MA51135A - Anticorps anti-alpha-synucléine - Google Patents

Anticorps anti-alpha-synucléine

Info

Publication number
MA51135A
MA51135A MA051135A MA51135A MA51135A MA 51135 A MA51135 A MA 51135A MA 051135 A MA051135 A MA 051135A MA 51135 A MA51135 A MA 51135A MA 51135 A MA51135 A MA 51135A
Authority
MA
Morocco
Prior art keywords
alpha
synuclein antibody
synuclein
antibody
Prior art date
Application number
MA051135A
Other languages
English (en)
Inventor
Ralph Adams
Terence Seward Baker
Lichtervelde Lorenzo De
Patrick Downey
Daniel John Lightwood
David James Mcmillan
Kerry Louise Tyson
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of MA51135A publication Critical patent/MA51135A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2835Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA051135A 2017-12-15 2018-12-13 Anticorps anti-alpha-synucléine MA51135A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1720975.0A GB201720975D0 (en) 2017-12-15 2017-12-15 Anti-alpha synuclein antibodies

Publications (1)

Publication Number Publication Date
MA51135A true MA51135A (fr) 2021-03-24

Family

ID=61009086

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051135A MA51135A (fr) 2017-12-15 2018-12-13 Anticorps anti-alpha-synucléine

Country Status (25)

Country Link
US (2) US11261242B2 (fr)
EP (1) EP3724224A1 (fr)
JP (2) JP7292279B2 (fr)
KR (1) KR20200099160A (fr)
CN (1) CN111479826A (fr)
AR (1) AR115192A1 (fr)
AU (1) AU2018382530A1 (fr)
BR (1) BR112020010504A2 (fr)
CA (1) CA3083199A1 (fr)
CL (1) CL2020001605A1 (fr)
EA (1) EA202091478A1 (fr)
EC (1) ECSP20039623A (fr)
GB (1) GB201720975D0 (fr)
IL (1) IL275187A (fr)
MA (1) MA51135A (fr)
MX (1) MX2020005691A (fr)
PE (1) PE20201061A1 (fr)
PH (1) PH12020551007A1 (fr)
SG (1) SG11202004502SA (fr)
TN (2) TN2021000169A1 (fr)
TW (2) TW202332692A (fr)
UA (1) UA126295C2 (fr)
UY (1) UY38010A (fr)
WO (1) WO2019115674A1 (fr)
ZA (2) ZA202003542B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102573778B1 (ko) 2017-02-17 2023-08-31 브리스톨-마이어스 스큅 컴퍼니 알파-시뉴클레인에 대한 항체 및 그의 용도
WO2020079113A1 (fr) * 2018-10-19 2020-04-23 Janssen Vaccines & Prevention B.V. Anticorps anti-synucléine
WO2021055881A1 (fr) * 2019-09-20 2021-03-25 Denali Therapeutics Inc. Anticorps anti-alpha-synucléine et leurs procédés d'utilisation
WO2021113464A1 (fr) * 2019-12-04 2021-06-10 Friedman Simon Ensemble de blocage de protéines et procédés de fabrication et d'utilisation

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WO2003045128A2 (fr) 2001-11-21 2003-06-05 New York University Polypeptides immunogenes synthetiques ne formant pas de depots et peptides homologues destines a des repetitions amyloide $g(b), proteine prion, amyline, $g(a)-synucleine, ou polyglutamine pour induction d'une reponse immunitaire a ceux-ci
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Also Published As

Publication number Publication date
TWI801469B (zh) 2023-05-11
AU2018382530A1 (en) 2020-06-18
JP2021509012A (ja) 2021-03-18
RU2020123274A3 (fr) 2022-01-17
UY38010A (es) 2019-07-31
TW201930354A (zh) 2019-08-01
KR20200099160A (ko) 2020-08-21
JP7292279B2 (ja) 2023-06-16
TN2021000169A1 (en) 2023-04-04
IL275187A (en) 2020-07-30
JP2023127585A (ja) 2023-09-13
US20220220192A1 (en) 2022-07-14
US11261242B2 (en) 2022-03-01
PH12020551007A1 (en) 2021-08-16
TN2020000069A1 (en) 2022-01-06
CL2020001605A1 (es) 2020-08-28
ZA202003542B (en) 2022-12-21
RU2020123274A (ru) 2022-01-17
ZA202103456B (en) 2023-01-25
US20210107971A1 (en) 2021-04-15
GB201720975D0 (en) 2018-01-31
EP3724224A1 (fr) 2020-10-21
TW202332692A (zh) 2023-08-16
PE20201061A1 (es) 2020-10-16
SG11202004502SA (en) 2020-06-29
MX2020005691A (es) 2020-08-20
EA202091478A1 (ru) 2020-09-04
CN111479826A (zh) 2020-07-31
WO2019115674A1 (fr) 2019-06-20
CA3083199A1 (fr) 2019-06-20
ECSP20039623A (es) 2020-08-31
AR115192A1 (es) 2020-12-09
UA126295C2 (uk) 2022-09-14
BR112020010504A2 (pt) 2020-11-24

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