MX2007008784A - Derivados de pirazol para la inhibicion de las cdks y gsks. - Google Patents

Derivados de pirazol para la inhibicion de las cdks y gsks.

Info

Publication number
MX2007008784A
MX2007008784A MX2007008784A MX2007008784A MX2007008784A MX 2007008784 A MX2007008784 A MX 2007008784A MX 2007008784 A MX2007008784 A MX 2007008784A MX 2007008784 A MX2007008784 A MX 2007008784A MX 2007008784 A MX2007008784 A MX 2007008784A
Authority
MX
Mexico
Prior art keywords
sup
kinases
cdk
gsk
inhibition
Prior art date
Application number
MX2007008784A
Other languages
English (en)
Inventor
Valerio Berdini
Michael Alistair O'brien
Eva Figueroa Navarro
Adrian Liam Gill
Gary Trewartha
Andrew James Woodhead
Paul Graham Wyatt
Theresa Rachel Phillips
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0501480A external-priority patent/GB0501480D0/en
Priority claimed from GB0501748A external-priority patent/GB0501748D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of MX2007008784A publication Critical patent/MX2007008784A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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Abstract

La invencion proporciona compuestos de la Formula (I) (ver Formula (I)): o sales, tautomeros, N-oxidos, o solvatos de los mismos, en donde: R1 se selecciona a partir de: (a) 2,6-diclorofenilo; (b) 2,6-difluorofenilo; (c) un grupo fenilo 2,3,6-trisustituido, en donde los sustituyentes para el grupo fenilo se seleccionan a partir de fluor, cloro, metilo, y metoxilo; (d) un grupo R0, en donde R0 es un grupo carbociclico o heterociclico que tiene de 3 a 12 miembros del anillo; o un grupo hidrocarbilo de 1 a 8 atomos de carbono opcionalmente sustituido; R2a y R2b son cada uno hidrogeno o metilo; y R3 es como se define en las reivindicaciones. Los compuestos tienen actividad como inhibidores de la Cinasa Dependiente de Ciclina (CDK) y Cinasas de Sintasa de Glicogeno (GSK), cinasas y que son utiles en el tratamiento o en la profilaxis de estados de enfermedad o condiciones mediadas por las cinasas.
MX2007008784A 2005-01-21 2006-01-20 Derivados de pirazol para la inhibicion de las cdks y gsks. MX2007008784A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64621705P 2005-01-21 2005-01-21
GB0501480A GB0501480D0 (en) 2005-01-22 2005-01-22 Pharmaceutical compounds
GB0501748A GB0501748D0 (en) 2005-01-27 2005-01-27 Pharmaceutical compounds
US65133905P 2005-02-09 2005-02-09
PCT/GB2006/000196 WO2006077419A1 (en) 2005-01-21 2006-01-20 Pyrazole derivatives for the inhibition of cdk' s and gsk' s

Publications (1)

Publication Number Publication Date
MX2007008784A true MX2007008784A (es) 2007-09-11

Family

ID=35967182

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2007008780A MX2007008780A (es) 2005-01-21 2006-01-20 Derivados de pirazol para la inhibicion de las cdks y gsks.
MX2007008782A MX2007008782A (es) 2005-01-21 2006-01-20 Derivados de pirazol para la inhibicion de las cdks y gsks.
MX2007008784A MX2007008784A (es) 2005-01-21 2006-01-20 Derivados de pirazol para la inhibicion de las cdks y gsks.

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MX2007008780A MX2007008780A (es) 2005-01-21 2006-01-20 Derivados de pirazol para la inhibicion de las cdks y gsks.
MX2007008782A MX2007008782A (es) 2005-01-21 2006-01-20 Derivados de pirazol para la inhibicion de las cdks y gsks.

Country Status (15)

Country Link
US (2) US20080194562A1 (es)
EP (3) EP1853600A1 (es)
JP (3) JP2008528465A (es)
KR (3) KR20070107049A (es)
AR (3) AR053662A1 (es)
AU (3) AU2006207313A1 (es)
BR (2) BRPI0606317A2 (es)
CA (3) CA2593468A1 (es)
IL (3) IL184502A0 (es)
MA (3) MA29255B1 (es)
MX (3) MX2007008780A (es)
NO (3) NO20073955L (es)
PE (3) PE20061198A1 (es)
TN (3) TNSN07278A1 (es)
WO (3) WO2006077419A1 (es)

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KR101204247B1 (ko) 2003-07-22 2012-11-22 아스텍스 테라퓨틱스 리미티드 3,4-이치환된 1ｈ-피라졸 화합물 및 그의 시클린 의존성키나제 (ｃｄｋ) 및 글리코겐 합성효소 키나제-3(ｇｓｋ-3) 조정제로서 용도
TW200533657A (en) 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
JP5475235B2 (ja) * 2005-01-21 2014-04-16 アステックス・セラピューティクス・リミテッド 医薬化合物
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
JP2008528469A (ja) * 2005-01-21 2008-07-31 アステックス・セラピューティクス・リミテッド ピラゾールキナーゼ阻害剤およびさらなる抗癌剤の組合せ剤
AR053662A1 (es) * 2005-01-21 2007-05-16 Astex Therapeutics Ltd Compuestos de pirazol inhibidores de la actividad quinasa cdk y gsk
US20080139620A1 (en) * 2005-01-21 2008-06-12 Astex Therapeutics Limited Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's
WO2006077424A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
EP1862478B1 (en) * 2005-03-03 2012-01-25 Mitsubishi Rayon Co., Ltd. Polymer particle, resin composition containing same, and molded body
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