MX365074B - Terapia contra el cancer que utiliza anticuerpos dirigidos a la cldn6 objetivo in vivo. - Google Patents
Terapia contra el cancer que utiliza anticuerpos dirigidos a la cldn6 objetivo in vivo.Info
- Publication number
- MX365074B MX365074B MX2015016555A MX2015016555A MX365074B MX 365074 B MX365074 B MX 365074B MX 2015016555 A MX2015016555 A MX 2015016555A MX 2015016555 A MX2015016555 A MX 2015016555A MX 365074 B MX365074 B MX 365074B
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- Prior art keywords
- cldn6
- antibodies
- tumor
- vivo
- cancer therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Pregnancy & Childbirth (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere al tratamiento y/o prevención de padecimientos tumorales asociados con células que expresan la CLDN6, en particular cáncer y metástasis de cáncer utilizando anticuerpos que se unen a la CLDN6. La presente solicitud demuestra que la unión de los anticuerpos a la CLDN6 en la superficie de las células tumorales es suficiente para inhibir el crecimiento del tumor y para prolongar la supervivencia y extender la esperanza de vida de pacientes con tumores. Además, la unión de los anticuerpos a la CLDN6 es eficiente para inhibir el crecimiento de tumores de células germinales positivas a la CLDN6 tales como teratocarcinomas o carcinomas embrionarios, en particular tumores de células germinales de los testículos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36163210P | 2010-07-06 | 2010-07-06 | |
EP10006957A EP2404936A1 (en) | 2010-07-06 | 2010-07-06 | Cancer therapy using CLDN6 target-directed antibodies in vivo |
PCT/EP2011/003312 WO2012003956A1 (en) | 2010-07-06 | 2011-07-04 | Cancer therapy using cldn6 target-directed antibodies in vivo |
Publications (1)
Publication Number | Publication Date |
---|---|
MX365074B true MX365074B (es) | 2019-05-22 |
Family
ID=42799889
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012015131A MX2012015131A (es) | 2010-07-06 | 2011-07-04 | Terapia contra el cancer que utiliza anticuerpos dirigidos a la cldn6 objetivo in vivo. |
MX2015016555A MX365074B (es) | 2010-07-06 | 2011-07-04 | Terapia contra el cancer que utiliza anticuerpos dirigidos a la cldn6 objetivo in vivo. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012015131A MX2012015131A (es) | 2010-07-06 | 2011-07-04 | Terapia contra el cancer que utiliza anticuerpos dirigidos a la cldn6 objetivo in vivo. |
Country Status (11)
Country | Link |
---|---|
US (5) | US9718886B2 (es) |
EP (2) | EP2404936A1 (es) |
JP (2) | JP6263386B2 (es) |
KR (1) | KR101960004B1 (es) |
CN (2) | CN103140501B (es) |
AU (1) | AU2011276158B2 (es) |
CA (1) | CA2804242A1 (es) |
ES (1) | ES2805283T3 (es) |
MX (2) | MX2012015131A (es) |
RU (2) | RU2017145280A (es) |
WO (1) | WO2012003956A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107028969A (zh) | 2009-02-20 | 2017-08-11 | 加尼梅德药物公司 | 用于癌症诊断和治疗的方法和组合物 |
ES2649389T3 (es) | 2009-11-11 | 2018-01-11 | Ganymed Pharmaceuticals Gmbh | Anticuerpos específicos para claudina 6 (CLDN6) |
EP2404936A1 (en) | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
RS54627B1 (en) | 2011-05-13 | 2016-08-31 | Ganymed Pharmaceuticals Ag | CANCER EXPRESSION ANTIBODIES THAT EXPLAIN CLAUDINE 6 |
CN103320381B (zh) * | 2012-03-23 | 2015-04-15 | 上海市儿童医院 | 一种多能干细胞表面标志物及其用途 |
US9708601B2 (en) * | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
PL3027208T3 (pl) * | 2013-07-31 | 2020-11-02 | BioNTech SE | Diagnoza i terapia nowotworu z udziałem nowotworowych komórek macierzystych |
WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
KR20160070191A (ko) * | 2013-11-06 | 2016-06-17 | 스템센트알엑스 인코포레이티드 | 신규한 항-클라우딘 항체 및 사용 방법 |
EA201600354A1 (ru) | 2013-11-11 | 2016-12-30 | Чугаи Сеияку Кабушики Каиша | Антигенсвязывающая молекула, содержащая вариабельную область антитела |
CN113150109A (zh) | 2014-04-01 | 2021-07-23 | 拜恩科技细胞&基因治疗有限公司 | 密封蛋白-6特异性免疫受体和t细胞表位 |
MA40921A (fr) * | 2014-11-05 | 2017-09-12 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation |
JP7125248B2 (ja) | 2014-11-11 | 2022-08-24 | 中外製薬株式会社 | 改変された抗体可変領域を含む抗原結合分子のライブラリ |
WO2019048040A1 (en) | 2017-09-06 | 2019-03-14 | Ganymed Pharmaceuticals Gmbh | ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER |
EP3826667B1 (en) * | 2017-09-18 | 2024-04-17 | The Regents of the University of California | Claudin6 antibodies and methods of treating cancer |
CN117003875A (zh) | 2017-09-29 | 2023-11-07 | 第一三共株式会社 | 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用 |
TW201938194A (zh) | 2017-12-05 | 2019-10-01 | 日商中外製藥股份有限公司 | 包含結合cd3及cd137的改變的抗體可變區之抗原結合分子 |
EA202192146A1 (ru) * | 2019-02-15 | 2021-11-09 | Интиграл Молекьюлар, Инк. | Антитела к клаудину 6 и их применение |
CN114206934A (zh) * | 2019-03-20 | 2022-03-18 | 加利福尼亚大学董事会 | 密封蛋白-6双特异性抗体 |
WO2020191342A1 (en) * | 2019-03-20 | 2020-09-24 | The Regents Of The University Of California | Claudin-6 antibodies and drug conjugates |
EP3997230A4 (en) | 2019-07-10 | 2023-08-02 | Chugai Seiyaku Kabushiki Kaisha | CLAUDIN-6 BINDING MOLECULES AND USES THEREOF |
WO2021200939A1 (en) | 2020-03-31 | 2021-10-07 | Chugai Seiyaku Kabushiki Kaisha | Claudin-6 targeting multispecific antigen-binding molecules and uses thereof |
WO2023053282A1 (ja) | 2021-09-29 | 2023-04-06 | 中外製薬株式会社 | がんの治療に用いるための細胞傷害誘導治療剤 |
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WO2024022512A1 (en) * | 2022-07-29 | 2024-02-01 | Nanjing Legend Biotech Co., Ltd. | Claudin-6 binding moieties and uses thereof |
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2010
- 2010-07-06 EP EP10006957A patent/EP2404936A1/en not_active Withdrawn
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2011
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- 2011-07-04 WO PCT/EP2011/003312 patent/WO2012003956A1/en active Application Filing
- 2011-07-04 CN CN201180033503.3A patent/CN103140501B/zh active Active
- 2011-07-04 AU AU2011276158A patent/AU2011276158B2/en not_active Ceased
- 2011-07-04 JP JP2013517099A patent/JP6263386B2/ja active Active
- 2011-07-04 EP EP11730907.0A patent/EP2591003B1/en active Active
- 2011-07-04 RU RU2013104830A patent/RU2642305C2/ru active
- 2011-07-04 CN CN201610806725.9A patent/CN106519035B/zh active Active
- 2011-07-04 KR KR1020137000528A patent/KR101960004B1/ko active IP Right Grant
- 2011-07-04 MX MX2012015131A patent/MX2012015131A/es unknown
- 2011-07-04 CA CA2804242A patent/CA2804242A1/en not_active Abandoned
- 2011-07-04 MX MX2015016555A patent/MX365074B/es unknown
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2016
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2018
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2020
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Also Published As
Publication number | Publication date |
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WO2012003956A1 (en) | 2012-01-12 |
CN106519035A (zh) | 2017-03-22 |
RU2642305C2 (ru) | 2018-01-24 |
JP6263386B2 (ja) | 2018-01-17 |
CN106519035B (zh) | 2020-03-10 |
US20160355604A1 (en) | 2016-12-08 |
JP2017043609A (ja) | 2017-03-02 |
US20180142033A1 (en) | 2018-05-24 |
CA2804242A1 (en) | 2012-01-12 |
EP2591003B1 (en) | 2020-05-13 |
US20240084033A1 (en) | 2024-03-14 |
US20210079113A1 (en) | 2021-03-18 |
US10844133B2 (en) | 2020-11-24 |
ES2805283T3 (es) | 2021-02-11 |
KR20140005837A (ko) | 2014-01-15 |
AU2011276158B2 (en) | 2016-02-25 |
JP2013533247A (ja) | 2013-08-22 |
KR101960004B1 (ko) | 2019-03-20 |
US20130183305A1 (en) | 2013-07-18 |
CN103140501A (zh) | 2013-06-05 |
US9718886B2 (en) | 2017-08-01 |
CN103140501B (zh) | 2016-10-05 |
RU2017145280A (ru) | 2019-02-18 |
MX2012015131A (es) | 2013-03-05 |
AU2011276158A1 (en) | 2013-01-10 |
US9902778B2 (en) | 2018-02-27 |
RU2013104830A (ru) | 2014-08-20 |
EP2591003A1 (en) | 2013-05-15 |
EP2404936A1 (en) | 2012-01-11 |
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