MA31714B1 - Derive de pyrazole substitue - Google Patents
Derive de pyrazole substitueInfo
- Publication number
- MA31714B1 MA31714B1 MA32720A MA32720A MA31714B1 MA 31714 B1 MA31714 B1 MA 31714B1 MA 32720 A MA32720 A MA 32720A MA 32720 A MA32720 A MA 32720A MA 31714 B1 MA31714 B1 MA 31714B1
- Authority
- MA
- Morocco
- Prior art keywords
- group
- atom serving
- bonding agent
- serving
- pyrazole derivative
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La présente invention concerne un dérivé inédit du pyrazole et un antagoniste du récepteur aux androgènes contenant ledit dérivé de pyrazole. L'invention concerne, plus précisément, un composé de formule (i') ci-dessous ou un sel de celle-ci. (dans la formule, r1 représente un atome d'hydrogène, un groupe comportant un atome de carbone servant d'agent de liaison, un groupe comportant un atome d'azote servant d'agent de liaison, un groupe comportant un atome d'oxygène servant d'agent de liaison ou un groupe comportant un atome de soufre servant d'agent de liaison; r2 représente un groupe phényle comportant un groupe cyano (et qui peut, en outre, comporter un substituant autre qu'un groupe cyano); r3 représente un atome d'hydrogène, un groupe comportant un atome de carbone servant d'agent de liaison, un groupe comportant un atome d'azote servant d'agent de liaison, un groupe comportant un atome d'oxygène servant d'agent de liaison ou un groupe comportant un atome de soufre servant d'agent de liaison; r4 représente un groupe cyclique éventuellement substitué; et x représente un groupe co ou méthylène éventuellement substitué.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007224910 | 2007-08-30 | ||
PCT/JP2008/065286 WO2009028543A1 (fr) | 2007-08-30 | 2008-08-27 | Dérivé de pyrazole substitué |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31714B1 true MA31714B1 (fr) | 2010-09-01 |
Family
ID=40387261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32720A MA31714B1 (fr) | 2007-08-30 | 2010-03-26 | Derive de pyrazole substitue |
Country Status (20)
Country | Link |
---|---|
US (2) | US20090270359A1 (fr) |
EP (1) | EP2194045A4 (fr) |
JP (1) | JPWO2009028543A1 (fr) |
KR (1) | KR20100046275A (fr) |
CN (1) | CN101842357A (fr) |
AR (1) | AR068813A1 (fr) |
AU (1) | AU2008292429A1 (fr) |
BR (1) | BRPI0816095A2 (fr) |
CA (1) | CA2697663A1 (fr) |
CL (1) | CL2008002521A1 (fr) |
CO (1) | CO6190530A2 (fr) |
DO (1) | DOP2010000068A (fr) |
EA (1) | EA201070323A1 (fr) |
EC (1) | ECSP10010060A (fr) |
MA (1) | MA31714B1 (fr) |
MX (1) | MX2010002266A (fr) |
PE (1) | PE20090610A1 (fr) |
TN (1) | TN2010000091A1 (fr) |
TW (1) | TW200913993A (fr) |
WO (1) | WO2009028543A1 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2264017A4 (fr) * | 2008-04-04 | 2011-07-27 | Takeda Pharmaceutical | Dérivé hétérocyclique et son utilisation |
EP2475366A1 (fr) * | 2009-09-11 | 2012-07-18 | Bayer Pharma Aktiengesellschaft | Thiohydantoïnes à substitution hétéroarylméthyle, en tant que médicaments anticancer |
AR078793A1 (es) | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
US9079880B2 (en) | 2010-07-07 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
US8697911B2 (en) | 2010-07-07 | 2014-04-15 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
JP5769326B2 (ja) | 2010-10-19 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Rhoキナーゼ阻害薬 |
WO2012053630A1 (fr) | 2010-10-22 | 2012-04-26 | アステラス製薬株式会社 | Antagoniste du récepteur muté des androgènes |
CA2829755A1 (fr) | 2011-03-23 | 2012-09-27 | Semorex Technologies Ltd. | Traitement des troubles de la proliferation |
BR112013026905B1 (pt) | 2011-04-21 | 2021-09-14 | Orion Corporation | Compostos de carboxamida moduladora do receptor de andrógeno e seu uso no tratamento e prevenção de câncer de próstata, bem como composições farmacêuticas compreendendo os ditos compostos |
US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
JP6057698B2 (ja) * | 2012-12-25 | 2017-01-11 | 東レ・ダウコーニング株式会社 | イミド基含有有機ケイ素化合物の製造方法 |
DK3180315T3 (da) * | 2014-08-15 | 2020-04-06 | Janssen Pharmaceuticals Inc | Pyrazoler |
EP3180329B1 (fr) | 2014-08-15 | 2020-03-18 | Janssen Pharmaceuticals, Inc. | Derives de triazole comme des inhibiteurs de recepteur nr2b |
US10865184B2 (en) | 2015-04-21 | 2020-12-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10806720B2 (en) | 2015-04-21 | 2020-10-20 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10654809B2 (en) | 2016-06-10 | 2020-05-19 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10093613B2 (en) | 2015-04-21 | 2018-10-09 | Gtx, Inc. | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
EP3319963B1 (fr) | 2015-07-09 | 2020-01-08 | Janssen Pharmaceutica NV | 4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b |
JP6923543B2 (ja) | 2016-02-10 | 2021-08-18 | ヤンセン ファーマシューティカ エヌ.ベー. | Nr2b選択的nmda調節因子としての置換1,2,3−トリアゾール |
US10806719B2 (en) | 2016-06-10 | 2020-10-20 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
WO2017214634A1 (fr) | 2016-06-10 | 2017-12-14 | University Of Tennessee Research Foundation | Ligands de sard - composés de dégradation sélectifs de récepteurs des androgènes - et méthodes d'utilisation |
US11230523B2 (en) | 2016-06-10 | 2022-01-25 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途 |
EP3612522A4 (fr) | 2017-04-18 | 2021-07-07 | Celgene Quanticel Research, Inc. | Composés thérapeutiques |
CN107903213A (zh) * | 2017-09-28 | 2018-04-13 | 山东大学 | 5‑甲基‑1h‑吡唑衍生物及其制备方法和应用 |
MA52244A (fr) | 2018-04-04 | 2021-02-17 | Janssen Pharmaceutica Nv | Pyridine et pyrimidines substituées et leur utilisation en tant que modulateurs du récepteur glun2b |
CN108676001A (zh) * | 2018-06-12 | 2018-10-19 | 江西师范大学 | 一种3-取代-5-异噁唑基-4-取代-1-1,2,3-三氮唑基甲烷化合物 |
MA56196A (fr) | 2019-06-14 | 2022-04-20 | Janssen Pharmaceutica Nv | Pyrazolo-pyridine amides substitués et leur utilisation en tant que modulateurs du récepteur glun2b |
JP2022536773A (ja) | 2019-06-14 | 2022-08-18 | ヤンセン ファーマシューティカ エヌ.ベー. | 置換ピラゾロピラジン及びglun2b受容体調節因子としてのそれらの使用 |
CA3143276A1 (fr) | 2019-06-14 | 2020-12-17 | Janssen Pharmaceutica Nv | Pyrazolo-pyridines heteroaromatiques substituees et leur utilisation en tant que modulateurs du recepteur glun2b |
CA3143102A1 (fr) | 2019-06-14 | 2020-12-17 | Janssen Pharmaceutica Nv | Pyrazolo[4,3-b]pyridines substituees et leur utilisation en tant que modulateurs du recepteur glun2b |
BR112021023562A2 (pt) | 2019-06-14 | 2022-01-04 | Janssen Pharmaceutica Nv | Carbamatos de pirazina e seus usos como moduladores do receptor de glun2b |
CA3143103A1 (fr) | 2019-06-14 | 2020-12-17 | Janssen Pharmaceutica Nv | Carbamates de pyridine et leur utilisation en tant que modulateurs du recepteur glun2b |
JP7288665B2 (ja) * | 2019-08-02 | 2023-06-08 | 株式会社デ・ウエスタン・セラピテクス研究所 | エチルアニリノトルエンスルホン酸誘導体の製造方法 |
CN111499539B (zh) * | 2020-04-20 | 2022-10-11 | 南昌大学 | 一种以芳基羧酸为原料的芳基氰化物合成方法 |
TW202404963A (zh) * | 2022-07-15 | 2024-02-01 | 韓商鐘根堂股份有限公司 | 作為組蛋白去乙醯酶6抑制劑之1,3,4-㗁二唑三唑化合物及包含其之醫藥組合物 |
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SE0002603D0 (sv) * | 2000-07-07 | 2000-07-07 | Astrazeneca Ab | New compounds |
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AU2002364906B2 (en) * | 2001-12-21 | 2007-08-16 | Merck & Co., Inc. | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 |
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US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
US20050101657A1 (en) * | 2001-12-28 | 2005-05-12 | Takeda Chemical Industries Ltd. | Androgen receptor antagonists |
JP2005532291A (ja) * | 2002-04-12 | 2005-10-27 | ファイザー株式会社 | 抗炎症薬および鎮痛薬としてのピラゾール化合物 |
US20040127519A1 (en) * | 2002-12-12 | 2004-07-01 | Pharmacia Corporation | Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors |
US20040142978A1 (en) * | 2002-12-12 | 2004-07-22 | Pharmacia Corporation | Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2 |
US20040127511A1 (en) * | 2002-12-12 | 2004-07-01 | Pharmacia Corporation | Tricyclic aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2 |
US7880001B2 (en) * | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
JP2007535553A (ja) * | 2004-04-29 | 2007-12-06 | アボット・ラボラトリーズ | アミノ−テトラゾール類縁体および使用方法 |
TW200628446A (en) * | 2004-12-14 | 2006-08-16 | Takeda Pharmaceuticals Co | Substituted pyrrole derivative |
CN103497184A (zh) * | 2006-04-04 | 2014-01-08 | 菲布罗根有限公司 | 作为hif调节剂的吡咯并吡啶和噻唑并吡啶化合物 |
JP2007332053A (ja) * | 2006-06-13 | 2007-12-27 | Takeda Chem Ind Ltd | 置換ピロール誘導体 |
MX2009013213A (es) * | 2007-06-08 | 2010-03-30 | Abbott Lab | Indazoles 5-sustituidos 5-heteroarilo como inhibidores de cinasa. |
US20090270361A1 (en) * | 2008-03-26 | 2009-10-29 | Takeda Pharmaceutical Company Limited | Substituted pyrazole derivatives and use thereof |
-
2008
- 2008-08-27 KR KR1020107006668A patent/KR20100046275A/ko not_active Application Discontinuation
- 2008-08-27 US US12/199,008 patent/US20090270359A1/en not_active Abandoned
- 2008-08-27 BR BRPI0816095-3A2A patent/BRPI0816095A2/pt not_active Application Discontinuation
- 2008-08-27 AR ARP080103710A patent/AR068813A1/es unknown
- 2008-08-27 MX MX2010002266A patent/MX2010002266A/es not_active Application Discontinuation
- 2008-08-27 CL CL2008002521A patent/CL2008002521A1/es unknown
- 2008-08-27 AU AU2008292429A patent/AU2008292429A1/en not_active Abandoned
- 2008-08-27 EA EA201070323A patent/EA201070323A1/ru unknown
- 2008-08-27 JP JP2009530148A patent/JPWO2009028543A1/ja not_active Withdrawn
- 2008-08-27 TW TW097132642A patent/TW200913993A/zh unknown
- 2008-08-27 WO PCT/JP2008/065286 patent/WO2009028543A1/fr active Application Filing
- 2008-08-27 EP EP08828418A patent/EP2194045A4/fr not_active Withdrawn
- 2008-08-27 US US12/675,748 patent/US20100227846A1/en not_active Abandoned
- 2008-08-27 CN CN200880114151A patent/CN101842357A/zh active Pending
- 2008-08-27 PE PE2008001451A patent/PE20090610A1/es not_active Application Discontinuation
- 2008-08-27 CA CA2697663A patent/CA2697663A1/fr not_active Abandoned
-
2010
- 2010-02-23 TN TNP2010000091A patent/TN2010000091A1/fr unknown
- 2010-02-26 DO DO2010000068A patent/DOP2010000068A/es unknown
- 2010-03-26 MA MA32720A patent/MA31714B1/fr unknown
- 2010-03-26 CO CO10036555A patent/CO6190530A2/es not_active Application Discontinuation
- 2010-03-30 EC EC2010010060A patent/ECSP10010060A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO6190530A2 (es) | 2010-08-19 |
DOP2010000068A (es) | 2010-03-15 |
CL2008002521A1 (es) | 2009-11-20 |
TW200913993A (en) | 2009-04-01 |
EA201070323A1 (ru) | 2010-10-29 |
US20100227846A1 (en) | 2010-09-09 |
ECSP10010060A (es) | 2010-04-30 |
PE20090610A1 (es) | 2009-06-11 |
US20090270359A1 (en) | 2009-10-29 |
TN2010000091A1 (en) | 2011-09-26 |
JPWO2009028543A1 (ja) | 2010-12-02 |
KR20100046275A (ko) | 2010-05-06 |
AU2008292429A1 (en) | 2009-03-05 |
BRPI0816095A2 (pt) | 2015-03-03 |
CA2697663A1 (fr) | 2009-03-05 |
AR068813A1 (es) | 2009-12-09 |
EP2194045A1 (fr) | 2010-06-09 |
WO2009028543A1 (fr) | 2009-03-05 |
MX2010002266A (es) | 2010-03-25 |
EP2194045A4 (fr) | 2011-09-21 |
CN101842357A (zh) | 2010-09-22 |
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