MA51134A - Anticorps anti-alpha-synucléine - Google Patents

Anticorps anti-alpha-synucléine

Info

Publication number
MA51134A
MA51134A MA051134A MA51134A MA51134A MA 51134 A MA51134 A MA 51134A MA 051134 A MA051134 A MA 051134A MA 51134 A MA51134 A MA 51134A MA 51134 A MA51134 A MA 51134A
Authority
MA
Morocco
Prior art keywords
alpha
synuclein antibody
synuclein
antibody
Prior art date
Application number
MA051134A
Other languages
English (en)
Inventor
Terence Seward Baker
Lichtervelde Lorenzo De
Patrick Downey
Peter Charles Elliott
Marco Kriek
Daniel John Lightwood
David James Mcmillan
Kerry Louise Tyson
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of MA51134A publication Critical patent/MA51134A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Psychology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
MA051134A 2017-12-15 2018-12-13 Anticorps anti-alpha-synucléine MA51134A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1720970.1A GB201720970D0 (en) 2017-12-15 2017-12-15 Antibodies

Publications (1)

Publication Number Publication Date
MA51134A true MA51134A (fr) 2021-03-24

Family

ID=61008785

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051134A MA51134A (fr) 2017-12-15 2018-12-13 Anticorps anti-alpha-synucléine

Country Status (25)

Country Link
US (2) US11292831B2 (fr)
EP (1) EP3724228A1 (fr)
JP (1) JP7326281B2 (fr)
KR (1) KR102781727B1 (fr)
CN (1) CN111655727B (fr)
AU (1) AU2018382527B2 (fr)
BR (1) BR112020010508A2 (fr)
CA (1) CA3084106A1 (fr)
CL (1) CL2020001607A1 (fr)
EA (1) EA202091482A1 (fr)
EC (1) ECSP20039610A (fr)
GB (1) GB201720970D0 (fr)
IL (2) IL275223B2 (fr)
MA (1) MA51134A (fr)
MX (1) MX2020005810A (fr)
MY (1) MY203402A (fr)
PE (1) PE20201062A1 (fr)
PH (1) PH12020551006A1 (fr)
SG (1) SG11202004740RA (fr)
TN (1) TN2020000077A1 (fr)
TW (2) TWI806940B (fr)
UA (1) UA130114C2 (fr)
UY (1) UY38012A (fr)
WO (1) WO2019115671A1 (fr)
ZA (2) ZA202003414B (fr)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
EP3824906A1 (fr) 2016-12-21 2021-05-26 Amgen Inc. Formulations d'anticorps anti-tnf alpha
JP7136790B2 (ja) 2017-02-17 2022-09-13 ブリストル－マイヤーズ スクイブ カンパニー アルファ－シヌクレインに対する抗体およびその使用
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
WO2021055881A1 (fr) * 2019-09-20 2021-03-25 Denali Therapeutics Inc. Anticorps anti-alpha-synucléine et leurs procédés d'utilisation
MX2022006676A (es) * 2019-12-04 2022-07-05 Ac Immune Sa Nuevas moleculas para terapia y diagnostico.
JP7670419B2 (ja) 2020-08-07 2025-04-30 エルジー・ケム・リミテッド 熱可塑性樹脂組成物
CN113912715B (zh) * 2021-12-15 2022-03-01 北京凯祥弘康生物科技有限公司 一种抗α-突触核蛋白抗体及其相关产品和应用
CN119233987B (zh) * 2022-05-20 2025-08-29 长春金赛药业有限责任公司 抗α-Synuclein抗体及其用途
CN115043927B (zh) * 2022-06-17 2024-03-19 武汉大学 针对抗α-突触核蛋白K80Hcy抗体的抗原肽及其应用
AU2024360083A1 (en) * 2023-10-12 2026-05-21 Universite Laval Anti-alpha-synuclein antibodies and uses thereof

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Also Published As

Publication number Publication date
KR102781727B1 (ko) 2025-03-13
TW201927810A (zh) 2019-07-16
IL303672A (en) 2023-08-01
WO2019115671A1 (fr) 2019-06-20
US20220340648A1 (en) 2022-10-27
JP7326281B2 (ja) 2023-08-15
PE20201062A1 (es) 2020-10-16
IL303672B1 (en) 2024-05-01
IL275223B1 (en) 2023-07-01
MY203402A (en) 2024-06-26
ZA202106370B (en) 2023-06-28
SG11202004740RA (en) 2020-06-29
TW202346343A (zh) 2023-12-01
TWI806940B (zh) 2023-07-01
EA202091482A1 (ru) 2020-09-10
BR112020010508A2 (pt) 2020-11-24
GB201720970D0 (en) 2018-01-31
ECSP20039610A (es) 2020-08-31
TWI860014B (zh) 2024-10-21
KR20200099168A (ko) 2020-08-21
RU2020123300A3 (fr) 2022-01-18
CA3084106A1 (fr) 2019-06-20
IL303672B2 (en) 2024-09-01
US11292831B2 (en) 2022-04-05
MX2020005810A (es) 2020-08-20
ZA202003414B (en) 2022-03-30
RU2020123300A (ru) 2022-01-18
UY38012A (es) 2019-07-31
UA130114C2 (uk) 2025-11-19
EP3724228A1 (fr) 2020-10-21
US20210101964A1 (en) 2021-04-08
IL275223B2 (en) 2023-11-01
IL275223A (en) 2020-07-30
PH12020551006A1 (en) 2021-09-06
TN2020000077A1 (en) 2022-01-06
CN111655727A (zh) 2020-09-11
CL2020001607A1 (es) 2020-10-02
JP2021507693A (ja) 2021-02-25
NZ765643A (en) 2024-11-29
US12410244B2 (en) 2025-09-09
AU2018382527A1 (en) 2020-07-16
AU2018382527B2 (en) 2025-04-03
CN111655727B (zh) 2024-10-29

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