SG158885A1 - Synthesis of himbacine analogs - Google Patents

Synthesis of himbacine analogs

Info

Publication number
SG158885A1
SG158885A1 SG201000275-6A SG2010002756A SG158885A1 SG 158885 A1 SG158885 A1 SG 158885A1 SG 2010002756 A SG2010002756 A SG 2010002756A SG 158885 A1 SG158885 A1 SG 158885A1
Authority
SG
Singapore
Prior art keywords
synthesis
improved process
analogs
himbacine
himbacine analogs
Prior art date
Application number
SG201000275-6A
Other languages
English (en)
Inventor
Tiruvettipuram K Thiruvengadam
Tao Wang
Jing Liao
John S Chiu
David J S Tsai
Hong-Chang Lee
Wenxue Wu
Xiaoyong Fu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of SG158885A1 publication Critical patent/SG158885A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C07D307/885—3,3-Diphenylphthalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
SG201000275-6A 2005-01-14 2006-01-12 Synthesis of himbacine analogs SG158885A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64393205P 2005-01-14 2005-01-14

Publications (1)

Publication Number Publication Date
SG158885A1 true SG158885A1 (en) 2010-02-26

Family

ID=36228637

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201000275-6A SG158885A1 (en) 2005-01-14 2006-01-12 Synthesis of himbacine analogs

Country Status (13)

Country Link
EP (1) EP1853592B1 (pt)
JP (2) JP4681617B2 (pt)
CN (1) CN101137647A (pt)
AR (1) AR052870A1 (pt)
AT (1) ATE500249T1 (pt)
CA (1) CA2594741A1 (pt)
DE (1) DE602006020414D1 (pt)
ES (1) ES2360721T3 (pt)
MX (1) MX2007008631A (pt)
PT (1) PT1853592E (pt)
SG (1) SG158885A1 (pt)
WO (1) WO2006076564A1 (pt)
ZA (1) ZA200705792B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2196454B1 (en) * 2005-01-14 2014-08-27 Merck Sharp & Dohme Corp. Exo-and diastereo-selective syntheses of himbacine analogs
WO2011128420A1 (de) 2010-04-16 2011-10-20 Sanofi Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren
EP2558465B1 (de) 2010-04-16 2014-12-17 Sanofi Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren
WO2015013083A1 (en) * 2013-07-22 2015-01-29 Merck Sharp & Dohme Corp. Co-crystal of the par-1 receptor antagonist vorapaxar and aspirin
CN105330689B (zh) * 2014-08-08 2018-08-17 博瑞生物医药（苏州）股份有限公司 制备Himbacine类似物中间体的制备方法
CN105985303B (zh) * 2015-02-13 2020-08-14 上海彩迩文生化科技有限公司 抗凝血剂的制备方法、中间体及其制备方法
CN106478608A (zh) * 2015-09-01 2017-03-08 博瑞生物医药（苏州）股份有限公司 沃拉帕沙的硫酸盐的结晶多晶型物
CN105348241B (zh) * 2015-12-11 2017-09-05 南京华威医药科技开发有限公司 一种硫酸沃拉帕沙中间体的合成方法
ITUB20160876A1 (it) 2016-02-19 2017-08-19 Dambrosio Enzo Maria Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo
CN107129477A (zh) * 2016-02-26 2017-09-05 上海星泰医药科技有限公司 ((1R,3aR,4aR,6R,8aR,9S,9aR)-9-甲酰基-1-甲基-3-氧杂十二氢萘[2,3-c]-6-呋喃基)羧酸乙酯的制备方法
CN106749138B (zh) * 2016-12-07 2019-08-16 扬子江药业集团四川海蓉药业有限公司 一种硫酸沃拉帕沙中间体醛的制备方法
CN107955014B (zh) * 2017-11-10 2019-06-28 南阳师范学院 萘并呋喃酮类化合物及制备与在制备抗肿瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID24726A (id) * 1997-11-25 2000-08-03 Schering Corp Antagonis-antagonis reseptor trombin
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
ATE525378T1 (de) * 2001-10-18 2011-10-15 Schering Corp Himbacinanaloga als thrombinrezeptorantagonisten
CA2482858C (en) * 2002-04-16 2010-11-30 Schering Corporation Tricyclic thrombin receptor antagonists
EP2196454B1 (en) * 2005-01-14 2014-08-27 Merck Sharp & Dohme Corp. Exo-and diastereo-selective syntheses of himbacine analogs

Also Published As

Publication number Publication date
ES2360721T3 (es) 2011-06-08
AR052870A1 (es) 2007-04-11
EP1853592B1 (en) 2011-03-02
WO2006076564A1 (en) 2006-07-20
ZA200705792B (en) 2008-08-27
JP4681617B2 (ja) 2011-05-11
CA2594741A1 (en) 2006-07-20
DE602006020414D1 (en) 2011-04-14
PT1853592E (pt) 2011-05-10
CN101137647A (zh) 2008-03-05
EP1853592A1 (en) 2007-11-14
JP2008526981A (ja) 2008-07-24
ATE500249T1 (de) 2011-03-15
JP2011046751A (ja) 2011-03-10
MX2007008631A (es) 2007-09-12

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