MD426C2 - Procedeu de obţinere a derivaţilor cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestora - Google Patents
Procedeu de obţinere a derivaţilor cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestoraInfo
- Publication number
- MD426C2 MD426C2 MD95-0077A MD950077A MD426C2 MD 426 C2 MD426 C2 MD 426C2 MD 950077 A MD950077 A MD 950077A MD 426 C2 MD426 C2 MD 426C2
- Authority
- MD
- Moldova
- Prior art keywords
- ethers
- hydrates
- esters
- salts
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la procedeul de obţinere a derivaţilor noi ai cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestora, care poseda proprietăţi biologic active.Scopul invenţiei constă în obţinerea derivaţilor noi ai cefalosporinei, care extind arsenalul de mijloace cu acţiune asupra organismului viu.Procedeul constă în aceea că în compusul cu formula generalăîn care X reprezintă grupa 2,5-dihidro-6-oxi-2-metil-5-oxo-as-triazin-3-il, care se află într-un echilibru tautometric cu grupa 1,2,5,6-tetrahidro-2-metil-5,6-dioxo-as-triazin-3-il; R reprezintă atom de clor, brom sau iod şi carboxigrupa poate fi în formă protejată, se separă grupa halogenoacetil amină de protecţie şi, în cazul respectiv, dacă grupa carboxilă este protejată, se separă grupa carboxilă de protecţie şi în cazul respectiv, dacă grupa carboxilă este protejată, se separă grupa carboxilă de protecţie prin tratarea cu tiouree în dizolvant apos sau anhidru în mediu acid, neutru sau alcalin.Produsul preferabil, obţinut prin procedeul propus, reprezintă acidul (6R, 7R)-7-[2-(2-amino-4-tiazolil)-2-(Z-metoziimino)acetamido]-3-{[(2,5-dihidro-6-ozi-2-metl-5-oxo-as-triazin-3-il)tio]-metil}-8-oxo-5-tia-l-azabiciclo(4,2,0)oct-2-en-2-carbonic.În caz de necesitate, produsul special se transferă în esterul, eterul sau sarea acestuia, sau în hidratul acestuia, sau hidratul esterului, eterului sau sării acestuia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH588278A CH641468A5 (de) | 1978-05-30 | 1978-05-30 | Cephemderivate. |
Publications (1)
Publication Number | Publication Date |
---|---|
MD426C2 true MD426C2 (ro) | 1996-07-31 |
Family
ID=4300898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD95-0077A MD426C2 (ro) | 1978-05-30 | 1994-12-30 | Procedeu de obţinere a derivaţilor cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestora |
Country Status (9)
Country | Link |
---|---|
US (1) | US4327210A (ro) |
KR (1) | KR830000853B1 (ro) |
AR (1) | AR231642A1 (ro) |
CH (1) | CH641468A5 (ro) |
GE (1) | GEP19970803B (ro) |
IN (1) | IN151115B (ro) |
MD (1) | MD426C2 (ro) |
SU (1) | SU927119A3 (ro) |
ZA (1) | ZA792517B (ro) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4409387A (en) * | 1979-11-29 | 1983-10-11 | Hoffmann-La Roche Inc. | Cephalosporin derivatives |
DK379581A (da) * | 1980-10-06 | 1982-04-07 | Hoffmann La Roche | Fremgangsmaade til fremstilling af acylderivater |
EP0058250A3 (de) * | 1981-02-17 | 1983-08-17 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Cephalosporinderivate, deren Herstellung und entsprechende pharmazeutische Präparate |
US4472574A (en) * | 1981-05-22 | 1984-09-18 | Hoffman-La Roche Inc. | Process for the manufacture of a cephem carboxylic acid derivative |
CA1256799A (en) * | 1984-02-22 | 1989-07-04 | Walter Fuller | Suppositories |
US4695565A (en) * | 1984-10-04 | 1987-09-22 | Merck & Co., Inc. | Antibacterial 7β-heterocyclic-cephem |
US4698338A (en) * | 1986-02-19 | 1987-10-06 | Eli Lilly And Company | 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins |
KR940000112B1 (ko) * | 1990-07-05 | 1994-01-05 | 주식회사 대웅제약 | 신규의 3-치환 세펨화합물 및 그의 제조방법 |
KR950014571B1 (ko) * | 1991-11-18 | 1995-12-08 | 제일제당주식회사 | 세펨 유도체의 제조방법 |
AT398764B (de) * | 1992-01-28 | 1995-01-25 | Lek Tovarna Farmacevtskih | Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat |
AT399877B (de) * | 1992-02-20 | 1995-08-25 | Biochemie Gmbh | Neues verfahren zur herstellung von ceftriaxon |
US5318781A (en) * | 1993-04-06 | 1994-06-07 | Hoffmann-La Roche Inc. | Absorption enhancement of antibiotics |
US20020115852A1 (en) * | 1997-04-01 | 2002-08-22 | Gerd Ascher | Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates |
US6906187B2 (en) * | 2003-02-27 | 2005-06-14 | Miat S.P.A. | Manufacture of cefalosporins and intermediates |
US6956375B2 (en) * | 2004-01-09 | 2005-10-18 | General Electric Company | Magnetic resonance imaging magnetic field generator |
US7569691B2 (en) * | 2005-04-20 | 2009-08-04 | Shin-Etsu Chemical Co., Ltd. | Protected piperazino group-bearing organoxysilane compound and making method |
WO2006118948A2 (en) * | 2005-04-29 | 2006-11-09 | Cubist Pharmaceuticals, Inc. | Therapeutic compositions |
CN101418015B (zh) * | 2007-10-24 | 2011-04-27 | 山东轩竹医药科技有限公司 | 头孢曲松磷酰化衍生物 |
RU2504548C1 (ru) * | 2012-09-28 | 2014-01-20 | Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" (Сфу) | ПРОИЗВОДНОЕ β-ЛАКТАМНОГО АНТИБИОТИКА ЦЕФТРИАКСОНА |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU243A1 (ru) * | 1920-06-07 | 1924-09-15 | В.Т. Бовин | Вагонетка дл кабельной вис чей дороги, переносной радиально вокруг центральной опоры |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4091211A (en) * | 1974-05-05 | 1978-05-23 | Hoffmann-La Roche Inc. | Cephalosporins |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
DE2760484C2 (ro) | 1976-04-14 | 1992-12-03 | Takeda Chemical Industries, Ltd., Osaka, Jp | |
US4061861A (en) * | 1976-06-21 | 1977-12-06 | Eli Lilly And Company | 7-[α-(2,3-DIHYDRO-2-OXO-1H-benzimidazol-1-ylcarbonyl-amino)arylacetamido]cephalosporins |
FR2387971A1 (fr) * | 1977-04-19 | 1978-11-17 | Delalande Sa | Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique |
US4200745A (en) * | 1977-12-20 | 1980-04-29 | Eli Lilly And Company | 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins |
-
1978
- 1978-05-30 CH CH588278A patent/CH641468A5/de not_active IP Right Cessation
- 1978-11-24 US US05/963,255 patent/US4327210A/en not_active Expired - Lifetime
-
1979
- 1979-05-18 IN IN517/CAL/79A patent/IN151115B/en unknown
- 1979-05-23 ZA ZA792517A patent/ZA792517B/xx unknown
- 1979-05-28 SU SU792768351A patent/SU927119A3/ru active
- 1979-05-29 KR KR1019790001749A patent/KR830000853B1/ko active
- 1979-05-30 AR AR276732A patent/AR231642A1/es active
-
1993
- 1993-07-12 GE GEAP19931001A patent/GEP19970803B/en unknown
-
1994
- 1994-12-30 MD MD95-0077A patent/MD426C2/ro unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU243A1 (ru) * | 1920-06-07 | 1924-09-15 | В.Т. Бовин | Вагонетка дл кабельной вис чей дороги, переносной радиально вокруг центральной опоры |
Also Published As
Publication number | Publication date |
---|---|
CH641468A5 (de) | 1984-02-29 |
SU927119A3 (ru) | 1982-05-07 |
KR830000853B1 (ko) | 1983-04-21 |
US4327210A (en) | 1982-04-27 |
GEP19970803B (en) | 1997-01-16 |
AR231642A1 (es) | 1985-01-31 |
ZA792517B (en) | 1980-06-25 |
IN151115B (ro) | 1983-02-26 |
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