PL3348258T3 - Preparaty doustne i do wstrzykiwania związków tetracyklinowych - Google Patents

Preparaty doustne i do wstrzykiwania związków tetracyklinowych

Info

Publication number
PL3348258T3
PL3348258T3 PL18158017T PL18158017T PL3348258T3 PL 3348258 T3 PL3348258 T3 PL 3348258T3 PL 18158017 T PL18158017 T PL 18158017T PL 18158017 T PL18158017 T PL 18158017T PL 3348258 T3 PL3348258 T3 PL 3348258T3
Authority
PL
Poland
Prior art keywords
oral
injectable formulations
tetracycline compounds
tetracycline
compounds
Prior art date
Application number
PL18158017T
Other languages
English (en)
Inventor
Sean Johnston
Original Assignee
Paratek Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41114256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3348258(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Paratek Pharmaceuticals, Inc. filed Critical Paratek Pharmaceuticals, Inc.
Publication of PL3348258T3 publication Critical patent/PL3348258T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL18158017T 2008-03-28 2009-03-30 Preparaty doustne i do wstrzykiwania związków tetracyklinowych PL3348258T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4039808P 2008-03-28 2008-03-28
EP09723896.8A EP2271348B1 (en) 2008-03-28 2009-03-30 Oral tablet formulation of tetracycline compound
PCT/US2009/001973 WO2009120389A1 (en) 2008-03-28 2009-03-30 Oral and injectable formulations of tetracycline compounds
EP18158017.6A EP3348258B1 (en) 2008-03-28 2009-03-30 Oral and injectable formulations of tetracycline compounds

Publications (1)

Publication Number Publication Date
PL3348258T3 true PL3348258T3 (pl) 2021-03-08

Family

ID=41114256

Family Applications (2)

Application Number Title Priority Date Filing Date
PL09723896T PL2271348T3 (pl) 2008-03-28 2009-03-30 Doustny preparat związków tetracyklinowych w postaci tabletki
PL18158017T PL3348258T3 (pl) 2008-03-28 2009-03-30 Preparaty doustne i do wstrzykiwania związków tetracyklinowych

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL09723896T PL2271348T3 (pl) 2008-03-28 2009-03-30 Doustny preparat związków tetracyklinowych w postaci tabletki

Country Status (31)

Country Link
US (2) US9314475B2 (pl)
EP (3) EP3348258B1 (pl)
JP (7) JP2011515473A (pl)
KR (3) KR101893740B1 (pl)
CN (1) CN102046177B (pl)
AU (1) AU2009229174A1 (pl)
BR (2) BRPI0909211B8 (pl)
CA (2) CA2719751C (pl)
CL (1) CL2010000281A1 (pl)
CO (1) CO6300935A2 (pl)
CY (2) CY1120240T1 (pl)
DK (2) DK2271348T3 (pl)
EC (1) ECSP10010576A (pl)
ES (2) ES2674708T3 (pl)
HK (1) HK1257928A1 (pl)
HR (2) HRP20180836T1 (pl)
HU (2) HUE052201T2 (pl)
IL (1) IL208440A0 (pl)
LT (2) LT3348258T (pl)
MA (1) MA32275B1 (pl)
MX (1) MX2010010585A (pl)
NO (1) NO2271348T3 (pl)
NZ (1) NZ588428A (pl)
PL (2) PL2271348T3 (pl)
PT (2) PT2271348T (pl)
RU (1) RU2010144130A (pl)
SI (2) SI2271348T1 (pl)
TR (1) TR201806893T4 (pl)
UA (2) UA122762C2 (pl)
WO (1) WO2009120389A1 (pl)
ZA (1) ZA201007013B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102015602A (zh) 2008-03-05 2011-04-13 帕拉特克药品公司 米诺环素化合物及其使用方法
TW202216656A (zh) 2008-05-23 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
ES2613738T3 (es) 2010-05-12 2017-05-25 Rempex Pharmaceuticals, Inc. Composiciones de tetraciclina
MX2018013271A (es) * 2016-05-02 2019-03-28 Paratek Pharm Innc Compuestos 9-aminometil minociclina y metodos para utilizarlos en el tratamiento de infeccion de vias urinarias (ivu).
US10166912B2 (en) 2016-08-19 2019-01-01 Sl Corporation Automotive LED driving apparatus
CA3042514A1 (en) 2016-11-01 2018-05-11 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
MX2021002503A (es) * 2018-09-04 2021-06-15 Paratek Pharm Innc Métodos de tratamiento de infecciones micobacterianas usando compuestos de tetraciclina.
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2699054A (en) 1953-10-09 1955-01-11 Lloyd H Conover Tetracycline
US2712517A (en) 1954-03-03 1955-07-05 Bristol Lab Inc Production of tetracycline and substituted tetracyclines
US3019173A (en) 1956-06-04 1962-01-30 American Cyanamid Co Method for preparing tetracycline
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US3005023A (en) 1957-04-05 1961-10-17 American Cyanamid Co Production of tetracycline
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US2886595A (en) 1958-09-30 1959-05-12 Bristol Lab Inc Tetracycline recovery
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3019260A (en) 1959-05-13 1962-01-30 American Cyanamid Co Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
FR1430859A (pl) 1960-05-23 1966-05-25
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3301899A (en) 1963-11-27 1967-01-31 Bristol Myers Co Purification of tetracycline
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (pl) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
EP0536515B1 (en) 1991-10-04 2001-12-19 American Cyanamid Company Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US6465431B1 (en) * 1999-11-17 2002-10-15 Boston Life Sciences, Inc. Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
CN1268888A (zh) 1997-08-29 2000-10-04 Dsm公司 不含赋形剂的颗粒
KR100252699B1 (ko) * 1998-03-17 2000-12-01 강재헌 치주염 치료용 미노사이클린 조성물
EP1137410B1 (en) 1998-11-18 2006-08-16 Collagenex Pharmaceuticals, Inc. Novel 4-dedimethyl aminotetracycline derivatives
US6448323B1 (en) 1999-07-09 2002-09-10 Bpsi Holdings, Inc. Film coatings and film coating compositions based on polyvinyl alcohol
EP1254666A4 (en) * 1999-12-28 2004-12-22 Chugai Pharmaceutical Co Ltd STABLE ANTIBODY COMPOSITIONS AND INJECTION FORMULATIONS
EP1679305B1 (en) 2000-07-07 2012-02-08 Trustees Of Tufts College 9-Substituted minocycline compounds
ATE404528T1 (de) 2001-03-13 2008-08-15 Paratek Pharm Innc 7,9 substituierte tetracyclinverbindungen
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072031A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
EP1383483A4 (en) * 2001-04-05 2006-08-09 Collagenex Pharm Inc CONTROLLED RELEASE OF TETRACYCLIN COMPOUNDS AND TETRACYCLINE DERIVATIVES
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2301550A1 (en) * 2001-07-13 2011-03-30 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
KR101014918B1 (ko) 2002-03-08 2011-02-15 파라테크 파마슈티컬스, 인크. 아미노-메틸 치환된 테트라시클린 화합물
CN1390550A (zh) * 2002-07-25 2003-01-15 于航 盐酸米诺环素冻干粉针剂及其制备方法
EP2277504A1 (en) * 2002-10-24 2011-01-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US8173624B2 (en) * 2002-10-24 2012-05-08 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate RNA
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
BRPI0407096A (pt) * 2003-02-03 2006-01-24 Neopharm Inc Taxano encapsulado em lipossomo estável, estéril e filtrável e outros fármacos antineoplásicos
WO2004078111A2 (en) * 2003-03-06 2004-09-16 Ranbaxy Laboratories Limited Extended release minocycline compositions and processes for their preparation
WO2004091513A2 (en) * 2003-04-10 2004-10-28 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
US20060287283A1 (en) 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EA201100956A1 (ru) * 2003-07-09 2012-01-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
AU2004259661B2 (en) * 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2332904A3 (en) * 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
GB2414668B (en) * 2004-06-03 2009-07-29 Dexcel Ltd Tetracycline modified release delivery system
BRPI0608464A2 (pt) * 2005-03-14 2010-01-05 Wyeth Corp composições de tigeciclina e processos de preparação
AU2007208214B2 (en) * 2006-01-24 2013-02-14 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
US20090246276A1 (en) * 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
CN102015602A (zh) * 2008-03-05 2011-04-13 帕拉特克药品公司 米诺环素化合物及其使用方法

Also Published As

Publication number Publication date
DK3348258T3 (da) 2020-12-07
WO2009120389A8 (en) 2009-12-30
ECSP10010576A (es) 2010-12-30
CA2719751C (en) 2018-01-02
MX2010010585A (es) 2010-11-09
EP3789030A1 (en) 2021-03-10
BR122020011180B1 (pt) 2021-03-23
JP2021167355A (ja) 2021-10-21
EP2271348B1 (en) 2018-03-28
JP2011515473A (ja) 2011-05-19
JP2023144043A (ja) 2023-10-06
JP2016145260A (ja) 2016-08-12
CY1120240T1 (el) 2019-07-10
BRPI0909211B1 (pt) 2020-08-25
DK2271348T3 (en) 2018-06-14
LT3348258T (lt) 2020-12-10
HRP20201883T1 (hr) 2021-01-22
US20100056638A1 (en) 2010-03-04
TR201806893T4 (tr) 2018-06-21
KR101893740B1 (ko) 2018-08-30
LT2271348T (lt) 2018-06-25
CA2984301A1 (en) 2009-10-01
CN102046177B (zh) 2012-12-19
IL208440A0 (en) 2010-12-30
PT2271348T (pt) 2018-04-16
EP2271348A1 (en) 2011-01-12
CL2010000281A1 (es) 2012-03-30
HRP20180836T1 (hr) 2018-07-27
BR122020011180B8 (pt) 2021-07-27
AU2009229174A1 (en) 2009-10-01
HK1257928A1 (zh) 2019-11-01
UA109627C2 (uk) 2015-09-25
PL2271348T3 (pl) 2018-08-31
KR20160105532A (ko) 2016-09-06
JP6412521B2 (ja) 2018-10-24
JP5940119B2 (ja) 2016-06-29
MA32275B1 (fr) 2011-05-02
WO2009120389A1 (en) 2009-10-01
UA122762C2 (uk) 2021-01-06
HUE038257T2 (hu) 2018-10-29
EP3348258A1 (en) 2018-07-18
US20160279151A1 (en) 2016-09-29
ES2674708T3 (es) 2018-07-03
CY1123382T1 (el) 2021-12-31
JP2019196408A (ja) 2019-11-14
BRPI0909211A2 (pt) 2016-11-29
NZ588428A (en) 2012-08-31
KR101746228B1 (ko) 2017-06-12
PT3348258T (pt) 2020-11-25
JP6577645B2 (ja) 2019-09-18
EP2271348A4 (en) 2011-05-25
CA2719751A1 (en) 2009-10-01
SI3348258T1 (sl) 2020-12-31
JP2014221820A (ja) 2014-11-27
US9314475B2 (en) 2016-04-19
EP3348258B1 (en) 2020-09-09
KR20180026799A (ko) 2018-03-13
CN102046177A (zh) 2011-05-04
JP2018203778A (ja) 2018-12-27
CO6300935A2 (es) 2011-07-21
NO2271348T3 (pl) 2018-08-25
ES2836448T3 (es) 2021-06-25
HUE052201T2 (hu) 2021-04-28
KR20110008057A (ko) 2011-01-25
KR101835574B1 (ko) 2018-03-08
ZA201007013B (en) 2013-11-27
BRPI0909211B8 (pt) 2021-05-25
CA2984301C (en) 2020-10-27
RU2010144130A (ru) 2012-05-10
SI2271348T1 (en) 2018-08-31

Similar Documents

Publication Publication Date Title
HK1257928A1 (zh) 四環素化合物的口服和注射製劑
HK1223558A1 (zh) 用於口服給予艾塞那肽的方法和組合物
ZA201008887B (en) Oral compositions and uses thereof
EP2448406A4 (en) ORAL PHARMACEUTICAL COMPOSITIONS OF 3-HYDROXY-N-METHYLMORPHINAN WITH DELAYED RELEASE AND METHOD OF USE THEREOF
ZA201200054B (en) Therapeutic compounds and compositions
EP2473043A4 (en) ORAL CARE PROCESSES AND COMPOSITIONS WITH CHITOSANE DERIVATIVE COMPONENTS
ZA201007920B (en) Oral compositions and uses thereof
IL206835A0 (en) Methods and compositions for oral administration of insulin
EP2262754A4 (en) MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF
PT2173345E (pt) Formulação oral de metadoxina
HK1154484A1 (en) Oral dosage composition
ZA201107847B (en) Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof
EP2241304A4 (en) DENTAL ORAL COMPOSITION
EP2001400A4 (en) ORAL FORMULATIONS OF GLYCYL-2-METHYLPROLYL-GLUTAMATE
ZA201102446B (en) Oral formulation
PL2285450T3 (pl) Kompozycje do higieny jamy ustnej i sposoby
EP2361087A4 (en) INFLAMMATORY COMPOUNDS AND COMPOSITIONS THEREFOR
IL213559A0 (en) Oral formulations
ZA201100944B (en) Oral formulations of chemotherapeutic agents
GB0902648D0 (en) Pharmaceutical compounds and compositions
ZA201204530B (en) Oral care compositions and methods
IL208967A0 (en) Methods and compositions for oral administration of exenatide
SG10201402363YA (en) Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof
GB0903945D0 (en) Pharmaceutical compounds and compositions
GB0902651D0 (en) Pharmaceutical compounds and compositions