MEP47208A - 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors - Google Patents
4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitorsInfo
- Publication number
- MEP47208A MEP47208A MEP-472/08A MEP47208A MEP47208A ME P47208 A MEP47208 A ME P47208A ME P47208 A MEP47208 A ME P47208A ME P47208 A MEP47208 A ME P47208A
- Authority
- ME
- Montenegro
- Prior art keywords
- quinazolines
- quinolines
- phenylamino
- tyrosine kinase
- kinase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10214412A DE10214412A1 (de) | 2002-03-30 | 2002-03-30 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE2002131711 DE10231711A1 (de) | 2002-07-13 | 2002-07-13 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
PCT/EP2003/003062 WO2003082290A1 (fr) | 2002-03-30 | 2003-03-25 | 4-(n-phenylamino)-quinazolines / quinolines en tant qu'inhibiteurs de la tyrosine kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
MEP47208A true MEP47208A (en) | 2011-02-10 |
Family
ID=28676040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-472/08A MEP47208A (en) | 2002-03-30 | 2003-03-25 | 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1492536B1 (fr) |
JP (1) | JP4776882B2 (fr) |
KR (1) | KR101064530B1 (fr) |
CN (1) | CN1642552B (fr) |
AR (1) | AR039187A1 (fr) |
AT (1) | ATE557008T1 (fr) |
AU (1) | AU2003226705B2 (fr) |
BR (1) | BR0308902A (fr) |
CA (1) | CA2476008C (fr) |
EA (2) | EA009300B1 (fr) |
HK (1) | HK1079095A1 (fr) |
HR (1) | HRP20040898A2 (fr) |
IL (1) | IL164167A0 (fr) |
ME (1) | MEP47208A (fr) |
MX (1) | MXPA04009536A (fr) |
MY (1) | MY127771A (fr) |
NO (1) | NO329271B1 (fr) |
NZ (1) | NZ536114A (fr) |
PE (1) | PE20040169A1 (fr) |
PL (1) | PL371188A1 (fr) |
RS (1) | RS85404A (fr) |
TW (2) | TW201024269A (fr) |
UY (1) | UY27737A1 (fr) |
WO (1) | WO2003082290A1 (fr) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1731511B1 (fr) | 1999-06-21 | 2015-08-12 | Boehringer Ingelheim Pharma GmbH & Co. KG | Heterocycles bicycliques, medicaments contenant ces composés, leur utilisation et procédés permettant de les préparer |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
JP4703183B2 (ja) * | 2002-07-15 | 2011-06-15 | シンフォニー エボルーション, インク. | 受容体型キナーゼモジュレーターおよびその使用方法 |
EP1636195A1 (fr) * | 2003-05-27 | 2006-03-22 | Pfizer Products Inc. | Quinazolines et pyrido 3,4-d] pyrimidines utilises comme inhibiteurs de recepteurs tyrosine kinase |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
DE10334226A1 (de) * | 2003-07-28 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
MXPA06001079A (es) * | 2003-07-29 | 2006-04-11 | Astrazeneca Ab | Derivados de piperidil quinazolina como inhibidores de cinasa de tirosina. |
SI1667991T1 (sl) * | 2003-09-16 | 2008-10-31 | Astrazeneca Ab | Kinazolinski derivati kot inhibitorji tirozin kinaze |
EP1664028A1 (fr) * | 2003-09-16 | 2006-06-07 | AstraZeneca AB | Dérivés de quinozaline en tant qu'inhibiteurs de la tyrosine kinase |
ATE352550T1 (de) * | 2003-09-19 | 2007-02-15 | Astrazeneca Ab | Chinazolinderivate |
EP1670782B1 (fr) * | 2003-09-19 | 2007-02-14 | AstraZeneca AB | Derives de quinazoline |
GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
US7456189B2 (en) | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
DE10345875A1 (de) * | 2003-09-30 | 2005-04-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Vewendung und Verfahren zu ihrer Herstellung |
DE10350717A1 (de) * | 2003-10-30 | 2005-06-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
CN1893944B (zh) | 2003-12-18 | 2011-07-06 | 詹森药业有限公司 | 具有抗增殖活性的3-氰基喹啉衍生物 |
WO2005058913A1 (fr) | 2003-12-18 | 2005-06-30 | Janssen Pharmaceutica N.V. | Anti-proliferants a base de derives pyrido- et pyrimidopyrimidine |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
ATE501148T1 (de) | 2004-12-14 | 2011-03-15 | Astrazeneca Ab | Pyrazolopyrimidinverbindungen als antitumormittel |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
EP1833482A4 (fr) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | Composés bicycliques azotés et utilisation thérapeutique associée |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
EA200701619A1 (ru) * | 2005-02-04 | 2008-02-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Применение ингибиторов тирозинкиназы для лечения хронического риносинусита |
WO2006081741A1 (fr) * | 2005-02-05 | 2006-08-10 | Piaoyang Sun | Dérivés de quinazoline ou leurs sels de qualité pharmaceutique, synthèse et applications médicales desdites substances |
MX2007010399A (es) * | 2005-02-26 | 2007-09-25 | Astrazeneca Ab | Derivados de quinazolina en la forma de inhibidores de cinasa de tirosina. |
WO2007023073A2 (fr) * | 2005-08-22 | 2007-03-01 | Boehringer Ingelheim International Gmbh | Heterocycles bicycliques, produits pharmaceutiques contenant ces composes, leur utilisation et procede pour les preparer |
ATE488513T1 (de) | 2005-09-20 | 2010-12-15 | Astrazeneca Ab | 4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs |
WO2007054550A1 (fr) | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Derives de quinazoline pour le traitement des affections cancereuses |
AU2006326157A1 (en) * | 2005-12-12 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for the production thereof |
EP1996561A1 (fr) * | 2006-03-09 | 2008-12-03 | Boehringer Ingelheim International GmbH | Heterocycles bicycliques, medicaments contenant ces composes, leur utilisation et leur procede de fabrication |
AU2007274284B2 (en) | 2006-07-13 | 2012-04-26 | Janssen Pharmaceutica N.V. | Mtki quinazoline derivatives |
JP2010502743A (ja) * | 2006-09-11 | 2010-01-28 | キュリス,インコーポレイテッド | 抗増殖薬剤としての多機能性低分子 |
MX2009002585A (es) * | 2006-09-11 | 2009-08-24 | Curis Inc | Inhibidores e egfr a base de quinolina que contienen porcion de enlace de zinc. |
DK2068880T3 (da) | 2006-09-18 | 2012-07-23 | Boehringer Ingelheim Int | Fremgangsmåde til behandling af cancer, der huser EGFR-mutationer |
EP1921070A1 (fr) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | heterocycles bicycliques, medicaments á base de ces composes, leur usage et procédé pour leur preparation |
EP2118075A1 (fr) * | 2007-02-06 | 2009-11-18 | Boehringer Ingelheim International GmbH | Hétérocycles bicycliques, agents pharmaceutiques contenant ces composés, leur utilisation et leur procédé de préparation |
EP1956010A1 (fr) * | 2007-02-06 | 2008-08-13 | Boehringer Ingelheim Pharma GmbH & Co. KG | Hétérocycles bicycliques, médicament contenant cette composition, son utilisation et son procédé de fabrication |
TWI377944B (en) | 2007-06-05 | 2012-12-01 | Hanmi Holdings Co Ltd | Novel amide derivative for inhibiting the growth of cancer cells |
DK2185562T3 (en) | 2007-07-27 | 2016-02-22 | Janssen Pharmaceutica Nv | PYRROLOPYRIMIDINES SUITABLE FOR TREATING PROLIFERATIVE DISEASES |
RS52573B (en) * | 2008-02-07 | 2013-04-30 | Boehringer Ingelheim International Gmbh | SPIROCYCLIC HETEROCYCLES, THE MEDICINAL PRODUCTS CONTAINING THIS UNIT, THEIR APPLICATION AND THE PROCEDURE FOR THEIR MANUFACTURING |
NZ589883A (en) * | 2008-05-13 | 2012-06-29 | Astrazeneca Ab | Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy} quinazoline |
US8263768B2 (en) * | 2008-08-08 | 2012-09-11 | Boehringer Ingelheim International Gmbh | Process for the stereoselective preparation of bicyclic heterocycles |
US8372855B2 (en) | 2008-08-08 | 2013-02-12 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy-substituted heterocyclics, medicines containing these compounds and method for the production thereof |
EP2313397B1 (fr) | 2008-08-08 | 2016-04-20 | Boehringer Ingelheim International GmbH | Hétérocycles substitués par cyclohexyloxy, médicament contenant ces liaisons, leur utilisation et leur procédé de fabrication |
CN101659657B (zh) * | 2008-08-29 | 2014-05-14 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物及其制备方法和用途 |
CN101659658B (zh) * | 2008-08-29 | 2014-04-02 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物 |
EP2346507A1 (fr) * | 2008-09-03 | 2011-07-27 | Boehringer Ingelheim International GmbH | Utilisation de dérivés de quinazoline pour le traitement de maladies virales |
SI2451445T1 (sl) | 2009-07-06 | 2019-07-31 | Boehringer Ingelheim International Gmbh | Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino |
CN102030742B (zh) | 2009-09-28 | 2013-06-19 | 齐鲁制药有限公司 | 作为酪氨酸激酶抑制剂的4-(取代苯胺基)喹唑啉衍生物 |
AR080176A1 (es) * | 2010-02-15 | 2012-03-21 | Boehringer Ingelheim Int | Sales e hidratos de la 4-((3-cloro-4-fluoro-fenil)amino)-6-(cis-4-(n-((morf-1-olin-4-il)carbonil)-n-metil-amino)-ciclohexan-1-iloxi)-7-metoxi-quinazolina, su uso como medicamento y su preparacion |
CN102452988B (zh) * | 2010-10-27 | 2016-01-27 | 中国科学院化学研究所 | 一种喹唑啉衍生物及其制备方法 |
MX2013008870A (es) * | 2011-02-01 | 2013-08-14 | Boehringer Ingelheim Int | Dimaleato de 9-[4-(3-cloro-2-fluoro-fenilamino)-7-metoxi-quinazoli n-6-iloxi]-1,4-diaza-espiro[5.5]undecan-5-ona, su uso como medicamento y su preparacion. |
KR101317809B1 (ko) | 2011-06-07 | 2013-10-16 | 한미약품 주식회사 | 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물 |
AU2013218119A1 (en) | 2012-02-09 | 2014-07-17 | Boehringer Ingelheim International Gmbh | Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes |
EP2752413B1 (fr) | 2012-03-26 | 2016-03-23 | Fujian Institute Of Research On The Structure Of Matter, Chinese Academy Of Sciences | Dérivé de quinazoline et son application |
EP2875020B1 (fr) | 2012-07-19 | 2017-09-06 | Boehringer Ingelheim International GmbH | Procédé de pràparation de une sel d'acide fumarique de la 9-[4-(3-chloro-2-fluoro-phénylamino)-7-méthoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undécan-5-one |
KR20140096571A (ko) | 2013-01-28 | 2014-08-06 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
CA2901269C (fr) * | 2013-03-06 | 2022-01-18 | Astrazeneca Ab | Inhibiteurs quinazoline de l'activation des formes mutantes du recepteur de croissance epidermique (egfr) |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
TWI771327B (zh) * | 2016-10-05 | 2022-07-21 | 英商使命醫療公司 | 新穎化合物 |
JP2022529518A (ja) | 2019-04-25 | 2022-06-22 | ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム | チロシンキナーゼの複素環式阻害剤 |
AR120406A1 (es) | 2019-11-06 | 2022-02-09 | Yuhan Corp | Compuestos de pirrolidina y piperidina |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
GB9910577D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
DE10042059A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE10042058A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
-
2003
- 2003-03-25 AU AU2003226705A patent/AU2003226705B2/en not_active Ceased
- 2003-03-25 KR KR1020047015565A patent/KR101064530B1/ko not_active IP Right Cessation
- 2003-03-25 MX MXPA04009536A patent/MXPA04009536A/es active IP Right Grant
- 2003-03-25 EP EP03745271A patent/EP1492536B1/fr not_active Expired - Lifetime
- 2003-03-25 EA EA200401191A patent/EA009300B1/ru not_active IP Right Cessation
- 2003-03-25 WO PCT/EP2003/003062 patent/WO2003082290A1/fr active Application Filing
- 2003-03-25 ME MEP-472/08A patent/MEP47208A/xx unknown
- 2003-03-25 IL IL16416703A patent/IL164167A0/xx not_active IP Right Cessation
- 2003-03-25 CA CA2476008A patent/CA2476008C/fr not_active Expired - Fee Related
- 2003-03-25 CN CN038072424A patent/CN1642552B/zh not_active Expired - Fee Related
- 2003-03-25 AT AT03745271T patent/ATE557008T1/de active
- 2003-03-25 EA EA200701302A patent/EA200701302A1/ru unknown
- 2003-03-25 JP JP2003579827A patent/JP4776882B2/ja not_active Expired - Fee Related
- 2003-03-25 PL PL03371188A patent/PL371188A1/xx unknown
- 2003-03-25 BR BR0308902-9A patent/BR0308902A/pt not_active Expired - Fee Related
- 2003-03-25 RS YUP-854/04A patent/RS85404A/sr unknown
- 2003-03-25 NZ NZ536114A patent/NZ536114A/en not_active IP Right Cessation
- 2003-03-27 UY UY27737A patent/UY27737A1/es not_active Application Discontinuation
- 2003-03-28 PE PE2003000322A patent/PE20040169A1/es not_active Application Discontinuation
- 2003-03-28 TW TW099102687A patent/TW201024269A/zh unknown
- 2003-03-28 TW TW092107113A patent/TWI331604B/zh not_active IP Right Cessation
- 2003-03-28 MY MYPI20031160A patent/MY127771A/en unknown
- 2003-03-28 AR ARP030101100A patent/AR039187A1/es not_active Suspension/Interruption
-
2004
- 2004-09-23 NO NO20043997A patent/NO329271B1/no not_active IP Right Cessation
- 2004-09-29 HR HR20040898A patent/HRP20040898A2/hr not_active Application Discontinuation
-
2005
- 2005-12-02 HK HK05111036.8A patent/HK1079095A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1642552A (zh) | 2005-07-20 |
KR101064530B1 (ko) | 2011-09-14 |
ATE557008T1 (de) | 2012-05-15 |
CA2476008C (fr) | 2011-12-13 |
KR20040094898A (ko) | 2004-11-10 |
AR039187A1 (es) | 2005-02-09 |
NZ536114A (en) | 2007-11-30 |
MXPA04009536A (es) | 2005-01-25 |
TW201024269A (en) | 2010-07-01 |
UY27737A1 (es) | 2003-10-31 |
BR0308902A (pt) | 2005-01-04 |
EA200701302A1 (ru) | 2007-12-28 |
AU2003226705B2 (en) | 2008-11-06 |
NO20043997L (no) | 2004-10-27 |
TWI331604B (en) | 2010-10-11 |
EP1492536A1 (fr) | 2005-01-05 |
TW200406211A (en) | 2004-05-01 |
MY127771A (en) | 2006-12-29 |
JP4776882B2 (ja) | 2011-09-21 |
AU2003226705A1 (en) | 2003-10-13 |
RS85404A (en) | 2007-02-05 |
CN1642552B (zh) | 2010-05-12 |
PE20040169A1 (es) | 2004-05-24 |
JP2005529090A (ja) | 2005-09-29 |
CA2476008A1 (fr) | 2003-10-09 |
EA200401191A1 (ru) | 2005-04-28 |
NO329271B1 (no) | 2010-09-20 |
IL164167A0 (en) | 2005-12-18 |
EP1492536B1 (fr) | 2012-05-09 |
PL371188A1 (en) | 2005-06-13 |
EA009300B1 (ru) | 2007-12-28 |
WO2003082290A1 (fr) | 2003-10-09 |
HK1079095A1 (en) | 2006-03-31 |
HRP20040898A2 (en) | 2005-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MEP47208A (en) | 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors | |
MEP59508A (en) | Quinazoline derivatives, medicaments containing said compounds, their utilization and method for the production thereof | |
MEP58708A (en) | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof | |
YU65801A (sh) | Biciklična heterociklična jedinjenja, farmaceutske kompozicije koje sadrže ova jedinjenja i postupci za njihovo pripremanje | |
MEP45508A (en) | Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof | |
TW200730508A (en) | Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same | |
TW200505912A (en) | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | |
ATE536353T1 (de) | 2-(4-amino-1,2,5-oxadiazol-4-yl)-imidazol- verbindungen als protein kinase inhibitoren | |
TR200102505T2 (tr) | 4-amino-kinazolin ve kinolin türevleri. | |
DE60332433D1 (de) | Azolylaminoazine als proteinkinasehemmer | |
ATE371656T1 (de) | Heteroaryl-pyrimidinderivate als jak-inhibitoren | |
ATE468336T1 (de) | Azolylaminoazine als proteinkinasehemmer | |
ATE365733T1 (de) | Zusammensetzungen brauchbar als protein-kinase- inhibitoren | |
NO971038D0 (no) | Pyrimido£5,4-D|pyrimidiner, legemidler inneholdende disse forbindelser, deres anvendelse og fremgangsmåte for fremstilling av dem | |
MY150290A (en) | Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production | |
UY26902A1 (es) | Heterocíclicos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación | |
TW200510341A (en) | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | |
DE60206911D1 (de) | Imidazol-2-carbonsäureamid derivate als raf-kinase-inhibitoren | |
ATE386530T1 (de) | Chinazoline derivate und ihre anwendung in der krebsbehandlung | |
ATE412632T1 (de) | Neue aryl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel | |
MX2009007610A (es) | Heterociclicos biciclicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion. | |
ATE305787T1 (de) | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren | |
DE60108626D1 (de) | Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b] pyridinen als cyclin-abhängige kinase-hemmer | |
ATE321572T1 (de) | Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren | |
YU60501A (sh) | Derivati 4-amino-hinazolina i hinolina koji imaju inhibitorno dejstvo na prenos signala posredovanog tirozin kinazom |