LV10961B - Novel colon- or ileum-specific steroid derivatives - Google Patents

Novel colon- or ileum-specific steroid derivatives Download PDF

Info

Publication number
LV10961B
LV10961B LVP-95-207A LV950207A LV10961B LV 10961 B LV10961 B LV 10961B LV 950207 A LV950207 A LV 950207A LV 10961 B LV10961 B LV 10961B
Authority
LV
Latvia
Prior art keywords
compound according
epimer
gcs
sugar
formula
Prior art date
Application number
LVP-95-207A
Other languages
English (en)
Latvian (lv)
Other versions
LV10961A (lv
Inventor
Ralph Lennart Brattsand
Peter Edman
Thomas Hoegberg
Stinabritt Nilsson
Bror Arne Thalen
Jan Erik Ulmius
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of LV10961A publication Critical patent/LV10961A/xx
Publication of LV10961B publication Critical patent/LV10961B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
LVP-95-207A 1993-01-08 1995-07-05 Novel colon- or ileum-specific steroid derivatives LV10961B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
PCT/SE1993/001081 WO1994015947A1 (fr) 1993-01-08 1993-12-17 Nouveaux derives steroidiens specifiques du colon ou de l'ileon

Publications (2)

Publication Number Publication Date
LV10961A LV10961A (lv) 1995-12-20
LV10961B true LV10961B (en) 1996-08-20

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-95-207A LV10961B (en) 1993-01-08 1995-07-05 Novel colon- or ileum-specific steroid derivatives

Country Status (22)

Country Link
US (2) US5908833A (fr)
EP (1) EP0678097B1 (fr)
JP (1) JP3366640B2 (fr)
KR (1) KR960700266A (fr)
AT (1) ATE183192T1 (fr)
BR (1) BR9307746A (fr)
CA (1) CA2152374A1 (fr)
CZ (1) CZ171095A3 (fr)
DK (1) DK0678097T3 (fr)
ES (1) ES2137353T3 (fr)
FI (1) FI953358A0 (fr)
GR (1) GR3031789T3 (fr)
HU (1) HU221584B (fr)
IS (1) IS4111A (fr)
LV (1) LV10961B (fr)
NO (1) NO305367B1 (fr)
NZ (1) NZ259596A (fr)
PL (1) PL178307B1 (fr)
RU (1) RU95115547A (fr)
SK (1) SK87295A3 (fr)
TW (1) TW261615B (fr)
WO (1) WO1994015947A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ171095A3 (en) * 1993-01-08 1996-01-17 Astra Ab Novel steroidal derivatives specific for colon or ilium
EP0721956B1 (fr) * 1993-09-29 2000-08-02 Nissin Shokuhin Kabushiki Kaisha Compose steroide substitue en position 21
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
CN1250563C (zh) 1999-05-04 2006-04-12 斯特拉坎有限公司 雄激素糖苷及其产生雄性征的活性
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
JP4790950B2 (ja) 1999-06-14 2011-10-12 コスモ・テクノロジーズ・リミテッド 制御放出および味感遮蔽経口医薬組成物
WO2001051057A2 (fr) * 2000-01-14 2001-07-19 Strakan Limited Glycosides et glycosides d'orthoester de glucocorticoides et leurs utilisations
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
ES2315600T3 (es) * 2004-08-09 2009-04-01 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Conjugados de albumina que contienen un ligador glucuronico.
US20080200441A1 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
AU2017359043B2 (en) 2016-11-08 2022-06-16 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
WO2018177381A1 (fr) * 2017-03-30 2018-10-04 合肥合源药业有限公司 Composé de glycoside de lactulose, procédé de préparation et son utilisation
JP7364471B2 (ja) 2017-05-18 2023-10-18 レゲネロン ファーマシューティカルス，インコーポレーテッド シクロデキストリンタンパク質薬物コンジュゲート
SG11202006510XA (en) * 2018-01-08 2020-08-28 Regeneron Pharma Steroids and antibody-conjugates thereof
SG11202010909RA (en) 2018-05-09 2020-12-30 Regeneron Pharma Anti-msr1 antibodies and methods of use thereof

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE378110B (fr) * 1972-05-19 1975-08-18 Bofors Ab
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378109B (fr) * 1972-05-19 1975-08-18 Bofors Ab
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
BG33738A3 (en) * 1978-01-25 1983-04-15 Schering Ag,De Method for obtaining of substituated in 17- th position steroids from pregnan row
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (fr) * 1983-04-14 1984-10-25 Univ California Systeme d'administration de medicaments specifiques du colon
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
US5023239A (en) * 1986-05-12 1991-06-11 Mect Corporation Sialosyl cholesterol, process for producing the same, and neuropathy remedy comprising the same
CA1299653C (fr) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Appareil de mesure des liquides biologiques
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
WO1993022334A1 (fr) * 1992-05-04 1993-11-11 Sri International Compositions pharmaceutiques et procedes pour l'apport de corticosteroides au colon
CZ171095A3 (en) * 1993-01-08 1996-01-17 Astra Ab Novel steroidal derivatives specific for colon or ilium

Also Published As

Publication number Publication date
WO1994015947A1 (fr) 1994-07-21
PL178307B1 (pl) 2000-04-28
EP0678097B1 (fr) 1999-08-11
TW261615B (fr) 1995-11-01
HU221584B (hu) 2002-11-28
AU678803B2 (en) 1997-06-12
AU5844794A (en) 1994-08-15
DK0678097T3 (da) 2000-02-07
JPH08505616A (ja) 1996-06-18
ATE183192T1 (de) 1999-08-15
PL309777A1 (en) 1995-11-13
CA2152374A1 (fr) 1994-07-21
GR3031789T3 (en) 2000-02-29
US5908833A (en) 1999-06-01
HUT73227A (en) 1996-07-29
RU95115547A (ru) 1997-06-10
NO952683D0 (no) 1995-07-06
JP3366640B2 (ja) 2003-01-14
EP0678097A1 (fr) 1995-10-25
US6140308A (en) 2000-10-31
IS4111A (is) 1994-07-09
CZ171095A3 (en) 1996-01-17
FI953358A (fi) 1995-07-07
NO952683L (no) 1995-07-06
NO305367B1 (no) 1999-05-18
HU9502087D0 (en) 1995-09-28
SK87295A3 (en) 1996-04-03
KR960700266A (ko) 1996-01-19
FI953358A0 (fi) 1995-07-07
LV10961A (lv) 1995-12-20
BR9307746A (pt) 1995-11-14
ES2137353T3 (es) 1999-12-16
NZ259596A (en) 1997-04-24

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