MA32892B1 - Anticorps anti-cmet - Google Patents

Anticorps anti-cmet

Info

Publication number
MA32892B1
MA32892B1 MA33933A MA33933A MA32892B1 MA 32892 B1 MA32892 B1 MA 32892B1 MA 33933 A MA33933 A MA 33933A MA 33933 A MA33933 A MA 33933A MA 32892 B1 MA32892 B1 MA 32892B1
Authority
MA
Morocco
Prior art keywords
antibody
receptor
cmet
antibodies
met
Prior art date
Application number
MA33933A
Other languages
Arabic (ar)
English (en)
French (fr)
Inventor
Liliane Goetsch
Thierry Wurch
Cédric Bes
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41693124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32892(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/IB2008/055663 external-priority patent/WO2010064089A1/en
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of MA32892B1 publication Critical patent/MA32892B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Connection Of Motors, Electrical Generators, Mechanical Devices, And The Like (AREA)
  • Medicinal Preparation (AREA)
MA33933A 2008-12-02 2011-06-10 Anticorps anti-cmet MA32892B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IB2008/055663 WO2010064089A1 (en) 2008-12-02 2008-12-02 Novel anti-cmet antibody
US18450209P 2009-06-05 2009-06-05
PCT/EP2009/066201 WO2010069765A1 (en) 2008-12-02 2009-12-02 ANTI-cMET ANTIBODY

Publications (1)

Publication Number Publication Date
MA32892B1 true MA32892B1 (fr) 2011-12-01

Family

ID=41693124

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33933A MA32892B1 (fr) 2008-12-02 2011-06-10 Anticorps anti-cmet

Country Status (38)

Country Link
US (4) US8741290B2 (enExample)
EP (4) EP3135691B1 (enExample)
JP (3) JP5863458B2 (enExample)
KR (1) KR101838299B1 (enExample)
CN (2) CN102227446B (enExample)
AR (1) AR074439A1 (enExample)
AU (3) AU2009328318C1 (enExample)
BR (2) BR122019023930B1 (enExample)
CA (1) CA2743433C (enExample)
CL (2) CL2011001296A1 (enExample)
CO (1) CO6382139A2 (enExample)
CR (1) CR20110324A (enExample)
CY (2) CY1119172T1 (enExample)
DK (2) DK3135691T3 (enExample)
EC (1) ECSP11011127A (enExample)
ES (3) ES2629855T3 (enExample)
GE (2) GEP20146207B (enExample)
HR (2) HRP20171011T8 (enExample)
HU (3) HUE035047T2 (enExample)
IL (2) IL213273A0 (enExample)
LT (2) LT2370468T (enExample)
MA (1) MA32892B1 (enExample)
MX (2) MX2011005677A (enExample)
MY (2) MY192567A (enExample)
NZ (1) NZ593853A (enExample)
PE (1) PE20120343A1 (enExample)
PH (1) PH12015501515A1 (enExample)
PL (3) PL3135691T3 (enExample)
PT (3) PT3135691T (enExample)
RS (2) RS58018B1 (enExample)
RU (2) RU2015127471A (enExample)
SA (2) SA112331005B1 (enExample)
SG (2) SG171851A1 (enExample)
SI (3) SI2370468T1 (enExample)
TN (1) TN2011000216A1 (enExample)
TW (2) TWI459964B (enExample)
WO (1) WO2010069765A1 (enExample)
ZA (1) ZA201105164B (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2014681A1 (en) 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
US8545839B2 (en) * 2008-12-02 2013-10-01 Pierre Fabre Medicament Anti-c-Met antibody
EP2287197A1 (en) * 2009-08-21 2011-02-23 Pierre Fabre Medicament Anti-cMET antibody and its use for the detection and the diagnosis of cancer
EP3511342B1 (en) 2010-03-10 2024-01-17 Genmab A/S Monoclonal antibodies against c-met
RU2013114783A (ru) 2010-09-03 2014-10-10 Академиа Синика Anti-с-мет антитела и способы их применения
BR122014027420A2 (pt) 2010-11-03 2019-08-20 Argenx Bvba Anticorpos anti c-met
CN107936121B (zh) 2011-05-16 2022-01-14 埃泰美德(香港)有限公司 多特异性fab融合蛋白及其使用方法
KR101865223B1 (ko) 2011-10-05 2018-06-08 삼성전자주식회사 항 c-Met 인간화 항체 및 그의 용도
KR20130036993A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 c-Met의 SEMA 도메인 내의 에피토프에 특이적으로 결합하는 항체
EP2773660A2 (en) 2011-11-03 2014-09-10 Argen-X B.V. Chimeric human-camel antigens and their use
KR101463098B1 (ko) * 2011-11-28 2014-11-27 한국생명공학연구원 c-Met에 대한 인간항체에 약물이 접합된 약물 복합체 및 이의 용도
US8900582B2 (en) 2011-12-22 2014-12-02 Samsung Electronics Co., Ltd. Deimmunized anti c-Met humanized antibodies and uses thereof
EP2863946A4 (en) 2012-06-21 2016-04-13 Sorrento Therapeutics Inc ANTIGEN-BINDING PROTEINS THAT BIND TO C-MET
EP2708556B1 (en) 2012-09-12 2018-11-07 Samsung Electronics Co., Ltd Pharmaceutical composition for the use in a combination therapy for prevention or treatment of c-met or angiogenesis factor induced diseases
WO2014057074A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
AU2014230735B2 (en) 2013-03-13 2018-03-15 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
KR102049990B1 (ko) * 2013-03-28 2019-12-03 삼성전자주식회사 c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질
US9994644B2 (en) 2013-04-30 2018-06-12 Agency For Science, Technology And Research mAB 2 anti-Met antibody
US9567641B2 (en) * 2013-07-03 2017-02-14 Samsung Electronics Co., Ltd. Combination therapy for the treatment of cancer using an anti-C-met antibody
US9717715B2 (en) 2013-11-15 2017-08-01 Samsung Electronics Co., Ltd. Method of combination therapy using an anti-C-Met antibody
ES2729797T3 (es) * 2013-12-20 2019-11-06 Dev Ct Biotechnology Anticuerpos específicos de la alfa-enolasa y métodos de uso en terapias contra el cáncer
US10188746B2 (en) 2014-09-10 2019-01-29 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US20180057595A1 (en) * 2015-03-16 2018-03-01 Celldex Therapeutics, Inc. Anti-MET Antibodies and Methods of Use Thereof
EP3411067B1 (en) * 2016-02-05 2021-10-20 Helixmith Co., Ltd Anti-c-met antibodies and uses thereof
US10870701B2 (en) 2016-03-15 2020-12-22 Generon (Shanghai) Corporation Ltd. Multispecific fab fusion proteins and use thereof
MX2018014175A (es) * 2016-05-17 2020-02-07 Abbvie Biotherapeutics Inc Conjugados de anticuerpo-fármaco anti-cmet y métodos para su uso.
US10457726B2 (en) 2016-06-30 2019-10-29 University Of Connecticut Antibody and antigen-binding fragment compositions targeting cell surface antigens in tumors and methods of use thereof
US20200023072A1 (en) 2016-10-11 2020-01-23 Medimmune Limited Antibody-drug conjugates with immune-mediated therapy agents
WO2018088933A1 (en) * 2016-11-14 2018-05-17 Limited Liability Company "Panacela Labs" Anti-tumor effects of a viral vector encoding a toll-like receptor and a toll-like receptor agonist
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
US20180230218A1 (en) * 2017-01-04 2018-08-16 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
CN109771642B (zh) * 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET激动型抗体及其用途
GB201803892D0 (en) * 2018-03-12 2018-04-25 Ultrahuman Six Ltd C-met binding agents
BR112020023846A2 (pt) 2018-05-23 2021-04-13 Adc Therapeutics Sa Adjuvante molecular
MA53284A (fr) * 2018-08-08 2022-01-26 Dragonfly Therapeutics Inc Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
CN109541221B (zh) * 2018-10-24 2022-03-22 益善生物技术股份有限公司 一种c-Met特异性抗体、组合物及试剂盒
KR102353568B1 (ko) 2018-11-14 2022-01-20 주식회사 헬릭스미스 안정성이 향상된 항 c-Met 항체 또는 그의 항원 결합 단편
JP7662531B2 (ja) * 2019-03-28 2025-04-15 ダニスコ・ユーエス・インク 改変抗体
CN114340684B (zh) 2019-09-16 2025-09-12 瑞泽恩制药公司 用于免疫pet成像的放射性标记的met结合蛋白
WO2022079211A1 (en) 2020-10-16 2022-04-21 Adc Therapeutics Sa Glycoconjugates
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant
AU2022253888A1 (en) 2021-04-06 2023-09-28 AbbVie Manufacturing Management Unlimited Company Methods of treatment of non-small-cell lung carcinoma using telisotuzumab vedotin
WO2022214517A1 (en) * 2021-04-08 2022-10-13 Byondis B.V. Anti-c-met antibodies and antibody-drug conjugates
UY39743A (es) * 2021-04-29 2022-11-30 Abbvie Inc Conjugados de anticuerpo anti-c-met y fármaco
WO2022078524A2 (en) 2021-11-03 2022-04-21 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody
WO2023173109A1 (en) 2022-03-11 2023-09-14 Abbvie Biotherapeutics Inc. Methods of treatment of non-small-cell lung carcinoma using telisotuzumab vedotin and osimertinib
AU2024276234A1 (en) 2023-05-23 2025-12-04 AbbVie Manufacturing Management Unlimited Company Methods of treatment using anti-c-met antibody drug conjugates
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4424200A (en) 1979-05-14 1984-01-03 Nuc Med Inc. Method for radiolabeling proteins with technetium-99m
US4479930A (en) 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4831175A (en) 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8924581D0 (en) 1989-11-01 1989-12-20 Pa Consulting Services Bleaching of hair
GB9014932D0 (en) 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
JPH05244982A (ja) 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd 擬人化b−b10
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
EP1349574A2 (en) * 2001-01-09 2003-10-08 MERCK PATENT GmbH Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors
CA2516236A1 (en) * 2003-02-13 2004-08-26 Pharmacia Corporation Antibodies to c-met for the treatment of cancers
HN2004000285A (es) 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
CN1922208A (zh) * 2003-12-11 2007-02-28 健泰科生物技术公司 用于抑制c-met二聚化及活化的方法和组合物
ME01803B (me) 2004-08-05 2010-12-31 Genentech Inc Humanizovani anti-cmet antagonisti
JP5255435B2 (ja) * 2005-04-26 2013-08-07 メディミューン,エルエルシー ヒンジドメイン操作による抗体エフェクター機能の調節
RS54984B1 (sr) 2005-07-18 2016-11-30 Amgen Inc Humana anti-b7rp1 neutrališuća antitela
JP5457671B2 (ja) * 2005-07-28 2014-04-02 ノバルティス アーゲー M−csf特異的モノクローナル抗体およびその使用
CN103183738B (zh) * 2006-03-30 2014-08-06 诺瓦提斯公司 c-Met抗体的组合物和使用方法
EP2014681A1 (en) * 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
US8545839B2 (en) 2008-12-02 2013-10-01 Pierre Fabre Medicament Anti-c-Met antibody

Also Published As

Publication number Publication date
EP2370468A1 (en) 2011-10-05
JP2017099392A (ja) 2017-06-08
CN103351438A (zh) 2013-10-16
TWI523866B (zh) 2016-03-01
SA109300720B1 (ar) 2013-05-25
CN102227446A (zh) 2011-10-26
US8765128B2 (en) 2014-07-01
EP3431502A1 (en) 2019-01-23
RU2015127471A (ru) 2018-12-21
SG171851A1 (en) 2011-07-28
CA2743433C (en) 2019-06-11
EP3135691A1 (en) 2017-03-01
SA112331005B1 (ar) 2015-09-13
CY1121025T1 (el) 2019-12-11
CL2011001296A1 (es) 2011-08-26
US8747850B2 (en) 2014-06-10
HUE035047T2 (en) 2018-05-02
CL2014000181A1 (es) 2014-07-25
AR074439A1 (es) 2011-01-19
PT3135691T (pt) 2018-11-27
HRP20171011T8 (hr) 2019-01-25
IL213273A0 (en) 2011-07-31
CN103351438B (zh) 2016-04-20
SI3135691T1 (sl) 2018-12-31
MX341014B (es) 2016-08-03
MY192567A (en) 2022-08-29
MX2011005677A (es) 2011-06-30
RS56204B1 (sr) 2017-11-30
DK2370468T3 (en) 2017-06-19
SI3431502T1 (sl) 2021-01-29
JP5863458B2 (ja) 2016-02-16
RS58018B1 (sr) 2019-02-28
JP6309657B2 (ja) 2018-04-11
US8729249B2 (en) 2014-05-20
AU2016200725A1 (en) 2016-02-25
KR20110097839A (ko) 2011-08-31
AU2009328318B2 (en) 2015-11-05
HK1162536A1 (zh) 2012-08-31
PL2370468T3 (pl) 2017-09-29
SI2370468T1 (sl) 2017-08-31
GEP20146207B (en) 2014-12-10
NZ593853A (en) 2013-03-28
US20110239316A1 (en) 2011-09-29
KR101838299B1 (ko) 2018-03-14
BR122019023930B1 (pt) 2021-05-04
LT2370468T (lt) 2017-07-10
AU2016200725C1 (en) 2017-10-19
CO6382139A2 (es) 2012-02-15
CY1119172T1 (el) 2018-02-14
PT2370468T (pt) 2017-07-13
TN2011000216A1 (en) 2012-12-17
HUE040553T2 (hu) 2019-03-28
ES2629855T3 (es) 2017-08-16
EP2370468B1 (en) 2017-04-05
PE20120343A1 (es) 2012-04-16
US8741290B2 (en) 2014-06-03
AU2016200725B2 (en) 2017-05-25
HRP20181868T1 (hr) 2019-01-11
BRPI0923231A2 (pt) 2016-01-26
PL3135691T3 (pl) 2019-02-28
JP2012510280A (ja) 2012-05-10
ZA201105164B (en) 2012-03-28
US20130109840A1 (en) 2013-05-02
CR20110324A (es) 2011-07-28
HK1190414A1 (zh) 2014-07-04
IL231525A0 (en) 2014-04-30
LT3135691T (lt) 2018-11-12
AU2009328318C1 (en) 2017-11-02
ES2697098T3 (es) 2019-01-22
US20130109844A1 (en) 2013-05-02
JP2016117721A (ja) 2016-06-30
CN102227446B (zh) 2015-10-21
AU2009328318A1 (en) 2011-07-28
PH12015501515A1 (en) 2015-12-14
MY185200A (en) 2021-04-30
RU2011124751A (ru) 2013-01-10
BRPI0923231B8 (pt) 2021-05-25
HUE051288T2 (hu) 2021-03-01
TW201446805A (zh) 2014-12-16
AU2017203929B2 (en) 2019-03-28
AU2017203929A1 (en) 2017-07-06
ECSP11011127A (es) 2011-07-29
HRP20171011T1 (hr) 2017-09-22
US20130109841A1 (en) 2013-05-02
JP6074018B2 (ja) 2017-02-01
DK3135691T3 (en) 2018-11-19
RU2560257C2 (ru) 2015-08-20
BRPI0923231B1 (pt) 2020-04-28
ES2827277T3 (es) 2021-05-20
WO2010069765A1 (en) 2010-06-24
EP3135691B1 (en) 2018-08-15
TWI459964B (zh) 2014-11-11
CA2743433A1 (en) 2010-06-24
TW201023892A (en) 2010-07-01
EP3431502B1 (en) 2020-07-22
IL231525B (en) 2019-07-31
PL3431502T3 (pl) 2020-12-28
GEP20135930B (en) 2013-10-10
PT3431502T (pt) 2020-10-29
EP3757132A1 (en) 2020-12-30
SG187518A1 (en) 2013-02-28

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