en) 2004-04-07 2004-05-12 Univ York Ionic liquids

Also Published As

Publication number Publication date
EP2192117B1 (en) 2014-06-04
ZA201002001B (en) 2011-05-25
ES2470740T3 (es) 2014-06-24
EP2192117A4 (en) 2011-04-20
WO2009041473A1 (ja) 2009-04-02
NZ584157A (en) 2012-04-27
US20100286394A1 (en) 2010-11-11
BRPI0817305A2 (pt) 2015-03-17
IL204516A (en) 2014-02-27
CA2700490C (en) 2015-10-27
IL204516A0 (en) 2010-11-30
KR101574567B1 (ko) 2015-12-07
CN101809003A (zh) 2010-08-18
AU2008304956B2 (en) 2013-05-16
CN104672153B (zh) 2019-04-23
PT2192117E (pt) 2014-07-09
KR20150100958A (ko) 2015-09-02
CY1115218T1 (el) 2017-01-04
BRPI0817305B1 (pt) 2021-10-19
DK2192117T3 (da) 2014-06-30
RU2010116390A (ru) 2011-11-10
RU2470924C2 (ru) 2012-12-27
JPWO2009041473A1 (ja) 2011-01-27
AU2008304956A1 (en) 2009-04-02
CA2700490A1 (en) 2009-04-02
SI2192117T1 (sl) 2014-10-30
EP2192117A1 (en) 2010-06-02
PL2192117T3 (pl) 2014-10-31
JP5550347B2 (ja) 2014-07-16
KR101686813B1 (ko) 2016-12-16
US8168789B2 (en) 2012-05-01
KR20100061701A (ko) 2010-06-08
CN104672153A (zh) 2015-06-03
HRP20140837T1 (hr) 2014-10-10

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