ITUB20160876A1 - Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo - Google Patents
Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomoInfo
- Publication number
- ITUB20160876A1 ITUB20160876A1 ITUB2016A000876A ITUB20160876A ITUB20160876A1 IT UB20160876 A1 ITUB20160876 A1 IT UB20160876A1 IT UB2016A000876 A ITUB2016A000876 A IT UB2016A000876A IT UB20160876 A ITUB20160876 A IT UB20160876A IT UB20160876 A1 ITUB20160876 A1 IT UB20160876A1
- Authority
- IT
- Italy
- Prior art keywords
- miopia
- arrest
- man
- prevention
- combination
- Prior art date
Links
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000000043 antiallergic agent Substances 0.000 title 1
- 229940052760 dopamine agonists Drugs 0.000 title 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUB2016A000876A ITUB20160876A1 (it) | 2016-02-19 | 2016-02-19 | Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo |
| JP2018543132A JP2019505542A (ja) | 2016-02-19 | 2017-02-17 | ヒトにおける軸性近視の予防／阻止に使用するための抗アレルギー薬とムスカリン性アンタゴニストおよび／またはドパミン作動薬との組み合わせ |
| HRP20250270TT HRP20250270T1 (hr) | 2016-02-19 | 2017-02-17 | Kombinacija antialergijskog sredstva s muskarinskim antagonistom i/ili dopaminergičkim agonistom za uporabu u sprječavanju/zaustavljanju aksialne miopije kod ljudi |
| RU2018133026A RU2793238C2 (ru) | 2016-02-19 | 2017-02-17 | Применение бензтропина с целью остановки прогрессирования аксиальной миопии у человека |
| PL17710482.5T PL3416617T3 (pl) | 2016-02-19 | 2017-02-17 | Połączenie środka przeciwalergicznego z antagonistą receptorów muskarynowych i/lub agonistą receptorów dopaminergicznych do zastosowania w zapobieganiu/zatrzymywaniu postępu krótkowzroczności osiowej u człowieka |
| CN201780011993.4A CN108883060A (zh) | 2016-02-19 | 2017-02-17 | 用于预防/阻止人轴性近视的抗过敏剂与毒蕈碱拮抗剂和/或多巴胺能激动剂的组合 |
| SG10202007417SA SG10202007417SA (en) | 2016-02-19 | 2017-02-17 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
| AU2017220640A AU2017220640B2 (en) | 2016-02-19 | 2017-02-17 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
| HUE17710482A HUE070966T2 (hu) | 2016-02-19 | 2017-02-17 | Emberek esetében a tengelyi rövidlátás megakadályozására/megszüntetésére alkalmazható, muszkarin-antagonistát és/vagy dopaminerg agonistát tartalmazó, antiallergiás hatású szerkombináció |
| US15/999,784 US20200253951A1 (en) | 2016-02-19 | 2017-02-17 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
| CA3013846A CA3013846A1 (en) | 2016-02-19 | 2017-02-17 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
| KR1020187026872A KR20180117642A (ko) | 2016-02-19 | 2017-02-17 | 인간에서 축성 근시를 예방/중단하는데 사용하기 위한 무스카린성 길항제 및/또는 도파민성 작용제를 갖는 항알레르기제의 배합물 |
| BR112018016845A BR112018016845A2 (pt) | 2016-02-19 | 2017-02-17 | combinação de um agente antialérgico com um antagonista muscarínico e/ou um agonista dopaminérgico para uso na prevenção/suspensão de miopia axial em humanos |
| EP17710482.5A EP3416617B1 (en) | 2016-02-19 | 2017-02-17 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
| PCT/EP2017/053619 WO2017140846A1 (en) | 2016-02-19 | 2017-02-17 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
| ES17710482T ES3009760T3 (en) | 2016-02-19 | 2017-02-17 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
| SG11201806599SA SG11201806599SA (en) | 2016-02-19 | 2017-02-17 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
| IL260893A IL260893B2 (en) | 2016-02-19 | 2018-07-31 | A combination of an anti-allergic agent with a muscarinic antagonist and/or a dopaminergic agonist for use in the prevention/termination of axial myopia in humans |
| CL2018002196A CL2018002196A1 (es) | 2016-02-19 | 2018-08-09 | Combinación de un agente antialérgico con un antagonista muscarínico y/o agonista dopaminérgico para el uso en la prevención/detención de la miopía axial en humanos. |
| US18/096,165 US20230172904A1 (en) | 2016-02-19 | 2023-01-12 | Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUB2016A000876A ITUB20160876A1 (it) | 2016-02-19 | 2016-02-19 | Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITUB20160876A1 true ITUB20160876A1 (it) | 2017-08-19 |
Family
ID=55948995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITUB2016A000876A ITUB20160876A1 (it) | 2016-02-19 | 2016-02-19 | Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20200253951A1 (it) |
| EP (1) | EP3416617B1 (it) |
| JP (1) | JP2019505542A (it) |
| KR (1) | KR20180117642A (it) |
| CN (1) | CN108883060A (it) |
| AU (1) | AU2017220640B2 (it) |
| BR (1) | BR112018016845A2 (it) |
| CA (1) | CA3013846A1 (it) |
| CL (1) | CL2018002196A1 (it) |
| ES (1) | ES3009760T3 (it) |
| HR (1) | HRP20250270T1 (it) |
| HU (1) | HUE070966T2 (it) |
| IL (1) | IL260893B2 (it) |
| IT (1) | ITUB20160876A1 (it) |
| PL (1) | PL3416617T3 (it) |
| SG (2) | SG11201806599SA (it) |
| WO (1) | WO2017140846A1 (it) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201800005599A1 (it) | 2018-05-22 | 2019-11-22 | Lente a contatto morbida | |
| CN109044965A (zh) * | 2018-10-17 | 2018-12-21 | 广州大光制药有限公司 | 格隆溴铵的眼用药物组合物及医药用途 |
| CA3181292A1 (en) * | 2020-06-02 | 2021-12-09 | Andrei V. Tkatchenko | Methods and compositions for preventing and treating myopia with levocabastine, a selective histamine h1-receptor antagonist, and derivatives thereof |
| CN114558069A (zh) * | 2022-04-06 | 2022-05-31 | 杭州美依生物科技有限公司 | 一种眼部舒缓涂抹液及其制备方法 |
| CN115137314B (zh) * | 2022-09-02 | 2022-11-15 | 首都医科大学附属北京同仁医院 | 近视风险评估方法、装置及穿戴设备 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012090170A1 (en) * | 2010-12-30 | 2012-07-05 | Enable Innovations S.P.A. | Products for ophtalmic use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69029734T2 (de) | 1989-06-21 | 1997-05-28 | Univ Pennsylvania | Verwendung von Pirenzepine, Telenzepine oder O-Methoxy -sila-hexocyclium zur Herstellung eines Medikaments zur BEHANDLUNG UND REGULIERUNG DER AUGENENTWICKLUNG |
| ES2311996T3 (es) | 2004-05-28 | 2009-02-16 | Schering Corporation | Analogos retringidos de himbacina como antagonistas del receptor de trombina. |
| PT1853592E (pt) | 2005-01-14 | 2011-05-10 | Schering Corp | S?ntese de an?logos da himbacina |
| BRPI0714587A2 (pt) * | 2006-07-25 | 2013-05-07 | Osmotica Corp | suluÇço oftÁlmica aquosa e uso da nesna |
| SG151148A1 (en) * | 2007-10-05 | 2009-04-30 | Singapore Health Services Pte | Method and/or kit for determining response to muscarinic receptor antagonist treatment |
-
2016
- 2016-02-19 IT ITUB2016A000876A patent/ITUB20160876A1/it unknown
-
2017
- 2017-02-17 CA CA3013846A patent/CA3013846A1/en active Pending
- 2017-02-17 JP JP2018543132A patent/JP2019505542A/ja active Pending
- 2017-02-17 KR KR1020187026872A patent/KR20180117642A/ko not_active Ceased
- 2017-02-17 EP EP17710482.5A patent/EP3416617B1/en active Active
- 2017-02-17 SG SG11201806599SA patent/SG11201806599SA/en unknown
- 2017-02-17 AU AU2017220640A patent/AU2017220640B2/en active Active
- 2017-02-17 CN CN201780011993.4A patent/CN108883060A/zh active Pending
- 2017-02-17 PL PL17710482.5T patent/PL3416617T3/pl unknown
- 2017-02-17 HU HUE17710482A patent/HUE070966T2/hu unknown
- 2017-02-17 BR BR112018016845A patent/BR112018016845A2/pt not_active Application Discontinuation
- 2017-02-17 SG SG10202007417SA patent/SG10202007417SA/en unknown
- 2017-02-17 WO PCT/EP2017/053619 patent/WO2017140846A1/en active Application Filing
- 2017-02-17 US US15/999,784 patent/US20200253951A1/en not_active Abandoned
- 2017-02-17 HR HRP20250270TT patent/HRP20250270T1/hr unknown
- 2017-02-17 ES ES17710482T patent/ES3009760T3/es active Active
-
2018
- 2018-07-31 IL IL260893A patent/IL260893B2/en unknown
- 2018-08-09 CL CL2018002196A patent/CL2018002196A1/es unknown
-
2023
- 2023-01-12 US US18/096,165 patent/US20230172904A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012090170A1 (en) * | 2010-12-30 | 2012-07-05 | Enable Innovations S.P.A. | Products for ophtalmic use |
Non-Patent Citations (5)
| Title |
|---|
| AUDREY CHIA ET AL: "Atropine for the Treatment of Childhood Myopia: Safety and Efficacy of 0.5%, 0.1%, and 0.01% Doses (Atropine for the Treatment of Myopia 2)", OPHTHALMOLOGY, J. B. LIPPINCOTT CO., PHILADELPHIA, PA, US, vol. 119, no. 2, 20 July 2011 (2011-07-20), pages 347 - 354, XP028395893, ISSN: 0161-6420, [retrieved on 20110725], DOI: 10.1016/J.OPHTHA.2011.07.031 * |
| DEL CUVILLO ET AL: "Allergic Conjunctivitis and H 1 Antihistamines", J INVESTIG ALLERGOL CLIN IMMUNOL, 1 January 2009 (2009-01-01), pages 11 - 18, XP055308704, Retrieved from the Internet <URL:http://www.jiaci.org/issues/vol19s1/3.pdf> [retrieved on 20161009] * |
| LUFT W A ET AL: "Variable effects of previously untested muscarinic receptor antagonists on experimental myopia", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE - IOVS, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 44, no. 3, 1 March 2003 (2003-03-01), pages 1330 - 1338, XP002315956, ISSN: 0146-0404, DOI: 10.1167/IOVS.02-0796 * |
| MARTÍN ANDREA P ET AL: "The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study", BMC OPHTHALMOLOGY, BIOMED CENTRAL, LONDON, GB, vol. 3, no. 1, 6 January 2003 (2003-01-06), pages 2, XP021016312, ISSN: 1471-2415, DOI: 10.1186/1471-2415-3-2 * |
| PREMA GANESAN ET AL: "Pharmaceutical intervention for myopia control", EXPERT REVIEW OF OPHTHALMOLOGY, vol. 5, no. 6, 9 December 2010 (2010-12-09), GB, pages 759 - 787, XP055308425, ISSN: 1746-9899, DOI: 10.1586/eop.10.67 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019505542A (ja) | 2019-02-28 |
| US20230172904A1 (en) | 2023-06-08 |
| AU2017220640B2 (en) | 2022-08-25 |
| RU2018133026A (ru) | 2020-03-19 |
| IL260893B2 (en) | 2023-08-01 |
| EP3416617B1 (en) | 2024-12-18 |
| HRP20250270T1 (hr) | 2025-04-25 |
| BR112018016845A2 (pt) | 2018-12-26 |
| KR20180117642A (ko) | 2018-10-29 |
| PL3416617T3 (pl) | 2025-06-02 |
| IL260893A (it) | 2018-09-20 |
| CL2018002196A1 (es) | 2019-01-25 |
| SG10202007417SA (en) | 2020-09-29 |
| ES3009760T3 (en) | 2025-03-31 |
| CA3013846A1 (en) | 2017-08-24 |
| SG11201806599SA (en) | 2018-09-27 |
| CN108883060A (zh) | 2018-11-23 |
| US20200253951A1 (en) | 2020-08-13 |
| EP3416617A1 (en) | 2018-12-26 |
| IL260893B1 (en) | 2023-04-01 |
| EP3416617C0 (en) | 2024-12-18 |
| AU2017220640A1 (en) | 2018-10-04 |
| WO2017140846A1 (en) | 2017-08-24 |
| HUE070966T2 (hu) | 2025-07-28 |
| RU2018133026A3 (it) | 2020-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3635603C0 (en) | REAL-TIME DETECTION AND PROTECTION OF MALWARE AND STEGANOGRAPHY IN A KERNEL MODE | |
| ITUB20160876A1 (it) | Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo | |
| BR112016025910A2 (pt) | uso de uma quantidade eficaz de glyx-13, uso de glyx-13 e um antagonista de nmdar e composição farmaceuticamente aceitável compreendendo os mesmos | |
| IL273031A (en) | Combined treatment of lasmiditan and a CGRP antagonist for use in the treatment of migraine | |
| EP3482760A4 (en) | COMBINATION OF AN EP4 ANTAGONIST AND AN IMMUNCHECKPOINT INHIBITOR | |
| EP3437659A4 (en) | MEDICINE PRODUCED BY COMBINATION OF FXR AGONIST AND ARB | |
| MA46430A (fr) | Thérapie combinée d'agonistes de cnp à libération contrôlée | |
| CO2020015923A2 (es) | Antagonista de gremlin-1 para la prevención y tratamiento del cáncer | |
| ES2784639T8 (es) | Uso combinado de un vector que codifica un receptor modificado y su agonista exógeno en el tratamiento de convulsiones | |
| IL280827A (en) | Integrin alpha 4 antagonists and compositions comprising same for use in treating ocular conditions | |
| FI20165284A7 (fi) | Kuntoutuslaite ja sen käyttö olkapään alueen harjoittamiseen | |
| PT2948559T (pt) | ¿antagonistas de kv1.3 e métodos de utilização | |
| SG11201704756YA (en) | Dislodgement and release of hsc using alpha 9 integrin antagonist and cxcr4 antagonist | |
| IT201700085412A1 (it) | Composizione per uso nella prevenzione e nel trattamento di patologie dell'apparato cardiovascolare | |
| IT201700089258A1 (it) | Composizione per uso nella prevenzione e nel trattamento di carenza di ferro | |
| MA47290A (fr) | Combinaison d'un agoniste sélectif de l'il-2rbeta et d'un agoniste de l'il-15 à action prolongée | |
| EP3416676A4 (en) | DOSAGE AND USE OF LONG-ACTING CLR / RAMP AGONISTS | |
| FR3023003B1 (fr) | Combinaison synergique de biomarqueurs pour la detection et l'evaluation d'une fibrose hepatique | |
| ITUA20161865A1 (it) | Uso di lentinano per il trattamento e la prevenzione di endometriosi. | |
| IT201600130706A1 (it) | 4 amino-2-pirido-biciclo pirimidine e lo uso come medicamenti | |
| BR112017021120A2 (pt) | forma de dosagem de combinação de um antagonista de receptor mu opioide e um agente opioide | |
| IL282142A (en) | The history of 4-pyrazine-2-ylmethyl-morpholine and its use as a medicine | |
| IT201700109607A1 (it) | Composizione per l'uso nella prevenzione e/o nel trattamento del glaucoma. | |
| HUE050606T2 (hu) | Kv1.3 inhibitorok és gyógyászati alkalmazásuk | |
| HK40097436A (en) | Combination therapy of lasmiditan and a cgrp antagonist for use in the treatment of migraine |