CY1115218T1 - Αλας οργανικης αμινης 6-φθορο-3-υδροξυ-2-πυραζινοκαρβονιτριλιου και μεθοδος για την παραγωγη αυτου - Google Patents

Αλας οργανικης αμινης 6-φθορο-3-υδροξυ-2-πυραζινοκαρβονιτριλιου και μεθοδος για την παραγωγη αυτου

Info

Publication number
CY1115218T1
CY1115218T1 CY20141100481T CY141100481T CY1115218T1 CY 1115218 T1 CY1115218 T1 CY 1115218T1 CY 20141100481 T CY20141100481 T CY 20141100481T CY 141100481 T CY141100481 T CY 141100481T CY 1115218 T1 CY1115218 T1 CY 1115218T1
Authority
CY
Cyprus
Prior art keywords
fluoro
hydroxy
production
organic amine
salt
Prior art date
Application number
CY20141100481T
Other languages
English (en)
Inventor
Tamotsu Takamatsu
Kenji Yonezawa
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of CY1115218T1 publication Critical patent/CY1115218T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Εδώ αποκαλύπτεται ένα άλας οργανικής αμίνης 6-φθορο-3-υδροξυ-2-πυραζινοκαρβονιτριλίου, το οποίο είναι εξαιρετικό σε κρυσταλλικότητα και χρήσιμο ως ένα ενδιάμεσο παραγωγής για το 6-φθορο-3-υδροξυ-2-πυραζινοκαρβοξαμίδιο.
CY20141100481T 2007-09-27 2014-07-01 Αλας οργανικης αμινης 6-φθορο-3-υδροξυ-2-πυραζινοκαρβονιτριλιου και μεθοδος για την παραγωγη αυτου CY1115218T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007251191 2007-09-27
EP08832816.6A EP2192117B1 (en) 2007-09-27 2008-09-25 Organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile and method for producing the same

Publications (1)

Publication Number Publication Date
CY1115218T1 true CY1115218T1 (el) 2017-01-04

Family

ID=40511356

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100481T CY1115218T1 (el) 2007-09-27 2014-07-01 Αλας οργανικης αμινης 6-φθορο-3-υδροξυ-2-πυραζινοκαρβονιτριλιου και μεθοδος για την παραγωγη αυτου

Country Status (21)

Country Link
US (1) US8168789B2 (el)
EP (1) EP2192117B1 (el)
JP (1) JP5550347B2 (el)
KR (2) KR101574567B1 (el)
CN (2) CN104672153B (el)
AU (1) AU2008304956B2 (el)
BR (1) BRPI0817305B1 (el)
CA (1) CA2700490C (el)
CY (1) CY1115218T1 (el)
DK (1) DK2192117T3 (el)
ES (1) ES2470740T3 (el)
HR (1) HRP20140837T1 (el)
IL (1) IL204516A (el)
MX (1) MX2010003333A (el)
NZ (1) NZ584157A (el)
PL (1) PL2192117T3 (el)
PT (1) PT2192117E (el)
RU (1) RU2470924C2 (el)
SI (1) SI2192117T1 (el)
WO (1) WO2009041473A1 (el)
ZA (1) ZA201002001B (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY161757A (en) * 2010-09-30 2017-05-15 Toyama Chemical Co Ltd Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
JPWO2012043700A1 (ja) * 2010-09-30 2014-02-24 富山化学工業株式会社 ６−フルオロ−３−ヒドロキシ−２−ピラジンカルボキサミドのナトリウム塩
CN103347884B (zh) 2010-11-12 2015-12-02 富士胶片株式会社 吡嗪并[2,3-d]异*唑衍生物
CN104496917B (zh) * 2014-12-15 2017-06-20 南京华威医药科技开发有限公司 一种法匹拉韦的合成方法
EP3309149B1 (en) 2015-06-09 2021-04-07 FUJIFILM Toyama Chemical Co., Ltd. 6-bromo-3-hydroxy-2-pyrazinecarboxamide crystal and method for producing same
CN107641106A (zh) * 2016-07-22 2018-01-30 大连鸿凯化工科技发展有限公司 法匹拉韦中间体以及法匹拉韦的合成方法
CN113248450B (zh) * 2020-02-07 2024-04-12 北京四环制药有限公司 一种法匹拉韦的制备方法
WO2021260516A1 (en) * 2020-06-22 2021-12-30 Pi Industries Ltd. An organic amine salt of favipiravir and a process for the purification of favipiravir
WO2022009036A1 (en) * 2020-07-06 2022-01-13 Optimus Drugs (P) Ltd Synthesis of favipiravir
CN112645889A (zh) * 2020-12-24 2021-04-13 杭州煌森生物科技有限公司 一种法匹拉韦的精制方法
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB879259A (en) 1956-11-20 1961-10-11 Riker Laboratories Inc Acid addition salts of 2-dimethylaminoethanol and central nervous system stimulant compositions containing them
CZ282939B6 (cs) * 1992-03-04 1997-11-12 Lonza A.G. Mikrobiologický způsob hydroxylace dusíkatých heterocyklických karboxylových kyselin
BRPI0116967B8 (pt) * 2000-02-16 2021-05-25 Fujifilm Toyama Chemical Co Ltd derivado de pirazina ou um sal deste, composição farmacêutica, e, derivado de fluoropirazina ou um sal deste
RU2297414C2 (ru) * 2001-02-14 2007-04-20 Тояма Кемикал Ко., Лтд. Производные пиразина или их соли, фармацевтическая композиция, содержащая данные соединения, и промежуточные соединения для их получения
JP4398631B2 (ja) * 2002-07-12 2010-01-13 富山化学工業株式会社 新規なピラジン誘導体またはその塩並びにそれらを含有する抗ウイルス剤
GB0407908D0 (en) 2004-04-07 2004-05-12 Univ York Ionic liquids

Also Published As

Publication number Publication date
EP2192117A4 (en) 2011-04-20
HRP20140837T1 (hr) 2014-10-10
KR20150100958A (ko) 2015-09-02
ES2470740T3 (es) 2014-06-24
CA2700490C (en) 2015-10-27
EP2192117A1 (en) 2010-06-02
RU2470924C2 (ru) 2012-12-27
RU2010116390A (ru) 2011-11-10
JP5550347B2 (ja) 2014-07-16
BRPI0817305A2 (pt) 2015-03-17
CN101809003A (zh) 2010-08-18
DK2192117T3 (da) 2014-06-30
IL204516A (en) 2014-02-27
WO2009041473A1 (ja) 2009-04-02
AU2008304956B2 (en) 2013-05-16
CN104672153B (zh) 2019-04-23
ZA201002001B (en) 2011-05-25
KR101686813B1 (ko) 2016-12-16
MX2010003333A (es) 2010-04-09
PT2192117E (pt) 2014-07-09
IL204516A0 (en) 2010-11-30
KR101574567B1 (ko) 2015-12-07
US20100286394A1 (en) 2010-11-11
BRPI0817305B1 (pt) 2021-10-19
NZ584157A (en) 2012-04-27
PL2192117T3 (pl) 2014-10-31
EP2192117B1 (en) 2014-06-04
CN104672153A (zh) 2015-06-03
US8168789B2 (en) 2012-05-01
SI2192117T1 (sl) 2014-10-30
AU2008304956A1 (en) 2009-04-02
KR20100061701A (ko) 2010-06-08
CA2700490A1 (en) 2009-04-02
JPWO2009041473A1 (ja) 2011-01-27

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