PT1853592E - S?ntese de an?logos da himbacina - Google Patents
S?ntese de an?logos da himbacina Download PDFInfo
- Publication number
- PT1853592E PT1853592E PT06718299T PT06718299T PT1853592E PT 1853592 E PT1853592 E PT 1853592E PT 06718299 T PT06718299 T PT 06718299T PT 06718299 T PT06718299 T PT 06718299T PT 1853592 E PT1853592 E PT 1853592E
- Authority
- PT
- Portugal
- Prior art keywords
- synthesis
- himbacine analogs
- himbacine
- analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- C07D307/885—3,3-Diphenylphthalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64393205P | 2005-01-14 | 2005-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1853592E true PT1853592E (pt) | 2011-05-10 |
Family
ID=36228637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06718299T PT1853592E (pt) | 2005-01-14 | 2006-01-12 | S?ntese de an?logos da himbacina |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1853592B1 (pt) |
| JP (2) | JP4681617B2 (pt) |
| CN (1) | CN101137647A (pt) |
| AR (1) | AR052870A1 (pt) |
| AT (1) | ATE500249T1 (pt) |
| CA (1) | CA2594741A1 (pt) |
| DE (1) | DE602006020414D1 (pt) |
| ES (1) | ES2360721T3 (pt) |
| MX (1) | MX2007008631A (pt) |
| PT (1) | PT1853592E (pt) |
| SG (1) | SG158885A1 (pt) |
| WO (1) | WO2006076564A1 (pt) |
| ZA (1) | ZA200705792B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1848705T3 (da) * | 2005-01-14 | 2010-06-14 | Schering Corp | EXO- og diastereoselektive synteser af himbacin-analoger |
| WO2011128421A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi | Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren |
| PL2558462T3 (pl) | 2010-04-16 | 2015-03-31 | Sanofi Sa | Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1 |
| US9604971B2 (en) * | 2013-07-22 | 2017-03-28 | Aralez Pharmaceuticals Trading Dac | Co-crystal of the PAR-1 receptor antagonists vorapaxar and aspirin |
| CN105330689B (zh) * | 2014-08-08 | 2018-08-17 | 博瑞生物医药（苏州）股份有限公司 | 制备Himbacine类似物中间体的制备方法 |
| CN105985303B (zh) * | 2015-02-13 | 2020-08-14 | 上海彩迩文生化科技有限公司 | 抗凝血剂的制备方法、中间体及其制备方法 |
| CN106478608A (zh) * | 2015-09-01 | 2017-03-08 | 博瑞生物医药（苏州）股份有限公司 | 沃拉帕沙的硫酸盐的结晶多晶型物 |
| CN105348241B (zh) * | 2015-12-11 | 2017-09-05 | 南京华威医药科技开发有限公司 | 一种硫酸沃拉帕沙中间体的合成方法 |
| ITUB20160876A1 (it) | 2016-02-19 | 2017-08-19 | Dambrosio Enzo Maria | Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo |
| CN107129477A (zh) * | 2016-02-26 | 2017-09-05 | 上海星泰医药科技有限公司 | ((1R,3aR,4aR,6R,8aR,9S,9aR)-9-甲酰基-1-甲基-3-氧杂十二氢萘[2,3-c]-6-呋喃基)羧酸乙酯的制备方法 |
| CN106749138B (zh) * | 2016-12-07 | 2019-08-16 | 扬子江药业集团四川海蓉药业有限公司 | 一种硫酸沃拉帕沙中间体醛的制备方法 |
| CN107955014B (zh) * | 2017-11-10 | 2019-06-28 | 南阳师范学院 | 萘并呋喃酮类化合物及制备与在制备抗肿瘤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
| CO4990946A1 (es) * | 1997-11-25 | 2000-12-26 | Schering Corp | Antagonistas del receptor de trombina |
| US7235567B2 (en) * | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| EP1436298B1 (en) * | 2001-10-18 | 2011-09-21 | Schering Corporation | Himbacine analogues as thrombin receptor antagonists |
| ATE494284T1 (de) * | 2002-04-16 | 2011-01-15 | Schering Corp | Tricyclischer thrombinrezeptorantagonist |
| DK1848705T3 (da) * | 2005-01-14 | 2010-06-14 | Schering Corp | EXO- og diastereoselektive synteser af himbacin-analoger |
-
2006
- 2006-01-12 CN CNA2006800080207A patent/CN101137647A/zh active Pending
- 2006-01-12 DE DE602006020414T patent/DE602006020414D1/de active Active
- 2006-01-12 ES ES06718299T patent/ES2360721T3/es active Active
- 2006-01-12 MX MX2007008631A patent/MX2007008631A/es active IP Right Grant
- 2006-01-12 CA CA002594741A patent/CA2594741A1/en not_active Abandoned
- 2006-01-12 PT PT06718299T patent/PT1853592E/pt unknown
- 2006-01-12 SG SG201000275-6A patent/SG158885A1/en unknown
- 2006-01-12 JP JP2007551396A patent/JP4681617B2/ja not_active Expired - Fee Related
- 2006-01-12 AT AT06718299T patent/ATE500249T1/de active
- 2006-01-12 EP EP06718299A patent/EP1853592B1/en active Active
- 2006-01-12 AR ARP060100125A patent/AR052870A1/es not_active Application Discontinuation
- 2006-01-12 WO PCT/US2006/001208 patent/WO2006076564A1/en active Application Filing
-
2007
- 2007-07-13 ZA ZA200705792A patent/ZA200705792B/xx unknown
-
2010
- 2010-12-09 JP JP2010275168A patent/JP2011046751A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AR052870A1 (es) | 2007-04-11 |
| MX2007008631A (es) | 2007-09-12 |
| JP2008526981A (ja) | 2008-07-24 |
| EP1853592A1 (en) | 2007-11-14 |
| CA2594741A1 (en) | 2006-07-20 |
| ATE500249T1 (de) | 2011-03-15 |
| JP2011046751A (ja) | 2011-03-10 |
| JP4681617B2 (ja) | 2011-05-11 |
| ES2360721T3 (es) | 2011-06-08 |
| DE602006020414D1 (en) | 2011-04-14 |
| SG158885A1 (en) | 2010-02-26 |
| ZA200705792B (en) | 2008-08-27 |
| EP1853592B1 (en) | 2011-03-02 |
| CN101137647A (zh) | 2008-03-05 |
| WO2006076564A1 (en) | 2006-07-20 |
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