MD247C2 - Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-[2-(2-amino-4-tiazolil)-2-metoxiiminoacetamido] -cef-3-em-4-carbonic, a sin-izomerului - Google Patents
Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-[2-(2-amino-4-tiazolil)-2-metoxiiminoacetamido] -cef-3-em-4-carbonic, a sin-izomeruluiInfo
- Publication number
- MD247C2 MD247C2 MD94-0275A MD940275A MD247C2 MD 247 C2 MD247 C2 MD 247C2 MD 940275 A MD940275 A MD 940275A MD 247 C2 MD247 C2 MD 247C2
- Authority
- MD
- Moldova
- Prior art keywords
- cef
- amino
- crystalline form
- carbonic acid
- natrium
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7725142A FR2400519A1 (fr) | 1977-08-17 | 1977-08-17 | Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament |
SU782645701A SU799666A3 (ru) | 1977-08-17 | 1978-08-09 | Способ получени гидратированной крис-ТАлличЕСКОй фОРМы НАТРиЕВОй СОли 3-АцЕТОКСи-МЕТил-7 2-(2-АМиНО-4-ТиАзОлил)-2-МЕТОКСи-иМиНОАцЕТАМидО цЕф-3-EM-4-КАРбОНОВОй КиС-лОТы,СиН-изОМЕРА |
Publications (2)
Publication Number | Publication Date |
---|---|
MD247B1 MD247B1 (ro) | 1995-07-31 |
MD247C2 true MD247C2 (ro) | 1995-12-31 |
Family
ID=9194564
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0275A MD247C2 (ro) | 1977-08-17 | 1994-09-08 | Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-[2-(2-amino-4-tiazolil)-2-metoxiiminoacetamido] -cef-3-em-4-carbonic, a sin-izomerului |
MD94-0267A MD225C2 (ro) | 1977-08-17 | 1994-09-08 | Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-12-(2-amino-4-tiazolil)-2-metoxiiminoacetamido-cef-3-em-4-carbonic, sin-izomerului |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0267A MD225C2 (ro) | 1977-08-17 | 1994-09-08 | Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-12-(2-amino-4-tiazolil)-2-metoxiiminoacetamido-cef-3-em-4-carbonic, sin-izomerului |
Country Status (34)
Country | Link |
---|---|
US (1) | US4224371A (el) |
EP (1) | EP0001024B1 (el) |
JP (1) | JPS5441890A (el) |
AT (2) | AT366049B (el) |
AU (1) | AU520898B2 (el) |
BG (2) | BG33887A3 (el) |
CA (1) | CA1121343A (el) |
CS (2) | CS207646B2 (el) |
DD (1) | DD137588A5 (el) |
DE (1) | DE2860358D1 (el) |
DK (2) | DK152213C (el) |
EG (1) | EG13520A (el) |
ES (1) | ES472381A1 (el) |
FI (1) | FI65433C (el) |
FR (1) | FR2400519A1 (el) |
GE (2) | GEP19960475B (el) |
GR (1) | GR73661B (el) |
HR (1) | HRP931395B1 (el) |
HU (1) | HU181497B (el) |
IE (1) | IE47230B1 (el) |
IL (1) | IL55186A (el) |
IT (1) | IT1107961B (el) |
MD (2) | MD247C2 (el) |
MX (2) | MX155976A (el) |
NO (1) | NO156168C (el) |
NZ (1) | NZ188163A (el) |
OA (1) | OA06016A (el) |
PL (1) | PL126619B1 (el) |
PT (1) | PT68431A (el) |
RO (1) | RO79999A (el) |
SI (1) | SI7811917A8 (el) |
SU (2) | SU799666A3 (el) |
YU (1) | YU42166B (el) |
ZA (1) | ZA784187B (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60120886A (ja) * | 1983-12-02 | 1985-06-28 | Takeda Chem Ind Ltd | セフェムカルボン酸のナトリウム塩の結晶 |
DE3485860T2 (de) * | 1983-12-29 | 1993-01-14 | Mochida Pharm Co Ltd | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
JPS60142987A (ja) * | 1983-12-29 | 1985-07-29 | Mochida Pharmaceut Co Ltd | セフアロスポリン誘導体 |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
WO1987001117A2 (en) * | 1985-08-12 | 1987-02-26 | The Upjohn Company | Conversion of cephalosporin hydrohalide salt to alkali metal salt |
JPS63132893A (ja) * | 1986-11-25 | 1988-06-04 | Mochida Pharmaceut Co Ltd | 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤 |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
RU2021274C1 (ru) | 1991-05-17 | 1994-10-15 | Польска Акадэмия Наук Институт Хэмии Органичнэй | Способ получения аминотиазолильных производных цефалоспорина |
US5318781A (en) * | 1993-04-06 | 1994-06-07 | Hoffmann-La Roche Inc. | Absorption enhancement of antibiotics |
US5574154A (en) * | 1994-09-29 | 1996-11-12 | Alnejma Bulk Pharmaceutical Co. A.B.P.C. | Process for the preparation of cephalosporanic compounds |
GB9423459D0 (en) * | 1994-11-21 | 1995-01-11 | Biochemie Gmbh | Silylation process |
AT402928B (de) * | 1994-12-23 | 1997-09-25 | Biochemie Gmbh | Neues verfahren zur herstellung von cefotaxim |
AU690482B2 (en) * | 1996-03-18 | 1998-04-23 | Ranbaxy Laboratories Limited | Process for producing cephalosporin antibiotics |
GB9717629D0 (en) * | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
WO2001092254A1 (fr) * | 2000-05-30 | 2001-12-06 | Fujisawa Pharmaceutical Co., Ltd. | Procede permettant de remplacer des solvants contenus dans des cristaux de type clathrates |
WO2004063203A1 (en) * | 2003-01-10 | 2004-07-29 | Orchid Chemicals & Pharmaceuticals Ltd | Process for the preparation of cefotaxime sodium |
CN100361995C (zh) * | 2004-10-27 | 2008-01-16 | 山东瑞阳制药有限公司 | 注射级无菌头孢噻肟钠的一步法制备工艺 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3970651A (en) * | 1974-01-07 | 1976-07-20 | Bristol-Myers Company | Crystalline cephalosporin derivative |
US3985747A (en) * | 1974-05-24 | 1976-10-12 | Bristol-Myers Company | Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
US4006138A (en) * | 1975-04-11 | 1977-02-01 | Eli Lilly And Company | Crystalline form of sodium O-formylcefamandole |
SE440655B (sv) * | 1976-01-23 | 1985-08-12 | Roussel Uclaf | Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra |
DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
-
1977
- 1977-08-17 FR FR7725142A patent/FR2400519A1/fr active Granted
-
1978
- 1978-07-20 IL IL55186A patent/IL55186A/xx active IP Right Grant
- 1978-07-22 OA OA56566A patent/OA06016A/xx unknown
- 1978-07-24 ZA ZA00784187A patent/ZA784187B/xx unknown
- 1978-08-02 DD DD78207090A patent/DD137588A5/xx unknown
- 1978-08-03 DE DE7878400072T patent/DE2860358D1/de not_active Expired
- 1978-08-03 EP EP78400072A patent/EP0001024B1/fr not_active Expired
- 1978-08-03 AT AT0563578A patent/AT366049B/de not_active IP Right Cessation
- 1978-08-04 ES ES472381A patent/ES472381A1/es not_active Expired
- 1978-08-08 CS CS785183A patent/CS207646B2/cs unknown
- 1978-08-08 IT IT50648/78A patent/IT1107961B/it active Protection Beyond IP Right Term
- 1978-08-09 SU SU782645701A patent/SU799666A3/ru active
- 1978-08-10 YU YU1917/78A patent/YU42166B/xx unknown
- 1978-08-10 US US05/932,437 patent/US4224371A/en not_active Expired - Lifetime
- 1978-08-10 SI SI7811917A patent/SI7811917A8/sl unknown
- 1978-08-11 MX MX7926A patent/MX155976A/es unknown
- 1978-08-11 MX MX787309U patent/MX5448E/es unknown
- 1978-08-11 GR GR56985A patent/GR73661B/el unknown
- 1978-08-15 BG BG7840671A patent/BG33887A3/xx unknown
- 1978-08-15 BG BG7942035A patent/BG33888A3/xx unknown
- 1978-08-16 FI FI782494A patent/FI65433C/fi not_active IP Right Cessation
- 1978-08-16 RO RO78101982A patent/RO79999A/ro unknown
- 1978-08-16 PT PT68431A patent/PT68431A/pt unknown
- 1978-08-16 DK DK361078A patent/DK152213C/da not_active IP Right Cessation
- 1978-08-16 NO NO782782A patent/NO156168C/no unknown
- 1978-08-16 HU HU78RO993A patent/HU181497B/hu unknown
- 1978-08-16 AU AU38965/78A patent/AU520898B2/en not_active Expired
- 1978-08-16 NZ NZ188163A patent/NZ188163A/xx unknown
- 1978-08-16 PL PL1978209080A patent/PL126619B1/pl unknown
- 1978-08-16 CA CA000309454A patent/CA1121343A/fr not_active Expired
- 1978-08-16 EG EG510/78A patent/EG13520A/xx active
- 1978-08-17 IE IE1669/78A patent/IE47230B1/en not_active IP Right Cessation
- 1978-08-17 JP JP9958078A patent/JPS5441890A/ja active Granted
-
1979
- 1979-06-27 CS CS794439A patent/CS207647B2/cs unknown
-
1980
- 1980-01-31 AT AT0052280A patent/AT366050B/de not_active IP Right Cessation
- 1980-03-12 SU SU802891755A patent/SU852175A3/ru active
-
1986
- 1986-04-09 DK DK159786A patent/DK163514C/da not_active IP Right Cessation
-
1993
- 1993-07-31 GE GEAP19931371A patent/GEP19960475B/en unknown
- 1993-07-31 GE GEAP19931355A patent/GEP19960476B/en unknown
- 1993-11-11 HR HRP-1917/78A patent/HRP931395B1/xx not_active IP Right Cessation
-
1994
- 1994-09-08 MD MD94-0275A patent/MD247C2/ro unknown
- 1994-09-08 MD MD94-0267A patent/MD225C2/ro unknown
Non-Patent Citations (1)
Title |
---|
Cererea nr. 2439818/23-04, SU, Int. cl. C 07 D 501/60, 1976 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD247C2 (ro) | Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-[2-(2-amino-4-tiazolil)-2-metoxiiminoacetamido] -cef-3-em-4-carbonic, a sin-izomerului | |
ES8202546A1 (es) | Metodo de producir derivados de tiazolidina | |
GR3005315T3 (el) | ||
IE41528L (en) | Furfuryl-benzomorphane derivatives. | |
ES462065A1 (es) | Procedimiento para la preparacion de derivados de tiazolidi-na. | |
GB1489609A (en) | 1-substituted 1h-tetrazole-5-thiols and the preparation thereof | |
ES8106535A1 (es) | Un procedimiento de produccion de un derivado de 2-fenilimi-dazo (2,1-b) benzotiazol | |
IE780899L (en) | Azetidinopyrrole derivatives | |
ES8503339A1 (es) | Procedimiento para la obtencion de tetrahidropiridazinonas | |
IE41440L (en) | Thiatetracyclines | |
IE40335L (en) | Pyrazole derivatives | |
ES451979A1 (es) | Un metodo de preparacion de compuestos antialergicos. | |
IE44339L (en) | Piperazine derivatives. | |
SE8003351L (sv) | Forfarande for framstellning av heterocykliska foreningar med terapeutisk verkan | |
GB1169945A (en) | Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives | |
JPS5424895A (en) | Pyranochromone derivatives and remedies for allergic disorder | |
GB1139458A (en) | 2-phenylamino-2-oxazolines and their production | |
GB1498535A (en) | Heterocyclic compounds | |
SE436137B (sv) | Forfarande for framstellning av proteasinhibitorer, benemnda procidiner, genom odling av den nya stammen atcc 31233, tillhorande slektet actinomadura | |
IE39770L (en) | Thiazole derivatives | |
ES8300775A1 (es) | "procedimiento para la fabricacion de un n-bencenosulfonil derivado de la cefamicina c". | |
ES8100255A1 (es) | Procedimiento para la preparacion de derivados de uretano | |
JPS54106491A (en) | Cephalosporin analog or its salt, their preparation, and prophylactics and remedies for microbisms consisting mainly of them | |
GB1473981A (en) | Hydrazino-cephalosporanic acid derivatives | |
JPS574981A (en) | Novel amino glucoside |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
1K4A | Payment of annual fees |