MX2007008631A - Sintesis de analogos de himbacina. - Google Patents

Sintesis de analogos de himbacina.

Info

Publication number
MX2007008631A
MX2007008631A MX2007008631A MX2007008631A MX2007008631A MX 2007008631 A MX2007008631 A MX 2007008631A MX 2007008631 A MX2007008631 A MX 2007008631A MX 2007008631 A MX2007008631 A MX 2007008631A MX 2007008631 A MX2007008631 A MX 2007008631A
Authority
MX
Mexico
Prior art keywords
synthesis
improved process
analogs
himbacine
himbacine analogs
Prior art date
Application number
MX2007008631A
Other languages
English (en)
Inventor
Tao Wang
Xiaoyong Fu
Wenxue Wu
Tiruvettipuram K Thiruvengadam
John S Chiu
David J S Tsai
Hong-Chang Lee
Jing Liao
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2007008631A publication Critical patent/MX2007008631A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C07D307/885—3,3-Diphenylphthalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

La presente invencion se refiere a un procedimiento mejorado para preparar analogos de himbacina; los compuestos son utiles como antagonistas de los receptores de trombina; el procedimiento mejorado puede permitir al menos una purificacion mediante cristalizacion, escalabilidad o rendimiento de procedimiento mejorado del enantiomero deseado mas sencillo; un ejemplo de una etapa en la sintesis de ese tipo de analogo de himbacina es el siguiente: Formula (I).
MX2007008631A 2005-01-14 2006-01-12 Sintesis de analogos de himbacina. MX2007008631A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64393205P 2005-01-14 2005-01-14
PCT/US2006/001208 WO2006076564A1 (en) 2005-01-14 2006-01-12 Synthesis of himbacine analogs

Publications (1)

Publication Number Publication Date
MX2007008631A true MX2007008631A (es) 2007-09-12

Family

ID=36228637

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007008631A MX2007008631A (es) 2005-01-14 2006-01-12 Sintesis de analogos de himbacina.

Country Status (13)

Country Link
EP (1) EP1853592B1 (es)
JP (2) JP4681617B2 (es)
CN (1) CN101137647A (es)
AR (1) AR052870A1 (es)
AT (1) ATE500249T1 (es)
CA (1) CA2594741A1 (es)
DE (1) DE602006020414D1 (es)
ES (1) ES2360721T3 (es)
MX (1) MX2007008631A (es)
PT (1) PT1853592E (es)
SG (1) SG158885A1 (es)
WO (1) WO2006076564A1 (es)
ZA (1) ZA200705792B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2206697T3 (da) * 2005-01-14 2012-02-13 Schering Corp Exo- og diastereo-selektive synteser af himbacinanaloger
ES2527535T3 (es) 2010-04-16 2015-01-26 Sanofi Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1
ES2532902T3 (es) 2010-04-16 2015-04-01 Sanofi Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
EP3024550A4 (en) * 2013-07-22 2016-12-07 Merck Sharp & Dohme CO-CRYSTAL OF VORAPAXAR PAR-1 RECEPTOR ANTAGONIST AND ASPIRINE
CN105330689B (zh) * 2014-08-08 2018-08-17 博瑞生物医药（苏州）股份有限公司 制备Himbacine类似物中间体的制备方法
CN105985303B (zh) * 2015-02-13 2020-08-14 上海彩迩文生化科技有限公司 抗凝血剂的制备方法、中间体及其制备方法
CN106478608A (zh) * 2015-09-01 2017-03-08 博瑞生物医药（苏州）股份有限公司 沃拉帕沙的硫酸盐的结晶多晶型物
CN105348241B (zh) * 2015-12-11 2017-09-05 南京华威医药科技开发有限公司 一种硫酸沃拉帕沙中间体的合成方法
ITUB20160876A1 (it) 2016-02-19 2017-08-19 Dambrosio Enzo Maria Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo
CN107129477A (zh) * 2016-02-26 2017-09-05 上海星泰医药科技有限公司 ((1R,3aR,4aR,6R,8aR,9S,9aR)-9-甲酰基-1-甲基-3-氧杂十二氢萘[2,3-c]-6-呋喃基)羧酸乙酯的制备方法
CN106749138B (zh) * 2016-12-07 2019-08-16 扬子江药业集团四川海蓉药业有限公司 一种硫酸沃拉帕沙中间体醛的制备方法
CN107955014B (zh) * 2017-11-10 2019-06-28 南阳师范学院 萘并呋喃酮类化合物及制备与在制备抗肿瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
JP3449620B2 (ja) * 1997-11-25 2003-09-22 シェーリング コーポレイション トロンビンレセプターアンタゴニスト
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
IL160918A0 (en) * 2001-10-18 2004-08-31 Schering Corp Himbacine analogues as thrombin receptor antagonists
KR101026929B1 (ko) * 2002-04-16 2011-04-04 쉐링 코포레이션 트리사이클릭 트롬빈 수용체 길항제
DK2206697T3 (da) * 2005-01-14 2012-02-13 Schering Corp Exo- og diastereo-selektive synteser af himbacinanaloger

Also Published As

Publication number Publication date
WO2006076564A1 (en) 2006-07-20
ES2360721T3 (es) 2011-06-08
JP2011046751A (ja) 2011-03-10
CN101137647A (zh) 2008-03-05
SG158885A1 (en) 2010-02-26
CA2594741A1 (en) 2006-07-20
JP4681617B2 (ja) 2011-05-11
EP1853592B1 (en) 2011-03-02
JP2008526981A (ja) 2008-07-24
DE602006020414D1 (en) 2011-04-14
EP1853592A1 (en) 2007-11-14
ATE500249T1 (de) 2011-03-15
AR052870A1 (es) 2007-04-11
PT1853592E (pt) 2011-05-10
ZA200705792B (en) 2008-08-27

Similar Documents

Publication Publication Date Title
SG158885A1 (en) Synthesis of himbacine analogs
WO2011015522A3 (en) Process for the manufacture of pharmaceutically active compounds
HK1145684A1 (en) Process for preparing benzofurans
NO20092762L (no) 2-aza-bicyklo[3.1.0]heksanderivater
PT1888541E (pt) Compostos de benzo(d)isoxazol-3-il-amina substituídos como analgésicos
TW200619215A (en) Asymmetric synthesis of dihydrobenzofuran derivatives
TW200621739A (en) Asymmetric synthesis of substituted dihydrobenzofurans
HK1080088A1 (zh) 製備c-7取代的5-雄甾烯的方法
NZ586187A (en) Processes for the synthesis of sinomenine derivatives and their intermediate
MX2009013212A (es) Proceso para la sintesis de intermediarios de los inhibidores de renina tales como alisquireno.
MA30079B1 (fr) Procede de synthese de ferri-succinylcaseine
SG158884A1 (en) An exo-selective synthesis of himbacine analogs
MX2007007446A (es) Procesos para la produccion de 4-aminoquinazolinas.
MY171292A (en) Synthesis of polymer conjugates of indolocarbazole compounds
EP3020704A3 (en) Crystalline polymorphs of clevidipine butyrate
MY143324A (en) Process for preparing phosphorus compounds having phosphate-phosphonate bond
EA201000464A1 (ru) Способ получения очищенного синтез-газа из синтез-газа, содержащего следовые количества примеси сернистых соединений, с помощью металлорганической структуры
MX2007003922A (es) Nuevas propenonas ciclicas y aciclicas para tratar trastornos del sistema nervioso central.
MX2008000011A (es) Procesos para preparar derivados de pirazol-o-glucosido y nuevos intermediarios de dichos procesos.
TW200624435A (en) Process for preparing iridium(Ⅲ) ketoketonates
MX2007004785A (es) Procedimiento para preparar compuestos de purina.
EA200701862A1 (ru) Улучшенный способ очистки периндоприла
WO2010012797A3 (en) Synthesis of 3,4-diaryl-4,5-dihydro-(1h)-pyrazole-1- carboxamidine derivatives
TW200621734A (en) Process for preparing diarylcycloalkyl derivatives
HK1100776A1 (en) A process for the semisynthesis of deserpidine

Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status