MA32275B1 - Preparations orales et injectables de composes de tetracycline - Google Patents

Preparations orales et injectables de composes de tetracycline

Info

Publication number
MA32275B1
MA32275B1 MA33281A MA33281A MA32275B1 MA 32275 B1 MA32275 B1 MA 32275B1 MA 33281 A MA33281 A MA 33281A MA 33281 A MA33281 A MA 33281A MA 32275 B1 MA32275 B1 MA 32275B1
Authority
MA
Morocco
Prior art keywords
oral
injectable preparations
tricyclic compounds
preparations
relates
Prior art date
Application number
MA33281A
Other languages
Arabic (ar)
English (en)
Inventor
Sean Johnston
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41114256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32275(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Publication of MA32275B1 publication Critical patent/MA32275B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des préparations injectables et orales d'un composé de tétracycline. Dans un mode de réalisation, l'invention concerne une préparation orale de composé de 9-aminométhyl tétracycline, ou de son sel, sous forme de comprimé ou de capsule. Les préparations peuvent être utilisées, par exemple, pour traiter des infections.
MA33281A 2008-03-28 2010-10-25 Preparations orales et injectables de composes de tetracycline MA32275B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4039808P 2008-03-28 2008-03-28
PCT/US2009/001973 WO2009120389A1 (fr) 2008-03-28 2009-03-30 Préparations orales et injectables de composés de tétracycline

Publications (1)

Publication Number Publication Date
MA32275B1 true MA32275B1 (fr) 2011-05-02

Family

ID=41114256

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33281A MA32275B1 (fr) 2008-03-28 2010-10-25 Preparations orales et injectables de composes de tetracycline

Country Status (31)

Country Link
US (2) US9314475B2 (fr)
EP (3) EP2271348B1 (fr)
JP (7) JP2011515473A (fr)
KR (3) KR101746228B1 (fr)
CN (1) CN102046177B (fr)
AU (1) AU2009229174A1 (fr)
BR (2) BR122020011180B8 (fr)
CA (2) CA2719751C (fr)
CL (1) CL2010000281A1 (fr)
CO (1) CO6300935A2 (fr)
CY (2) CY1120240T1 (fr)
DK (2) DK2271348T3 (fr)
EC (1) ECSP10010576A (fr)
ES (2) ES2836448T3 (fr)
HK (1) HK1257928A1 (fr)
HR (2) HRP20180836T1 (fr)
HU (2) HUE038257T2 (fr)
IL (1) IL208440A0 (fr)
LT (2) LT2271348T (fr)
MA (1) MA32275B1 (fr)
MX (1) MX2010010585A (fr)
NO (1) NO2271348T3 (fr)
NZ (1) NZ588428A (fr)
PL (2) PL2271348T3 (fr)
PT (2) PT2271348T (fr)
RU (1) RU2010144130A (fr)
SI (2) SI3348258T1 (fr)
TR (1) TR201806893T4 (fr)
UA (2) UA122762C2 (fr)
WO (1) WO2009120389A1 (fr)
ZA (1) ZA201007013B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111064A2 (fr) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Composés de minocycline et procédés d’utilisation de ceux-ci
TW202021946A (zh) * 2008-05-23 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
RU2647972C2 (ru) 2010-05-12 2018-03-21 Ремпекс Фармацеутикалс, Инк. Тетрациклиновая композиция
AU2017259960A1 (en) * 2016-05-02 2018-12-06 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and methods of use thereof in urinary tract infection (UTI) treatment
US10166912B2 (en) 2016-08-19 2019-01-01 Sl Corporation Automotive LED driving apparatus
US10383884B2 (en) 2016-11-01 2019-08-20 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (CABP)
MX2021002503A (es) * 2018-09-04 2021-06-15 Paratek Pharm Innc Métodos de tratamiento de infecciones micobacterianas usando compuestos de tetraciclina.
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2699054A (en) * 1953-10-09 1955-01-11 Lloyd H Conover Tetracycline
US2712517A (en) * 1954-03-03 1955-07-05 Bristol Lab Inc Production of tetracycline and substituted tetracyclines
US3019173A (en) * 1956-06-04 1962-01-30 American Cyanamid Co Method for preparing tetracycline
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US3005023A (en) * 1957-04-05 1961-10-17 American Cyanamid Co Production of tetracycline
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US2886595A (en) * 1958-09-30 1959-05-12 Bristol Lab Inc Tetracycline recovery
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3019260A (en) * 1959-05-13 1962-01-30 American Cyanamid Co Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
FR1430859A (fr) * 1960-05-23 1966-05-25
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3301899A (en) * 1963-11-27 1967-01-31 Bristol Myers Co Purification of tetracycline
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (fr) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
EP0536515B1 (fr) 1991-10-04 2001-12-19 American Cyanamid Company 6-Deméthyl-6-déoxy-tétracyclines substituées en 7 et substituées en 9 par un groupe amino substitué
US6465431B1 (en) * 1999-11-17 2002-10-15 Boston Life Sciences, Inc. Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
WO1999011261A1 (fr) 1997-08-29 1999-03-11 Dsm N.V. Granules exempts d'excipients
KR100252699B1 (ko) * 1998-03-17 2000-12-01 강재헌 치주염 치료용 미노사이클린 조성물
AU766200B2 (en) 1998-11-18 2003-10-09 Collagenex Pharmaceuticals, Inc. Novel 4-dedimethy laminotetra cycline derivatives
US6448323B1 (en) 1999-07-09 2002-09-10 Bpsi Holdings, Inc. Film coatings and film coating compositions based on polyvinyl alcohol
WO2001047554A1 (fr) * 1999-12-28 2001-07-05 Chugai Seiyaku Kabushiki Kaisha Compositions d'anticorps stables et preparations pour injection
KR100699390B1 (ko) * 2000-07-07 2007-03-28 트러스티즈 오브 터프츠 칼리지 9-치환된 미노사이클린 화합물
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
MXPA03008165A (es) 2001-03-13 2003-12-12 Paratek Pharm Innc Compuestos tetraciclina sustituidos en la posicion 7,9.
WO2002072031A2 (fr) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
EP2311440A1 (fr) * 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Administration contrôlée de composés de tétracycline et de dérivés de tétracycline
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
WO2003005971A2 (fr) * 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Composes de tetracycline a activites therapeutiques cibles
EA200802365A1 (ru) * 2002-03-08 2009-08-28 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
CN1390550A (zh) * 2002-07-25 2003-01-15 于航 盐酸米诺环素冻干粉针剂及其制备方法
EP2277504A1 (fr) * 2002-10-24 2011-01-26 Paratek Pharmaceuticals, Inc. Composes tetracycline substituee servant au traitement du paludisme
WO2004038000A2 (fr) * 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Procedes d'utilisation de composes tetracycline substituee pour moduler l'arn
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
WO2004064728A2 (fr) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Composes de tetracycline possedant des activites therapeutiques ciblees
KR20050105451A (ko) * 2003-02-03 2005-11-04 네오팜 인코포레이티드 안정한 멸균 여과가능한 리포좀 캡슐화 탁산 및 다른항종양제
WO2004078111A2 (fr) 2003-03-06 2004-09-16 Ranbaxy Laboratories Limited Compositions de minocycline a liberation prolongee et leurs procedes de preparation
WO2004091513A2 (fr) * 2003-04-10 2004-10-28 Paratek Pharmaceuticals, Inc. Composes de la minocycline substitues par 9-aminomethyle
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
AU2004259661B2 (en) * 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
JP4733028B2 (ja) * 2003-07-09 2011-07-27 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
EP1716101A1 (fr) * 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Derives a cycle aromatique a provenant de composes de tetracycline
GB2414668B (en) * 2004-06-03 2009-07-29 Dexcel Ltd Tetracycline modified release delivery system
KR101354093B1 (ko) * 2005-03-14 2014-01-24 와이어쓰 엘엘씨 티게사이클린 조성물 및 이의 제조방법
JP2009524675A (ja) * 2006-01-24 2009-07-02 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリンの経口バイオアベイラビリティーを増加する方法
US20090246276A1 (en) * 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
WO2009111064A2 (fr) * 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Composés de minocycline et procédés d’utilisation de ceux-ci

Also Published As

Publication number Publication date
EP3789030A1 (fr) 2021-03-10
CN102046177B (zh) 2012-12-19
KR101835574B1 (ko) 2018-03-08
JP2023144043A (ja) 2023-10-06
WO2009120389A8 (fr) 2009-12-30
JP2019196408A (ja) 2019-11-14
JP2018203778A (ja) 2018-12-27
CY1123382T1 (el) 2021-12-31
BR122020011180B1 (pt) 2021-03-23
EP2271348A1 (fr) 2011-01-12
JP6577645B2 (ja) 2019-09-18
CL2010000281A1 (es) 2012-03-30
LT2271348T (lt) 2018-06-25
JP2011515473A (ja) 2011-05-19
EP2271348A4 (fr) 2011-05-25
BRPI0909211B8 (pt) 2021-05-25
CA2984301A1 (fr) 2009-10-01
PL3348258T3 (pl) 2021-03-08
EP3348258A1 (fr) 2018-07-18
AU2009229174A1 (en) 2009-10-01
SI3348258T1 (sl) 2020-12-31
BRPI0909211A2 (pt) 2016-11-29
NZ588428A (en) 2012-08-31
HK1257928A1 (zh) 2019-11-01
JP2021167355A (ja) 2021-10-21
HUE052201T2 (hu) 2021-04-28
BR122020011180B8 (pt) 2021-07-27
HUE038257T2 (hu) 2018-10-29
BRPI0909211B1 (pt) 2020-08-25
NO2271348T3 (fr) 2018-08-25
KR101893740B1 (ko) 2018-08-30
JP2014221820A (ja) 2014-11-27
PL2271348T3 (pl) 2018-08-31
IL208440A0 (en) 2010-12-30
HRP20180836T1 (hr) 2018-07-27
HRP20201883T1 (hr) 2021-01-22
WO2009120389A1 (fr) 2009-10-01
EP2271348B1 (fr) 2018-03-28
CY1120240T1 (el) 2019-07-10
KR20160105532A (ko) 2016-09-06
US20100056638A1 (en) 2010-03-04
SI2271348T1 (en) 2018-08-31
TR201806893T4 (tr) 2018-06-21
CA2719751A1 (fr) 2009-10-01
CO6300935A2 (es) 2011-07-21
PT2271348T (pt) 2018-04-16
DK3348258T3 (da) 2020-12-07
KR101746228B1 (ko) 2017-06-12
KR20180026799A (ko) 2018-03-13
ES2836448T3 (es) 2021-06-25
DK2271348T3 (en) 2018-06-14
LT3348258T (lt) 2020-12-10
ECSP10010576A (es) 2010-12-30
UA109627C2 (uk) 2015-09-25
RU2010144130A (ru) 2012-05-10
MX2010010585A (es) 2010-11-09
CA2984301C (fr) 2020-10-27
UA122762C2 (uk) 2021-01-06
ZA201007013B (en) 2013-11-27
JP5940119B2 (ja) 2016-06-29
KR20110008057A (ko) 2011-01-25
US20160279151A1 (en) 2016-09-29
US9314475B2 (en) 2016-04-19
PT3348258T (pt) 2020-11-25
EP3348258B1 (fr) 2020-09-09
JP2016145260A (ja) 2016-08-12
JP6412521B2 (ja) 2018-10-24
ES2674708T3 (es) 2018-07-03
CN102046177A (zh) 2011-05-04
CA2719751C (fr) 2018-01-02

Similar Documents

Publication Publication Date Title
MA32275B1 (fr) Preparations orales et injectables de composes de tetracycline
MA51204B1 (fr) Formes pharmaceutiques comprenant un inhibiteur de la kallicréine plasmatique
MA46452B1 (fr) Composés de benzo[b]thiophéne en tant qu'agonistes de sting
MA40254B1 (fr) Polymorphes du selinexor
MA40768A (fr) Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue
MA37866B1 (fr) Dérivés de type aza-indazole ou diaza-indazole pour le traitement de la douleur
MA35753B1 (fr) Aryl-dihydropyridinones et pipéridinones en tant qu'inhibiteurs de mgat2
MA39040A1 (fr) Nouveau traitement combiné pour la leucémie aiguë myéloïde (lam)
TW200612936A (en) Indole derivatives
MA42811A (fr) Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
CL2009000882A1 (es) Un compuesto n-(4-cloro-3-(piridin-2-il)fenil)-4-(2-hidroxi-2-metilpropilsulfonil)-2-metilbenzamida, inhibidor de la via de señalización hedgehog; composición farmacéutica que comprende a dicho compuesto; y su uso para tratar el cancer.
UA96449C2 (en) Stable laquinimod preparations
EA201200096A1 (ru) Фармацевтическая композиция ингибитора протеазы вируса гепатита c
MY145074A (en) Thiazolidin-4-one derivatives
EA201100795A1 (ru) Фармацевтическая композиция эффективного ингибитора всг для перорального введения
MA32458B1 (fr) Combinaison d'un antagoniste de c-met et d'un compose aminoheteroaryle pour le traitement d'un cancer
TW200800967A (en) Benzimidazole thiophene compounds
TW200640857A (en) Substituted pyrroles and imidazoles, compositions containing same, manufacturing process therefor and use thereof
MA38679A1 (fr) Modulateurs du récepteur de cxcr7
EA201591649A1 (ru) Составы с органическими соединениями
WO2007087026A3 (fr) Forme solide de amg 706 et compositions pharmaceutiques contenant ledit composé
RS53002B (en) ANTI-CANCER UNIT AND PHARMACEUTICAL COPMOSITION CONTAINING IT
IL191670A0 (en) Compounds for the inhibition of apoptosis
ATE508737T1 (de) Clopidogrel-hydrogensulfat von polymorph 1 form enthaltende pharmazeutische zusammensetzung
NI200700218A (es) Derivados de amida como ligandos de canales iónicos y composiciones farmacéuticas y métodos para usar los mismos.