LV12469B - Disks analīžu veikšanai - Google Patents

Disks analīžu veikšanai Download PDF

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Publication number
LV12469B
LV12469B LVP-99-137A LV990137A LV12469B LV 12469 B LV12469 B LV 12469B LV 990137 A LV990137 A LV 990137A LV 12469 B LV12469 B LV 12469B
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LV
Latvia
Prior art keywords
analyte
sample
disk
reader
sector
Prior art date
Application number
LVP-99-137A
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English (en)
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LV12469A (lv
Inventor
Jorma Virtanen
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Burstein Laboratories, Inc.
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Application filed by Burstein Laboratories, Inc. filed Critical Burstein Laboratories, Inc.
Publication of LV12469A publication Critical patent/LV12469A/lv
Publication of LV12469B publication Critical patent/LV12469B/lv

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
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    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
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    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Steroid Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Claims (19)

  1. LV 12469 IZGUDROJUMA FORMULA 1. Optisks disks, kas piemērots lasīšanai ar lāzera lasītāju, ietver pirmo sektoru ar būtībā neatkarīgām analīzes ierīcēm paraugā iespējamā analīta saistīšanai vai reaģēšanai vismaz vienā, iepriekšnoteiktā atrašanās vietā pirmajā sektorā, un pēc izvēles otru sektoru, kas ietver analīzes vadīšanas kontrolierīces un analīta atrašanās vietas datus attiecībā uz paraugā iespējamajiem vienu vai vairākiem analītiem, pieejamus lasītājam, un kur analīta klātbūtne vai iztrūkšana minētajā atrašanās vietā ir nosakāma ar lasītāju, izmantojot kontrolierīces un atrašanās vietas datus un parauga ieejas portu.
  2. 2. Optisks disks saskaņā ar 1. punktu, kur parauga ieejas ports atrodas šķidruma saskares vietā ar analīzes ierīcēm.
  3. 3. Aparāts analīzes vadīšanai, kas ietver optisku disku, lāzera lasītāju un informācijas procesoru, kur disks ietver parauga ieejas portu, pirmo sektoru ar būtībā neatkarīgām analīzes ierīcēm paraugā iespējamā analīta saistīšanai vai reaģēšanai vismaz vienā, iepriekšnoteiktā atrašanās vietā pirmajā sektorā, un pēc izvēles otru sektoru, kas ietver kontroldatus analīzes vadīšanai un analīta atrašanās vietas datus attiecībā uz paraugā iespējamiem vienu vai vairākiem analītiem, pieejamiem lasītājam un apstrādājamiem ar informācijas procesoru, kur disks ir piemērots lasīšanai ar lasītāju un informācijas procesors ir piemērots analīta klātbūtnes vai iztrūkšanas noteikšanai minētajā atrašanās vietā, izmantojot kontroles datus un atrašanās vietas datus.
  4. 4. Aparāts saskaņā ar 3. punktu, kur lasītājs ir piemērots saslēgšanai ar informācijas procesoru.
  5. 5. Aparāts saskaņā ar 5. punktu, kur informācijas procesors ir personālais dators.
  6. 6. Disks saskaņā ar 1. punktu, kur analīzes ierīces ietver šķidruma uzglabāšanas ierīces un šķidruma pārvades ierīces, kas izveidotas diska virsmā.
  7. 7. Disks saskaņā ar 6. punktu, kur šķidruma pārvades ierīces ietver kapilāru cauruli.
  8. 8. Disks saskaņā ar 7. punktu, kur šķidruma pārvades ierīces satur vārstu.
  9. 9. Disks saskaņā ar 6. punktu, kur disks satur elektroķīmiskas enerģijas ierīces.
  10. 10. Disks saskaņā ar 1. punktu, kur analīzes ierīces satur parauga portu, parauga sagatavošanas sektoru, analīta izdalīšanas sektoru un analīzes sektoru, kur analīts ir lokalizēts.
  11. 11. Disks saskaņā ar 6. punktu, kur šķidruma pārvades ierīces ir jūtīgas attiecībā uz centrbēdzes spēkiem vai elektrisku lauku.
  12. 12. Disks saskaņā ar 1. punktu, kur disks ietver daudzus pirmos sektorus, kas piemēroti liela skaita analītu analizēšanai. 2
  13. 13. Disks saskaņā ar 1. punktu, kas tālāk satur daudzus pirmos sektorus, kas piemēroti tāda paša analīta vai atšķirīgu analītu analīzei, kur katrs no minētajiem daudzajiem sektoriem ir piemērots šķidrumžhsaskarei ar parauga portu.
  14. 14. Analīzes elements, kas satur substrātu, pie substrāta saistītu pirmo oligonukleotīdu, telpisku molekulu, kas piesaistīta pirmā oligonukleotīda pirmajam galam ar otru nukleotīdu, kas ir papildinājums pirmajam oligonukleotīdam, kur telpiskā molekula bez tam satur ierīces piesaistīšanai analītam paraugā, un otru galu, kas ir detektējams ar detektēšanas ierīcēm, bez tam telpiskā molekula starp pirmo un otro galu satur vietu, kas ir atšķeļama, saistīšanas ierīcēm ir pirmā daļa starp telpiskās molekulas pirmo galu un atšķeļamo vietu piesaistīšanai pie analīta pirmās daļas un otra daļa starp telpiskās molekulas otro galu un atšķeļamo vietu piesaistīšanai pie analīta otras daļas, kur atšķeļamo vietu var atšķelt bez ķīmiskas iedarbības uz analīta saistīšanas zonu.
  15. 15. Analīzes komponents, kas piemērots lasīšanai ar CD-ROM vai DVD lasītāju, ietver optisku disku ar parauga ieejas portu un būtībā neatkarīgas analīzes ierīces diskā, lai paraugā iespējamo analītu piesaistītu vismaz vienai, iepriekšnoteiktai atrašanās vietai uz diska, un ierīces minētajā atrašanās vietā analīta klātbūtnes vai iztrūkšanas iespējamajai detektēšanai ar CD-Rom vai DVD lasītāju.
  16. 16. Optisks disks, kas piemērots lasīšanai ar CD-ROM vai DVD lasītāju, ietver parauga ieejas portu, būtībā neatkarīgas analīzes ierīces paraugā iespējamā analīta lokalizēšanai vismaz vienā, iepriekšnoteiktā atrašanās vietā uz diska un ierīces minētajā atrašanās vietā analīta klātbūtnes vai iztrūkšanas detektēšanai ar CD-Rom vai DVD lasītāju.
  17. 17. Optiskais disks saskaņā ar 3. punktu, kur lāzerlasītājs ir CD-ROM vai DVD diska lasītājs.
  18. 18. Aparāts saskaņā ar 3. punktu, kur lāzerlasītājs ir CD-ROM vai DVD diska lasītājs.
  19. 19. Analīzes elements, kas satur substrātu, pirmo oligonukleotīda saiti pie substrāta, telpiskas molekulas saiti pirmā oligonukleotīda pirmajā galā ar otru nukleotīdu, kas ir papildinājums pirmajam oligonukleotīdam, kur telpiskā molekula bez tam satur ierīces piesaistīšanai pie analīta paraugā, un otru galu, kas ir detektējams ar detektēšanas ierīcēm, bez tam telpiskā molekula starp pirmo un otro galu satur vietu, kas ir atšķeļama, saistīšanas ierīcēm ir pirmā daļa starp telpiskās molekulas pirmo galu un atšķeļamo vietu piesaistīšanai pie analīta pirmās daļas un otra daļa starp telpiskās molekulas otro galu un atšķeļamo vietu piesaistīšanai pie analīta otras daļas, kur atšķeļamo vietu var atšķelt neatkarīgi no analīta.
LVP-99-137A 1997-02-28 1999-09-17 Disks analīžu veikšanai LV12469B (lv)

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