MX2007007877A - Conjugados de polimero-factor de von willebrand. - Google Patents
Conjugados de polimero-factor de von willebrand.Info
- Publication number
- MX2007007877A MX2007007877A MX2007007877A MX2007007877A MX2007007877A MX 2007007877 A MX2007007877 A MX 2007007877A MX 2007007877 A MX2007007877 A MX 2007007877A MX 2007007877 A MX2007007877 A MX 2007007877A MX 2007007877 A MX2007007877 A MX 2007007877A
- Authority
- MX
- Mexico
- Prior art keywords
- vwf
- fviii
- von willebrand
- willebrand factor
- polymer
- Prior art date
Links
- 108010047303 von Willebrand Factor Proteins 0.000 abstract 5
- 102100036537 von Willebrand factor Human genes 0.000 abstract 5
- 229960001134 von willebrand factor Drugs 0.000 abstract 5
- 108010054218 Factor VIII Proteins 0.000 abstract 4
- 102000001690 Factor VIII Human genes 0.000 abstract 4
- 229960000301 factor viii Drugs 0.000 abstract 4
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000007849 functional defect Effects 0.000 abstract 1
- 208000031169 hemorrhagic disease Diseases 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63924404P | 2004-12-27 | 2004-12-27 | |
| US66837805P | 2005-04-04 | 2005-04-04 | |
| US67190105P | 2005-04-15 | 2005-04-15 | |
| US68508605P | 2005-05-26 | 2005-05-26 | |
| PCT/US2005/046879 WO2006071801A2 (en) | 2004-12-27 | 2005-12-23 | Polymer-von willebrand factor-conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007007877A true MX2007007877A (es) | 2007-08-21 |
Family
ID=36540284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007007877A MX2007007877A (es) | 2004-12-27 | 2005-12-23 | Conjugados de polimero-factor de von willebrand. |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7884075B2 (Direct) |
| EP (1) | EP1835938B1 (Direct) |
| JP (2) | JP5022231B2 (Direct) |
| KR (1) | KR20070092754A (Direct) |
| CN (1) | CN101163506B (Direct) |
| AU (1) | AU2005322067B8 (Direct) |
| BR (1) | BRPI0519562A2 (Direct) |
| CA (1) | CA2591852A1 (Direct) |
| DK (1) | DK1835938T3 (Direct) |
| ES (1) | ES2434035T3 (Direct) |
| IL (1) | IL183634A (Direct) |
| MX (1) | MX2007007877A (Direct) |
| PL (1) | PL1835938T3 (Direct) |
| PT (1) | PT1835938E (Direct) |
| WO (1) | WO2006071801A2 (Direct) |
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| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプｒａｍのチエツク方法 |
| PT1835938E (pt) | 2004-12-27 | 2013-11-06 | Baxter Int | Conjugados de polímero-factor de von willebrand |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| BRPI0708832A2 (pt) | 2006-03-31 | 2011-06-14 | Baxter Int | construÇço proteinÁcea |
| ES2531934T3 (es) | 2006-09-01 | 2015-03-20 | Novo Nordisk Health Care Ag | Glicoproteínas modificadas |
| CA2670618C (en) * | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| CN101678119B (zh) * | 2006-12-27 | 2014-02-12 | 尼克塔治疗公司 | 具有可释放的键合的血管性血友病因子-和因子ⅷ-聚合物轭合物 |
| WO2008143977A1 (en) * | 2007-05-18 | 2008-11-27 | Baxter International Inc. | Method for producing mature vwf from vwf pro-peptide |
| US9107902B2 (en) * | 2007-06-13 | 2015-08-18 | Csl Behring Gmbh | Use of VWF stabilized FVIII preparations and of VWF preparations without FVIII for extravascular administration in the therapy and prophylactic treatment of bleeding disorders |
| CN101687048B (zh) * | 2007-06-26 | 2013-02-27 | 巴克斯特国际公司 | 可水解的聚合fmoc-连接体 |
| CA2704234A1 (en) * | 2007-11-09 | 2009-05-14 | Baxter International Inc. | Modified recombinant factor viii and von willebrand factor and methods of use |
| NZ585530A (en) | 2007-12-27 | 2012-06-29 | Baxter Int | Methods for differentiating plasma-derived protein from recombinant protein in a sample |
| KR20170072365A (ko) | 2007-12-27 | 2017-06-26 | 백스터 인터내셔널 인코포레이티드 | 생리학적으로 수용가능한 중합체 분자를 특이적으로 검출하기 위한 방법 및 조성물 |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| AR069989A1 (es) | 2007-12-28 | 2010-03-03 | Baxter Int | Formulaciones de vwf recombinantes |
| TWI492951B (zh) * | 2007-12-31 | 2015-07-21 | Baxter Int | 表現人類凝血因子的基因轉殖非人類動物及其用途 |
| KR20110028444A (ko) * | 2008-05-06 | 2011-03-18 | 옥타파마 아게 | 헤파린 결합 단백질 및 헤파린―히드록시알킬 전분 접합체를 포함하는 복합체 |
| DK2865760T3 (en) * | 2008-06-24 | 2018-01-15 | Csl Behring Gmbh | Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life |
| PE20110221A1 (es) * | 2008-07-23 | 2011-04-06 | Hanmi Science Co Ltd | Un complejo polipeptidico que consiste en un polimero no-peptidil que posee tres terminaciones funcionales |
| US8575102B2 (en) | 2008-08-01 | 2013-11-05 | Nektar Therapeutics | Conjugates having a releasable linkage |
| NZ592688A (en) | 2008-10-17 | 2012-12-21 | Baxter Int | Modified blood factors comprising a low degree of water soluble polymer |
| CA2741209C (en) * | 2008-10-20 | 2016-12-20 | Usv Limited | An improved process for pegylation of proteins |
| WO2010048184A2 (en) * | 2008-10-21 | 2010-04-29 | Baxter International Inc. | Methods for determining active ingredients in pro-drug peg protein conjugates with releasable peg reagents (in vitro de-pegylation) |
| NZ592704A (en) | 2008-10-21 | 2013-02-22 | Baxter Int | Lyophilized recombinant von willebrand factor (rVWF) formulation comprising buffering agents, amino acids, stabilising agents and surfactants |
| DK2356467T3 (da) * | 2008-12-11 | 2013-10-14 | Baxter Int | Påvisning af fysiologisk acceptable polymermolekyler under anvendelse af nær-infrarød spektroskopi |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| ES2856055T3 (es) * | 2009-07-27 | 2021-09-27 | Baxalta GmbH | Glicopolisialilación de proteínas diferentes de las proteínas de coagulación de la sangre |
| NZ597600A (en) | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
| WO2011017055A2 (en) | 2009-07-27 | 2011-02-10 | Baxter International Inc. | Blood coagulation protein conjugates |
| EP2462231A2 (en) | 2009-08-04 | 2012-06-13 | Baxter International Inc | Transgenic mouse lacking endogenous fviii and vwf - a model of hemophilia a |
| IN2012DN01849A (Direct) | 2009-08-20 | 2015-08-21 | Baxter Int | |
| EP3222287A1 (en) | 2009-08-24 | 2017-09-27 | Amunix Operating Inc. | Coagulation factor ix compositions and methods of making and using same |
| KR101808751B1 (ko) * | 2009-11-13 | 2017-12-13 | 그리폴스 테라퓨틱스 인코포레이티드 | 폰 빌레브란트 인자(ｖＷＦ)-함유 제제, 및 그와 관련된 방법, 키트 및 용도 |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| PL2598172T3 (pl) | 2010-07-30 | 2019-09-30 | Baxalta GmbH | Katalizatory nukleofilowe do wiązania oksymowego |
| KR101309566B1 (ko) | 2010-12-10 | 2013-09-17 | 포항공과대학교 산학협력단 | 히알루론산-단백질 컨쥬게이트 및 이의 제조 방법 |
| WO2012087838A1 (en) | 2010-12-22 | 2012-06-28 | Baxter International Inc. | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
| EP3412314A1 (en) | 2011-05-27 | 2018-12-12 | Baxalta GmbH | Therapeutic proteins conjugated to polysialic acid and methods of preparing same |
| KR20190041032A (ko) * | 2011-06-10 | 2019-04-19 | 박스알타 인코퍼레이티드 | 재조합 vwf의 투여에 의한 응고 질환의 치료 |
| CN111499760A (zh) * | 2012-01-12 | 2020-08-07 | 比奥贝拉蒂治疗公司 | 嵌合因子viii多肽及其用途 |
| EP2814502B1 (en) | 2012-02-15 | 2017-09-13 | CSL Behring GmbH | Von willebrand factor variants having improved factor viii binding affinity |
| DK2822577T3 (en) | 2012-02-15 | 2019-04-01 | Bioverativ Therapeutics Inc | RECOMBINANT FACTOR VIII PROTEINS |
| ES2771208T3 (es) | 2012-02-15 | 2020-07-06 | Bioverativ Therapeutics Inc | Composiciones de factor VIII y métodos de preparación y uso de las mismas |
| AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
| SI2882450T1 (sl) * | 2012-07-11 | 2020-02-28 | Bioverativ Therapeutics Inc. | Kompleks faktorja VIII z XTEN in s proteinom von Willebrandovega faktorja in njegove uporabe |
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| US10947269B2 (en) * | 2013-08-08 | 2021-03-16 | Bioverativ Therapeutics Inc. | Purification of chimeric FVIII molecules |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| NZ721544A (en) * | 2014-01-10 | 2022-10-28 | Bioverativ Therapeutics Inc | Factor viii chimeric proteins and uses thereof |
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| ES2844232T3 (es) | 2014-07-02 | 2021-07-21 | CSL Behring Lengnau AG | Factor de Von Willebrand modificado |
| CN104491917B (zh) * | 2014-12-30 | 2018-01-09 | 广州市拜特凇医药科技有限公司 | 一种含有peg或其衍生物的生物材料 |
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| BR112017024714A2 (pt) | 2015-05-22 | 2018-09-11 | Csl Behring Recombinant Facility Ag | métodos para preparação do fator de von willebrand modificado |
| WO2016188907A1 (en) | 2015-05-22 | 2016-12-01 | Csl Behring Recombinant Facility Ag | Truncated von willebrand factor polypeptides for treating hemophilia |
| JP2015155469A (ja) * | 2015-06-01 | 2015-08-27 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 第ｆｖｉｉｉ因子ポリマー結合体 |
| TWI741992B (zh) | 2015-08-03 | 2021-10-11 | 美商百歐維拉提夫治療公司 | 因子ｉｘ融合蛋白以及其製備及使用方法 |
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| MX2018008337A (es) | 2016-01-07 | 2018-09-17 | CSL Behring Lengnau AG | Factor de von willebrand truncado mutado. |
| US11890327B2 (en) | 2016-11-11 | 2024-02-06 | CSL Behring Lengnau AG | Truncated von Willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
| SG11201903950UA (en) | 2016-11-11 | 2019-05-30 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| MX2019006444A (es) | 2016-12-02 | 2019-10-30 | Bioverativ Therapeutics Inc | Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos. |
| KR102788331B1 (ko) | 2017-07-07 | 2025-03-27 | 다케다 야쿠힌 고교 가부시키가이샤 | 재조합 vwf의 투여에 의해 대기 수술을 받은 중증 폰 빌레브란트 병을 가지고 있는 환자의 치료 |
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| US20200199176A1 (en) | 2017-08-23 | 2020-06-25 | Csl Behring Gmbh | Method for virus filtration of von willebrand factor |
| JP2018115170A (ja) * | 2018-03-02 | 2018-07-26 | バクスアルタ ゲーエムベーハー | 第ｆｖｉｉｉ因子ポリマー結合体 |
| CN112533940A (zh) | 2018-03-21 | 2021-03-19 | 百深公司 | 通过色谱方法分离vwf和vwf前肽 |
| MA52630B1 (fr) | 2018-05-18 | 2025-07-31 | Bioverativ Therapeutics Inc. | Procédés de traitement de l'hémophilie a |
| CA3128498A1 (en) | 2019-02-01 | 2020-08-06 | Bjorn Mellgard | Methods of prophylactic treatment using recombinant vwf (rvwf) |
| CN114929260A (zh) | 2019-09-11 | 2022-08-19 | 武田药品工业株式会社 | 与冯维勒布兰德因子和补体c1q的复合物相关的治疗方法 |
| BR112022015326A2 (pt) | 2020-02-04 | 2022-10-11 | Takeda Pharmaceuticals Co | Tratamento de menorragia em pacientes com doença de von willebrand severa por administração de vwf recombinante |
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-
2005
- 2005-12-23 PT PT58554429T patent/PT1835938E/pt unknown
- 2005-12-23 CN CN2005800445983A patent/CN101163506B/zh not_active Expired - Lifetime
- 2005-12-23 BR BRPI0519562-4A patent/BRPI0519562A2/pt not_active IP Right Cessation
- 2005-12-23 CA CA002591852A patent/CA2591852A1/en not_active Abandoned
- 2005-12-23 MX MX2007007877A patent/MX2007007877A/es active IP Right Grant
- 2005-12-23 KR KR1020077017261A patent/KR20070092754A/ko not_active Withdrawn
- 2005-12-23 US US11/317,582 patent/US7884075B2/en active Active
- 2005-12-23 EP EP05855442.9A patent/EP1835938B1/en not_active Expired - Lifetime
- 2005-12-23 JP JP2007548552A patent/JP5022231B2/ja not_active Expired - Lifetime
- 2005-12-23 AU AU2005322067A patent/AU2005322067B8/en not_active Expired
- 2005-12-23 ES ES05855442T patent/ES2434035T3/es not_active Expired - Lifetime
- 2005-12-23 DK DK05855442.9T patent/DK1835938T3/da active
- 2005-12-23 PL PL05855442T patent/PL1835938T3/pl unknown
- 2005-12-23 WO PCT/US2005/046879 patent/WO2006071801A2/en not_active Ceased
-
2007
- 2007-06-04 IL IL183634A patent/IL183634A/en active IP Right Grant
-
2011
- 2011-01-14 US US13/007,208 patent/US8076463B2/en not_active Expired - Lifetime
- 2011-11-28 US US13/305,334 patent/US8357779B2/en not_active Expired - Lifetime
-
2012
- 2012-03-30 JP JP2012081700A patent/JP5715983B2/ja not_active Expired - Lifetime
- 2012-12-21 US US13/724,831 patent/US8835388B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070092754A (ko) | 2007-09-13 |
| US20120135462A1 (en) | 2012-05-31 |
| US8076463B2 (en) | 2011-12-13 |
| JP2012126750A (ja) | 2012-07-05 |
| US7884075B2 (en) | 2011-02-08 |
| JP2008525491A (ja) | 2008-07-17 |
| AU2005322067B8 (en) | 2012-07-26 |
| CN101163506A (zh) | 2008-04-16 |
| CA2591852A1 (en) | 2006-07-06 |
| EP1835938A2 (en) | 2007-09-26 |
| US20060160948A1 (en) | 2006-07-20 |
| CN101163506B (zh) | 2012-09-26 |
| PT1835938E (pt) | 2013-11-06 |
| BRPI0519562A2 (pt) | 2009-01-27 |
| US20110111455A1 (en) | 2011-05-12 |
| US8835388B2 (en) | 2014-09-16 |
| AU2005322067A1 (en) | 2006-07-06 |
| IL183634A0 (en) | 2007-09-20 |
| WO2006071801A2 (en) | 2006-07-06 |
| JP5022231B2 (ja) | 2012-09-12 |
| US20130190242A1 (en) | 2013-07-25 |
| AU2005322067B2 (en) | 2012-07-05 |
| PL1835938T3 (pl) | 2014-01-31 |
| ES2434035T3 (es) | 2013-12-13 |
| WO2006071801A3 (en) | 2007-08-16 |
| DK1835938T3 (da) | 2013-11-04 |
| JP5715983B2 (ja) | 2015-05-13 |
| HK1105276A1 (en) | 2008-02-06 |
| US8357779B2 (en) | 2013-01-22 |
| EP1835938B1 (en) | 2013-08-07 |
| IL183634A (en) | 2012-02-29 |
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