MD3368541T2 - Compoziții și procedee de inhibare a activității arginazei - Google Patents

Info

Publication number

MD3368541T2

MD3368541T2 MDE20180870T MDE20180870T MD3368541T2 MD 3368541 T2 MD3368541 T2 MD 3368541T2 MD E20180870 T MDE20180870 T MD E20180870T MD E20180870 T MDE20180870 T MD E20180870T MD 3368541 T2 MD3368541 T2 MD 3368541T2

Authority

MD

Moldova

Prior art keywords

cancer

compound

use according

tumor

alkyl

Prior art date

2015-10-30

Links

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• Global Dossier
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• 238000000034 method Methods 0.000 title claims abstract description 57
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• 108700024123 Arginases Proteins 0.000 title abstract description 20
• 230000002401 inhibitory effect Effects 0.000 title abstract description 4
• 239000000203 mixture Substances 0.000 title description 68
• 230000000694 effects Effects 0.000 title description 16
• 150000001875 compounds Chemical class 0.000 claims abstract description 202
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• 201000011510 cancer Diseases 0.000 claims abstract description 56
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 30
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• -1 campotecin Chemical compound 0.000 claims description 60
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• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims description 41
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