LV11949B - N,n'-diacetilcistīna organiski sāļi - Google Patents

N,n'-diacetilcistīna organiski sāļi Download PDF

Info

Publication number
LV11949B
LV11949B LVP-97-158A LV970158A LV11949B LV 11949 B LV11949 B LV 11949B LV 970158 A LV970158 A LV 970158A LV 11949 B LV11949 B LV 11949B
Authority
LV
Latvia
Prior art keywords
salt
pharmaceutical composition
dinac
diacetyl
organic base
Prior art date
Application number
LVP-97-158A
Other languages
English (en)
Other versions
LV11949A (lv
Inventor
Carl-Magnus Andersson
Hakan Bergstrand
Edib Jakupovic
Bo-G�ran JOSEFSSON
Magnus Lindvall
Bengt S�RNSTRAND
Eric Teneberg
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of LV11949A publication Critical patent/LV11949A/lv
Publication of LV11949B publication Critical patent/LV11949B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (14)

  1. LV 11949 IZGUDROJUMA FORMULA 1. Organiskas bāzes un Ν,Ν’-diacetilcistīna sāls tā individuālu izomēru, tas ir D-, L- un mezo-formās, kā arī tā racemiskās formas [DiNAc], kas atšķiras 5 ar vispārējo formulu 10 vai '00 'COO* NHCOCH, NHCOCHj 2R+ la ’OOC 15 Y^s-s ^Yco°' NHCOCHj NHCOCH3 i2+ Ib kur R+ un R2+ ir organiskas bāzes lizīna, etilēndiamina, Ν,Ν’-di-benziletilēndiamīna, adamantānamīna, N-benzil-2-feniletilamīna vai piperazīna katjons. 20
  2. 2. N,N’-diacetil-L-cistīna sāls saskaņā ar 1. punktu.
  3. 3. Metode savienojuma sāls saskaņā ar 1. vai 2. punktu iegūšanai, apstrādājot DiNAc ar organisku bāzi vai sāli, kas satur šos organiskās 25 bāzes katjonus, un izolējot sāli, kas var neobligāti būt hidrāta vai solvāta formā, pie tam reaģējošās vielas ir izšķīdinātas vai disperģētas šķīdinātājā vai šķīdinātāju maisījumā.
  4. 4. Metode sāls saskaņā ar 1. vai 2. punktu iegūšanai, oksidējot N-ace- 30 tilcisteīna un organiskas bāzes sāli un izolējot DiNAc sāli, kas var neobligāti būt hidrāta vai solvāta formā.
  5. 5. Farmaceitiska kompozīcija, kas ka aktīvo sastāvdaļu satur DiNAc sāli saskaņā ar 1. vai 2. punktu. 35 2
  6. 6. Farmaceitiska kompozīcija saskaņā ar 5. punktu pielietošanai no dozējoša inhalatora zem spiediena vai no sausa pulvera inhalatora, vai no sausa pulvera inhalatora, kur izmantotas želatīna, plastmasas vai citas kapsulas.
  7. 7. Farmaceitiska kompozīcija saskaņā ar 5. vai 6. punktu, kas ietver farmaceitiski saderīgu nesēju, kurš ir pievienots kompozīcijai.
  8. 8. Farmaceitiska kompozīcija saskaņā ar 5. punktu kapsulu vai tablešu formā.
  9. 9. Farmaceitiska kompozīcija saskaņā ar 8. punktu, kas ietver farmaceitiski sadehgu nesēju.
  10. 10. Farmaceitiska kompozīcija saskaņā ar 5. punktu pielietošanai šķīdumā, to izsmidzinot.
  11. 11. Sāls saskaņā ar 1. vai 2. punktu izmantošanai par terapeitiski aktīvu vielu.
  12. 12. Sāls saskaņā ar 1. vai 2. punktu izmantošanai ļaundabīgu slimību ārstēšanā.
  13. 13. Sāls saskaņā ar 1. vai 2. punktu izmantošana medikamenta ar imunomodulēšanas aktivitāti iegūšanai.
  14. 14. Sāls saskaņā ar 1. vai 2. punktu izmantošana medikamenta iegūšanai izmantošanai ļaundabīgu slimību ārstēšanā.
LVP-97-158A 1991-11-29 1997-08-28 N,n'-diacetilcistīna organiski sāļi LV11949B (lv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine

Publications (2)

Publication Number Publication Date
LV11949A LV11949A (lv) 1998-01-20
LV11949B true LV11949B (lv) 1998-07-20

Family

ID=20384494

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-97-158A LV11949B (lv) 1991-11-29 1997-08-28 N,n'-diacetilcistīna organiski sāļi

Country Status (38)

Country Link
US (5) US5385904A (lv)
EP (1) EP0621862B1 (lv)
JP (1) JP3302018B2 (lv)
KR (1) KR100256185B1 (lv)
CN (1) CN1039586C (lv)
AP (1) AP350A (lv)
AT (1) ATE141913T1 (lv)
AU (1) AU657827B2 (lv)
CA (1) CA2123516A1 (lv)
CZ (1) CZ282085B6 (lv)
DE (1) DE69213256T2 (lv)
DK (1) DK0621862T3 (lv)
DZ (1) DZ1637A1 (lv)
EE (1) EE03025B1 (lv)
ES (1) ES2090713T3 (lv)
FI (1) FI942504A (lv)
GR (1) GR3021546T3 (lv)
HK (1) HK62297A (lv)
HR (1) HRP921322B1 (lv)
HU (1) HU215390B (lv)
IL (1) IL103778A (lv)
IS (1) IS1645B (lv)
LV (1) LV11949B (lv)
MA (1) MA22716A1 (lv)
MX (1) MX9206851A (lv)
MY (1) MY110523A (lv)
NO (1) NO301325B1 (lv)
NZ (1) NZ245077A (lv)
PL (2) PL171336B1 (lv)
RU (1) RU2135468C1 (lv)
SE (1) SE9103572D0 (lv)
SG (1) SG73962A1 (lv)
SI (1) SI9200351A (lv)
SK (1) SK281697B6 (lv)
TN (1) TNSN92108A1 (lv)
WO (1) WO1993011104A1 (lv)
YU (1) YU48594B (lv)
ZA (1) ZA928739B (lv)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865463A (en) * 1973-11-12 1975-02-11 Busch & Co Inc Ag Electrical adapter plug
DK0494405T3 (da) * 1991-01-10 1996-11-18 Transcend Therapeutics Inc Anvendelse af thiazolidin-4-carboxylatderivater til behandling af lungesygdomme
US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
SE9500897D0 (sv) * 1995-03-14 1995-03-14 Astra Ab The pharmacological use of certain cystine derivatives
SE9602262D0 (sv) * 1996-06-06 1996-06-06 Astra Ab New use of derivatives of cystine
AR007398A1 (es) * 1996-06-18 1999-10-27 Astrazeneca Ab Proceso para preparar sales inorganicas de n-n'-diacetilcistina
US6017959A (en) * 1996-06-18 2000-01-25 Astra Aktiebolag Forms of organic salts of N,N'-diacetylcystine
SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
CN1059907C (zh) * 1997-05-23 2000-12-27 中国石油化工集团公司巴陵石化岳阳石油化工总厂 一种含共轭二烯轻聚合物的选择氢化方法
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
SE9800932D0 (sv) 1998-03-20 1998-03-20 Astra Ab New compunds
EP1004302A3 (en) * 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulator
SE9900438D0 (sv) * 1999-02-10 1999-02-10 Astra Ab The pharmacological use of certian cystine derivatives
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
SE518784C2 (sv) * 2000-12-27 2002-11-19 Nactilus Ab "N-Acetyl-L-cystein med kompositioner för behandling av neoplasier"
JPWO2002072040A1 (ja) * 2001-03-13 2004-07-02 味の素株式会社 化粧料または皮膚外用剤
DE60318938T2 (de) 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
EP1786784B1 (en) 2004-08-20 2010-10-27 MannKind Corporation Catalysis of diketopiperazine synthesis
CA2578175C (en) 2004-08-23 2014-10-14 Mannkind Corporation Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery
US7803404B2 (en) 2005-09-14 2010-09-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
EP2570147B1 (en) * 2008-06-13 2017-10-18 MannKind Corporation A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9364619B2 (en) * 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
KR20180079458A (ko) 2009-06-12 2018-07-10 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
CA2906817C (en) 2013-03-15 2022-01-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP4142677A1 (en) * 2020-04-28 2023-03-08 Unilever IP Holdings B.V. Personal care compositions with enhanced solubility actives
US20230372272A1 (en) * 2020-09-28 2023-11-23 Georgia Tech Research Corporation Use of cystine and derivatives thereof as anti-thrombotic and thrombolytic agents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB592631A (en) * 1945-04-04 1947-09-24 Du Pont Cysteine and cystine
GB954268A (en) 1962-02-26 1964-04-02 Mead Johnson & Co Decongestant compositions comprising n-acylated sulphydryl compounds
FR8205M (lv) * 1968-12-20 1970-09-14
US3647834A (en) 1969-08-11 1972-03-07 Mead Johnson & Co Zinc mercaptide n-acetylcysteine carboxylate salts
US3878305A (en) 1972-05-25 1975-04-15 Procter & Gamble Fortification of foodstuffs with n-acyl derivatives of sulphur-containing l-amino acids
US3952115A (en) * 1975-04-02 1976-04-20 The Procter & Gamble Company Fortification of foodstuffs with N-acyl derivatives of sulfur-containing L-amino acid esters
US4141734A (en) * 1975-09-11 1979-02-27 Ciba-Geiby Ag Photographic developing process
US4093739A (en) * 1977-06-15 1978-06-06 Mead Johnson & Company Mercaptoacylamidobenzoyl glycine and mucolytic process
JPS6011888B2 (ja) * 1978-10-11 1985-03-28 参天製薬株式会社 リウマチ疾患治療薬
JPS56155298A (en) * 1980-05-02 1981-12-01 Tanabe Seiyaku Co Shampoo composition
GB2097256B (en) * 1981-04-02 1985-05-30 Morelle Jean V Compositions containing n-butyryl alphaaminoacids
FR2503151A1 (fr) * 1981-04-02 1982-10-08 Morelle Jean Butyryminoacides soufres. mode de preparation. emploi comme element keratogenique chez l'homme et l'animal et comme agent de fertilisation chez les vegetaux
JPS58164566A (ja) * 1982-03-09 1983-09-29 Kenji Okawa シスチン類の製造法
US4724239A (en) * 1985-09-16 1988-02-09 Morgan Lee R Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine
US4708965A (en) * 1985-09-16 1987-11-24 Morgan Lee R Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
US4827016A (en) * 1985-09-16 1989-05-02 Morgan Lee R Method and compounds for reducing dermal inflammations
JPH0660157B2 (ja) * 1985-11-20 1994-08-10 三井東圧化学株式会社 システインからシスチンを製造する方法
JPS62195356A (ja) * 1986-02-20 1987-08-28 Seiwa Kasei:Kk シスチン誘導体及びその塩
AT402931B (de) * 1986-11-07 1997-09-25 Pharmacia Gmbh Verfahren zur herstellung von neuen cystinverbindungen und derenverwendung
SE8704542D0 (sv) * 1987-11-19 1987-11-19 Draco Ab New derivatives of cysteine
IL98310A (en) * 1990-06-08 1996-08-04 Astra Ab Medicinal preparations containing a history of cystine
TW221376B (lv) * 1990-06-28 1994-03-01 Astra Ab
GB9111885D0 (en) * 1991-06-03 1991-07-24 Erba Carlo Spa Nerve growth factor for use in the prevention and treatment of viral infections

Also Published As

Publication number Publication date
ES2090713T3 (es) 1996-10-16
KR100256185B1 (ko) 2000-05-15
CZ129794A3 (en) 1995-01-18
IS1645B (is) 1997-03-25
PL170787B1 (en) 1997-01-31
DZ1637A1 (fr) 2002-02-17
WO1993011104A1 (en) 1993-06-10
JPH07501539A (ja) 1995-02-16
NZ245077A (en) 1995-04-27
HU9401473D0 (en) 1994-08-29
SK63294A3 (en) 1995-02-08
TNSN92108A1 (fr) 1993-06-08
EE03025B1 (et) 1997-08-15
HRP921322B1 (en) 1998-12-31
JP3302018B2 (ja) 2002-07-15
US5650538A (en) 1997-07-22
RU2135468C1 (ru) 1999-08-27
SK281697B6 (sk) 2001-06-11
US5693858A (en) 1997-12-02
NO301325B1 (no) 1997-10-13
EP0621862B1 (en) 1996-08-28
AP350A (en) 1994-08-09
CZ282085B6 (cs) 1997-05-14
CN1039586C (zh) 1998-08-26
IL103778A (en) 1997-08-14
GR3021546T3 (en) 1997-02-28
MX9206851A (es) 1993-05-01
CN1073683A (zh) 1993-06-30
FI942504A0 (fi) 1994-05-27
DE69213256D1 (de) 1996-10-02
FI942504A (fi) 1994-05-27
HRP921322A2 (en) 1996-10-31
MA22716A1 (fr) 1993-07-01
MY110523A (en) 1998-07-31
PL171336B1 (en) 1997-04-30
AU657827B2 (en) 1995-03-23
AP9200448A0 (en) 1993-01-31
CA2123516A1 (en) 1993-06-10
IS3949A (is) 1993-05-30
YU48594B (sh) 1998-12-23
HU215390B (hu) 1998-12-28
HK62297A (en) 1997-05-16
NO941968D0 (no) 1994-05-26
EP0621862A1 (en) 1994-11-02
DE69213256T2 (de) 1997-01-23
US5385904A (en) 1995-01-31
YU99092A (sh) 1995-12-04
US5804582A (en) 1998-09-08
AU3099692A (en) 1993-06-28
ATE141913T1 (de) 1996-09-15
ZA928739B (en) 1993-06-09
SI9200351A (en) 1993-06-30
HUT70851A (en) 1995-11-28
LV11949A (lv) 1998-01-20
DK0621862T3 (da) 1996-09-16
US5824681A (en) 1998-10-20
NO941968L (no) 1994-05-26
SE9103572D0 (sv) 1991-11-29
SG73962A1 (en) 2000-07-18
IL103778A0 (en) 1993-04-04

Similar Documents

Publication Publication Date Title
AP350A (en) Organic salts of N,N-Diacetyl cystine.
IE49701B1 (en) Amides of acyl-carnitines,process for preparing same and pharmaceutical compositions containing such amides
NZ289157A (en) Amidino sulphoxides and sulphones; medicaments for selective inhibition of inducible nitric oxide synthase
US5780508A (en) Pharmacological preparations comprising a cystine derivative
HU185516B (en) Process for producking bispidine derivatives
JP3891503B2 (ja) 製薬学的に活性なβ−アミノ酸類の許容性の改善
US6288250B1 (en) Compounds
CA2258205A1 (en) New forms of organic salts of n'n-diacetylcystine
MXPA00008966A (en) New compounds
CZ20003414A3 (cs) Nové trisulfidy, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
JPH0352853A (ja) アクリル酸アミド誘導体類、それらの製造方法、それらを含む医薬組成物及び薬剤におけるそれらの使用