IN2015DN00914A - - Google Patents

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Publication number
IN2015DN00914A
IN2015DN00914A IN914DEN2015A IN2015DN00914A IN 2015DN00914 A IN2015DN00914 A IN 2015DN00914A IN 914DEN2015 A IN914DEN2015 A IN 914DEN2015A IN 2015DN00914 A IN2015DN00914 A IN 2015DN00914A
Authority
IN
India
Prior art keywords
methods
etk
txk
bmx
itk
Prior art date
Application number
Inventor
Xiao Xu
Xiaobo Wang
Long Mao
Li Zhao
Biao Xi
Original Assignee
Acea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/843,554 external-priority patent/US9034885B2/en
Application filed by Acea Biosciences Inc filed Critical Acea Biosciences Inc
Publication of IN2015DN00914A publication Critical patent/IN2015DN00914A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions con taining them, and methods of using them, including methods for the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not lim ited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways.
IN914DEN2015 2012-08-06 2013-07-11 IN2015DN00914A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261680231P 2012-08-06 2012-08-06
US13/843,554 US9034885B2 (en) 2012-01-13 2013-03-15 EGFR modulators and uses thereof
US201361814147P 2013-04-19 2013-04-19
US13/917,514 US8685988B2 (en) 2012-08-06 2013-06-13 EGFR modulators and uses thereof
PCT/US2013/050163 WO2014025486A1 (en) 2012-08-06 2013-07-11 Novel pyrrolopyrimidine compounds as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
IN2015DN00914A true IN2015DN00914A (en) 2015-06-12

Family

ID=50068479

Family Applications (1)

Application Number Title Priority Date Filing Date
IN914DEN2015 IN2015DN00914A (en) 2012-08-06 2013-07-11

Country Status (22)

Country Link
EP (2) EP3170825B1 (en)
JP (2) JP6215938B2 (en)
KR (1) KR102181365B1 (en)
CN (2) CN103748096B (en)
AU (1) AU2013300106B2 (en)
BR (1) BR112015002709B1 (en)
CA (1) CA2881275C (en)
CY (1) CY1120844T1 (en)
DK (1) DK2880035T3 (en)
ES (2) ES2733576T3 (en)
HK (1) HK1210471A1 (en)
HR (1) HRP20170311T1 (en)
HU (1) HUE031955T2 (en)
IN (1) IN2015DN00914A (en)
LT (1) LT2880035T (en)
MX (1) MX361992B (en)
NZ (1) NZ629807A (en)
PT (1) PT2880035T (en)
RU (2) RU2018104702A (en)
SG (1) SG11201500872SA (en)
WO (1) WO2014025486A1 (en)
ZA (2) ZA201500762B (en)

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US9034885B2 (en) 2012-01-13 2015-05-19 Acea Biosciences Inc. EGFR modulators and uses thereof
US9464089B2 (en) 2012-01-13 2016-10-11 Acea Biosciences Inc. Heterocyclic compounds and uses thereof
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JP2018104290A (en) * 2015-04-28 2018-07-05 アステラス製薬株式会社 Pharmaceutical composition containing pyrazinecarboxamide compound as active ingredient
CN107614503B (en) 2015-04-29 2020-03-10 广东众生药业股份有限公司 Fused or tricyclic aryl pyrimidine compounds as kinase inhibitors
WO2017011720A1 (en) * 2015-07-16 2017-01-19 Signal Pharmaceuticals, Llc Solod forms 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d] oxazol-6-yl)17h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
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CN105646496B (en) * 2016-01-20 2018-07-20 华侨大学 A kind of 7H- pyrrolo-es [2,3-d] pyrimidine derivatives, its synthetic method and application
CN107540661A (en) * 2016-06-24 2018-01-05 正大天晴药业集团股份有限公司 Crystallization as the Aniline pyrimidine compound of EGFR inhibitor
CN107663207B (en) * 2016-07-27 2021-07-30 南京圣和药业股份有限公司 Mesylate crystal of EGFR kinase inhibitor and preparation method thereof
CN107663208B (en) * 2016-07-27 2021-10-15 南京圣和药业股份有限公司 Medicinal salt of novel EGFR kinase inhibitor and preparation method and application thereof
CN107955019B (en) * 2016-10-17 2021-09-14 广东众生药业股份有限公司 Salt form and crystal form of EGFR inhibitor and preparation method thereof
CN106749266B (en) * 2016-11-14 2019-01-22 山东大学 The high efficiency preparation method of pyrrolo- [2,3-d] pyrimidines
CN108299419B (en) * 2017-01-11 2022-04-26 南京圣和药业股份有限公司 Novel crystal forms of novel EGFR kinase inhibitor and preparation method thereof
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JP6995428B2 (en) * 2017-12-28 2022-01-14 デウン ファーマシューティカル カンパニー リミテッド Oxy-fluoropiperidine derivative as a kinase inhibitor
KR102577241B1 (en) * 2017-12-28 2023-09-11 주식회사 대웅제약 Amino-fluoropiperidine derivatives as kinase inhibitor
KR102577242B1 (en) * 2017-12-28 2023-09-11 주식회사 대웅제약 Amino-methylpiperidine derivatives as kinase inhibitor
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Also Published As

Publication number Publication date
KR20150068949A (en) 2015-06-22
ZA201600648B (en) 2021-09-29
CN107266453A (en) 2017-10-20
ES2733576T3 (en) 2019-12-02
WO2014025486A1 (en) 2014-02-13
CN107266453B (en) 2020-02-07
CN103748096B (en) 2017-10-20
JP2017061581A (en) 2017-03-30
CY1120844T1 (en) 2019-12-11
ZA201500762B (en) 2021-09-29
DK2880035T3 (en) 2017-03-06
AU2013300106A1 (en) 2015-02-19
LT2880035T (en) 2017-03-27
HUE031955T2 (en) 2017-08-28
BR112015002709A2 (en) 2017-07-04
RU2645672C2 (en) 2018-02-27
EP2880035B1 (en) 2016-12-07
MX2015001715A (en) 2015-07-06
AU2013300106B2 (en) 2017-11-30
EP3170825A1 (en) 2017-05-24
RU2018104702A (en) 2019-02-22
MX361992B (en) 2018-12-19
EP3170825B1 (en) 2019-04-10
SG11201500872SA (en) 2015-03-30
EP2880035A1 (en) 2015-06-10
HRP20170311T1 (en) 2017-04-21
RU2015107831A (en) 2016-09-27
BR112015002709B1 (en) 2022-09-20
NZ629807A (en) 2017-04-28
CA2881275A1 (en) 2014-02-13
KR102181365B1 (en) 2020-11-23
CN103748096A (en) 2014-04-23
PT2880035T (en) 2017-03-10
HK1210471A1 (en) 2016-04-22
ES2618007T3 (en) 2017-06-20
JP2015524468A (en) 2015-08-24
EP2880035B9 (en) 2017-05-17
CA2881275C (en) 2020-10-20
JP6215938B2 (en) 2017-10-18

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