MD523F1 - Derivati noi ai triazolpirimidinei, antagonisti ai receptorilor angiotensinei II, procedee de preparare a lor, compozitii farmaceutice ce le contin - Google Patents
Derivati noi ai triazolpirimidinei, antagonisti ai receptorilor angiotensinei II, procedee de preparare a lor, compozitii farmaceutice ce le continInfo
- Publication number
- MD523F1 MD523F1 MD95-0084A MD950084A MD523F1 MD 523 F1 MD523 F1 MD 523F1 MD 950084 A MD950084 A MD 950084A MD 523 F1 MD523 F1 MD 523F1
- Authority
- MD
- Moldova
- Prior art keywords
- triazolpyrymidine
- angiotenzine
- antagonists
- derivatives
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9108486A FR2678618B1 (fr) | 1991-07-05 | 1991-07-05 | Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
Publications (2)
Publication Number | Publication Date |
---|---|
MD523F1 true MD523F1 (ro) | 1996-04-30 |
MD523G2 MD523G2 (ro) | 1997-01-31 |
Family
ID=9414783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD95-0084A MD523G2 (ro) | 1991-07-05 | 1994-12-30 | Derivaţi noi ai triazolpirimidinei, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice ce le conţin |
Country Status (23)
Country | Link |
---|---|
US (1) | US5217973A (ro) |
EP (1) | EP0521768B1 (ro) |
JP (1) | JP3140566B2 (ro) |
KR (1) | KR100243628B1 (ro) |
AT (1) | ATE101153T1 (ro) |
AU (1) | AU655288B2 (ro) |
CA (1) | CA2072233C (ro) |
CZ (1) | CZ284757B6 (ro) |
DE (1) | DE69200045T2 (ro) |
DK (1) | DK0521768T3 (ro) |
EE (1) | EE03003B1 (ro) |
ES (1) | ES2063570T3 (ro) |
FR (1) | FR2678618B1 (ro) |
HU (2) | HU220225B (ro) |
IE (1) | IE65635B1 (ro) |
IL (1) | IL102367A (ro) |
LV (1) | LV10717B (ro) |
MD (1) | MD523G2 (ro) |
NZ (1) | NZ243443A (ro) |
RU (1) | RU2103270C1 (ro) |
SK (1) | SK279902B6 (ro) |
TW (1) | TW221445B (ro) |
ZA (1) | ZA924954B (ro) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5358950A (en) * | 1991-07-05 | 1994-10-25 | Laboratoires Upsa | Triazolopyrimidine derivatives which are angiotensin II receptor antagonists |
US5387747A (en) * | 1992-02-24 | 1995-02-07 | Laboratoires Upsa | Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present |
FR2687677B1 (fr) * | 1992-02-24 | 1996-10-11 | Union Pharma Scient Appl | Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
US5389632A (en) * | 1992-02-24 | 1995-02-14 | Laboratoires Upsa | Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists |
IT1263804B (it) * | 1993-01-22 | 1996-09-03 | Luso Farmaco Inst | Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista |
US5358947A (en) * | 1993-09-13 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones |
AU743910B2 (en) | 1997-03-24 | 2002-02-07 | Kyowa Hakko Kirin Co., Ltd. | {1,2,4}triazolo{1,5-c}pyrimidine derivatives |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
EP3239170B1 (en) | 2008-06-04 | 2019-03-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2009158309A2 (en) * | 2008-06-25 | 2009-12-30 | Ligand Pharmaceuticals Inc. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
WO2023066299A1 (en) * | 2021-10-19 | 2023-04-27 | Impact Therapeutics (Shanghai) , Inc | Substituted triazoloheteroaryl compounds as usp1 inhibitors and the use thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US269980A (en) * | 1883-01-02 | Horse power | ||
GB859287A (en) * | 1958-10-03 | 1961-01-18 | Ici Ltd | Triazolopyrimidine derivatives and their preparation |
GB897870A (en) * | 1959-06-15 | 1962-05-30 | Ici Ltd | s-triazolo[2, 3-c]pyrimidine derivatives |
GB951652A (en) * | 1960-06-28 | 1964-03-11 | Wallace Broadbent | Sulphamyl triazolopyrimidines and their preparation |
US4269980A (en) * | 1979-12-17 | 1981-05-26 | American Cyanamid Company | (Substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines |
US4572910A (en) * | 1983-03-03 | 1986-02-25 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
US4528288A (en) * | 1983-05-02 | 1985-07-09 | Riker Laboratories, Inc. | Substituted triazolo[1,5-c]pyrimidines |
US4532242A (en) * | 1983-05-02 | 1985-07-30 | Riker Laboratories, Inc. | Substituted triazolo[4,3-c]pyrimidines |
US4562192A (en) * | 1984-02-03 | 1985-12-31 | G. D. Searle & Co. | 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazole[1,5-c]pyrimidines, and pharmaceutical compositions containing them |
US4728652A (en) * | 1985-05-20 | 1988-03-01 | E. R. Squibb & Sons, Inc. | 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure |
US5010195A (en) * | 1988-05-25 | 1991-04-23 | The Dow Chemical Company | Herbicidal alkoxy-1,2,4-triazolo(1,5-c)primidine-2-sulfonamides |
US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
EP0435827A3 (en) * | 1989-12-28 | 1991-11-13 | Ciba-Geigy Ag | Diaza compounds |
WO1991015209A1 (en) * | 1990-03-30 | 1991-10-17 | Merck & Co., Inc. | Substituted pyrimidines, pyrimidinones and pyridopyrimidines |
US5177206A (en) * | 1991-10-08 | 1993-01-05 | Dowelanco | Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides |
-
1991
- 1991-07-05 FR FR9108486A patent/FR2678618B1/fr not_active Expired - Lifetime
- 1991-08-07 US US07/741,134 patent/US5217973A/en not_active Expired - Lifetime
-
1992
- 1992-06-24 CA CA002072233A patent/CA2072233C/en not_active Expired - Lifetime
- 1992-06-30 IL IL102367A patent/IL102367A/xx not_active IP Right Cessation
- 1992-06-30 AT AT92401850T patent/ATE101153T1/de active
- 1992-06-30 DE DE69200045T patent/DE69200045T2/de not_active Expired - Lifetime
- 1992-06-30 ES ES92401850T patent/ES2063570T3/es not_active Expired - Lifetime
- 1992-06-30 DK DK92401850.0T patent/DK0521768T3/da active
- 1992-06-30 EP EP92401850A patent/EP0521768B1/fr not_active Expired - Lifetime
- 1992-07-01 IE IE922015A patent/IE65635B1/en not_active IP Right Cessation
- 1992-07-02 CZ CS922078A patent/CZ284757B6/cs not_active IP Right Cessation
- 1992-07-02 AU AU19396/92A patent/AU655288B2/en not_active Expired
- 1992-07-02 SK SK2078-92A patent/SK279902B6/sk not_active IP Right Cessation
- 1992-07-03 RU SU5052543A patent/RU2103270C1/ru active
- 1992-07-03 HU HU9202227A patent/HU220225B/hu unknown
- 1992-07-03 NZ NZ243443A patent/NZ243443A/xx not_active IP Right Cessation
- 1992-07-03 ZA ZA924954A patent/ZA924954B/xx unknown
- 1992-07-04 TW TW081105325A patent/TW221445B/zh not_active IP Right Cessation
- 1992-07-04 KR KR1019920011916A patent/KR100243628B1/ko not_active IP Right Cessation
- 1992-07-06 JP JP04200200A patent/JP3140566B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-29 LV LVP-94-60A patent/LV10717B/en unknown
- 1994-11-22 EE EE9400308A patent/EE03003B1/xx unknown
- 1994-12-30 MD MD95-0084A patent/MD523G2/ro active IP Right Grant
-
1995
- 1995-06-27 HU HU95P/P00446P patent/HU211473A9/hu unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Granted patent for invention | ||
IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20141230 |
|
MK4A | Patent for invention expired |