MA37751B1 - Procédé de préparation de composés d'acides aminés - Google Patents

Procédé de préparation de composés d'acides aminés

Info

Publication number
MA37751B1
MA37751B1 MA37751A MA37751A MA37751B1 MA 37751 B1 MA37751 B1 MA 37751B1 MA 37751 A MA37751 A MA 37751A MA 37751 A MA37751 A MA 37751A MA 37751 B1 MA37751 B1 MA 37751B1
Authority
MA
Morocco
Prior art keywords
preparation
amino acid
acid compounds
isopropylamino
cyclopenta
Prior art date
Application number
MA37751A
Other languages
English (en)
Other versions
MA37751A1 (fr
Inventor
Travis Remarchuk
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MA37751A1 publication Critical patent/MA37751A1/fr
Publication of MA37751B1 publication Critical patent/MA37751B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention concerne de nouveaux procédés de préparation et de purification de composés d'acides aminés, qui sont utiles dans la préparation des inhibiteurs d'akt utilisés dans le traitement des maladies telles que le cancer, comprenant le composé de (s)-2-(4-chlorophényl)-1-(4-((5r,7r)- 7-hydroxy-5-méthyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl)pipérazin-1-yl)-3-(isopropylamino)propan-1-one.
MA37751A 2012-05-17 2013-05-17 Procédé de préparation de composés d'acides aminés MA37751B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261648534P 2012-05-17 2012-05-17
PCT/US2013/041687 WO2013173779A1 (fr) 2012-05-17 2013-05-17 Procédé de préparation de composés d'acides aminés

Publications (2)

Publication Number Publication Date
MA37751A1 MA37751A1 (fr) 2018-01-31
MA37751B1 true MA37751B1 (fr) 2018-08-31

Family

ID=48483247

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37751A MA37751B1 (fr) 2012-05-17 2013-05-17 Procédé de préparation de composés d'acides aminés

Country Status (22)

Country Link
US (1) US9278917B2 (fr)
EP (1) EP2850054B1 (fr)
JP (1) JP6196294B2 (fr)
KR (1) KR102074535B1 (fr)
CN (1) CN104520263B (fr)
AU (1) AU2013262516B2 (fr)
BR (1) BR112014028585B1 (fr)
CA (1) CA2873658C (fr)
ES (1) ES2668477T3 (fr)
HK (1) HK1208857A1 (fr)
HR (1) HRP20180948T1 (fr)
IL (1) IL235630A (fr)
MA (1) MA37751B1 (fr)
MX (1) MX350443B (fr)
MY (1) MY171538A (fr)
NZ (1) NZ702939A (fr)
PL (1) PL2850054T3 (fr)
RU (1) RU2643146C2 (fr)
SG (1) SG11201407625WA (fr)
SI (1) SI2850054T1 (fr)
TR (1) TR201807444T4 (fr)
WO (1) WO2013173779A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2858989T (lt) 2012-05-17 2020-08-10 Genentech, Inc. Akt inhibuojančio pirimidinil-ciklopentano junginio amorfinė forma, jo kompozicijos ir būdai
DK2861582T3 (en) 2012-05-17 2016-08-22 Array Biopharma Inc A process for preparing hydroxylated compounds cyclopentylpyrimidin
ES2588878T3 (es) 2012-05-17 2016-11-07 Array Biopharma, Inc. Proceso para preparar compuestos de ciclopentilpirimidina hidroxilada
KR102123131B1 (ko) 2012-05-17 2020-06-15 제넨테크, 인크. 하이드록실화 사이클로펜타피리미딘 화합물 및 이의 염의 제조 방법
EP4282973A3 (fr) 2013-11-15 2024-03-27 F. Hoffmann-La Roche AG Procédés de préparation pour dérivés de pyrmidinecyclopentane
BR112017005931B1 (pt) * 2014-09-26 2024-04-30 F. Hoffmann-La Roche Ag Processos para preparar um composto de ciclopentil[d]pirimidin-4-il) piperazina e composto de ciclopentil[d]pirimidin-4-il)piperazina

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663327A (en) * 1984-05-23 1987-05-05 Bayer Aktiengesellschaft 1-heteroaryl-4-aryl-pyrazolin-5-ones
WO1995015684A1 (fr) 1993-12-12 1995-06-15 Agrogene, Ltd. Nouveau procede servant a proteger des vegetaux des infections fongiques
AU724216B2 (en) 1997-04-07 2000-09-14 Merck & Co., Inc. A method of treating cancer
US6201023B1 (en) 1997-06-10 2001-03-13 Agrogene Ltd. Methods and compositions to protect crops against plant parasitic nematodes
EP0982300A3 (fr) 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines comme antagonistes du recepteur histamine H3 et leur application thérapeutique
EP1158982A4 (fr) 1999-03-03 2002-06-12 Merck & Co Inc Inhibiteurs de la prenyle-proteine transferase
AU7715300A (en) 1999-09-27 2001-04-30 Merck & Co., Inc. Method of preventing osteoporosis
PE20050630A1 (es) 2003-06-09 2005-09-22 Boehringer Ingelheim Int Compuestos heterociclicos como inhibidores del papiloma virus
FR2892416B1 (fr) * 2005-10-20 2008-06-27 Sanofi Aventis Sa Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines
UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2209775A1 (fr) 2007-10-09 2010-07-28 UCB Pharma, S.A. Composés hétérobicycliques utiles comme antagonistes du récepteur h4 de l'histamine
CN102459165B (zh) 2009-04-15 2015-09-02 Abbvie公司 抗病毒化合物
EP2491032B1 (fr) 2009-10-23 2014-04-16 Eli Lilly and Company Inhibiteurs d'akt
EP2592933B1 (fr) 2010-07-16 2017-04-05 Anderson Gaweco Inhibiteurs mif et leurs utilisations
WO2012177925A1 (fr) 2011-06-21 2012-12-27 The Board Institute, Inc. Inhibiteurs akt pour le traitement d'un cancer exprimant un gène de fusion magi3 - akt3
KR102123131B1 (ko) 2012-05-17 2020-06-15 제넨테크, 인크. 하이드록실화 사이클로펜타피리미딘 화합물 및 이의 염의 제조 방법
ES2588878T3 (es) 2012-05-17 2016-11-07 Array Biopharma, Inc. Proceso para preparar compuestos de ciclopentilpirimidina hidroxilada
CA2889855A1 (fr) 2012-11-01 2014-05-08 Robert S. Katz Methodes de traitement de la fibromyalgie
JP2016513112A (ja) 2013-02-18 2016-05-12 ザ スクリプス リサーチ インスティテュート 治療的潜在能力を有するバソプレッシン受容体のモジュレーター
CA2904662A1 (fr) 2013-03-15 2014-09-25 Shifa Biomedical Corporation Composes anti-pcsk9 et methodes de traitement et/ou de prevention de maladies cardio-vasculaires

Also Published As

Publication number Publication date
MX2014013863A (es) 2015-05-07
IL235630A0 (en) 2015-02-01
MA37751A1 (fr) 2018-01-31
EP2850054B1 (fr) 2018-03-21
JP6196294B2 (ja) 2017-09-13
AU2013262516A1 (en) 2015-01-22
JP2015520165A (ja) 2015-07-16
US9278917B2 (en) 2016-03-08
AU2013262516B2 (en) 2017-10-19
TR201807444T4 (tr) 2018-06-21
BR112014028585A8 (pt) 2020-09-24
EP2850054A1 (fr) 2015-03-25
ES2668477T3 (es) 2018-05-18
CA2873658A1 (fr) 2013-11-21
US20150148559A1 (en) 2015-05-28
BR112014028585B1 (pt) 2020-12-22
MX350443B (es) 2017-09-06
CN104520263A (zh) 2015-04-15
RU2014150991A (ru) 2016-07-10
PL2850054T3 (pl) 2018-08-31
CN104520263B (zh) 2016-11-09
SI2850054T1 (en) 2018-06-29
WO2013173779A1 (fr) 2013-11-21
NZ702939A (en) 2016-08-26
MY171538A (en) 2019-10-17
CA2873658C (fr) 2021-01-26
SG11201407625WA (en) 2014-12-30
IL235630A (en) 2017-03-30
HK1208857A1 (en) 2016-03-18
RU2643146C2 (ru) 2018-01-31
BR112014028585A2 (pt) 2017-06-27
KR102074535B1 (ko) 2020-02-06
KR20150013808A (ko) 2015-02-05
HRP20180948T1 (hr) 2018-08-10

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