MA52648A - Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation - Google Patents

Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Info

Publication number
MA52648A
MA52648A MA052648A MA52648A MA52648A MA 52648 A MA52648 A MA 52648A MA 052648 A MA052648 A MA 052648A MA 52648 A MA52648 A MA 52648A MA 52648 A MA52648 A MA 52648A
Authority
MA
Morocco
Prior art keywords
compounds
pharmaceutical compositions
ppar agonists
use procedures
procedures
Prior art date
Application number
MA052648A
Other languages
English (en)
French (fr)
Inventor
Michael Downes
Ronald M Evans
Arthur Kluge
Bharat Lagu
Masanori Miura
Sunil Kumar Panigrahi
Michael Patane
Susanta Samajdar
Ramesh Senaiar
Taisuke Takahashi
Original Assignee
Mitobridge Inc
Salk Inst Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57200096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA52648(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitobridge Inc, Salk Inst Biological Studies filed Critical Mitobridge Inc
Publication of MA52648A publication Critical patent/MA52648A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA052648A 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation MA52648A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US201662352348P 2016-06-20 2016-06-20

Publications (1)

Publication Number Publication Date
MA52648A true MA52648A (fr) 2021-10-13

Family

ID=57200096

Family Applications (2)

Application Number Title Priority Date Filing Date
MA052648A MA52648A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation
MA052098A MA52098A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA052098A MA52098A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Country Status (26)

Country Link
US (6) US10399958B2 (enExample)
EP (3) EP3770146B1 (enExample)
JP (2) JP6657413B2 (enExample)
KR (2) KR102667386B1 (enExample)
CN (3) CN113004205B (enExample)
AU (3) AU2016333963C1 (enExample)
BR (1) BR112018006866B1 (enExample)
CA (1) CA3000431A1 (enExample)
CO (1) CO2018004473A2 (enExample)
DK (1) DK3359528T3 (enExample)
EA (1) EA037371B1 (enExample)
ES (3) ES2906379T3 (enExample)
HU (1) HUE058154T2 (enExample)
IL (3) IL258225B (enExample)
JO (3) JO3738B1 (enExample)
MA (2) MA52648A (enExample)
MX (3) MX392524B (enExample)
MY (1) MY203081A (enExample)
PH (1) PH12018500762A1 (enExample)
PL (1) PL3359528T3 (enExample)
PT (1) PT3359528T (enExample)
SG (1) SG10201906400SA (enExample)
TW (3) TWI730408B (enExample)
UA (1) UA122237C2 (enExample)
WO (1) WO2017062468A1 (enExample)
ZA (4) ZA201802029B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA52648A (fr) 2015-10-07 2021-10-13 Mitobridge Inc Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation
JP6925367B2 (ja) 2016-04-13 2021-08-25 ミトブリッジ,インコーポレーテッド Pparアゴニスト、化合物、医薬組成物、及びその使用方法
WO2018067860A1 (en) 2016-10-05 2018-04-12 Mitobridge, Inc. Crystalline and salt forms of ppar agonist compounds
DK3522880T3 (en) * 2016-10-05 2021-01-18 Mitokyne Inc Methods of treating acute kidney injury
US20220331267A1 (en) * 2019-09-05 2022-10-20 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
US20240358681A1 (en) 2021-06-02 2024-10-31 Mitobridge, Inc. Methods of use of ppar agonist compounds and pharmaceutical compositions thereof
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies
WO2025207099A1 (en) 2024-03-28 2025-10-02 Astellas Pharma Inc. Ppar-delta inhibitors for preventing post-operative atrial fibrillation

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228281A (en) 1977-09-23 1980-10-14 Ciba-Geigy Corporation Dicarboxylic acids containing triazine rings
DE4123341A1 (de) 1991-07-15 1993-01-21 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9511694D0 (en) 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
WO2000050391A1 (en) 1999-02-26 2000-08-31 Merck & Co., Inc. Novel sulfonamide compounds and uses thereof
GB9919413D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
ES2334101T3 (es) 2000-08-17 2010-03-05 Pfizer Limited Imidazoles sustituidos como inhibidores de tafia.
ES2342596T3 (es) * 2002-08-29 2010-07-09 MERCK SHARP & DOHME CORP. Indoles con actividad anti-diabetica.
EP1553075B1 (en) 2002-10-03 2013-08-14 Ono Pharmaceutical Co., Ltd. Lpa receptor antagonists
WO2004060367A1 (en) 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
MXPA06003357A (es) 2003-09-26 2006-06-08 Japan Tobacco Inc Metodo para inhibir la produccion de lipoproteina remanente.
KR20070047338A (ko) 2004-09-06 2007-05-04 에프. 호프만-라 로슈 아게 4-아미노메틸 벤즈아미딘 유도체 및 그의 ⅶa 인자억제제로서의 용도
BRPI0606997A2 (pt) 2005-02-15 2009-07-28 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os contêm, método para o tratamento e/ou prevenção de enfermidades que são moduladas por agonistas ppar(delta) e/ou ppar(alfa) e utilização dos compostos
BRPI0615948A2 (pt) 2005-09-07 2011-05-31 Plexxikon Inc composto ativo de ppar, sua composição, seu kit e seu uso
BRPI0707338A2 (pt) 2006-01-30 2011-05-03 Transtech Pharma Inc derivados de imidazol, composições, e métodos substituìdos de uso como inibidores de ptpase
US20100261758A1 (en) 2006-03-28 2010-10-14 Novartis Ag Heterocyclic amides for use as pharmaceuticals
KR101507173B1 (ko) 2006-04-18 2015-03-30 닛뽕 케미파 가부시키가이샤 페록시좀 증식제 활성화 수용체 δ 의 활성화제
DE102006023336A1 (de) 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
CN101085772A (zh) * 2006-06-07 2007-12-12 上海艾力斯医药科技有限公司 一类具有PPARγ激动剂活性的化合物及其应用
JPWO2008093639A1 (ja) 2007-01-29 2010-05-20 武田薬品工業株式会社 ピラゾール化合物
AU2008221718A1 (en) 2007-03-07 2008-09-12 Dong-A Pharm. Co., Ltd. Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
JP2008285452A (ja) 2007-05-21 2008-11-27 Ono Pharmaceut Co Ltd PPARα/γデュアルアゴニストおよび糖尿病治療薬を組み合わせてなる医薬
EP2234622A4 (en) 2007-12-28 2011-03-09 Salk Inst For Biological Studi METHODS ENHANCING PERFORMANCE AND MUSCLE TONUS
JP5895104B2 (ja) 2012-08-28 2016-03-30 コチ・ウニヴェルシテシKoc Universitesi 骨板
CA2908695A1 (en) * 2013-04-05 2014-10-09 Salk Institute For Biological Studies Ppar agonists
EP3756661A1 (en) 2013-09-09 2020-12-30 vTv Therapeutics LLC Use of a ppar-delta agonist for treating muscle atrophy
WO2016057322A1 (en) 2014-10-08 2016-04-14 Salk Institute For Biological Studies Ppar agonists and methods of use thereof
WO2016057658A1 (en) * 2014-10-08 2016-04-14 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
MA52648A (fr) * 2015-10-07 2021-10-13 Mitobridge Inc Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation
JP6925367B2 (ja) 2016-04-13 2021-08-25 ミトブリッジ,インコーポレーテッド Pparアゴニスト、化合物、医薬組成物、及びその使用方法
DK3522880T3 (en) 2016-10-05 2021-01-18 Mitokyne Inc Methods of treating acute kidney injury
WO2018067860A1 (en) * 2016-10-05 2018-04-12 Mitobridge, Inc. Crystalline and salt forms of ppar agonist compounds
PL3562822T3 (pl) * 2016-12-30 2021-09-13 Mitobridge, Inc. Inhibitory polimerazy poli(adp-rybozy) (parp)

Also Published As

Publication number Publication date
EP3770146B1 (en) 2024-07-24
TW201722919A (zh) 2017-07-01
US20210253549A1 (en) 2021-08-19
PT3359528T (pt) 2022-04-07
JP2020075939A (ja) 2020-05-21
ZA202003663B (en) 2022-08-31
MX2018004295A (es) 2018-08-09
EP3359528A1 (en) 2018-08-15
HUE058154T2 (hu) 2022-07-28
TWI730006B (zh) 2021-06-11
JOP20200231A1 (ar) 2022-10-30
WO2017062468A1 (en) 2017-04-13
IL275387B (en) 2021-08-31
KR20210126150A (ko) 2021-10-19
BR112018006866A2 (pt) 2018-10-16
EP3359528B1 (en) 2022-01-12
JP6866514B2 (ja) 2021-04-28
TW201943705A (zh) 2019-11-16
IL275392A (en) 2020-07-30
IL258225B (en) 2021-08-31
EP3770146A1 (en) 2021-01-27
MX392523B (es) 2025-03-24
US10906885B2 (en) 2021-02-02
MY203081A (en) 2024-06-07
AU2016333963A1 (en) 2018-04-12
AU2016333963C1 (en) 2021-05-27
IL275387A (en) 2020-07-30
AU2020281069A1 (en) 2021-01-07
EA037371B1 (ru) 2021-03-19
CO2018004473A2 (es) 2018-09-20
US10399958B2 (en) 2019-09-03
AU2016333963B2 (en) 2021-01-07
MX392524B (es) 2025-03-24
ES2906379T3 (es) 2022-04-18
HK1257907A1 (zh) 2019-11-01
AU2019283837A1 (en) 2020-01-16
US10479775B1 (en) 2019-11-19
KR102667385B1 (ko) 2024-05-21
CN108349904A (zh) 2018-07-31
ES2988059T3 (es) 2024-11-19
US20230373948A1 (en) 2023-11-23
PL3359528T3 (pl) 2022-05-30
MX380281B (es) 2025-03-12
MA52098A (fr) 2021-01-27
CA3000431A1 (en) 2017-04-13
JO3738B1 (ar) 2021-01-31
US20200157074A1 (en) 2020-05-21
IL275392B (en) 2022-05-01
CN113024467B (zh) 2024-08-06
ZA202003662B (en) 2022-08-31
JP2018534355A (ja) 2018-11-22
SG10201906400SA (en) 2019-08-27
PH12018500762A1 (en) 2018-10-29
AU2020281069B2 (en) 2022-10-27
JOP20200230A1 (ar) 2022-10-30
UA122237C2 (uk) 2020-10-12
NZ740846A (en) 2024-12-20
TWI730408B (zh) 2021-06-11
MX2020011100A (es) 2022-05-23
EP3795566B1 (en) 2023-04-19
WO2017062468A8 (en) 2017-05-11
AU2019283837B2 (en) 2020-12-24
EP3770146C0 (en) 2024-07-24
IL258225A (en) 2018-05-31
CN113004205A (zh) 2021-06-22
CN108349904B (zh) 2021-08-31
US20240417383A1 (en) 2024-12-19
DK3359528T3 (en) 2022-03-07
ZA201802029B (en) 2022-01-26
EP3795566A1 (en) 2021-03-24
EA201890776A1 (ru) 2018-09-28
JP6657413B2 (ja) 2020-03-04
CN113024467A (zh) 2021-06-25
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
TW202012375A (zh) 2020-04-01
US20190337920A1 (en) 2019-11-07
KR20180095797A (ko) 2018-08-28
TWI742479B (zh) 2021-10-11
CN113004205B (zh) 2024-07-02
US11578052B2 (en) 2023-02-14
US20190084958A1 (en) 2019-03-21
BR112018006866B1 (pt) 2023-11-21
ES2949852T3 (es) 2023-10-03
ZA202003664B (en) 2022-08-31

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