ZA200705792B - Synthesis of himbacine analogs - Google Patents

Synthesis of himbacine analogs

Info

Publication number
ZA200705792B
ZA200705792B ZA200705792A ZA200705792A ZA200705792B ZA 200705792 B ZA200705792 B ZA 200705792B ZA 200705792 A ZA200705792 A ZA 200705792A ZA 200705792 A ZA200705792 A ZA 200705792A ZA 200705792 B ZA200705792 B ZA 200705792B
Authority
ZA
South Africa
Prior art keywords
synthesis
himbacine analogs
himbacine
analogs
Prior art date
Application number
ZA200705792A
Other languages
English (en)
Inventor
Tiruvettipuram K Thiruvengadam
Liao Jing
David J S Tsai
Wu Wenxue
Wang Tao
John S Chiu
Lee Hong-Chang
Fu Xiaoyong
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200705792B publication Critical patent/ZA200705792B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C07D307/885—3,3-Diphenylphthalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA200705792A 2005-01-14 2007-07-13 Synthesis of himbacine analogs ZA200705792B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64393205P 2005-01-14 2005-01-14

Publications (1)

Publication Number Publication Date
ZA200705792B true ZA200705792B (en) 2008-08-27

Family

ID=36228637

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200705792A ZA200705792B (en) 2005-01-14 2007-07-13 Synthesis of himbacine analogs

Country Status (13)

Country Link
EP (1) EP1853592B1 (xx)
JP (2) JP4681617B2 (xx)
CN (1) CN101137647A (xx)
AR (1) AR052870A1 (xx)
AT (1) ATE500249T1 (xx)
CA (1) CA2594741A1 (xx)
DE (1) DE602006020414D1 (xx)
ES (1) ES2360721T3 (xx)
MX (1) MX2007008631A (xx)
PT (1) PT1853592E (xx)
SG (1) SG158885A1 (xx)
WO (1) WO2006076564A1 (xx)
ZA (1) ZA200705792B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1848705T1 (sl) * 2005-01-14 2010-06-30 Schering Corp Eksoselektivne in diastereoselektivne sinteze himbacinskih analogov
EP2558465B1 (de) 2010-04-16 2014-12-17 Sanofi Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren
ES2527535T3 (es) 2010-04-16 2015-01-26 Sanofi Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1
US9604971B2 (en) * 2013-07-22 2017-03-28 Aralez Pharmaceuticals Trading Dac Co-crystal of the PAR-1 receptor antagonists vorapaxar and aspirin
CN105330689B (zh) * 2014-08-08 2018-08-17 博瑞生物医药（苏州）股份有限公司 制备Himbacine类似物中间体的制备方法
CN105985303B (zh) * 2015-02-13 2020-08-14 上海彩迩文生化科技有限公司 抗凝血剂的制备方法、中间体及其制备方法
CN106478608A (zh) * 2015-09-01 2017-03-08 博瑞生物医药（苏州）股份有限公司 沃拉帕沙的硫酸盐的结晶多晶型物
CN105348241B (zh) * 2015-12-11 2017-09-05 南京华威医药科技开发有限公司 一种硫酸沃拉帕沙中间体的合成方法
ITUB20160876A1 (it) 2016-02-19 2017-08-19 Dambrosio Enzo Maria Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo
CN107129477A (zh) * 2016-02-26 2017-09-05 上海星泰医药科技有限公司 ((1R,3aR,4aR,6R,8aR,9S,9aR)-9-甲酰基-1-甲基-3-氧杂十二氢萘[2,3-c]-6-呋喃基)羧酸乙酯的制备方法
CN106749138B (zh) * 2016-12-07 2019-08-16 扬子江药业集团四川海蓉药业有限公司 一种硫酸沃拉帕沙中间体醛的制备方法
CN107955014B (zh) * 2017-11-10 2019-06-28 南阳师范学院 萘并呋喃酮类化合物及制备与在制备抗肿瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100393492B1 (ko) * 1997-11-25 2003-08-02 쉐링 코포레이션 트롬빈 수용체 길항제
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
IL160918A0 (en) * 2001-10-18 2004-08-31 Schering Corp Himbacine analogues as thrombin receptor antagonists
SG164279A1 (en) * 2002-04-16 2010-09-29 Schering Corp Tricyclic thrombin receptor antagonists
SI1848705T1 (sl) * 2005-01-14 2010-06-30 Schering Corp Eksoselektivne in diastereoselektivne sinteze himbacinskih analogov

Also Published As

Publication number Publication date
EP1853592B1 (en) 2011-03-02
CA2594741A1 (en) 2006-07-20
ATE500249T1 (de) 2011-03-15
JP2008526981A (ja) 2008-07-24
ES2360721T3 (es) 2011-06-08
EP1853592A1 (en) 2007-11-14
CN101137647A (zh) 2008-03-05
JP4681617B2 (ja) 2011-05-11
WO2006076564A1 (en) 2006-07-20
JP2011046751A (ja) 2011-03-10
PT1853592E (pt) 2011-05-10
AR052870A1 (es) 2007-04-11
SG158885A1 (en) 2010-02-26
MX2007008631A (es) 2007-09-12
DE602006020414D1 (en) 2011-04-14

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