FR2452492A1 - Procede de preparation de sulfoxydes de penicilline - Google Patents

Procede de preparation de sulfoxydes de penicilline

Info

Publication number
FR2452492A1
FR2452492A1 FR8006269A FR8006269A FR2452492A1 FR 2452492 A1 FR2452492 A1 FR 2452492A1 FR 8006269 A FR8006269 A FR 8006269A FR 8006269 A FR8006269 A FR 8006269A FR 2452492 A1 FR2452492 A1 FR 2452492A1
Authority
FR
France
Prior art keywords
penicillin
benzoyl
acetyl
preparation
chosen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8006269A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2452492A1 publication Critical patent/FR2452492A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDE D'OXYDATION D'UNE PENICILLINE EN PENICILLINE-SULFOXYDE, LADITE PENICILLINE AYANT LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST CHOISI DANS LE GROUPE COMPRENANT LES GROUPEMENTS PHENOXYACETYLE, BENZOYLE, THIENYL-2-ACETYLE OU PHENYL-GLYCYLE ET LES ATOMES D'HYDROGENE; ET R EST CHOISI DANS LE GROUPE COMPRENANT L'HYDROGENE, LES CATIONS DE METAUX ALCALINS ET LES GROUPEMENTS PROTECTEURS DU GROUPEMENT ACIDE CARBOXYLIQUE, CARACTERISE EN CE QU'ON FAIT REAGIR LADITE PENICILLINE AVEC UN PEROXYMONOSULFATE DANS UN MILIEU AQUEUX A UNE TEMPERATURE D'ENVIRON 0C A ENVIRON 50C. LES COMPOSES OBTENUS SONT DES INTERMEDIAIRES IMPORTANTS DANS LA PREPARATION DE CEPHALOSPORINES ANTIBIOTIQUES.
FR8006269A 1979-03-26 1980-03-20 Procede de preparation de sulfoxydes de penicilline Withdrawn FR2452492A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/023,875 US4230620A (en) 1979-03-26 1979-03-26 Process for preparing penicillin sulfoxides

Publications (1)

Publication Number Publication Date
FR2452492A1 true FR2452492A1 (fr) 1980-10-24

Family

ID=21817696

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8006269A Withdrawn FR2452492A1 (fr) 1979-03-26 1980-03-20 Procede de preparation de sulfoxydes de penicilline

Country Status (23)

Country Link
US (1) US4230620A (fr)
EP (1) EP0017419A1 (fr)
JP (1) JPS55130982A (fr)
KR (1) KR830001968B1 (fr)
AR (1) AR225170A1 (fr)
AU (1) AU5672980A (fr)
BE (1) BE882356A (fr)
CS (1) CS212343B2 (fr)
DD (1) DD149668A5 (fr)
DK (1) DK127680A (fr)
ES (1) ES8104299A1 (fr)
FI (1) FI800872A (fr)
FR (1) FR2452492A1 (fr)
GB (1) GB2047245A (fr)
GR (1) GR68012B (fr)
IL (1) IL59685A0 (fr)
IT (1) IT1130076B (fr)
LU (1) LU82290A1 (fr)
PH (1) PH14454A (fr)
PL (1) PL222865A1 (fr)
PT (1) PT70982A (fr)
YU (1) YU81180A (fr)
ZA (1) ZA801621B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70221A0 (en) * 1982-11-16 1984-02-29 Lilly Co Eli Process for sulfones
US4502988A (en) * 1983-08-08 1985-03-05 Eli Lilly And Company Oxidation process
DE3432365A1 (de) * 1984-09-03 1986-03-13 Deutsche Bp Ag, 2000 Hamburg Brennstoff auf basis von kohle
CA1256426A (fr) * 1985-09-06 1989-06-27 Jacobus J. Bos Preparation de 1,1-dioxyde d'acide 6-amino- penicillanique par oxydation d'acide 6-amino- penicillanique
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
CN102964355B (zh) * 2012-12-17 2015-07-01 华北制药河北华民药业有限责任公司 一种青霉素g亚砜的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197466A (en) * 1961-10-30 1965-07-27 Smith Kline French Lab Penicillin sulfoxides and process
US3544581A (en) * 1965-07-22 1970-12-01 Bristol Myers Co Production of 6-amino-penicillanic acid sulfoxide
US3586667A (en) * 1967-12-22 1971-06-22 Lilly Co Eli Penicillin esterification process
GB1442993A (en) * 1972-07-18 1976-07-21 Gist Brocades Nv Penicillin and cephalosporin r-sulphoxides
US4052387A (en) * 1974-12-24 1977-10-04 Eli Lilly And Company Method of preparation of 3-methylenecephams
CA1069126A (fr) * 1974-12-24 1980-01-01 Eli Lilly And Company Halogenures de sulfinyle et leur preparation a partir de sulfoxydes de penicilline
PL95709B1 (pl) * 1975-01-28 1977-11-30 Sposob wytwarzania selfotlenkow estrow penicylin

Also Published As

Publication number Publication date
BE882356A (fr) 1980-09-22
IL59685A0 (en) 1980-06-30
CS212343B2 (en) 1982-03-26
KR830001948A (ko) 1983-05-21
AU5672980A (en) 1980-10-02
FI800872A (fi) 1980-09-27
ES489909A0 (es) 1981-04-16
PT70982A (en) 1980-04-01
EP0017419A1 (fr) 1980-10-15
JPS55130982A (en) 1980-10-11
US4230620A (en) 1980-10-28
PH14454A (en) 1981-07-23
DK127680A (da) 1980-09-27
LU82290A1 (fr) 1980-07-01
IT8020873A0 (it) 1980-03-24
ZA801621B (en) 1981-10-28
ES8104299A1 (es) 1981-04-16
AR225170A1 (es) 1982-02-26
IT1130076B (it) 1986-06-11
YU81180A (en) 1983-02-28
GR68012B (fr) 1981-10-26
KR830001968B1 (ko) 1983-09-29
PL222865A1 (fr) 1980-12-01
DD149668A5 (de) 1981-07-22
GB2047245A (en) 1980-11-26

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Legal Events

Date Code Title Description
ST Notification of lapse