TN2021000169A1 - Anti-alpha-synuclein antibodies - Google Patents

Anti-alpha-synuclein antibodies

Info

Publication number
TN2021000169A1
TN2021000169A1 TNP/2021/000169A TN2021000169A TN2021000169A1 TN 2021000169 A1 TN2021000169 A1 TN 2021000169A1 TN 2021000169 A TN2021000169 A TN 2021000169A TN 2021000169 A1 TN2021000169 A1 TN 2021000169A1
Authority
TN
Tunisia
Prior art keywords
alpha
alpha synuclein
antibodies
synuclein antibodies
fibrils
Prior art date
Application number
TNP/2021/000169A
Inventor
Ralph Adams
Terence Seward Baker
Lichtervelde Lorenzo De
Patrick Downey
Daniel John Lightwood
David James Mcmillan
Kerry Louise Tyson
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of TN2021000169A1 publication Critical patent/TN2021000169A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
TNP/2021/000169A 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies TN2021000169A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1720975.0A GB201720975D0 (en) 2017-12-15 2017-12-15 Anti-alpha synuclein antibodies
PCT/EP2018/084697 WO2019115674A1 (en) 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies

Publications (1)

Publication Number Publication Date
TN2021000169A1 true TN2021000169A1 (en) 2023-04-04

Family

ID=61009086

Family Applications (2)

Application Number Title Priority Date Filing Date
TNP/2021/000169A TN2021000169A1 (en) 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies
TNP/2020/000069A TN2020000069A1 (en) 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
TNP/2020/000069A TN2020000069A1 (en) 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies

Country Status (25)

Country Link
US (2) US11261242B2 (en)
EP (1) EP3724224A1 (en)
JP (2) JP7292279B2 (en)
KR (1) KR20200099160A (en)
CN (1) CN111479826A (en)
AR (1) AR115192A1 (en)
AU (1) AU2018382530A1 (en)
BR (1) BR112020010504A2 (en)
CA (1) CA3083199A1 (en)
CL (1) CL2020001605A1 (en)
EA (1) EA202091478A1 (en)
EC (1) ECSP20039623A (en)
GB (1) GB201720975D0 (en)
IL (1) IL275187A (en)
MA (1) MA51135A (en)
MX (1) MX2020005691A (en)
PE (1) PE20201061A1 (en)
PH (1) PH12020551007A1 (en)
SG (1) SG11202004502SA (en)
TN (2) TN2021000169A1 (en)
TW (2) TWI801469B (en)
UA (1) UA126295C2 (en)
UY (1) UY38010A (en)
WO (1) WO2019115674A1 (en)
ZA (2) ZA202003542B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018151821A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
EP3867270A1 (en) * 2018-10-19 2021-08-25 Janssen Vaccines & Prevention B.V. Anti-synuclein antibodies
WO2021055881A1 (en) * 2019-09-20 2021-03-25 Denali Therapeutics Inc. Anti-alpha-synuclein antibodies and methods of use thereof
WO2021113464A1 (en) * 2019-12-04 2021-06-10 Friedman Simon Protein blocking assembly and methods of making and using

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
JP4055579B2 (en) 2000-12-13 2008-03-05 大正製薬株式会社 New antibody
US7479482B2 (en) 2001-11-21 2009-01-20 New York University Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid β, prion protein, amylin, α-synuclein, or polyglutamine repeats for induction of an immune response thereto
TW200509968A (en) 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US8697082B2 (en) 2002-11-01 2014-04-15 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US20080014194A1 (en) 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US8506959B2 (en) 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US7358331B2 (en) 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
HUE034320T2 (en) 2003-05-19 2018-02-28 Prothena Biosciences Ltd Truncated fragments of alpha-synuclein in lewy body disease
US7674599B2 (en) 2003-11-08 2010-03-09 Elan Pharmaceuticals, Inc. Methods of using antibodies to detect alpha-synuclein in fluid samples
EA013752B1 (en) 2004-08-09 2010-06-30 Элан Фармасьютикалз, Инк. Prevention and treatment of synucleinopathic and amyloidogenic disease
WO2007021255A1 (en) 2005-08-09 2007-02-22 Elan Pharmaceuticals, Inc. Antibodies to alpha-synuclein
US8147833B2 (en) 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
PL3067066T3 (en) * 2007-02-23 2019-09-30 Prothena Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
PL2118300T3 (en) 2007-02-23 2015-11-30 Prothena Biosciences Ltd Prevention and treatment of synucleinopathic and amyloidogenic disease
WO2009133521A2 (en) 2008-04-29 2009-11-05 Bioartic Neuroscience Ab Antibodies and vaccines for use in therapeutic and diagnostic methods for alpha-synuclein-related disorders
EP2949666B1 (en) 2008-12-19 2018-12-19 Biogen International Neuroscience GmbH Human anti-alpha-synuclein antibodies
US8609097B2 (en) * 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
JP5894939B2 (en) 2010-02-26 2016-03-30 バイオアークティック ニューロサイエンス アーベー Protofibril binding antibodies and their use in methods of treatment and diagnosis of Parkinson's disease, Lewy body dementia and other alpha-synucleinopathies
EP2366714A1 (en) 2010-03-03 2011-09-21 Dr. Rentschler Holding GmbH & Co. KG Naturally occuring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein
WO2012061786A1 (en) 2010-11-05 2012-05-10 Brandeis University Ice cleaved alpha-synuclein a biomarker
DE102011008153B4 (en) 2011-01-08 2018-08-09 Aj Roboscreen Gmbh Process for the preparation of a monoclonal antibody against oligomeric alpha-synuclein
AU2012272790B2 (en) 2011-06-23 2016-10-06 Biogen International Neuroscience Gmbh Anti-alpha synuclein binding molecules
EP3378535B1 (en) 2011-10-28 2023-01-04 Prothena Biosciences Limited Humanized antibodies that recognize alpha-synuclein
CA2863953A1 (en) 2012-01-27 2013-08-01 Neotope Biosciences Limited Humanized antibodies that recognize alpha-synuclein
DK2857419T3 (en) 2012-05-30 2021-03-29 Chugai Pharmaceutical Co Ltd Antigen-binding molecule for the elimination of aggregated antigens
UA118441C2 (en) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Antibodies recognizing alpha-synuclein
US9534044B2 (en) * 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof
US10035847B2 (en) 2013-10-02 2018-07-31 The Rockefeller University Amyloid protofibril antibodies and methods of use thereof
JP2017501848A (en) 2013-11-19 2017-01-19 プロセナ バイオサイエンシーズ リミテッド Monitoring immunotherapy of Lewy body disease from constipation symptoms
KR102358311B1 (en) * 2013-11-21 2022-02-08 에프. 호프만-라 로슈 아게 ANTI-alpha-SYNUCLEIN ANTIBODIES AND METHODS OF USE
US10562973B2 (en) 2014-04-08 2020-02-18 Prothena Bioscience Limited Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
US10155030B2 (en) 2014-05-23 2018-12-18 University Of South Florida Methods, antibodies, and vaccines utilizing epitopes of alpha synuclein for treatment of parkinsons disease
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
CN107208125A (en) 2014-09-11 2017-09-26 德克萨斯大学系统董事会 The detection of misfolded proteins matter
WO2016040903A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded amyloid beta protein
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
CN107074938A (en) 2014-10-16 2017-08-18 豪夫迈·罗氏有限公司 Anti alpha synapse nucleoprotein antibody and application method
GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10852309B2 (en) 2015-08-25 2020-12-01 Prothena Biosciences Limited Methods for detecting phosphorylated alpha-synuclein
EP3380622A4 (en) 2015-11-23 2019-08-07 Sangamo Therapeutics, Inc. Methods and compositions for engineering immunity
WO2017176835A2 (en) 2016-04-06 2017-10-12 Imago Pharmaceuticals, Inc. Therapeutic antibodies for treatment of neurodegeneration
AU2017272804B2 (en) 2016-06-02 2023-11-23 Medimmune Limited Antibodies to alpha-synuclein and uses thereof
GB201611840D0 (en) 2016-07-07 2016-08-24 Univ Court Of The Univ Of Edinburgh The Alpha-synuclein detection assay
US20190194324A1 (en) 2016-08-23 2019-06-27 The Johns Hopkins University THERAPEUTIC USES OF LAG3 THE (alpha)-SYNUCLEIN TRANSMISSION RECEPTOR
WO2018091444A1 (en) 2016-11-15 2018-05-24 H. Lundbeck A/S Agents, uses and methods for the treatment of synucleinopathy
US20180134775A1 (en) 2016-11-17 2018-05-17 United Arab Emirates University Alpha-Synuclein Antibodies (7A11)
US20180134776A1 (en) 2016-11-17 2018-05-17 United Arab Emirates University Alpha-Synuclein Antibodies (4H6)
US20180134777A1 (en) 2016-11-17 2018-05-17 United Arab Emirates University Alpha-Synuclein Antibodies (11D12)
AU2017376670A1 (en) 2016-12-12 2019-07-18 The Michael J. Fox Foundation For Parkinson's Research Antibodies to human alpha-synuclein
US11325968B2 (en) 2016-12-16 2022-05-10 H. Lundbeck A/S Alpha-synuclein antibodies
US10364286B2 (en) 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
EP3567054A4 (en) 2017-01-06 2021-03-10 ABL Bio Inc. Anti-alpha-syn antibody and use thereof
WO2018128722A1 (en) 2017-01-09 2018-07-12 California Institute Of Technology Use of gut microbiota in the diagnosis and therapeutics of parkinson's disease
WO2018151821A1 (en) * 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
JOP20190227A1 (en) 2017-03-31 2019-09-30 Biogen Int Neuroscience Gmbh Compositions and methods for treating synucleinopathies
MX2019013589A (en) 2017-05-16 2020-07-20 Claudio Soto Jara Detection of misfolded tau protein.
WO2018237338A1 (en) 2017-06-23 2018-12-27 Denali Therapeutics Inc. Anti-alpha-synuclein antibodies and methods of use thereof

Also Published As

Publication number Publication date
WO2019115674A1 (en) 2019-06-20
UA126295C2 (en) 2022-09-14
US20210107971A1 (en) 2021-04-15
CL2020001605A1 (en) 2020-08-28
BR112020010504A2 (en) 2020-11-24
MX2020005691A (en) 2020-08-20
JP2021509012A (en) 2021-03-18
EA202091478A1 (en) 2020-09-04
AU2018382530A1 (en) 2020-06-18
US20220220192A1 (en) 2022-07-14
TW202332692A (en) 2023-08-16
CN111479826A (en) 2020-07-31
KR20200099160A (en) 2020-08-21
ZA202003542B (en) 2022-12-21
AR115192A1 (en) 2020-12-09
MA51135A (en) 2021-03-24
IL275187A (en) 2020-07-30
RU2020123274A3 (en) 2022-01-17
ECSP20039623A (en) 2020-08-31
PH12020551007A1 (en) 2021-08-16
PE20201061A1 (en) 2020-10-16
SG11202004502SA (en) 2020-06-29
GB201720975D0 (en) 2018-01-31
JP2023127585A (en) 2023-09-13
JP7292279B2 (en) 2023-06-16
US11261242B2 (en) 2022-03-01
UY38010A (en) 2019-07-31
EP3724224A1 (en) 2020-10-21
RU2020123274A (en) 2022-01-17
ZA202103456B (en) 2023-01-25
TWI801469B (en) 2023-05-11
TW201930354A (en) 2019-08-01
TN2020000069A1 (en) 2022-01-06
CA3083199A1 (en) 2019-06-20

Similar Documents

Publication Publication Date Title
PH12020551006A1 (en) Anti-alpha synuclein antibodies
PH12020551007A1 (en) Anti-alpha-synuclein antibodies
PH12019502793A1 (en) Aadc polynucleotides for the treatment of parkinson`s disease
MX2019012233A (en) Anti-sirp alpha antibodies.
MD4733B1 (en) Anti-TIGIT antibodies
MX2017005834A (en) Aadc polynucleotides for the treatment of parkinson's disease.
MX2020001513A (en) Clec9a binding agents and use thereof.
NZ739499A (en) Single domain antibody for programmed death-ligand (pd-l1) and derived protein thereof
MX2019009117A (en) Antibodies to alpha-synuclein and uses thereof.
PH12017500032A1 (en) Improved a� protofibril binding antibodies
UA117096C2 (en) Polypeptides binding to human complement c5
MX2015015249A (en) Therapeutic peptides.
WO2011112867A8 (en) The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
MX2022002635A (en) Angiopoietin-like 4 antibodies and methods of use.
TW201613977A (en) Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
MX2018014129A (en) Pharmaceutical composition comprising eteplirsen.
MX2020000636A (en) Synthetic proteins and therapeutic uses thereof.
MX2016008968A (en) Organic compounds.
IL260009B (en) Novel bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease
WO2019004970A3 (en) Heterobivalent ligands suitable for use in the treatment of parkinson's disease