LV11866B - Citotoksisko t-limfocītu atbildes reakciju indukcija - Google Patents
Citotoksisko t-limfocītu atbildes reakciju indukcija Download PDFInfo
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- LV11866B LV11866B LVP-97-132A LV970132A LV11866B LV 11866 B LV11866 B LV 11866B LV 970132 A LV970132 A LV 970132A LV 11866 B LV11866 B LV 11866B
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Claims (9)
- LV 11866 IZGUDROJUMA FORMULA 1. Kompozīcija, kas satur papilomas vīrusa antigēnu, kas sajaukts ar mikrofluidizētu antigēna sastāvu, kas satur: 5 a) stabilizējošu detergentu, b) micellas veidojošu aģentu un c) bioloģiski deģenerējamu un bioloģiski saderīgu eļļu, pie tam minētais antigēna sastāvs ir veidots kā stabila eļļa-ūdenī emulsija, minētais antigēna sastāvs ir būtībā bez imunostimulējošiem 10 peptīdiem, un kur minētā kompozīcija, tālāk pielietojot dzīvniekam, kas izvēlēts no grupas, kura sastāv no cilvēkiem, mājdzīvniekiem un lauksaimniecības dzīvniekiem, ir spējīga inducēt specifisku citotoksisku T-limfocītu atbildes reakciju pret papilomas vīrusa antigēnu, kas ietverts kompozīcijā. 15
- 2. Kompozīcija saskaņā ar 1. punktu, kur minētais papilomas vīrusa antigēns ir izvēlēts no grupas, kas sastāv no HPV16 E6 antigēna, HPV16 E7 antigēna, HPV18 E6 antigēna, HPV18 E7.antigēna, HPV6 E4 antigēna, HPV6 L1 antigēna; HPV11 E4 antigēna un HPV11 L1 antigēna. 20
- 3. Kompozīcija saskaņā ar 1. punktu, kur detergents ir izvēlēts no grupas, kas sastāv no tvīna (Tvveen) 20, tvīna 40 un tvīna 80; eļļa ir izvēlēta no grupas, kas sastāv no skvalāna, eikozāna un pristāna, un micellas veidojošais aģents ir izvēlēts no grupas, kas sastāv no pluronika L62LF 25 (Pluronic L62LF) un polioksamera 401 (polyoxamer 401).
- 4. Kompozīcija saskaņā ar 1. punktu, kur detergents ir polisorbāts 80 un micellas veidojošais aģents ir polioksamers 401.
- 5. Kompozīcija saskaņā ar 1. punktu, kur detergents ir izvēlēts no grupas, kas sastāv no polisorbāta 80, tvīna 20, tvīna 40; tvīna 60, cvitergenta 3-12, tīpola HB7 (Teepol HB7) un spana 85 (Span 85).
- 6. Kompozīcija saskaņā ar 1. punktu, kur minētais micellas veidojošais 35 aģents ir izvēlēts no grupas, kas sastāv no polioksamera 401, pluronika L62LF, pluronika L101, pluronika L64, EG1000, tetronika (Tetronic) 1501, 2 tetronika 150R1, tetronika 701, tetronika 901, tetronika 1301 un tetronika 130R1.
- 7. Kompozīcija saskaņā ar 1. punktu, kur daļiņu izmērs kompozīcijā ir 5 robežās no aptuveni 250 līdz 300 nanometriem.
- 8. Kompozīcijas saskaņā ar 1. punktu izmantošana medikamenta ražošanai dzemdes kakla vēža ārstēšanai.
- 9. Kompozīcijas saskaņā ar 1. punktu izmantošana medikamenta ražošanai smaiigala kondilomas ārstēšanai.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/351,001 US5709860A (en) | 1991-07-25 | 1994-12-07 | Induction of cytotoxic T-lymphocyte responses |
PCT/US1995/015433 WO1996017863A1 (en) | 1994-12-07 | 1995-11-29 | Induction of cytotoxic t-lymphocyte responses |
Publications (2)
Publication Number | Publication Date |
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LV11866A LV11866A (lv) | 1997-10-20 |
LV11866B true LV11866B (lv) | 1998-01-20 |
Family
ID=23379172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-97-132A LV11866B (lv) | 1994-12-07 | 1997-07-07 | Citotoksisko t-limfocītu atbildes reakciju indukcija |
Country Status (33)
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US (2) | US5709860A (lv) |
EP (1) | EP0801656A4 (lv) |
JP (1) | JPH10510264A (lv) |
CN (2) | CN1515319A (lv) |
AP (1) | AP661A (lv) |
AR (1) | AR002255A1 (lv) |
AU (1) | AU699044B2 (lv) |
BG (1) | BG63262B1 (lv) |
BR (1) | BR9509872A (lv) |
CA (1) | CA2204738A1 (lv) |
CZ (1) | CZ293439B6 (lv) |
EE (1) | EE03569B1 (lv) |
FI (1) | FI972431A (lv) |
GE (1) | GEP20012556B (lv) |
HK (1) | HK1008226A1 (lv) |
HU (1) | HUP9800946A2 (lv) |
IS (1) | IS4479A (lv) |
LT (1) | LT4308B (lv) |
LV (1) | LV11866B (lv) |
MD (1) | MD1586G2 (lv) |
MX (1) | MX9704097A (lv) |
NO (1) | NO972521L (lv) |
NZ (1) | NZ298582A (lv) |
OA (1) | OA10736A (lv) |
PL (1) | PL183954B1 (lv) |
RO (1) | RO120065B1 (lv) |
RU (1) | RU2201253C2 (lv) |
SI (1) | SI9520148A (lv) |
SK (1) | SK71397A3 (lv) |
TJ (1) | TJ384B (lv) |
TW (1) | TW487575B (lv) |
UA (1) | UA49814C2 (lv) |
WO (1) | WO1996017863A1 (lv) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6197311B1 (en) * | 1991-07-25 | 2001-03-06 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
EP0671926B1 (en) * | 1992-08-11 | 2002-11-13 | President And Fellows Of Harvard College | Immunomodulatory peptides |
ZA988461B (en) * | 1997-09-18 | 1999-03-30 | Idec Pharma Corp | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis |
US6013258A (en) * | 1997-10-09 | 2000-01-11 | Zycos Inc. | Immunogenic peptides from the HPV E7 protein |
US6183746B1 (en) | 1997-10-09 | 2001-02-06 | Zycos Inc. | Immunogenic peptides from the HPV E7 protein |
FR2771640B1 (fr) * | 1997-12-03 | 2000-02-11 | Inst Nat Sante Rech Med | Micelles mixtes de lipopeptides pour l'induction d'une reponse immunitaire et leurs utilisations a des fins therapeutiques |
AU3344299A (en) * | 1998-04-20 | 1999-11-08 | Shionogi & Co., Ltd. | Th2-migration promoters containing w/o emulsions |
US20010033839A1 (en) * | 1999-10-04 | 2001-10-25 | Emilio Barbera-Guillem | Vaccine and immunotherapy for solid nonlymphoid tumor and related immune dysregulation |
TW511264B (en) | 1999-02-18 | 2002-11-21 | Seiko Epson Corp | Semiconductor device, mounting substrate and its manufacturing method, circuit substrate and electronic machine |
ES2311451T3 (es) * | 1999-03-24 | 2009-02-16 | The Secretary Of State For Defence | Carbohidratos policationicos como immuestimulantes en vacunas. |
US20050100928A1 (en) * | 1999-09-16 | 2005-05-12 | Zycos Inc., A Delaware Corporation | Nucleic acids encoding polyepitope polypeptides |
FR2805163A1 (fr) * | 2000-02-21 | 2001-08-24 | Pf Medicament | Utilisation d'un detergent de type zwittergent pour la preparation d'une composition pharmaceutique destinee a etre administree par voie nasale |
WO2001098206A1 (en) * | 2000-06-22 | 2001-12-27 | Rxkinetix, Inc. | Delivery vehicle composition and methods for delivering antigens and other drugs |
FR2814957B1 (fr) * | 2000-10-06 | 2002-12-20 | Aventis Pasteur | Composition vaccinale et procede de stabilisation |
US20070073047A1 (en) * | 2002-06-10 | 2007-03-29 | Biogen Idec Ma Inc. | Genes overexpressed by ovarian cancer and their use in developing novel therapeutics |
AU2003254792A1 (en) * | 2002-08-02 | 2004-02-23 | Sumitomo Pharmaceuticals Company, Limited | Bacterial cell wall skeleton component preparaion |
EP1545575A4 (en) | 2002-09-19 | 2006-04-05 | Us Gov Health & Human Serv | POLYPEPTIDES OF P. ARIASI POLYPEPTIDES P. PERNICIOSUS AND METHODS OF USE |
ATE465753T1 (de) * | 2002-10-21 | 2010-05-15 | Eisai Inc | Zusammensetzungen und verfahren zurbehandlung von krankheiten, die durch das humane papillomavirus vermitteltwerden |
MXPA05004714A (es) | 2002-10-29 | 2006-03-17 | Us Gov Health & Human Serv | Polipeptidos de lutzomyia longipalpis y metodos de uso. |
EP1741438A4 (en) * | 2004-04-22 | 2009-08-26 | Dainippon Sumitomo Pharma Co | PHARMACEUTICAL PREPARATION CONTAINING SKELETAL COMPONENT OF BACTERIAL CELL WALL |
US8124397B2 (en) * | 2005-08-08 | 2012-02-28 | Oregon Health & Science University | Inactivating pathogens with oxidizing agents for vaccine production |
US20100130425A1 (en) | 2005-09-09 | 2010-05-27 | Oregon Health & Science University | Use of toll-like receptor ligands in treating excitotoxic injury, ischemia and/or hypoxia |
US7732166B2 (en) * | 2005-11-15 | 2010-06-08 | Oncohealth Corporation | Detection method for human pappilomavirus (HPV) and its application in cervical cancer |
BRPI0708865A8 (pt) | 2006-03-14 | 2019-01-22 | Univ Oregon Health & Science | métodos para produzir uma resposta imune à tuberculose |
US8293245B2 (en) | 2006-04-20 | 2012-10-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on Shiga toxin type 1 protein |
US8278056B2 (en) | 2008-06-13 | 2012-10-02 | Oncohealth Corp. | Detection of early stages and late stages HPV infection |
US8968995B2 (en) * | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
US8916342B2 (en) | 2006-11-13 | 2014-12-23 | Oncohealth Corp. | Identification of high grade or ≧ CIN2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (HPV) and HPV-associated cancers |
EP2125868B1 (en) | 2007-02-28 | 2015-06-10 | The Govt. Of U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services | Brachyury polypeptides and methods for use |
EP2324049B1 (en) | 2008-08-04 | 2016-05-25 | The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services | Membrane proximal region of hiv gp41 anchored to the lipid layer of a virus-like particle vaccine |
WO2010099472A2 (en) | 2009-02-27 | 2010-09-02 | The U.S.A. Of America, As Represented By The Secretary, Department Of Health And Human Services | Spanx-b polypeptides and their use |
WO2011041886A1 (en) | 2009-10-07 | 2011-04-14 | University Of Victoria Innovation And Development Corporation | Vaccines comprising heat-sensitive transgenes |
WO2011047340A1 (en) | 2009-10-16 | 2011-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Insertion of foreign genes in rubella virus and their stable expression in a live, attenuated viral vaccine |
US8961989B2 (en) | 2009-11-20 | 2015-02-24 | Oregon Health & Science University | Methods for producing an immune response to tuberculosis |
EP2521914A4 (en) | 2010-01-08 | 2013-07-10 | Oncohealth Corp | CELL-BASED HPV IMMUNOTESTS HAVE A HIGH PERFORMANCE FOR DIAGNOSIS AND SCANNING OF HPV ASSOCIATED CANCER |
WO2011112599A2 (en) | 2010-03-12 | 2011-09-15 | The United States Of America, As Represented By The Secretary. Department Of Health & Human Services | Immunogenic pote peptides and methods of use |
ES2625406T3 (es) | 2010-03-25 | 2017-07-19 | Oregon Health & Science University | Glicoproteínas de CMV y vectores recombinantes |
CN102125698A (zh) * | 2010-11-29 | 2011-07-20 | 昆明理工大学 | 具有正常免疫功能的小鼠移植肿瘤模型的建立方法 |
SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
CA2842180C (en) | 2011-07-18 | 2020-06-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for inhibiting polyomavirus-associated pathology |
US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
WO2013152352A1 (en) | 2012-04-06 | 2013-10-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Live, attenuated rubella vector to express vaccine antigens |
NZ701881A (en) | 2012-05-16 | 2016-10-28 | Immune Design Corp | Vaccines for hsv-2 |
EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
WO2014043518A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
JP2016502507A (ja) | 2012-10-19 | 2016-01-28 | バヴァリアン・ノルディック・インコーポレイテッド | 癌治療のための組成物および方法 |
EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
JP6758185B2 (ja) | 2013-12-13 | 2020-09-23 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | マルチエピトープtarpペプチドワクチンおよびその使用 |
WO2015095770A1 (en) | 2013-12-20 | 2015-06-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunogenic jc polyomavirus compositions and methods of use |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
CN108289940B (zh) | 2015-08-03 | 2023-01-13 | 美国卫生和人力服务部 | Brachyury缺失突变体、编码brachyury缺失突变体的非酵母载体及其用途 |
EP3430131B1 (en) * | 2016-03-17 | 2022-06-08 | Berkeley Lights, Inc. | Selection and cloning of t lymphocytes in a microfluidic device |
ES2929274T3 (es) | 2016-05-10 | 2022-11-28 | Najit Tech Inc | Inactivación de patógenos y producción de vacunas inactivadas altamente inmunógenas utilizando un proceso de oxidación dual |
US11235046B2 (en) | 2017-11-04 | 2022-02-01 | Nevada Research & Innovation Corporation | Immunogenic conjugates and methods of use thereof |
KR20210124205A (ko) | 2018-12-04 | 2021-10-14 | 더 락커펠러 유니버시티 | Hiv 백신 면역원 |
WO2022072431A1 (en) | 2020-09-30 | 2022-04-07 | Zoetis Services Llc | Novel pasteurella multocida strains and vaccines having hyac and nanp deletions |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4117113A (en) * | 1974-06-25 | 1978-09-26 | National Research Development Corporation | Immunological preparations |
GB1502774A (en) * | 1974-06-25 | 1978-03-01 | Nat Res Dev | Immunological preparations |
US4770874A (en) * | 1983-08-22 | 1988-09-13 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
US4772466A (en) * | 1983-08-22 | 1988-09-20 | Syntex (U.S.A.) Inc. | Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants |
JPS6147500A (ja) * | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
US5114708A (en) * | 1985-06-18 | 1992-05-19 | Emory University | Method for stimulating growth in animals |
US5234683A (en) * | 1985-06-18 | 1993-08-10 | Emory University | Method of stimulating the immune system |
US4877611A (en) * | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
WO1988002634A1 (en) * | 1986-10-20 | 1988-04-21 | Chiron Corporation | Vaccine for use in the therapeutic treatment of hsv |
US4778784A (en) * | 1987-01-07 | 1988-10-18 | Baylor College Of Medicine | Cyclic peptide and method of use for inducing an immunological response to hepatitis B virus |
US4963354A (en) * | 1987-01-21 | 1990-10-16 | Genentech, Inc. | Use of tumor necrosis factor (TNF) as an adjuvant |
JP2746272B2 (ja) * | 1987-11-03 | 1998-05-06 | シンテツクス(ユー エス エイ)インコーポレーテツド | ワクチンアジュバント |
IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
HU212924B (en) * | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
DE4018442A1 (de) * | 1990-06-08 | 1991-12-12 | Boehringer Mannheim Gmbh | Rekombinante dna und verfahren zur herstellung chimaerer antikoerper |
AU1025692A (en) * | 1991-02-06 | 1992-08-13 | Ciba-Geigy Ag | Novel chimeric antiidiotypic monoclonal antibodies |
IL102639A (en) * | 1991-07-25 | 1997-03-18 | Idec Pharma Corp | Compositions for inducing cytotoxic t lymphocyte responses |
DE4443414A1 (de) * | 1994-12-07 | 1996-06-13 | Basf Ag | Benzopyranfarbstoffe und deren Zwischenprodukte |
US7735069B2 (en) | 2006-02-09 | 2010-06-08 | International Business Machines Corporation | Creating software debug breakpoints activated by specific call patterns |
US8919787B1 (en) | 2010-10-08 | 2014-12-30 | James Timothy Wilcher | Reciprocating tool attachment assembly and methods |
-
1994
- 1994-12-07 US US08/351,001 patent/US5709860A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/472,311 patent/US5695770A/en not_active Expired - Fee Related
- 1995-11-29 SK SK713-97A patent/SK71397A3/sk unknown
- 1995-11-29 CZ CZ19971741A patent/CZ293439B6/cs not_active IP Right Cessation
- 1995-11-29 CN CNA031088449A patent/CN1515319A/zh active Pending
- 1995-11-29 AP APAP/P/1997/001056A patent/AP661A/en active
- 1995-11-29 GE GEAP19953809A patent/GEP20012556B/en unknown
- 1995-11-29 BR BR9509872A patent/BR9509872A/pt not_active Application Discontinuation
- 1995-11-29 CN CN95197570A patent/CN1109046C/zh not_active Expired - Fee Related
- 1995-11-29 SI SI9520148A patent/SI9520148A/sl unknown
- 1995-11-29 EE EE9700100A patent/EE03569B1/xx not_active IP Right Cessation
- 1995-11-29 WO PCT/US1995/015433 patent/WO1996017863A1/en not_active Application Discontinuation
- 1995-11-29 JP JP51764196A patent/JPH10510264A/ja not_active Ceased
- 1995-11-29 UA UA97063426A patent/UA49814C2/uk unknown
- 1995-11-29 RO RO97-01046A patent/RO120065B1/ro unknown
- 1995-11-29 MD MD97-0199A patent/MD1586G2/ro not_active IP Right Cessation
- 1995-11-29 PL PL95320612A patent/PL183954B1/pl not_active IP Right Cessation
- 1995-11-29 RU RU97111160A patent/RU2201253C2/ru not_active IP Right Cessation
- 1995-11-29 CA CA 2204738 patent/CA2204738A1/en not_active Abandoned
- 1995-11-29 HU HU9800946A patent/HUP9800946A2/hu unknown
- 1995-11-29 NZ NZ298582A patent/NZ298582A/en unknown
- 1995-11-29 EP EP95942921A patent/EP0801656A4/en not_active Withdrawn
- 1995-11-29 AU AU44104/96A patent/AU699044B2/en not_active Ceased
- 1995-11-29 TJ TJ97000475A patent/TJ384B/xx unknown
- 1995-12-06 AR AR10045895A patent/AR002255A1/es active IP Right Grant
- 1995-12-07 TW TW84113021A patent/TW487575B/zh not_active IP Right Cessation
-
1997
- 1997-05-07 IS IS4479A patent/IS4479A/is unknown
- 1997-06-03 MX MX9704097A patent/MX9704097A/es not_active IP Right Cessation
- 1997-06-03 NO NO972521A patent/NO972521L/no not_active Application Discontinuation
- 1997-06-06 FI FI972431A patent/FI972431A/fi not_active IP Right Cessation
- 1997-06-08 OA OA70021A patent/OA10736A/en unknown
- 1997-06-23 BG BG101656A patent/BG63262B1/bg unknown
- 1997-07-04 LT LT97-115A patent/LT4308B/lt not_active IP Right Cessation
- 1997-07-07 LV LVP-97-132A patent/LV11866B/lv unknown
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1998
- 1998-07-17 HK HK98109248A patent/HK1008226A1/xx not_active IP Right Cessation
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