ME00584A - N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereof - Google Patents
N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereofInfo
- Publication number
- ME00584A ME00584A MEP-18/09A MEP1809A ME00584A ME 00584 A ME00584 A ME 00584A ME P1809 A MEP1809 A ME P1809A ME 00584 A ME00584 A ME 00584A
- Authority
- ME
- Montenegro
- Prior art keywords
- cycloalkyl
- alkyl
- aryl
- alkylene
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Pronalazak se odnosi na jedinjenja opšte formule (1) u kojoj je X1 atom vodonika ili halogena C1-C6-alkil, C3-C7 cikloalkil, C3-C7 cikloalkil- C1-C6-alkilien-fl oroalkil, cijano C(0)NR1R2, nitro, C1-C6-ti oalkil, -S(O)- C1-C6-alkil, S(O)2-C1-C6-alkil, SO2NR1NR2, aril- C1-C6-alkilien, aril ili heteroaril grupu, pri čemu su aril i heteroaril po izboru supsti tuisani; X2 je atom vodonika ili halogena ili C1-C6-alkil, C3-C7 cikloalkil, C3-C7 cikloalkil- C1-C3-alkilien, C1-C6-fl oroalkil, C1-C6-alkoksil, C3-C7 cikloalkil-C1-C6-alkilien-0-, C1-C6 fl uoroalksil, cijano, C(0) NR1NR2,, C1-C6-ti oalkil,- S(O)- C1-C6-alkil, S(O)2- C1-C6-alkil, SO2NR1NR2, aril- C1-C6-alkilien, aril ili heteroaril grupu pri čemu su aril i heteroaril po izboru supsti tuisani; X3 i X4 nezavisno jedan od drugog, atom vodonika i l i halogena ili C1-C6-alkil, C3-C7 cikloalkil, C3-C7 cikloalkil-C1-C3-alkilien, C1-C6 fl uoroalkil, C1-C6-alkoksil, C3-C7 cikloalkil- C1-C6-alkilien-O-, C1-C6 fl uoralkoksil cijano C(0)NR1R2, nitro, NR1R2, C1-C6-ti oalkil, -S(0)- C1-C6-alkil, -S(O)2- C1-C6-alkil, O2NR1NR2, NR3COR4, NR3SO2R5, aril C1-C6 alkilien aril ili heteroaril grupa, pri čemu su aril i heteroaril po izboru supsti tuisani Z1,Z2,Z3,Z4 su nezavisno jedan od drugog atom azota ili C(R6) grupa, n je jednak 0, 1, 2 ili 3; Y je po izboru supsti tuisan aril ili heteroaril Ra Rb su, nezavisno jedan od drugog atom vodonika ili C1-C6-alkil, C3-C7-cikloalkil, C3-C7 cikloalkil- C1-C6-alkilien, C1-C6-fl uoroalkil, hidroksil C1-C6-alkoksil, C3-C7 cikloalkil- C1-C6-alkilien-O-, C1-C6-fluoroalkoksil, aril ili heteroaril grupa, pri čemu Ra i Rb mogu po izboru biti supslituisani u obliku baze il i adicione soli kiseline, i takođe u obliku hidrata ili solvata. Proces za njihovo dobijanje i terapeutska upotreba.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0606742A FR2903985B1 (fr) | 2006-07-24 | 2006-07-24 | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
PCT/FR2007/001250 WO2008012418A1 (fr) | 2006-07-24 | 2007-07-20 | Derives de n- (amino-heteroaryl) - 1h-indole-2 -carboxamides comme antagonistes des recepteurs de type trpv1 ou vr1 |
Publications (1)
Publication Number | Publication Date |
---|---|
ME00584A true ME00584A (en) | 2011-12-20 |
Family
ID=37734283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-18/09A ME00584A (en) | 2006-07-24 | 2007-07-20 | N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereof |
Country Status (29)
Country | Link |
---|---|
US (2) | US8227489B2 (hr) |
EP (1) | EP2046775B1 (hr) |
JP (1) | JP5265541B2 (hr) |
KR (1) | KR20090042239A (hr) |
CN (1) | CN101495469B (hr) |
AR (1) | AR061946A1 (hr) |
AU (1) | AU2007279166C1 (hr) |
BR (1) | BRPI0714559A2 (hr) |
CA (1) | CA2656716C (hr) |
CO (1) | CO6150146A2 (hr) |
CY (1) | CY1113470T1 (hr) |
DK (1) | DK2046775T3 (hr) |
EA (1) | EA016829B1 (hr) |
ES (1) | ES2393630T3 (hr) |
FR (1) | FR2903985B1 (hr) |
IL (1) | IL196113A0 (hr) |
MA (1) | MA30694B1 (hr) |
ME (1) | ME00584A (hr) |
MX (1) | MX2009000649A (hr) |
MY (1) | MY147465A (hr) |
NO (1) | NO20090726L (hr) |
NZ (1) | NZ574265A (hr) |
PE (1) | PE20080947A1 (hr) |
PL (1) | PL2046775T3 (hr) |
PT (1) | PT2046775E (hr) |
SI (1) | SI2046775T1 (hr) |
TW (1) | TWI388554B (hr) |
WO (1) | WO2008012418A1 (hr) |
ZA (1) | ZA200900228B (hr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2926553B1 (fr) * | 2008-01-23 | 2010-02-19 | Sanofi Aventis | Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique |
CN104144913B (zh) | 2011-12-21 | 2017-05-17 | 诺维拉治疗公司 | B型肝炎抗病毒剂 |
TWI636036B (zh) | 2012-08-28 | 2018-09-21 | 健生科學愛爾蘭無限公司 | 胺磺醯基-芳基醯胺類及其作為用於治療b型肝炎的藥物之用途 |
US10125094B2 (en) | 2013-02-28 | 2018-11-13 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis B |
PL2981536T3 (pl) | 2013-04-03 | 2017-11-30 | Janssen Sciences Ireland Uc | Pochodne N-fenylo-karboksyamidu i ich zastosowanie jako leku do leczenia wirusowego zapalenia wątroby typu B |
PT2997019T (pt) | 2013-05-17 | 2018-11-21 | Janssen Sciences Ireland Uc | Derivados de sulfamoíltiofenamida e o seu uso como medicamentos para o tratamento da hepatite b |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
NO3024819T3 (hr) | 2013-07-25 | 2018-07-21 | ||
JP6452119B2 (ja) | 2013-10-23 | 2019-01-16 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | カルボキサミド誘導体およびb型肝炎の処置のための医薬品としてのその使用 |
US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
CN106232136A (zh) | 2014-02-05 | 2016-12-14 | 诺维拉治疗公司 | 用于治疗hbv感染的联合疗法 |
UY35980A (es) | 2014-02-06 | 2015-08-31 | Janssen Sciences Ireland Uc | Derivados de sulfamoilpirrolamida como inhibidores del hbv y composiciones farmacéuticas que los contienen |
US9884831B2 (en) | 2015-03-19 | 2018-02-06 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis B infections |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
HUE057041T2 (hu) | 2015-07-06 | 2022-04-28 | Alkermes Inc | Hiszton deacetiláz hetero-halogén gátlói |
US10421756B2 (en) | 2015-07-06 | 2019-09-24 | Rodin Therapeutics, Inc. | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase |
CN105295896B (zh) * | 2015-09-11 | 2017-12-29 | 浙江大学 | 一种特异性标记的辣椒素荧光探针及其合成方法和应用 |
JP6845231B2 (ja) | 2015-09-29 | 2021-03-17 | ノヴィラ・セラピューティクス・インコーポレイテッド | B型肝炎抗ウイルス薬の結晶形態 |
MX2018012557A (es) | 2016-04-15 | 2019-07-04 | Janssen Sciences Ireland Uc | Combinaciones y métodos que comprenden un inhibidor del ensamblaje de la cápside. |
MX2019008302A (es) | 2017-01-11 | 2019-12-02 | Rodin Therapeutics Inc | Inhibidores biciclicos de histona desacetilasa. |
MA49839B1 (fr) | 2017-08-07 | 2022-05-31 | Alkermes Inc | Inhibiteurs bicycliques de la histone déacétylase |
MX2020009531A (es) | 2018-03-14 | 2020-10-05 | Janssen Sciences Ireland Unlimited Co | Regimen posologico del modulador del ensamblaje de la capside. |
WO2020169784A1 (en) | 2019-02-22 | 2020-08-27 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases |
US11491148B2 (en) | 2019-05-06 | 2022-11-08 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
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NL248308A (hr) | 1958-09-30 | |||
US4104385A (en) | 1976-08-19 | 1978-08-01 | Sterling Drug Inc. | Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalonates |
JPS609062B2 (ja) * | 1977-08-03 | 1985-03-07 | 広栄化学工業株式会社 | 新規な2−置換アミノ−5−γ−ピコリン類またはこれらの塩およびそれらの製造法とそれらを含有する角質繊維用染料 |
JP2004520299A (ja) | 2000-12-12 | 2004-07-08 | ニューロジェン・コーポレーション | スピロ[イソベンゾフラン−1,4’−ピペリジン]−3−オン類及び3h−スピロイソベンゾフラン−1,4’−ピペリジン類 |
DE10147672A1 (de) * | 2001-09-27 | 2003-04-10 | Bayer Ag | Substituierte 2,5-Diamidoindole und ihre Verwendung |
MY141521A (en) | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
US20060183753A1 (en) * | 2002-12-20 | 2006-08-17 | Bayer Healthcare Ag | Use of substituted 2,5-diamidoindoles for the treatment of urological diseases |
EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
DE602004005960T2 (de) | 2003-01-16 | 2008-01-17 | Sb Pharmco Puerto Rico Inc. | Heteroaryl-substituierte pyrrolä2, 3- büpyridin-derivate als crf-rezeptor-antagonisten |
GB0314136D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
DK1666473T3 (da) | 2003-09-17 | 2013-03-25 | Ono Pharmaceutical Co | Carboxylsyreforbindelser og medicinske sammensætninger indeholdende samme som aktiv ingrediens |
GB0322016D0 (en) * | 2003-09-19 | 2003-10-22 | Merck Sharp & Dohme | New compounds |
BRPI0414663A (pt) | 2003-09-22 | 2006-11-21 | Pfizer | derivados triazol substituìdos como antagonistas de oxitocina |
WO2005035526A1 (en) | 2003-10-09 | 2005-04-21 | Argenta Discovery Ltd. | Bicyclic compounds and their therapeutic use |
US20090036485A1 (en) | 2004-10-12 | 2009-02-05 | Frederic Henri Jung | Quinoline derivatives |
FR2880625B1 (fr) * | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
WO2007011284A1 (en) | 2005-07-15 | 2007-01-25 | Astrazeneca Ab | Therapeutic agents |
BRPI0619052A2 (pt) | 2005-11-28 | 2011-09-20 | Hoffmann La Roche | compostos, processo para a sua preparação, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de diacilglicerol aciltransferase, e seu uso |
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2006
- 2006-07-24 FR FR0606742A patent/FR2903985B1/fr not_active Expired - Fee Related
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2007
- 2007-07-19 TW TW096126382A patent/TWI388554B/zh not_active IP Right Cessation
- 2007-07-20 NZ NZ574265A patent/NZ574265A/en not_active IP Right Cessation
- 2007-07-20 CA CA2656716A patent/CA2656716C/fr not_active Expired - Fee Related
- 2007-07-20 BR BRPI0714559-4A2A patent/BRPI0714559A2/pt not_active IP Right Cessation
- 2007-07-20 PL PL07823311T patent/PL2046775T3/pl unknown
- 2007-07-20 EP EP07823311A patent/EP2046775B1/fr active Active
- 2007-07-20 MY MYPI20090316A patent/MY147465A/en unknown
- 2007-07-20 EA EA200970149A patent/EA016829B1/ru not_active IP Right Cessation
- 2007-07-20 DK DK07823311.1T patent/DK2046775T3/da active
- 2007-07-20 MX MX2009000649A patent/MX2009000649A/es active IP Right Grant
- 2007-07-20 PT PT07823311T patent/PT2046775E/pt unknown
- 2007-07-20 ZA ZA200900228A patent/ZA200900228B/xx unknown
- 2007-07-20 JP JP2009521291A patent/JP5265541B2/ja not_active Expired - Fee Related
- 2007-07-20 AR ARP070103239A patent/AR061946A1/es not_active Application Discontinuation
- 2007-07-20 ME MEP-18/09A patent/ME00584A/xx unknown
- 2007-07-20 ES ES07823311T patent/ES2393630T3/es active Active
- 2007-07-20 AU AU2007279166A patent/AU2007279166C1/en not_active Ceased
- 2007-07-20 KR KR1020097001656A patent/KR20090042239A/ko not_active Application Discontinuation
- 2007-07-20 PE PE2007000947A patent/PE20080947A1/es not_active Application Discontinuation
- 2007-07-20 SI SI200731056T patent/SI2046775T1/sl unknown
- 2007-07-20 WO PCT/FR2007/001250 patent/WO2008012418A1/fr active Application Filing
- 2007-07-20 CN CN200780028161XA patent/CN101495469B/zh not_active Expired - Fee Related
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2008
- 2008-12-22 IL IL196113A patent/IL196113A0/en not_active IP Right Cessation
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2009
- 2009-01-15 CO CO09002769A patent/CO6150146A2/es unknown
- 2009-01-23 US US12/358,639 patent/US8227489B2/en not_active Expired - Fee Related
- 2009-02-13 NO NO20090726A patent/NO20090726L/no not_active Application Discontinuation
- 2009-02-13 MA MA31637A patent/MA30694B1/fr unknown
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2012
- 2012-06-22 US US13/530,261 patent/US8481745B2/en not_active Expired - Fee Related
- 2012-11-08 CY CY20121101063T patent/CY1113470T1/el unknown
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