MA29255B1 - Derives de pyrazole destines a inhiber les kinases dependantes des cyclines (cdk) et les glycogene synthases kinases (gsk) - Google Patents

Derives de pyrazole destines a inhiber les kinases dependantes des cyclines (cdk) et les glycogene synthases kinases (gsk)

Info

Publication number
MA29255B1
MA29255B1 MA30145A MA30145A MA29255B1 MA 29255 B1 MA29255 B1 MA 29255B1 MA 30145 A MA30145 A MA 30145A MA 30145 A MA30145 A MA 30145A MA 29255 B1 MA29255 B1 MA 29255B1
Authority
MA
Morocco
Prior art keywords
kinases
cdk
gsk
inhibiting
pyrazole derivatives
Prior art date
Application number
MA30145A
Other languages
English (en)
Inventor
Paul Graham Wyatt
Valerio Berdini
Adrian Liam Gill
Gary Trewartha
Andrew James Woodhead
Eva Figueroa Navarro
Michael Alistair O'brien
Theresa Rachel Phillips
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0501480A external-priority patent/GB0501480D0/en
Priority claimed from GB0501748A external-priority patent/GB0501748D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of MA29255B1 publication Critical patent/MA29255B1/fr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Physical Education & Sports Medicine (AREA)
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  • Hematology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS DE FORMULE (1), OU UN SEL, TAUTOMÈRE, SOLVATE OU N-OXYDES DE CEUX-CI ; R1 EST SÉLECTIONNÉ DANS LE GROUPE COMPOSÉ DE (A) 2,6-DICHLOROPHÉNYL; (B) 2,6-DIFLUOROPHÉNYL; (C) UN GROUPE PHÉNYLE TRISUBSTITUÉ EN 2,3,6 OÙ LES SUBSTITUANTS SONT FLUOR, CHLORE, MÉTHYLE OU MÉTHOXY ; ET (D) UN GROUPE R0 OÙ R0 EST UN GROUPE CARBOCYCLIQUE OU HÉTÉROCYCLIQUE À 3-12 MEMBRES ; OU HYDROCARBYLE EN C1-8 FACULTATIVEMENT SUBSTITUÉ ; R2A ET R2B REPRÉSENTENT CHACUN HYDROGÈNE OU MÉTHYLE ; ET R3 EST TEL QUE DÉFINI DANS LES REVENDICATIONS. LES COMPOSÉS PRÉSENTENT UNE ACTIVITÉ EN TANT QU'INHIBITEURS DES KINASES DÉPENDANTES DES CYCLINES (CDK) ET DES GLYCOGÈNE SYNTHASES KINASES, ET SONT UTILES POUR LE TRAITEMENT OU LA PROPHYLAXIE D'ÉTATS PATHOLOGIQUES OU DE TROUBLES INDUITS PAR LES KINASES.
MA30145A 2005-01-21 2007-08-16 Derives de pyrazole destines a inhiber les kinases dependantes des cyclines (cdk) et les glycogene synthases kinases (gsk) MA29255B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64621705P 2005-01-21 2005-01-21
GB0501480A GB0501480D0 (en) 2005-01-22 2005-01-22 Pharmaceutical compounds
GB0501748A GB0501748D0 (en) 2005-01-27 2005-01-27 Pharmaceutical compounds
US65133905P 2005-02-09 2005-02-09

Publications (1)

Publication Number Publication Date
MA29255B1 true MA29255B1 (fr) 2008-02-01

Family

ID=35967182

Family Applications (3)

Application Number Title Priority Date Filing Date
MA30145A MA29255B1 (fr) 2005-01-21 2007-08-16 Derives de pyrazole destines a inhiber les kinases dependantes des cyclines (cdk) et les glycogene synthases kinases (gsk)
MA30144A MA29254B1 (fr) 2005-01-21 2007-08-16 Derives de pyrazole servant a inhiber les kinases dependantes des cyclines (cdk) et les glycogene synthases kinases (gsk)
MA30143A MA29253B1 (fr) 2005-01-21 2007-08-16 Derives de pyrazole destines a inhiber les cdk et gsk

Family Applications After (2)

Application Number Title Priority Date Filing Date
MA30144A MA29254B1 (fr) 2005-01-21 2007-08-16 Derives de pyrazole servant a inhiber les kinases dependantes des cyclines (cdk) et les glycogene synthases kinases (gsk)
MA30143A MA29253B1 (fr) 2005-01-21 2007-08-16 Derives de pyrazole destines a inhiber les cdk et gsk

Country Status (15)

Country Link
US (2) US20080194562A1 (fr)
EP (3) EP1853600A1 (fr)
JP (3) JP2008528465A (fr)
KR (3) KR20070107049A (fr)
AR (3) AR053662A1 (fr)
AU (3) AU2006207313A1 (fr)
BR (2) BRPI0606317A2 (fr)
CA (3) CA2593468A1 (fr)
IL (3) IL184502A0 (fr)
MA (3) MA29255B1 (fr)
MX (3) MX2007008780A (fr)
NO (3) NO20073955L (fr)
PE (3) PE20061198A1 (fr)
TN (3) TNSN07278A1 (fr)
WO (3) WO2006077419A1 (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101204247B1 (ko) 2003-07-22 2012-11-22 아스텍스 테라퓨틱스 리미티드 3,4-이치환된 1ｈ-피라졸 화합물 및 그의 시클린 의존성키나제 (ｃｄｋ) 및 글리코겐 합성효소 키나제-3(ｇｓｋ-3) 조정제로서 용도
TW200533657A (en) 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
JP5475235B2 (ja) * 2005-01-21 2014-04-16 アステックス・セラピューティクス・リミテッド 医薬化合物
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
JP2008528469A (ja) * 2005-01-21 2008-07-31 アステックス・セラピューティクス・リミテッド ピラゾールキナーゼ阻害剤およびさらなる抗癌剤の組合せ剤
AR053662A1 (es) * 2005-01-21 2007-05-16 Astex Therapeutics Ltd Compuestos de pirazol inhibidores de la actividad quinasa cdk y gsk
US20080139620A1 (en) * 2005-01-21 2008-06-12 Astex Therapeutics Limited Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's
WO2006077424A1 (fr) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Composes pharmaceutiques
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AU2006207311A1 (en) 2006-07-27
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MA29254B1 (fr) 2008-02-01
EP1846395A1 (fr) 2007-10-24
WO2006077419A1 (fr) 2006-07-27
PE20061073A1 (es) 2006-11-29
EP1853600A1 (fr) 2007-11-14
US20080306069A1 (en) 2008-12-11
IL184499A0 (en) 2007-10-31
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