BR112014028585A8 - processo para fabricação de aminoácidos, e seus intermediários - Google Patents

processo para fabricação de aminoácidos, e seus intermediários

Info

Publication number
BR112014028585A8
BR112014028585A8 BR112014028585A BR112014028585A BR112014028585A8 BR 112014028585 A8 BR112014028585 A8 BR 112014028585A8 BR 112014028585 A BR112014028585 A BR 112014028585A BR 112014028585 A BR112014028585 A BR 112014028585A BR 112014028585 A8 BR112014028585 A8 BR 112014028585A8
Authority
BR
Brazil
Prior art keywords
intermediates
amino acids
manufacturing amino
manufacturing
isopropylamino
Prior art date
Application number
BR112014028585A
Other languages
English (en)
Other versions
BR112014028585B1 (pt
BR112014028585A2 (pt
Inventor
Remarchuk Travis
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112014028585A2 publication Critical patent/BR112014028585A2/pt
Publication of BR112014028585A8 publication Critical patent/BR112014028585A8/pt
Publication of BR112014028585B1 publication Critical patent/BR112014028585B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

processo para fabricação de aminoácidos, e seus intermediários. a presente invenção refere-se a novos processos para a fabricação e purificação de compostos de aminoácido, que são úteis na preparação de inibidores de akt usados no tratamento de doenças como câncer, incluindo o composto (s)-2-(4-clorofenila)-1-(4-((5 r, 7r)-7-hidróxi-5-metil-6,7-di-hidro-5h- -ciclopenta[d]pirimidin-4-il)piperazin-1-il)-3-(isopropilamino)propan-1-ona.
BR112014028585-3A 2012-05-17 2013-05-17 processo para fabricação de aminoácidos, e seus intermediários BR112014028585B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261648534P 2012-05-17 2012-05-17
US61/648,534 2012-05-17
PCT/US2013/041687 WO2013173779A1 (en) 2012-05-17 2013-05-17 Process for making amino acid compounds

Publications (3)

Publication Number Publication Date
BR112014028585A2 BR112014028585A2 (pt) 2017-06-27
BR112014028585A8 true BR112014028585A8 (pt) 2020-09-24
BR112014028585B1 BR112014028585B1 (pt) 2020-12-22

Family

ID=48483247

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014028585-3A BR112014028585B1 (pt) 2012-05-17 2013-05-17 processo para fabricação de aminoácidos, e seus intermediários

Country Status (22)

Country Link
US (1) US9278917B2 (pt)
EP (1) EP2850054B1 (pt)
JP (1) JP6196294B2 (pt)
KR (1) KR102074535B1 (pt)
CN (1) CN104520263B (pt)
AU (1) AU2013262516B2 (pt)
BR (1) BR112014028585B1 (pt)
CA (1) CA2873658C (pt)
ES (1) ES2668477T3 (pt)
HK (1) HK1208857A1 (pt)
HR (1) HRP20180948T1 (pt)
IL (1) IL235630A (pt)
MA (1) MA37751B1 (pt)
MX (1) MX350443B (pt)
MY (1) MY171538A (pt)
NZ (1) NZ702939A (pt)
PL (1) PL2850054T3 (pt)
RU (1) RU2643146C2 (pt)
SG (1) SG11201407625WA (pt)
SI (1) SI2850054T1 (pt)
TR (1) TR201807444T4 (pt)
WO (1) WO2013173779A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2861583T3 (pl) 2012-05-17 2016-12-30 Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidyny
JP6284928B2 (ja) 2012-05-17 2018-02-28 アレイ バイオファーマ、インコーポレイテッド ヒドロキシル化シクロペンチルピリミジン化合物を作製するためのプロセス
CN104471070B (zh) 2012-05-17 2018-09-25 基因泰克公司 制备羟基化环戊并嘧啶化合物和其盐的方法
US9290458B2 (en) 2012-05-17 2016-03-22 Genentech, Inc. Amorphous form of an AKT inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof
CN105899492B (zh) * 2013-11-15 2021-08-24 豪夫迈·罗氏有限公司 用于制备嘧啶基环戊烷化合物的方法
JP6676043B2 (ja) 2014-09-26 2020-04-08 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト （シクロペンチル［ｄ］ピリミジン−４−イル）ピペラジン化合物を調製する方法

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JP2001524079A (ja) 1997-04-07 2001-11-27 メルク エンド カンパニー インコーポレーテッド ガンの治療方法
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FR2892416B1 (fr) * 2005-10-20 2008-06-27 Sanofi Aventis Sa Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique
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US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
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WO2011050016A1 (en) 2009-10-23 2011-04-28 Eli Lilly And Company Akt inhibitors
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CN104471070B (zh) 2012-05-17 2018-09-25 基因泰克公司 制备羟基化环戊并嘧啶化合物和其盐的方法
PL2861583T3 (pl) 2012-05-17 2016-12-30 Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidyny
US20140121193A1 (en) 2012-11-01 2014-05-01 Robert S. Katz Methods for treating fibromyalgia
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Also Published As

Publication number Publication date
BR112014028585B1 (pt) 2020-12-22
JP6196294B2 (ja) 2017-09-13
MY171538A (en) 2019-10-17
ES2668477T3 (es) 2018-05-18
IL235630A0 (en) 2015-02-01
EP2850054B1 (en) 2018-03-21
HRP20180948T1 (hr) 2018-08-10
IL235630A (en) 2017-03-30
KR102074535B1 (ko) 2020-02-06
CA2873658C (en) 2021-01-26
CN104520263B (zh) 2016-11-09
CA2873658A1 (en) 2013-11-21
MX350443B (es) 2017-09-06
SI2850054T1 (en) 2018-06-29
NZ702939A (en) 2016-08-26
PL2850054T3 (pl) 2018-08-31
TR201807444T4 (tr) 2018-06-21
RU2643146C2 (ru) 2018-01-31
AU2013262516B2 (en) 2017-10-19
EP2850054A1 (en) 2015-03-25
RU2014150991A (ru) 2016-07-10
HK1208857A1 (en) 2016-03-18
US9278917B2 (en) 2016-03-08
MX2014013863A (es) 2015-05-07
MA37751A1 (fr) 2018-01-31
CN104520263A (zh) 2015-04-15
AU2013262516A1 (en) 2015-01-22
SG11201407625WA (en) 2014-12-30
MA37751B1 (fr) 2018-08-31
BR112014028585A2 (pt) 2017-06-27
JP2015520165A (ja) 2015-07-16
WO2013173779A1 (en) 2013-11-21
KR20150013808A (ko) 2015-02-05
US20150148559A1 (en) 2015-05-28

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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