LV11726B - Oil-in-water emulsions - Google Patents

Oil-in-water emulsions Download PDF

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Publication number
LV11726B
LV11726B LVP-96-323A LV960323A LV11726B LV 11726 B LV11726 B LV 11726B LV 960323 A LV960323 A LV 960323A LV 11726 B LV11726 B LV 11726B
Authority
LV
Latvia
Prior art keywords
oil
emulsion
vas
emulsifier
pharmaceutical composition
Prior art date
Application number
LVP-96-323A
Other languages
English (en)
Other versions
LV11726A (lv
Inventor
Carlsson Anders
Delogu Marina
Herslif Bengt
Original Assignee
Scotia Lipidteknik Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9400368A external-priority patent/SE9400368D0/xx
Priority claimed from SE9402454A external-priority patent/SE518823C2/sv
Application filed by Scotia Lipidteknik Ab filed Critical Scotia Lipidteknik Ab
Publication of LV11726A publication Critical patent/LV11726A/lv
Publication of LV11726B publication Critical patent/LV11726B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A23D7/0053—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L35/00—Food or foodstuffs not provided for in groups A23L5/00 – A23L33/00; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Edible Oils And Fats (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Claims (13)

  1. LV 11726 IZGUDROJUMA FORMULA 1. Emulsija eļļa ūdeni, kas satur 0.01-50 masas % no kopējā preparāta daudzuma, vislabāk 0.1-10 %, emulgatoru un 0.1-70 masas % no kopējā preparāta daudzuma eļļainu vielu, kas emuļģēta polārā šķīdinātājā, atšķiras ar to, ka emulgators ir galaktolipidviela, kas satur vismaz 50 % digalaktozildiacilglicerinus, un atlikums ir citi polāri lipīdi.
  2. 2. Emulsija saskaņā ar 1. punktu, kur galaktolipidviela satur apmēram 70-80 % digalaktozildiacilglicerinus un 20-30 % citus polāros lipidus.
  3. 3. Emulsija saskaņā ar 1. vai 2. punktu, kur galaktolipidviela satur līdz 100 % digalaktozildiacilglicerinus.
  4. 4. Emulsija saskaņā ar jebkuru no 1.-3. punktiem, kur eļļainā viela satur γ-linolēnskābi brīvas skābes, tās sāļu vai esteru formā.
  5. 5. Emulsija saskaņā ar jebkuru no 1.-4. punktiem, kur eļļainās vielas pamatā ir enoteras (Oenothera) eļļa vai borago (Borago) eļļa.
  6. 6. Emulsijas saskaņā ar jebkuru no 1.-5. punktiem izmantošana par aktīvās vielas nesēju farmaceitiskās, barības vai kosmētiskās kompozīcijās.
  7. 7. Farmaceitiska kompozīcija, kas satur emulsiju eļļa ūdenī saskaņā ar jebkuru no 1.-3. punktiem kombinācijā ar terapeitiski aktīvu vielu.
  8. 8. Farmaceitiska kompozīcija saskaņā ar 7. punktu, kur eļļainā viela satur γ-linolēnskābi brīvas skābes, tās sāļu vai esteru formā.
  9. 9. Farmaceitiska kompozīcija saskaņā ar 7. vai 8. punktu, kur eļļainās vielas pamatā ir enoteras (Oenothera) eļļa vai borago (Borago) eļļa. 2
  10. 10. Farmaceitiska kompozīcija saskaņā ar 7. punktu, kur eļļainā viela ir triacilglicerīneļļa, vislabāk vidēja garuma virknes triacilglicerineļļa (MCT), vai bioaktīva viela.
  11. 11. Farmaceitiska kompozīcija saskaņā ar jebkuru no 7.-10. punktiem, kas satur: - terapeitiski aktīvu vielu terapeitiski efektīvā daudzumā; - galaktolipīdemulgatoru, 0.1-5.0 masas % no kopējās kompozīcijas; - eļļainu vielu, 1-50 masas % no kopējās kompozīcijas; 10 - neobligāti, izotonisku aģentu izotoniski efektīvā daudzumā; un - polāru šķīdinātāju.
  12. 12. Farmaceitiska kompozīcija parenterālai ievadīšanai saskaņā ar 10. vai 11. punktu, kas satur, masas %-os no kopējās kompozīcijas: 15 - 0.2-3 % 2,6-diizopropilfenolu, - 0.3-5 % galaktolipidvielu, - 5-30 % triacilglicerīneļļu, - izotoniska aģenta izotoniski efektīvu daudzumu, - ūdeni, līdz 100%. 20
  13. 13. Farmaceitiska kompozīcija saskaņā ar jebkuru no 7.-11. punktiem perorālai, enterālai, parenterālai, rektālai, vaginālai, lokālai ievadīšanai, vai ievadīšanai acis, degunā vai ausīs.
LVP-96-323A 1994-02-04 1996-08-02 Oil-in-water emulsions LV11726B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9400368A SE9400368D0 (sv) 1994-02-04 1994-02-04 Glycolipid material
SE9402454A SE518823C2 (sv) 1994-07-12 1994-07-12 Olja-i-vatten-emulsioner
PCT/SE1995/000115 WO1995020943A1 (en) 1994-02-04 1995-02-06 Oil-in-water emulsions

Publications (2)

Publication Number Publication Date
LV11726A LV11726A (lv) 1997-04-20
LV11726B true LV11726B (en) 1997-10-20

Family

ID=26661954

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-96-323A LV11726B (en) 1994-02-04 1996-08-02 Oil-in-water emulsions

Country Status (24)

Country Link
US (1) US5688528A (lv)
EP (1) EP0797432B1 (lv)
JP (1) JP3117145B2 (lv)
KR (1) KR100193980B1 (lv)
CN (1) CN1098681C (lv)
AT (1) ATE201981T1 (lv)
AU (1) AU691248B2 (lv)
BR (1) BR9506681A (lv)
CA (1) CA2182575C (lv)
CZ (1) CZ285795B6 (lv)
DE (2) DE69521338T2 (lv)
DK (1) DK0797432T3 (lv)
EE (1) EE03220B1 (lv)
ES (1) ES2107397T3 (lv)
FI (1) FI117922B (lv)
GR (1) GR970300049T1 (lv)
HU (1) HU221477B (lv)
LV (1) LV11726B (lv)
MY (1) MY112798A (lv)
NO (1) NO312493B1 (lv)
NZ (1) NZ279952A (lv)
PL (1) PL178397B1 (lv)
TW (1) TW288979B (lv)
WO (1) WO1995020943A1 (lv)

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Also Published As

Publication number Publication date
JPH09508413A (ja) 1997-08-26
HU9602141D0 (en) 1996-09-30
CN1140406A (zh) 1997-01-15
DE69521338D1 (de) 2001-07-19
FI963064A (fi) 1996-09-30
PL178397B1 (pl) 2000-04-28
CN1098681C (zh) 2003-01-15
HUT75464A (en) 1997-05-28
HU221477B (en) 2002-10-28
KR100193980B1 (ko) 1999-06-15
CA2182575C (en) 2000-11-28
ES2107397T1 (es) 1997-12-01
EE03220B1 (et) 1999-10-15
LV11726A (lv) 1997-04-20
AU1723395A (en) 1995-08-21
TW288979B (lv) 1996-10-21
AU691248B2 (en) 1998-05-14
EP0797432B1 (en) 2001-06-13
PL315778A1 (en) 1996-12-09
DK0797432T3 (da) 2001-09-03
FI117922B (fi) 2007-04-30
MY112798A (en) 2001-09-29
ATE201981T1 (de) 2001-06-15
DE69521338T2 (de) 2002-02-28
NO963240D0 (no) 1996-08-02
FI963064A0 (fi) 1996-08-02
WO1995020943A1 (en) 1995-08-10
CZ285795B6 (cs) 1999-11-17
GR970300049T1 (en) 1998-01-30
NZ279952A (en) 1998-02-26
CZ221596A3 (en) 1996-11-13
NO963240L (no) 1996-08-02
BR9506681A (pt) 1997-11-18
JP3117145B2 (ja) 2000-12-11
NO312493B1 (no) 2002-05-21
ES2107397T3 (es) 2001-10-01
EP0797432A1 (en) 1997-10-01
CA2182575A1 (en) 1995-08-10
US5688528A (en) 1997-11-18
DE797432T1 (de) 1998-02-19

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