MD426C2 - Process for cephalosporin derivatives or esters, ethers or salts or hydrates, esters, ethers hydrates, ethers or salts thereof preparation. - Google Patents

Process for cephalosporin derivatives or esters, ethers or salts or hydrates, esters, ethers hydrates, ethers or salts thereof preparation.

Info

Publication number
MD426C2
MD426C2 MD95-0077A MD950077A MD426C2 MD 426 C2 MD426 C2 MD 426C2 MD 950077 A MD950077 A MD 950077A MD 426 C2 MD426 C2 MD 426C2
Authority
MD
Moldova
Prior art keywords
ethers
hydrates
esters
salts
preparation
Prior art date
Application number
MD95-0077A
Other languages
Romanian (ro)
Russian (ru)
Inventor
Montavon Dr.Marc
Roland Reiner Dr.
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of MD426C2 publication Critical patent/MD426C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the process for cephalosporin derivatives preparation, or esters, ethers or salts, or hydrates, esters, ether hydrates, ether or salts thereof preparation which possess the biologic active characteristics.The aim of the invention - preparation of the new cephalosporin derivatives, increasing the remedy gamma auctioning the vival body.The process consists in the fact that in the composition of formulawhere X-2,5-dihydro-6-oxi-2-methyl-5-oxo-as-triazine-3-yl-group, which is in the tautomeric equilibrium with the 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazine-3-yl-group; R - brom or iod atom clor and carboxigroup may be protected, the halogen acetylic aminoprotected group is detached, if the carboxigroup is protected, the carboxiprotected group is detached by the thiourea treatment in the water or waterless solvent in acid neutral or alkali medium.The preferable product obtained by the proposed process is (6R, 7R)-7-ő2-(2-amino-4-triazolyl)-2-(Z-methoxiimino)acetomidoú-Őő(2,5-dihydro-6-oxi-2-methyl-5-oxo-as-triazine-3yl)thioú-methylÚ-8-oxo-5-tria-1-azabicyclo(4,2,0)oct-2-en-2-2-carbon acid.I necessary the desired product is transfered into the ether thereof, ester or salt thereof or into the hydrate or ether hydrate thereof, ester or salt thereof.
MD95-0077A 1978-05-30 1994-12-30 Process for cephalosporin derivatives or esters, ethers or salts or hydrates, esters, ethers hydrates, ethers or salts thereof preparation. MD426C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH588278A CH641468A5 (en) 1978-05-30 1978-05-30 CEPHEM DERIVATIVES.

Publications (1)

Publication Number Publication Date
MD426C2 true MD426C2 (en) 1996-07-31

Family

ID=4300898

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0077A MD426C2 (en) 1978-05-30 1994-12-30 Process for cephalosporin derivatives or esters, ethers or salts or hydrates, esters, ethers hydrates, ethers or salts thereof preparation.

Country Status (9)

Country Link
US (1) US4327210A (en)
KR (1) KR830000853B1 (en)
AR (1) AR231642A1 (en)
CH (1) CH641468A5 (en)
GE (1) GEP19970803B (en)
IN (1) IN151115B (en)
MD (1) MD426C2 (en)
SU (1) SU927119A3 (en)
ZA (1) ZA792517B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409387A (en) * 1979-11-29 1983-10-11 Hoffmann-La Roche Inc. Cephalosporin derivatives
DK379581A (en) * 1980-10-06 1982-04-07 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF ACYL DERIVATIVES
EP0058250A3 (en) * 1981-02-17 1983-08-17 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporin derivatives, their preparation and pharmaceutical compositions containing them
US4472574A (en) * 1981-05-22 1984-09-18 Hoffman-La Roche Inc. Process for the manufacture of a cephem carboxylic acid derivative
CA1256799A (en) * 1984-02-22 1989-07-04 Walter Fuller Suppositories
US4695565A (en) * 1984-10-04 1987-09-22 Merck & Co., Inc. Antibacterial 7β-heterocyclic-cephem
US4698338A (en) * 1986-02-19 1987-10-06 Eli Lilly And Company 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins
KR940000112B1 (en) * 1990-07-05 1994-01-05 주식회사 대웅제약 3-substituted cephem compounds
KR950014571B1 (en) * 1991-11-18 1995-12-08 제일제당주식회사 Method for producing cefem derivatives
AT398764B (en) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih METHOD FOR PRODUCING CEFTRIAXONDINATRIUM SALZHEMIHEPTAHYDRATE
AT399877B (en) * 1992-02-20 1995-08-25 Biochemie Gmbh NEW METHOD FOR PRODUCING CEFTRIAXONE
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US20020115852A1 (en) * 1997-04-01 2002-08-22 Gerd Ascher Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
US6906187B2 (en) * 2003-02-27 2005-06-14 Miat S.P.A. Manufacture of cefalosporins and intermediates
US6956375B2 (en) * 2004-01-09 2005-10-18 General Electric Company Magnetic resonance imaging magnetic field generator
US7569691B2 (en) * 2005-04-20 2009-08-04 Shin-Etsu Chemical Co., Ltd. Protected piperazino group-bearing organoxysilane compound and making method
NZ580951A (en) * 2005-04-29 2011-06-30 Cubist Pharm Inc Therapeutic compositions
CN101418015B (en) * 2007-10-24 2011-04-27 山东轩竹医药科技有限公司 Ceftriaxone phosphorylation derivates
RU2504548C1 (en) * 2012-09-28 2014-01-20 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" (Сфу) DERIVATIVE OF β-LACTAM CEFTRIAXONE ANTIBIOTIC

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU243A1 (en) * 1920-06-07 1924-09-15 В.Т. Бовин Trolley for cable cable road, portable radially around the central support

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091211A (en) * 1974-05-05 1978-05-23 Hoffmann-La Roche Inc. Cephalosporins
DK154939C (en) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF
GR63088B (en) 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
US4061861A (en) * 1976-06-21 1977-12-06 Eli Lilly And Company 7-[α-(2,3-DIHYDRO-2-OXO-1H-benzimidazol-1-ylcarbonyl-amino)arylacetamido]cephalosporins
FR2387971A1 (en) * 1977-04-19 1978-11-17 Delalande Sa NEW TRIMETHOXY CINNAMOYLES PIPERAZINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU243A1 (en) * 1920-06-07 1924-09-15 В.Т. Бовин Trolley for cable cable road, portable radially around the central support

Also Published As

Publication number Publication date
CH641468A5 (en) 1984-02-29
IN151115B (en) 1983-02-26
AR231642A1 (en) 1985-01-31
SU927119A3 (en) 1982-05-07
ZA792517B (en) 1980-06-25
US4327210A (en) 1982-04-27
GEP19970803B (en) 1997-01-16
KR830000853B1 (en) 1983-04-21

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