MA39094B1 - Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers - Google Patents
Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancersInfo
- Publication number
- MA39094B1 MA39094B1 MA39094A MA39094A MA39094B1 MA 39094 B1 MA39094 B1 MA 39094B1 MA 39094 A MA39094 A MA 39094A MA 39094 A MA39094 A MA 39094A MA 39094 B1 MA39094 B1 MA 39094B1
- Authority
- MA
- Morocco
- Prior art keywords
- cancers
- treatment
- pharmaceutically active
- additional pharmaceutically
- active ingredients
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 229940083338 MDM2 inhibitor Drugs 0.000 title 1
- 239000012819 MDM2-Inhibitor Substances 0.000 title 1
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 101150024228 mdm2 gene Proteins 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La présente invention concerne une polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires, en particulier pour le traitement de cancers. L'invention a également trait à des compositions pharmaceutiques contenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361902717P | 2013-11-11 | 2013-11-11 | |
PCT/US2014/065034 WO2015070224A2 (fr) | 2013-11-11 | 2014-11-11 | Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39094A1 MA39094A1 (fr) | 2018-07-31 |
MA39094B1 true MA39094B1 (fr) | 2020-06-30 |
Family
ID=52001089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39094A MA39094B1 (fr) | 2013-11-11 | 2014-11-11 | Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers |
Country Status (30)
Country | Link |
---|---|
US (3) | US20160287569A1 (fr) |
EP (2) | EP4039256A1 (fr) |
JP (5) | JP2016535795A (fr) |
KR (3) | KR20220167335A (fr) |
CN (2) | CN105934255A (fr) |
AP (1) | AP2016009243A0 (fr) |
AU (3) | AU2014346354A1 (fr) |
BR (1) | BR112016010564A2 (fr) |
CA (1) | CA2930244A1 (fr) |
CL (1) | CL2016001131A1 (fr) |
DK (1) | DK3068393T5 (fr) |
EA (2) | EA036942B1 (fr) |
ES (1) | ES2916721T3 (fr) |
HR (1) | HRP20220718T1 (fr) |
HU (1) | HUE059351T2 (fr) |
IL (2) | IL245568B (fr) |
LT (1) | LT3068393T (fr) |
MA (1) | MA39094B1 (fr) |
MX (6) | MX2016006025A (fr) |
MY (1) | MY192088A (fr) |
NZ (2) | NZ758548A (fr) |
PH (1) | PH12016500871A1 (fr) |
PL (1) | PL3068393T3 (fr) |
PT (1) | PT3068393T (fr) |
RS (1) | RS63348B9 (fr) |
SG (1) | SG10201902429PA (fr) |
SI (1) | SI3068393T1 (fr) |
TN (1) | TN2016000176A1 (fr) |
UA (1) | UA120750C2 (fr) |
WO (1) | WO2015070224A2 (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101730708B (zh) | 2007-03-28 | 2013-09-18 | 哈佛大学校长及研究员协会 | 缝合多肽 |
SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
WO2013049250A1 (fr) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocycles utilises comme inhibiteurs de mdm2 dans le traitement du cancer |
WO2013059525A1 (fr) | 2011-10-18 | 2013-04-25 | Aileron Therapeutics, Inc. | Macrocycles peptidomimétiques |
EP2914256B1 (fr) | 2012-11-01 | 2019-07-31 | Aileron Therapeutics, Inc. | Acides aminés disubstitués et procédés de préparation et d'utilisation de ceux-ci |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
AU2014236812B2 (en) | 2013-03-14 | 2018-03-01 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
MX2016006025A (es) * | 2013-11-11 | 2016-12-02 | Amgen Inc | Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres. |
EP3197478A4 (fr) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Macrocycles peptidomimétiques et leurs utilisations |
BR112017005736A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e formulações dos mesmos |
CA2976752C (fr) | 2015-02-20 | 2019-12-17 | Daiichi Sankyo Company, Limited | Polytherapie pour traiter un cancer |
US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
EP3341023A1 (fr) * | 2015-08-28 | 2018-07-04 | Novartis AG | Polythérapie utilisant un inhibiteur de pi3k et un inhibiteur de mdm2 |
ES2962460T3 (es) * | 2015-08-28 | 2024-03-19 | Novartis Ag | Inhibidores de mdm2 y combinaciones de estos |
WO2017200826A1 (fr) * | 2016-05-16 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Dosages et composés pour le traitement du cancer |
ES2858151T3 (es) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | Conjugados de PROTAC-anticuerpo y procedimientos de uso |
KR20190068544A (ko) * | 2016-10-17 | 2019-06-18 | 다이이찌 산쿄 가부시키가이샤 | Mdm2 저해제와 dna 메틸트랜스페라아제 저해제의 병용 치료법 |
CN110291089B (zh) | 2017-01-17 | 2022-05-27 | 海帕瑞吉尼克斯股份有限公司 | 用于促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂 |
JOP20200273A1 (ar) * | 2018-04-30 | 2020-11-01 | Kartos Therapeutics Inc | طرق علاج السرطان |
KR20210043499A (ko) * | 2018-05-25 | 2021-04-21 | 카토스 테라퓨틱스, 인크. | 골수증식성 신생물 치료 방법 |
US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
CN110963958A (zh) * | 2018-09-30 | 2020-04-07 | 上海长森药业有限公司 | 一种mdm2抑制剂,及其制备方法、药物组合物和应用 |
TW202034918A (zh) * | 2018-12-11 | 2020-10-01 | 美商卡托斯醫療公司 | 治療眼睛病況之方法及組合物 |
CN111434353A (zh) * | 2019-02-02 | 2020-07-21 | 中国科学院上海营养与健康研究所 | Ras抑制剂筛选及疗效标志物 |
TW202118488A (zh) * | 2019-07-26 | 2021-05-16 | 大陸商蘇州亞盛藥業有限公司 | Mdm2抑制劑的藥物組合物及其在預防和/或治療疾病中的用途 |
TW202128156A (zh) * | 2019-11-14 | 2021-08-01 | 美商夸格智財控股有限公司 | 用於癌症治療之btk抑制劑及mdm2抑制劑之組合 |
WO2021254277A1 (fr) * | 2020-06-15 | 2021-12-23 | Ascentage Pharma (Suzhou) Co., Ltd. | Microsuspension d'un inhibiteur de mdm2 et ses applications thérapeutiques |
WO2022036067A1 (fr) * | 2020-08-12 | 2022-02-17 | Servier Pharmaceuticals, Llc | Polythérapies destinées à être utilisées dans le traitement du cancer |
WO2023056069A1 (fr) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation |
CN115089585A (zh) * | 2022-08-05 | 2022-09-23 | 中国科学院大学宁波华美医院 | Mdm2抑制剂rg7112联合依托泊苷在治疗肺癌中的应用 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU2503A (sh) | 2000-07-19 | 2006-05-25 | Warner-Lambert Company | Oksigenovani estri 4-jodo fenilamino benzhidroksamskih kiselina |
MX2007004551A (es) | 2004-10-18 | 2007-05-23 | Amgen Inc | Compuestos tiadiazol y metodos de uso. |
US7514566B2 (en) | 2006-01-18 | 2009-04-07 | Amgen, Inc. | Thiazole compounds and methods of use |
PT2139882E (pt) | 2007-03-23 | 2014-01-30 | Amgen Inc | Derivados de quinolina ou quinoxalina 3-substituídos e sua utilização como inibidores de fosfatidilinositol 3-cinase (pi3k) |
ES2563458T3 (es) | 2007-03-23 | 2016-03-15 | Amgen Inc. | Compuestos heterocíclicos y sus usos |
WO2008118454A2 (fr) | 2007-03-23 | 2008-10-02 | Amgen Inc. | Composés hétérocycliques et leurs utilisations |
US7625895B2 (en) | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
CA2689092C (fr) | 2007-06-07 | 2013-01-15 | Amgen Inc. | Modulators de la raf kinase et leurs methods d'utilisation |
AU2008276512A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of PKB |
JP2010533715A (ja) | 2007-07-17 | 2010-10-28 | アムジエン・インコーポレーテツド | 複素環系pkb調節剤 |
TW200911798A (en) | 2007-08-02 | 2009-03-16 | Amgen Inc | PI3 kinase modulators and methods of use |
CA2710194C (fr) | 2007-12-19 | 2014-04-22 | Amgen Inc. | Inhibiteurs de la p13 kinase |
MX2010006457A (es) | 2007-12-19 | 2010-07-05 | Amgen Inc | Compuestos fusionados de piridina, pirimidina y triazina como inhibidores de ciclo celular. |
ATE531372T1 (de) | 2008-04-07 | 2011-11-15 | Amgen Inc | Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren |
JP5599783B2 (ja) | 2008-05-30 | 2014-10-01 | アムジエン・インコーポレーテツド | Pi3キナーゼの阻害薬 |
US20110263647A1 (en) | 2009-01-15 | 2011-10-27 | Amgen Inc. | Fluoroisoquinoline substituted thiazole compounds and methods of use |
MX2011008674A (es) | 2009-02-18 | 2011-11-04 | Amgen Inc | Compuestos de indol/bencimidazol como inhibidores de quinasa mtor. |
CA2755285C (fr) | 2009-03-20 | 2014-02-11 | Yunxin Y. Bo | Inhibiteurs de pi3 kinase |
UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
EP2430013B1 (fr) | 2009-05-13 | 2014-10-15 | Amgen Inc. | Composés heteraryles comme inhibiteurs de la pikk |
US20100331306A1 (en) | 2009-06-25 | 2010-12-30 | Amgen Inc. | Heterocyclic compounds and their uses |
JP2012531436A (ja) | 2009-06-25 | 2012-12-10 | アムジエン・インコーポレーテツド | 複素環式化合物およびそれらのpi3k活性阻害剤としての使用 |
TW201111376A (en) | 2009-06-25 | 2011-04-01 | Amgen Inc | Heterocyclic compounds and their uses |
AU2010266064A1 (en) | 2009-06-25 | 2012-01-19 | Amgen Inc. | 4H - pyrido [1, 2 - a] pyrimidin - 4 - one derivatives as PI3 K inhibitors |
ES2528485T3 (es) | 2009-09-11 | 2015-02-10 | Amgen, Inc | N-(4-((3-(2-amino-4-pirimidinil)-2-piridinil)oxi)fenil)-4-(4-metil-2-tienil)-1-ftalazinamina para su uso en el tratamiento del cáncer resistente a agentes antimitóticos |
JO2998B1 (ar) * | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
KR20120031734A (ko) * | 2010-09-27 | 2012-04-04 | 삼성전자주식회사 | 급성 골수성 백혈병 환자의 시타라빈 민감성을 예측하기 위한 키트 및 방법 |
JP2014503597A (ja) * | 2011-01-31 | 2014-02-13 | セルジーン コーポレイション | シチジンアナログの医薬組成物及びその使用方法 |
WO2013049250A1 (fr) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocycles utilises comme inhibiteurs de mdm2 dans le traitement du cancer |
US9216170B2 (en) * | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
CA2868954A1 (fr) | 2012-03-30 | 2013-10-03 | Takeda Pharmaceutical Company Limited | Administration d'un inhibiteur de raf et d'un inhibiteur de mek dans le traitement du melanome |
US20160002185A1 (en) | 2013-02-19 | 2016-01-07 | Amgen Inc. | Cis-morpholinone and other compounds as mdm2 inhibitors for the treatment of cancer |
AU2014223547B2 (en) | 2013-02-28 | 2017-11-16 | Amgen Inc. | A benzoic acid derivative MDM2 inhibitor for the treatment of cancer |
AU2014236812B2 (en) | 2013-03-14 | 2018-03-01 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
US20150031642A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome i |
MX2016006025A (es) * | 2013-11-11 | 2016-12-02 | Amgen Inc | Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres. |
-
2014
- 2014-11-11 MX MX2016006025A patent/MX2016006025A/es unknown
- 2014-11-11 CN CN201480072891.XA patent/CN105934255A/zh active Pending
- 2014-11-11 SG SG10201902429PA patent/SG10201902429PA/en unknown
- 2014-11-11 JP JP2016553270A patent/JP2016535795A/ja not_active Ceased
- 2014-11-11 AP AP2016009243A patent/AP2016009243A0/en unknown
- 2014-11-11 EA EA201690980A patent/EA036942B1/ru unknown
- 2014-11-11 AU AU2014346354A patent/AU2014346354A1/en not_active Abandoned
- 2014-11-11 MX MX2020013670A patent/MX2020013670A/es unknown
- 2014-11-11 MA MA39094A patent/MA39094B1/fr unknown
- 2014-11-11 KR KR1020227041845A patent/KR20220167335A/ko not_active Application Discontinuation
- 2014-11-11 HU HUE14805743A patent/HUE059351T2/hu unknown
- 2014-11-11 WO PCT/US2014/065034 patent/WO2015070224A2/fr active Application Filing
- 2014-11-11 DK DK14805743.3T patent/DK3068393T5/da active
- 2014-11-11 NZ NZ758548A patent/NZ758548A/en unknown
- 2014-11-11 MX MX2020001550A patent/MX2020001550A/es unknown
- 2014-11-11 HR HRP20220718TT patent/HRP20220718T1/hr unknown
- 2014-11-11 UA UAA201606309A patent/UA120750C2/uk unknown
- 2014-11-11 MY MYPI2016000850A patent/MY192088A/en unknown
- 2014-11-11 EP EP22154212.9A patent/EP4039256A1/fr active Pending
- 2014-11-11 EP EP14805743.3A patent/EP3068393B9/fr active Active
- 2014-11-11 PT PT148057433T patent/PT3068393T/pt unknown
- 2014-11-11 EA EA202092456A patent/EA202092456A3/ru unknown
- 2014-11-11 TN TN2016000176A patent/TN2016000176A1/en unknown
- 2014-11-11 BR BR112016010564A patent/BR112016010564A2/pt not_active Application Discontinuation
- 2014-11-11 US US15/035,438 patent/US20160287569A1/en not_active Abandoned
- 2014-11-11 PL PL14805743.3T patent/PL3068393T3/pl unknown
- 2014-11-11 NZ NZ720766A patent/NZ720766A/en unknown
- 2014-11-11 LT LTEPPCT/US2014/065034T patent/LT3068393T/lt unknown
- 2014-11-11 CA CA2930244A patent/CA2930244A1/fr active Pending
- 2014-11-11 SI SI201431961T patent/SI3068393T1/sl unknown
- 2014-11-11 CN CN202011275297.4A patent/CN112933236A/zh active Pending
- 2014-11-11 ES ES14805743T patent/ES2916721T3/es active Active
- 2014-11-11 RS RS20220533A patent/RS63348B9/sr unknown
- 2014-11-11 KR KR1020217029928A patent/KR102473485B1/ko active IP Right Grant
- 2014-11-11 KR KR1020167015298A patent/KR102305351B1/ko active IP Right Grant
-
2016
- 2016-05-06 MX MX2022012320A patent/MX2022012320A/es unknown
- 2016-05-06 MX MX2019009853A patent/MX2019009853A/es unknown
- 2016-05-06 MX MX2022008175A patent/MX2022008175A/es unknown
- 2016-05-10 IL IL245568A patent/IL245568B/en unknown
- 2016-05-11 CL CL2016001131A patent/CL2016001131A1/es unknown
- 2016-05-11 PH PH12016500871A patent/PH12016500871A1/en unknown
-
2018
- 2018-12-21 US US16/229,150 patent/US10881648B2/en active Active
-
2019
- 2019-04-17 JP JP2019078325A patent/JP2019142916A/ja active Pending
-
2020
- 2020-02-24 AU AU2020201321A patent/AU2020201321B2/en not_active Ceased
- 2020-10-13 JP JP2020172367A patent/JP6972274B2/ja active Active
-
2021
- 2021-08-16 IL IL285646A patent/IL285646A/en unknown
- 2021-09-09 US US17/470,136 patent/US20220280495A1/en not_active Abandoned
- 2021-11-01 JP JP2021178554A patent/JP2022009805A/ja active Pending
-
2022
- 2022-03-03 AU AU2022201495A patent/AU2022201495A1/en not_active Abandoned
-
2023
- 2023-01-13 JP JP2023003579A patent/JP2023033414A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA39094B1 (fr) | Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers | |
MX2022002465A (es) | Inhibidores de kras g12d. | |
MX2020010412A (es) | Inhibidores de tirosina quinasa de bruton. | |
SA519402217B1 (ar) | مثبطات إيميدازو بيرازين لكيناز تيروسين بروتون | |
TN2015000174A1 (en) | Pyrrolopyrimidine compounds as kinase inhibitors | |
MA47313B1 (fr) | Formulations sous-cutanées d'anticorps her2 | |
PH12016500575A1 (en) | Inhibitors of bruton`s tyrosine kinase | |
EA201500393A1 (ru) | Ингибиторы тирозинкиназы брутона | |
MX2017015574A (es) | Inhibidores de tirosina quinasa de bruton. | |
TW201613919A (en) | Inhibitors of Bruton's tyrosine kinase | |
EA201300246A1 (ru) | Ингибиторы тирозинкиназы брутона | |
EA201492290A1 (ru) | Составы и способы для вагинальной доставки антипрогестинов | |
MA43876A (fr) | Compositions pharmaceutiques et leur utilisations contre les maladies de surcharge lysosomale | |
MA39447B1 (fr) | Pirlindole ou ses sels pharmaceutiquement acceptables pour une utilisation en médecine | |
EA201690302A1 (ru) | Композиции для местного применения для лечения избыточного потоотделения и способы их применения | |
WO2018033941A3 (fr) | Compositions pharmaceutiques à base d'ibrutinib | |
MA39448B1 (fr) | (r)-pirlindole et ses sels pharmaceutiquement acceptables destinés à un usage médical | |
MX2014011218A (es) | Uso de agentes tensoactivos anfotericos para la prevencion y tratamiento de biopeliculas vaginales patogenas en infecciones vaginales. | |
EA201791483A1 (ru) | Фармацевтическая композиция для лечения микоза | |
FR3074421B1 (fr) | Extrait d'helichrysum gymnocephalum pour le traitement et/ou la prevention des dermatoses inflammatoires | |
EA201990041A1 (ru) | Композиции, содержащие тимолол, и их применение при лечении розацеа при местном применении | |
EA202191415A1 (ru) | Комбинированная терапия, включающая ингибитор krasg12c и одно или несколько дополнительных фармацевтически активных средств, для лечения видов рака | |
MA46096B1 (fr) | Stimulateurs sgc bicycliques fusionnés | |
UA110910C2 (uk) | Карбоксамідні похідні піразолу як інгібітори тирозинкінази брутона, фармацевтична композиція на їх основі та спосіб лікування захворювань (варіанти) |