MX2010003315A - Derivados de benzoquinona e3330 en combinacion con agentes quimioterapeuticos para el tratamiento de cancer y angiogenesis. - Google Patents
Derivados de benzoquinona e3330 en combinacion con agentes quimioterapeuticos para el tratamiento de cancer y angiogenesis.Info
- Publication number
- MX2010003315A MX2010003315A MX2010003315A MX2010003315A MX2010003315A MX 2010003315 A MX2010003315 A MX 2010003315A MX 2010003315 A MX2010003315 A MX 2010003315A MX 2010003315 A MX2010003315 A MX 2010003315A MX 2010003315 A MX2010003315 A MX 2010003315A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- angiogenesis
- apel
- ref
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 230000033115 angiogenesis Effects 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 4
- 230000036952 cancer formation Effects 0.000 title abstract 2
- 150000004057 1,4-benzoquinones Chemical class 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- 101150059062 apln gene Proteins 0.000 abstract 4
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 108091023040 Transcription factor Proteins 0.000 abstract 1
- 102000040945 Transcription factor Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000004565 tumor cell growth Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Ophthalmology & Optometry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describen nuevos métodos para el tratamiento terapéutico de cáncer y angiogénesis. La enzima Apel/Ref-1, mediante su función de reducción-oxidación mejora la actividad de unión a DNA de factores de transcripción que están asociados con el progreso de cáncer. La presente invención describe el uso de agentes para inhibir de manera selectiva la función de reducción-oxidación de Apel/Ref-1 y reducir de este modo el crecimiento, supervivencia, migración y metástasis de células tumorales. Además, se muestra que la actividad inhibitoria de Apel/Ref-1 aumenta los efectos terapéuticos de otros productos terapéuticos y protege a las células normales contra la toxicidad. Además, se muestra que la inhibición de Apel/Ref-1 disminuye la angiogénesis, para el uso en el tratamiento de cáncer así como otras condiciones patológicas de las cuales es un componente la angiogénesis alterada.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97539607P | 2007-09-26 | 2007-09-26 | |
US98956607P | 2007-11-21 | 2007-11-21 | |
PCT/US2008/077210 WO2009042542A1 (en) | 2007-09-26 | 2008-09-22 | Benzoquinone derivative e3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010003315A true MX2010003315A (es) | 2011-03-15 |
Family
ID=39951652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010003315A MX2010003315A (es) | 2007-09-26 | 2008-09-22 | Derivados de benzoquinona e3330 en combinacion con agentes quimioterapeuticos para el tratamiento de cancer y angiogenesis. |
Country Status (13)
Country | Link |
---|---|
US (6) | US9040505B2 (es) |
EP (4) | EP3299015A1 (es) |
JP (4) | JP5646327B2 (es) |
KR (2) | KR101689796B1 (es) |
AU (5) | AU2008304619C1 (es) |
BR (1) | BRPI0817293A2 (es) |
CA (2) | CA2700365C (es) |
ES (2) | ES2675951T3 (es) |
IL (1) | IL204675A0 (es) |
MX (1) | MX2010003315A (es) |
RU (1) | RU2510270C2 (es) |
WO (2) | WO2009042544A1 (es) |
ZA (1) | ZA201002246B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
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MX2010003315A (es) * | 2007-09-26 | 2011-03-15 | Univ Indiana Res & Tech Corp | Derivados de benzoquinona e3330 en combinacion con agentes quimioterapeuticos para el tratamiento de cancer y angiogenesis. |
US11331294B2 (en) | 2007-09-26 | 2022-05-17 | Indiana University Research And Technology Corporation | Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of bladder cancer |
CN103298949A (zh) | 2010-10-29 | 2013-09-11 | 生命科技公司 | 生物素衍生物 |
WO2012145653A2 (en) * | 2011-04-22 | 2012-10-26 | University Of Florida Research Foundation Inc. | Therapeutic combinations for use in neoplasia |
RU2013152626A (ru) * | 2011-05-26 | 2015-07-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | ХИНОНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, ОПОСРЕДУЕМЫХ Ape1 |
US20140128398A1 (en) | 2011-06-03 | 2014-05-08 | Indiana University Research And Technology Corporation | Compounds, compositions and methods for treating oxidative dna damage disorders |
WO2013021953A1 (ja) * | 2011-08-05 | 2013-02-14 | 帝人株式会社 | 縮合多環芳香族化合物、芳香族重合体、及び芳香族化合物の合成方法 |
US9624235B2 (en) * | 2012-01-31 | 2017-04-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compounds and methods for inhibition of AP endonuclease-1/redox factor-1 (HAPE1) activity |
EP2825162B1 (en) | 2012-03-14 | 2018-09-12 | Indiana University Research and Technology Corporation | Compounds and methods for treating leukemia |
CN104470957B (zh) | 2012-05-30 | 2016-11-16 | 日本瑞翁株式会社 | 聚合性化合物、聚合性组合物、高分子、以及光学各向异性体 |
WO2014010325A1 (ja) | 2012-07-09 | 2014-01-16 | 日本ゼオン株式会社 | 重合性化合物、重合性組成物、高分子、光学異方体、及び重合性化合物の製造方法 |
US9995865B2 (en) | 2012-10-22 | 2018-06-12 | Zeon Corporation | Phase difference plate, circularly polarizing plate, and image display device |
WO2015025793A1 (ja) | 2013-08-22 | 2015-02-26 | 日本ゼオン株式会社 | 重合性化合物、重合性組成物、高分子、及び光学異方体 |
KR102315630B1 (ko) | 2013-10-31 | 2021-10-20 | 제온 코포레이션 | 중합성 화합물, 중합성 조성물, 고분자, 및 광학 이방체 |
KR101612097B1 (ko) | 2015-01-07 | 2016-04-12 | 충남대학교산학협력단 | 아세틸화된 산화환원조절단백-1의 제조방법 및 이를 함유하는 유방암 예방 및 치료용 조성물 |
KR102626269B1 (ko) | 2015-03-19 | 2024-01-16 | 니폰 제온 가부시키가이샤 | 액정성 조성물, 위상차층의 제조 방법 및 원편광판 |
CA2986248C (en) * | 2015-05-21 | 2023-09-26 | Indiana University Research & Technology Corporation | Methods of targeting ape1/ref-1 to inhibit hypoxia signaling genes |
JP6975040B2 (ja) | 2015-05-28 | 2021-12-01 | 日本ゼオン株式会社 | 円偏光分離フィルムの製造方法 |
KR20170052345A (ko) * | 2015-11-04 | 2017-05-12 | 충남대학교산학협력단 | 환원형 산화환원조절단백-1를 함유하는 염증 예방 및 치료용 약학 조성물 |
JPWO2017110638A1 (ja) | 2015-12-22 | 2018-10-11 | 日本ゼオン株式会社 | 液晶性組成物、液晶硬化層及びその製造方法、並びに、光学フィルム |
JP7052718B2 (ja) | 2016-03-08 | 2022-04-12 | 日本ゼオン株式会社 | 液晶性組成物、液晶硬化層及びその液晶硬化層の製造方法 |
WO2018140286A1 (en) * | 2017-01-25 | 2018-08-02 | Indiana University Research And Technology Corporation | Prophylaxis and treatment of acute myeloid leukemia |
EP3430057A4 (en) * | 2017-03-20 | 2020-03-11 | Indiana University Research & Technology Corporation | USE OF APE1 / REF-1 INHIBITORS IN COMBINATION THERAPIES FOR TREATING CANCER |
CN110392850A (zh) | 2017-03-24 | 2019-10-29 | 日本瑞翁株式会社 | 液晶固化膜及其制造方法 |
US20200024520A1 (en) | 2017-03-24 | 2020-01-23 | Zeon Corporation | Liquid crystal composition, liquid crystal cured film, and method for manufacturing same |
US20190117602A1 (en) * | 2017-04-17 | 2019-04-25 | Indiana University Research And Technology Corporation | Prevention and reversal of inflammation induced dna damage |
WO2018232238A1 (en) * | 2017-06-16 | 2018-12-20 | Indiana University Research And Technology Corporation | Therapeutic agent for tuberous sclerosis complex (tsc) |
EP3749633A4 (en) * | 2018-02-08 | 2021-11-03 | Indiana University Research and Technology Corporation | TARGETING EYE DISEASES WITH NEW APE1 / REF-1 INHIBITORS |
CN108440271A (zh) * | 2018-04-03 | 2018-08-24 | 中山大学 | 一种6-甲氧基萘嵌苯酮类化合物的制备方法 |
CN113613644A (zh) * | 2018-12-17 | 2021-11-05 | 印第安纳大学研究与技术公司 | 胃肠疾病及其症状的治疗 |
CN117500492A (zh) * | 2021-04-30 | 2024-02-02 | 奥库菲尔制药股份有限公司 | 用于治疗糖尿病视网膜病变和相关病症的方法和组合物 |
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JPS51128932A (en) * | 1975-04-30 | 1976-11-10 | Takeda Chem Ind Ltd | Organic compounds |
JPS58177934A (ja) * | 1982-04-13 | 1983-10-18 | Takeda Chem Ind Ltd | ベンゾキノン誘導体 |
FI102273B (fi) | 1989-09-11 | 1998-11-13 | Eisai Co Ltd | Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyt tö |
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JPH07291859A (ja) * | 1994-04-28 | 1995-11-07 | Eisai Co Ltd | 転写因子活性阻害剤 |
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US6406917B1 (en) * | 1996-06-11 | 2002-06-18 | Advanced Research And Technology Institute | Methods and compositions for the use of apurinic/apyrimidinic endonucleases |
EP0813866A3 (en) * | 1996-06-17 | 1999-01-20 | Eisai Co., Ltd. | Therapeutic agent for joint diseases |
FR2757860B1 (fr) * | 1996-12-27 | 1999-04-23 | Oxis International Sa | Composes organoselenies cycliques, leur preparation et leurs utilisations, notamment therapeutiques |
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AU5873000A (en) | 1999-06-24 | 2001-01-31 | Pharmacia Corporation | Combination of tumors necrocis factor (tnf) antagonists and cox-2 inhibitors forthe treatment of inflammation |
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MX2010003315A (es) * | 2007-09-26 | 2011-03-15 | Univ Indiana Res & Tech Corp | Derivados de benzoquinona e3330 en combinacion con agentes quimioterapeuticos para el tratamiento de cancer y angiogenesis. |
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2008
- 2008-09-22 MX MX2010003315A patent/MX2010003315A/es not_active Application Discontinuation
- 2008-09-22 JP JP2010527064A patent/JP5646327B2/ja active Active
- 2008-09-22 EP EP17197372.0A patent/EP3299015A1/en not_active Withdrawn
- 2008-09-22 US US12/679,824 patent/US9040505B2/en active Active
- 2008-09-22 EP EP08834585.5A patent/EP2203161B1/en active Active
- 2008-09-22 WO PCT/US2008/077213 patent/WO2009042544A1/en active Application Filing
- 2008-09-22 EP EP08832991.7A patent/EP2203162B1/en active Active
- 2008-09-22 US US12/679,828 patent/US9089605B2/en active Active
- 2008-09-22 CA CA2700365A patent/CA2700365C/en active Active
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