LU90310I2 - Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en parti - Google Patents
Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en partiInfo
- Publication number
- LU90310I2 LU90310I2 LU90310C LU90310C LU90310I2 LU 90310 I2 LU90310 I2 LU 90310I2 LU 90310 C LU90310 C LU 90310C LU 90310 C LU90310 C LU 90310C LU 90310 I2 LU90310 I2 LU 90310I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- amino acid
- trovafloxacin
- pharmaceutically acceptable
- precursors
- prodrugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1989/003489 WO1991002526A1 (en) | 1989-08-16 | 1989-08-16 | Azabicyclo quinolone carboxylic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU90310I2 true LU90310I2 (fr) | 1999-01-25 |
Family
ID=22215165
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU90311C LU90311I2 (fr) | 1989-08-16 | 1998-11-04 | Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci |
| LU90310C LU90310I2 (fr) | 1989-08-16 | 1998-11-04 | Trovafloxacine et ses sels pharmaceutiquement acceptables en particulier le sel mésylate de celui-ci et les précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en parti |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU90311C LU90311I2 (fr) | 1989-08-16 | 1998-11-04 | Précurseurs de médicament (prodrogues) de la trovafloxacine ayant des groupes d'acides aminés libres ces précurseurs comprenant un résidu d'acide aminé ou une chaîne de polypeptides de deux ou plusieurs résidus d'acides aminés qui sont liés de manière covalente par des liaisons peptidiques incluant l'alatrofloxacine optionnellement sous forme d'un sel pharmaceutiquement acceptable en particulier le sel mésylate de celui-ci |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP0413455B1 (hu) |
| JP (2) | JPH072734B2 (hu) |
| KR (1) | KR930004844B1 (hu) |
| CN (1) | CN1025192C (hu) |
| AT (1) | ATE124040T1 (hu) |
| AU (1) | AU623801B2 (hu) |
| BA (1) | BA98299A (hu) |
| CA (2) | CA2127561C (hu) |
| CY (1) | CY1969A (hu) |
| CZ (1) | CZ281127B6 (hu) |
| DD (1) | DD298399A5 (hu) |
| DE (3) | DE19875052I2 (hu) |
| DK (1) | DK0413455T3 (hu) |
| EG (1) | EG19251A (hu) |
| ES (1) | ES2074131T4 (hu) |
| FI (2) | FI108228B (hu) |
| GR (1) | GR3017072T3 (hu) |
| HK (1) | HK1000207A1 (hu) |
| HU (2) | HU219403B (hu) |
| IE (1) | IE66202B1 (hu) |
| IL (1) | IL95331A (hu) |
| LU (2) | LU90311I2 (hu) |
| NL (2) | NL980033I2 (hu) |
| NO (1) | NO300214B1 (hu) |
| NZ (1) | NZ234920A (hu) |
| PL (1) | PL166381B1 (hu) |
| PT (1) | PT94998B (hu) |
| RU (1) | RU2049777C1 (hu) |
| WO (1) | WO1991002526A1 (hu) |
| ZA (1) | ZA906450B (hu) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0449445A3 (en) * | 1990-03-27 | 1993-08-25 | Pfizer Inc. | Preparation of beta-ketoesters useful in preparing quinolone antibiotics |
| FR2675144B1 (fr) * | 1991-04-10 | 1995-06-16 | Bouchara Sa | Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant. |
| DK0641339T3 (da) * | 1991-06-19 | 1999-12-20 | Pfizer | Antibakterielle midler med azaspiroquinolon |
| US5256791A (en) * | 1992-03-02 | 1993-10-26 | Pfizer Inc. | Preparation of intermediates in the synthesis of quinoline antibiotics |
| EG20543A (en) * | 1992-10-30 | 1999-07-31 | Procter & Gamble | Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones |
| US5527910A (en) * | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
| US5591766A (en) * | 1993-12-03 | 1997-01-07 | Cheil Foods & Chemicals, Inc. | Solid oral formulations of pyridone carboxylic acids |
| ES2173175T3 (es) * | 1994-02-04 | 2002-10-16 | Dainippon Pharmaceutical Co | Derivado de acido piridonacarboxilico sustituido con un grupo amino biciclico, ester del mismo, sal del mismo, y amina biciclica como intermedio para su preparacion. |
| JPH08213881A (ja) * | 1995-02-02 | 1996-08-20 | Fujitsu Ltd | 周波数制御回路 |
| CA2212007C (en) * | 1995-02-02 | 2004-09-14 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivatives substitued by a bicyclic amino group |
| ES2199278T3 (es) * | 1995-02-07 | 2004-02-16 | Daiichi Pharmaceutical Co., Ltd. | Derivados de espiro heterociclicos. |
| SK280535B6 (sk) * | 1995-06-06 | 2000-03-13 | Pfizer Inc. | Kryštalická forma bezvodej soli kyseliny 7-([1a,5a |
| WO1997000268A1 (en) * | 1995-06-15 | 1997-01-03 | Pfizer Inc. | Process for preparing derivatives of azabicyclo naphthyridine carboxylic acid comprising a dipeptide |
| KR100276477B1 (ko) * | 1996-02-09 | 2000-12-15 | 나카노 가쓰히코 | 퀴놀론카복실산유도체또는그의염 |
| AP788A (en) * | 1996-08-26 | 1999-12-03 | Pfizer | Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt. |
| TW519542B (en) * | 1996-09-27 | 2003-02-01 | Daiichi Seiyaku Co | Bicyclic amine derivative |
| DK0947513T3 (da) | 1996-10-25 | 2004-08-30 | Daiichi Seiyaku Co | Tricykliske aminderivater |
| MA24500A1 (fr) | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | Derive du sel d'acide carboxylique de naphthyridine . |
| US20020032216A1 (en) | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
| DE19733439A1 (de) * | 1997-08-02 | 1999-02-04 | Bayer Ag | Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften |
| BR9812644B1 (pt) | 1997-09-15 | 2010-07-13 | quinolonas antimicrobianas, composição farmacêutica e uso das mesmas. | |
| US6184380B1 (en) * | 1999-01-25 | 2001-02-06 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
| PA8464701A1 (es) * | 1998-01-16 | 2000-09-29 | Pfizer Prod Inc | Procedimiento e intermedios para preparar naftiridonas |
| US7019142B2 (en) | 1998-01-16 | 2006-03-28 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
| GB9820405D0 (en) * | 1998-09-18 | 1998-11-11 | Smithkline Beecham Plc | Process |
| EP1161956A4 (en) | 1999-03-17 | 2005-03-16 | Daiichi Seiyaku Co | DRUG COMPOSITIONS |
| GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
| GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
| WO2002048143A2 (en) | 2000-12-14 | 2002-06-20 | The Procter & Gamble Company | Antimicrobial 2-pyridones, their compositions and uses |
| BR0116217A (pt) | 2000-12-14 | 2003-12-30 | Procter & Gamble | Quinolonas antimicrobianas, composição farmacêutica, bem como aplicação farmacêutica das referidas quinolonas |
| KR100517638B1 (ko) | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
| MXPA05000434A (es) | 2002-07-08 | 2005-04-19 | Ranbaxy Lab Ltd | Derivados de hexano [3.1.0] azabiciclo 3,6-disustituido utiles como antagonistas de receptor muscarinico. |
| DE60231341D1 (de) | 2002-08-23 | 2009-04-09 | Ranbaxy Lab Ltd | Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten |
| WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| BR0318242A (pt) | 2003-04-10 | 2006-04-04 | Ranbaxy Lab Ltd | derivados de azabiciclo hexano substituìdo como antagonistas de receptores muscarìnicos e processo para sua preparação |
| CN100436414C (zh) | 2003-04-11 | 2008-11-26 | 兰贝克赛实验室有限公司 | 作为毒蕈碱受体拮抗剂的氮杂双环衍生物 |
| EP1670759A1 (en) * | 2003-09-18 | 2006-06-21 | Ranbaxy Laboratories Limited | PROCESS FOR THE PREPARATION OF (1a, 5a, 6a)-6-AMINOME THYL-3-BENZYL-3-AZABICYCLO 3.1.0 HEXANE |
| EP1999125A2 (en) | 2006-03-28 | 2008-12-10 | The Procter and Gamble Company | A coupling process for preparing quinolone intermediates |
| ATE507219T1 (de) | 2006-03-28 | 2011-05-15 | Warner Chilcott Co Llc | Malatsalze und polymorphe von (3s,5s)-7-ä3-amino- 5-methyl-piperidinylü-1-cyclopropyl-1,4-dihydro 8-methoxy-4-oxo-3-chinolincarbonsäure |
| US7902227B2 (en) * | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
| JP2013542929A (ja) | 2010-09-28 | 2013-11-28 | パナセア バイオテック リミテッド | 新規ビシクロ環化合物 |
| EP3856735B1 (en) * | 2018-10-05 | 2023-09-06 | New York University | Fused bicyclic heterocycles as therapeutic agents |
| CN112442084B (zh) * | 2020-12-03 | 2022-09-09 | 国药集团致君（深圳）制药有限公司 | 一种抗菌药中间体的制备方法 |
| CN113307768B (zh) * | 2021-04-29 | 2023-12-12 | 中国农业科学院兰州畜牧与兽药研究所 | 喹诺酮类衍生物及其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0676400B2 (ja) * | 1987-08-25 | 1994-09-28 | 大日本製薬株式会社 | 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| JP2844079B2 (ja) * | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | ピリドンカルボン酸系抗菌剤 |
| US4973091A (en) * | 1989-09-20 | 1990-11-27 | Truth Incorporated | Sliding patio door dual point latch and lock |
-
1989
- 1989-08-16 HU HU9200460A patent/HU219403B/hu not_active IP Right Cessation
- 1989-08-16 RU SU5011662/04A patent/RU2049777C1/ru not_active IP Right Cessation
- 1989-08-16 PL PL90286484A patent/PL166381B1/pl unknown
- 1989-08-16 IE IE295090A patent/IE66202B1/en not_active IP Right Cessation
- 1989-08-16 WO PCT/US1989/003489 patent/WO1991002526A1/en active IP Right Grant
-
1990
- 1990-07-30 ES ES90308331T patent/ES2074131T4/es not_active Expired - Lifetime
- 1990-07-30 DE DE19875052C patent/DE19875052I2/de active Active
- 1990-07-30 EP EP90308331A patent/EP0413455B1/en not_active Expired - Lifetime
- 1990-07-30 DE DE69020262T patent/DE69020262T2/de not_active Expired - Fee Related
- 1990-07-30 DK DK90308331.9T patent/DK0413455T3/da active
- 1990-07-30 DE DE19875050C patent/DE19875050I2/de active Active
- 1990-07-30 AT AT90308331T patent/ATE124040T1/de active
- 1990-08-09 IL IL9533190A patent/IL95331A/en not_active IP Right Cessation
- 1990-08-14 KR KR1019900012528A patent/KR930004844B1/ko not_active IP Right Cessation
- 1990-08-14 PT PT94998A patent/PT94998B/pt not_active IP Right Cessation
- 1990-08-14 CA CA002127561A patent/CA2127561C/en not_active Expired - Lifetime
- 1990-08-14 EG EG48390A patent/EG19251A/xx active
- 1990-08-14 CA CA002023217A patent/CA2023217C/en not_active Expired - Lifetime
- 1990-08-15 AU AU61042/90A patent/AU623801B2/en not_active Expired
- 1990-08-15 CN CN90106794A patent/CN1025192C/zh not_active Expired - Fee Related
- 1990-08-15 DD DD90343474A patent/DD298399A5/de unknown
- 1990-08-15 ZA ZA906450A patent/ZA906450B/xx unknown
- 1990-08-15 NZ NZ234920A patent/NZ234920A/en unknown
- 1990-08-16 CZ CS904027A patent/CZ281127B6/cs not_active IP Right Cessation
- 1990-08-16 JP JP2216461A patent/JPH072734B2/ja not_active Expired - Fee Related
-
1992
- 1992-02-14 FI FI920632A patent/FI108228B/fi active Protection Beyond IP Right Term
- 1992-02-14 NO NO920599A patent/NO300214B1/no not_active IP Right Cessation
-
1994
- 1994-07-08 JP JP6157008A patent/JPH0819099B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-22 HU HU95P/P00380P patent/HU211681A9/hu unknown
- 1995-08-09 GR GR950402200T patent/GR3017072T3/el unknown
-
1996
- 1996-11-11 FI FI964520A patent/FI103879B1/fi active
-
1997
- 1997-09-05 CY CY196997A patent/CY1969A/xx unknown
- 1997-09-12 HK HK97101767A patent/HK1000207A1/xx not_active IP Right Cessation
-
1998
- 1998-03-30 BA BA980299A patent/BA98299A/bs unknown
- 1998-11-04 LU LU90311C patent/LU90311I2/xx unknown
- 1998-11-04 LU LU90310C patent/LU90310I2/xx unknown
- 1998-11-17 NL NL980033C patent/NL980033I2/nl unknown
- 1998-11-17 NL NL980032C patent/NL980032I2/nl unknown
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