MD426C2 - Procedeu de obţinere a derivaţilor cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestora - Google Patents

Procedeu de obţinere a derivaţilor cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestora

Info

Publication number
MD426C2
MD426C2 MD95-0077A MD950077A MD426C2 MD 426 C2 MD426 C2 MD 426C2 MD 950077 A MD950077 A MD 950077A MD 426 C2 MD426 C2 MD 426C2
Authority
MD
Moldova
Prior art keywords
ethers
hydrates
esters
salts
preparation
Prior art date
Application number
MD95-0077A
Other languages
English (en)
Russian (ru)
Inventor
Montavon Dr.Marc
Roland Reiner Dr.
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of MD426C2 publication Critical patent/MD426C2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Invenţia se referă la procedeul de obţinere a derivaţilor noi ai cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestora, care poseda proprietăţi biologic active.Scopul invenţiei constă în obţinerea derivaţilor noi ai cefalosporinei, care extind arsenalul de mijloace cu acţiune asupra organismului viu.Procedeul constă în aceea că în compusul cu formula generalăîn care X reprezintă grupa 2,5-dihidro-6-oxi-2-metil-5-oxo-as-triazin-3-il, care se află într-un echilibru tautometric cu grupa 1,2,5,6-tetrahidro-2-metil-5,6-dioxo-as-triazin-3-il; R reprezintă atom de clor, brom sau iod şi carboxigrupa poate fi în formă protejată, se separă grupa halogenoacetil amină de protecţie şi, în cazul respectiv, dacă grupa carboxilă este protejată, se separă grupa carboxilă de protecţie şi în cazul respectiv, dacă grupa carboxilă este protejată, se separă grupa carboxilă de protecţie prin tratarea cu tiouree în dizolvant apos sau anhidru în mediu acid, neutru sau alcalin.Produsul preferabil, obţinut prin procedeul propus, reprezintă acidul (6R, 7R)-7-[2-(2-amino-4-tiazolil)-2-(Z-metoziimino)acetamido]-3-{[(2,5-dihidro-6-ozi-2-metl-5-oxo-as-triazin-3-il)tio]-metil}-8-oxo-5-tia-l-azabiciclo(4,2,0)oct-2-en-2-carbonic.În caz de necesitate, produsul special se transferă în esterul, eterul sau sarea acestuia, sau în hidratul acestuia, sau hidratul esterului, eterului sau sării acestuia.
MD95-0077A 1978-05-30 1994-12-30 Procedeu de obţinere a derivaţilor cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestora MD426C2 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH588278A CH641468A5 (de) 1978-05-30 1978-05-30 Cephemderivate.

Publications (1)

Publication Number Publication Date
MD426C2 true MD426C2 (ro) 1996-07-31

Family

ID=4300898

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0077A MD426C2 (ro) 1978-05-30 1994-12-30 Procedeu de obţinere a derivaţilor cefalosporinei sau a esterilor, eterilor sau sărurilor acestora, sau a hidraţilor acestora, sau a hidraţilor esterilor, eterilor sau sărurilor acestora

Country Status (9)

Country Link
US (1) US4327210A (ro)
KR (1) KR830000853B1 (ro)
AR (1) AR231642A1 (ro)
CH (1) CH641468A5 (ro)
GE (1) GEP19970803B (ro)
IN (1) IN151115B (ro)
MD (1) MD426C2 (ro)
SU (1) SU927119A3 (ro)
ZA (1) ZA792517B (ro)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409387A (en) * 1979-11-29 1983-10-11 Hoffmann-La Roche Inc. Cephalosporin derivatives
DK379581A (da) * 1980-10-06 1982-04-07 Hoffmann La Roche Fremgangsmaade til fremstilling af acylderivater
EP0058250A3 (de) * 1981-02-17 1983-08-17 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporinderivate, deren Herstellung und entsprechende pharmazeutische Präparate
US4472574A (en) * 1981-05-22 1984-09-18 Hoffman-La Roche Inc. Process for the manufacture of a cephem carboxylic acid derivative
CA1256799A (en) * 1984-02-22 1989-07-04 Walter Fuller Suppositories
US4695565A (en) * 1984-10-04 1987-09-22 Merck & Co., Inc. Antibacterial 7β-heterocyclic-cephem
US4698338A (en) * 1986-02-19 1987-10-06 Eli Lilly And Company 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins
KR940000112B1 (ko) * 1990-07-05 1994-01-05 주식회사 대웅제약 신규의 3-치환 세펨화합물 및 그의 제조방법
KR950014571B1 (ko) * 1991-11-18 1995-12-08 제일제당주식회사 세펨 유도체의 제조방법
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US20020115852A1 (en) * 1997-04-01 2002-08-22 Gerd Ascher Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
US6906187B2 (en) * 2003-02-27 2005-06-14 Miat S.P.A. Manufacture of cefalosporins and intermediates
US6956375B2 (en) * 2004-01-09 2005-10-18 General Electric Company Magnetic resonance imaging magnetic field generator
US7569691B2 (en) * 2005-04-20 2009-08-04 Shin-Etsu Chemical Co., Ltd. Protected piperazino group-bearing organoxysilane compound and making method
NZ580951A (en) * 2005-04-29 2011-06-30 Cubist Pharm Inc Therapeutic compositions
CN101418015B (zh) * 2007-10-24 2011-04-27 山东轩竹医药科技有限公司 头孢曲松磷酰化衍生物
RU2504548C1 (ru) * 2012-09-28 2014-01-20 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" (Сфу) ПРОИЗВОДНОЕ β-ЛАКТАМНОГО АНТИБИОТИКА ЦЕФТРИАКСОНА

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU243A1 (ru) * 1920-06-07 1924-09-15 В.Т. Бовин Вагонетка дл кабельной вис чей дороги, переносной радиально вокруг центральной опоры

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091211A (en) * 1974-05-05 1978-05-23 Hoffmann-La Roche Inc. Cephalosporins
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GR63088B (en) 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
US4061861A (en) * 1976-06-21 1977-12-06 Eli Lilly And Company 7-[α-(2,3-DIHYDRO-2-OXO-1H-benzimidazol-1-ylcarbonyl-amino)arylacetamido]cephalosporins
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU243A1 (ru) * 1920-06-07 1924-09-15 В.Т. Бовин Вагонетка дл кабельной вис чей дороги, переносной радиально вокруг центральной опоры

Also Published As

Publication number Publication date
CH641468A5 (de) 1984-02-29
IN151115B (ro) 1983-02-26
AR231642A1 (es) 1985-01-31
SU927119A3 (ru) 1982-05-07
ZA792517B (en) 1980-06-25
US4327210A (en) 1982-04-27
GEP19970803B (en) 1997-01-16
KR830000853B1 (ko) 1983-04-21

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