MX361992B - Compuestos de pirrolopirimidina novedosos como inhibidores de proteínas quinasas. - Google Patents

Compuestos de pirrolopirimidina novedosos como inhibidores de proteínas quinasas.

Info

Publication number
MX361992B
MX361992B MX2015001715A MX2015001715A MX361992B MX 361992 B MX361992 B MX 361992B MX 2015001715 A MX2015001715 A MX 2015001715A MX 2015001715 A MX2015001715 A MX 2015001715A MX 361992 B MX361992 B MX 361992B
Authority
MX
Mexico
Prior art keywords
inhibitors
protein kinases
pyrrolopyrimidine compounds
novel pyrrolopyrimidine
methods
Prior art date
Application number
MX2015001715A
Other languages
English (en)
Other versions
MX2015001715A (es
Inventor
Xu Xiao
Wang Xiaobo
Mao Long
Zhao Li
Xi Biao
Original Assignee
Acea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/843,554 external-priority patent/US9034885B2/en
Application filed by Acea Biosciences Inc filed Critical Acea Biosciences Inc
Publication of MX2015001715A publication Critical patent/MX2015001715A/es
Publication of MX361992B publication Critical patent/MX361992B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

La presente invención se relaciona con determinados derivados de pirrolopirimidina, composiciones farmacéuticas que los contienen, y métodos para utilizarlos, que incluyen métodos para el tratamiento de trastornos de proliferación y otras enfermedades relacionadas con la desregulación de quinasa (tal como, pero no limitada a, EGFR (que incluye HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC y TXK) y/o las respetivas rutas.
MX2015001715A 2012-08-06 2013-07-11 Compuestos de pirrolopirimidina novedosos como inhibidores de proteínas quinasas. MX361992B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261680231P 2012-08-06 2012-08-06
US13/843,554 US9034885B2 (en) 2012-01-13 2013-03-15 EGFR modulators and uses thereof
US201361814147P 2013-04-19 2013-04-19
US13/917,514 US8685988B2 (en) 2012-08-06 2013-06-13 EGFR modulators and uses thereof
PCT/US2013/050163 WO2014025486A1 (en) 2012-08-06 2013-07-11 Novel pyrrolopyrimidine compounds as inhibitors of protein kinases

Publications (2)

Publication Number Publication Date
MX2015001715A MX2015001715A (es) 2015-07-06
MX361992B true MX361992B (es) 2018-12-19

Family

ID=50068479

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001715A MX361992B (es) 2012-08-06 2013-07-11 Compuestos de pirrolopirimidina novedosos como inhibidores de proteínas quinasas.

Country Status (22)

Country Link
EP (2) EP3170825B1 (es)
JP (2) JP6215938B2 (es)
KR (1) KR102181365B1 (es)
CN (2) CN103748096B (es)
AU (1) AU2013300106B2 (es)
BR (1) BR112015002709B1 (es)
CA (1) CA2881275C (es)
CY (1) CY1120844T1 (es)
DK (1) DK2880035T3 (es)
ES (2) ES2733576T3 (es)
HK (1) HK1210471A1 (es)
HR (1) HRP20170311T1 (es)
HU (1) HUE031955T2 (es)
IN (1) IN2015DN00914A (es)
LT (1) LT2880035T (es)
MX (1) MX361992B (es)
NZ (1) NZ629807A (es)
PT (1) PT2880035T (es)
RU (2) RU2018104702A (es)
SG (1) SG11201500872SA (es)
WO (1) WO2014025486A1 (es)
ZA (2) ZA201500762B (es)

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KR102577241B1 (ko) * 2017-12-28 2023-09-11 주식회사 대웅제약 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체
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Also Published As

Publication number Publication date
KR20150068949A (ko) 2015-06-22
ZA201600648B (en) 2021-09-29
CN107266453A (zh) 2017-10-20
ES2733576T3 (es) 2019-12-02
WO2014025486A1 (en) 2014-02-13
CN107266453B (zh) 2020-02-07
CN103748096B (zh) 2017-10-20
JP2017061581A (ja) 2017-03-30
CY1120844T1 (el) 2019-12-11
ZA201500762B (en) 2021-09-29
DK2880035T3 (en) 2017-03-06
AU2013300106A1 (en) 2015-02-19
LT2880035T (lt) 2017-03-27
HUE031955T2 (en) 2017-08-28
BR112015002709A2 (pt) 2017-07-04
RU2645672C2 (ru) 2018-02-27
EP2880035B1 (en) 2016-12-07
MX2015001715A (es) 2015-07-06
AU2013300106B2 (en) 2017-11-30
EP3170825A1 (en) 2017-05-24
RU2018104702A (ru) 2019-02-22
EP3170825B1 (en) 2019-04-10
SG11201500872SA (en) 2015-03-30
EP2880035A1 (en) 2015-06-10
HRP20170311T1 (hr) 2017-04-21
RU2015107831A (ru) 2016-09-27
IN2015DN00914A (es) 2015-06-12
BR112015002709B1 (pt) 2022-09-20
NZ629807A (en) 2017-04-28
CA2881275A1 (en) 2014-02-13
KR102181365B1 (ko) 2020-11-23
CN103748096A (zh) 2014-04-23
PT2880035T (pt) 2017-03-10
HK1210471A1 (en) 2016-04-22
ES2618007T3 (es) 2017-06-20
JP2015524468A (ja) 2015-08-24
EP2880035B9 (en) 2017-05-17
CA2881275C (en) 2020-10-20
JP6215938B2 (ja) 2017-10-18

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