LU87782A1 - Appareil destine a l'execution automatique et repetee d'un cycle thermique pour le traitement d'echantillons biologiques - Google Patents

Appareil destine a l'execution automatique et repetee d'un cycle thermique pour le traitement d'echantillons biologiques Download PDF

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Publication number
LU87782A1
LU87782A1 LU87782A LU87782A LU87782A1 LU 87782 A1 LU87782 A1 LU 87782A1 LU 87782 A LU87782 A LU 87782A LU 87782 A LU87782 A LU 87782A LU 87782 A1 LU87782 A1 LU 87782A1
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LU
Luxembourg
Prior art keywords
biological sample
enclosure
sample
moving
thermal
Prior art date
Application number
LU87782A
Other languages
English (en)
French (fr)
Inventor
Daniel Larzul
Original Assignee
Scras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scras filed Critical Scras
Publication of LU87782A1 publication Critical patent/LU87782A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage
LU87782A 1989-08-05 1990-08-02 Appareil destine a l'execution automatique et repetee d'un cycle thermique pour le traitement d'echantillons biologiques LU87782A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898917963A GB8917963D0 (en) 1989-08-05 1989-08-05 Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples

Publications (1)

Publication Number Publication Date
LU87782A1 true LU87782A1 (fr) 1990-12-11

Family

ID=10661242

Family Applications (1)

Application Number Title Priority Date Filing Date
LU87782A LU87782A1 (fr) 1989-08-05 1990-08-02 Appareil destine a l'execution automatique et repetee d'un cycle thermique pour le traitement d'echantillons biologiques

Country Status (30)

Country Link
US (1) US5176203A (it)
JP (1) JP3058661B2 (it)
AR (1) AR243600A1 (it)
AT (1) AT403165B (it)
AU (1) AU643225B2 (it)
BE (1) BE1004524A3 (it)
CA (1) CA2022564C (it)
CH (1) CH681431A5 (it)
DE (1) DE4024714C2 (it)
DK (1) DK185990A (it)
ES (1) ES2027111A6 (it)
FI (1) FI903856A0 (it)
FR (1) FR2650657A1 (it)
GB (2) GB8917963D0 (it)
GR (1) GR1000653B (it)
HK (1) HK33194A (it)
IE (1) IE65524B1 (it)
IN (1) IN177441B (it)
IT (1) IT1243976B (it)
LU (1) LU87782A1 (it)
MA (1) MA21926A1 (it)
MY (1) MY107255A (it)
NL (1) NL9001772A (it)
NO (1) NO903423L (it)
NZ (1) NZ234736A (it)
OA (1) OA09742A (it)
PT (1) PT94899B (it)
SE (1) SE9002566L (it)
TN (1) TNSN90110A1 (it)
ZA (1) ZA905935B (it)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935401A (en) * 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US6787338B2 (en) * 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
FR2672231A1 (fr) * 1991-02-01 1992-08-07 Eibet Appareil d'execution automatique repetee d'un cycle thermique, notamment pour l'amplification du nombre d'une sequence definie d'acide nucleique.
US5270183A (en) * 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
US7297313B1 (en) 1991-08-31 2007-11-20 The Regents Of The University Of California Microfabricated reactor, process for manufacturing the reactor, and method of amplification
ES2152933T3 (es) * 1991-10-23 2001-02-16 Baylor College Medicine Determinacion de huellas relativas a cepas bacterianas utilizando amplificacion de secuencias de adn repetitivas.
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US6953676B1 (en) * 1992-05-01 2005-10-11 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
DE69319427T2 (de) * 1992-05-01 1998-12-10 Univ Pennsylvania Analyse bei messung des durchflusswiderstandes
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
WO1994010564A1 (de) * 1992-11-05 1994-05-11 Evotec Biosystems Gmbh Verfahren zur trennung von substanzen aus verdünnten lösungen oder suspensionen
US5433141A (en) * 1993-04-08 1995-07-18 Kraft Foods, Inc. Development of a uniform temperature gradient in a block of cheese
ATE208658T1 (de) * 1993-07-28 2001-11-15 Pe Corp Ny Vorrichtung und verfahren zur nukleinsäurevervielfältigung
CA2130517C (en) * 1993-09-10 1999-10-05 Walter Fassbind Array of reaction containers for an apparatus for automatic performance of temperature cycles
CA2130013C (en) * 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
US5645801A (en) * 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
AU8073294A (en) * 1993-10-21 1995-05-08 Abbott Laboratories Apparatus and method for transfer of a fluid sample
JPH09508224A (ja) * 1994-01-11 1997-08-19 アボツト・ラボラトリーズ 熱サイクル核酸検定の装置および方法
US5840573A (en) * 1994-02-01 1998-11-24 Fields; Robert E. Molecular analyzer and method of use
DE4420732A1 (de) * 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
DE4435107C1 (de) * 1994-09-30 1996-04-04 Biometra Biomedizinische Analy Miniaturisierter Fluß-Thermocycler
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
DE69533554T2 (de) * 1994-11-10 2005-01-27 Orchid Biosciences, Inc. Flüssigkeitsverteilungssystem
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5533567A (en) * 1994-12-14 1996-07-09 The Regents Of The University Of California Method and apparatus for uniform heating and cooling
US5637226A (en) * 1995-08-18 1997-06-10 Az Industries, Incorporated Magnetic fluid treatment
WO1997016561A1 (en) * 1995-11-03 1997-05-09 Sarnoff Corporation Assay system and method for conducting assays
US5830657A (en) * 1996-05-01 1998-11-03 Visible Genetics Inc. Method for single-tube sequencing of nucleic acid polymers
EP1015116A1 (en) * 1996-05-01 2000-07-05 Visible Genetics Inc. Method and apparatus for thermal cycling and for automated sample preparation with thermal cycling
EP0927265A4 (en) * 1996-06-17 2000-07-12 Trustees Of Board Of THERMOCYCLING APPARATUS AND METHOD
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
GB9621357D0 (en) * 1996-10-12 1996-12-04 Central Research Lab Ltd Heating apparatus
US5882903A (en) * 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
DE19717085C2 (de) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
US5965410A (en) * 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
AUPO931797A0 (en) * 1997-09-22 1997-10-09 Diatech Pty Ltd Apparatus for amplification and determination of nucleic acids
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US5912129A (en) * 1998-03-05 1999-06-15 Vinayagamoorthy; Thuraiayah Multi-zone polymerase/ligase chain reaction
WO1999053093A1 (de) * 1998-04-08 1999-10-21 Universität Heidelberg Verfahren zur durchführung von reaktionen zwischen mindestens zwei reaktionspartnern in wässrigen reaktionsgemischen
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6780617B2 (en) * 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
CA2301153C (en) 1998-06-24 2008-08-26 Chen & Chen, Llc Fluid sample testing system
US6413780B1 (en) 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US6977145B2 (en) * 1999-07-28 2005-12-20 Serono Genetics Institute S.A. Method for carrying out a biochemical protocol in continuous flow in a microreactor
US7217699B2 (en) 2000-01-03 2007-05-15 Panagenic International, Inc. Compositions comprising genome segments and methods of using the same
GB0005434D0 (en) 2000-03-08 2000-04-26 Secr Defence Reaction system
WO2002022878A1 (en) * 2000-09-14 2002-03-21 Caliper Technologies Corp. Microfluidic devices and methods for performing temperature mediated reactions
JP2003024063A (ja) * 2001-07-12 2003-01-28 Toshio Kawai Ｄｎａの連続増幅方法とその装置
AUPR707101A0 (en) * 2001-08-16 2001-09-06 Corbett Research Pty Ltd Continuous flow thermal device
EP1427531B1 (en) 2001-09-11 2016-10-19 Iquum, Inc. Sample vessels
KR100442836B1 (ko) * 2001-11-10 2004-08-02 삼성전자주식회사 생화학 유체를 온도가 다른 폐쇄된 챔버 구간을 따라 회전이동시키는 폐쇄 유체 회로 시스템
US7179639B2 (en) * 2002-03-05 2007-02-20 Raveendran Pottathil Thermal strip thermocycler
US8349276B2 (en) 2002-09-24 2013-01-08 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US7718421B2 (en) 2003-02-05 2010-05-18 Iquum, Inc. Sample processing
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20040224425A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Biomolecule open channel solid phase extraction systems and methods
US20060257878A1 (en) * 2003-07-11 2006-11-16 Taiyo Yuden Co., Ltd. Nucleic acid amplifier and method of nucleic acid amplification
EP1735458B1 (en) * 2004-01-28 2013-07-24 454 Life Sciences Corporation Nucleic acid amplification with continuous flow emulsion
US8293471B2 (en) * 2004-01-28 2012-10-23 Marshall University Research Corporation Apparatus and method for a continuous rapid thermal cycle system
US7618811B2 (en) * 2004-02-24 2009-11-17 Thermal Gradient Thermal cycling device
US8043849B2 (en) * 2004-02-24 2011-10-25 Thermal Gradient Thermal cycling device
WO2005094981A1 (en) * 2004-03-29 2005-10-13 Agilent Technologies, Inc. Cyclic pcr system
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7398015B2 (en) * 2004-12-10 2008-07-08 Electronics And Telecommunications Research Institute Apparatus for controlling fluid-heating using polymer disk
US20060246493A1 (en) * 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
AU2006247752B2 (en) * 2005-05-11 2012-04-12 Advanced Liquid Logic, Inc. Method and device for conducting biochemical or chemical reactions at multiple temperatures
CN101351542A (zh) * 2005-07-15 2009-01-21 阿普尔拉公司 液体加工装置和方法
JP2009536313A (ja) 2006-01-11 2009-10-08 レインダンス テクノロジーズ， インコーポレイテッド ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
WO2007123908A2 (en) * 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US8980198B2 (en) * 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US7851184B2 (en) 2006-04-18 2010-12-14 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification method and apparatus
WO2009111769A2 (en) 2008-03-07 2009-09-11 Advanced Liquid Logic, Inc. Reagent and sample preparation and loading on a fluidic device
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530168B1 (en) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Microfluidic Devices
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
KR101422572B1 (ko) * 2006-09-05 2014-07-30 삼성전자주식회사 핵산 검출을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
US8273310B2 (en) * 2006-09-05 2012-09-25 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
CN101589157B (zh) * 2006-10-06 2014-04-02 万达利亚研究公司 用于连续快速热循环系统的方法
DE102006053451B4 (de) * 2006-11-11 2008-11-27 Microfluidic Chipshop Gmbh Mikrofluidische Plattform zur Temperierung von Substanzen und/oder zur Durchführung von zu temperierenden Reaktionen
US20080176292A1 (en) * 2007-01-23 2008-07-24 Texas A&M University System Portable buoyancy driven pcr thermocycler
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US9046514B2 (en) 2007-02-09 2015-06-02 Advanced Liquid Logic, Inc. Droplet actuator devices and methods employing magnetic beads
WO2011084703A2 (en) 2009-12-21 2011-07-14 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CN101970111B (zh) 2007-06-21 2013-09-11 简·探针公司 用于执行处理的仪器和容器
WO2009002920A1 (en) * 2007-06-22 2008-12-31 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification in a temperature gradient
WO2009021233A2 (en) * 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
GB2451900A (en) * 2007-08-17 2009-02-18 Uniqsis Ltd Flow apparatus
US8702938B2 (en) 2007-09-04 2014-04-22 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
US20090263870A1 (en) * 2007-09-10 2009-10-22 Agency For Science, Technology And Research System and method for amplifying a nucleic acid molecule
WO2013006312A2 (en) 2011-07-06 2013-01-10 Advanced Liquid Logic Inc Reagent storage on a droplet actuator
WO2009086403A2 (en) 2007-12-23 2009-07-09 Advanced Liquid Logic, Inc. Droplet actuator configurations and methods of conducting droplet operations
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
EP2672260A1 (en) * 2008-05-13 2013-12-11 Advanced Liquid Logic, Inc. Droplet actuator devices, systems and methods
US20110097763A1 (en) * 2008-05-13 2011-04-28 Advanced Liquid Logic, Inc. Thermal Cycling Method
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
EP2940153B1 (en) 2009-09-02 2020-05-13 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US9091649B2 (en) 2009-11-06 2015-07-28 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel; electrophoresis and molecular analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド デジタル検体分析
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP2550528B1 (en) 2010-03-25 2019-09-11 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
JP6155419B2 (ja) 2010-03-25 2017-07-05 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド 検出用の液滴輸送システム
JP2013524169A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴によるアッセイ用の検出システム
EP3447155A1 (en) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwich assays in droplets
SG190074A1 (en) 2010-11-01 2013-06-28 Bio Rad Laboratories System for forming emulsions
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
WO2012129187A1 (en) 2011-03-18 2012-09-27 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
EP2707131B1 (en) 2011-05-09 2019-04-24 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
WO2013009927A2 (en) 2011-07-11 2013-01-17 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based assays
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US9446404B2 (en) 2011-07-25 2016-09-20 Advanced Liquid Logic, Inc. Droplet actuator apparatus and system
US10731199B2 (en) 2011-11-21 2020-08-04 Advanced Liquid Logic, Inc. Glucose-6-phosphate dehydrogenase assays
WO2014004908A1 (en) 2012-06-27 2014-01-03 Advanced Liquid Logic Inc. Techniques and droplet actuator designs for reducing bubble formation
US20140255270A1 (en) * 2013-02-28 2014-09-11 California Institute Of Technology Removing sacrificial layer to form liquid containment structure and methods of use thereof
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
US9168533B2 (en) * 2013-07-17 2015-10-27 CrackerBio, Inc. Thermal cycler device
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
CA2926436A1 (en) 2013-10-07 2015-04-16 Judith Murrah Multimode image and spectral reader
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015142990A1 (en) 2014-03-18 2015-09-24 Apdn (B.V.I.) Inc. Encryped optical markers for security applications
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
JP2015223130A (ja) * 2014-05-28 2015-12-14 セイコーエプソン株式会社 物質増幅反応装置及び物質増幅方法
KR102415232B1 (ko) * 2015-04-20 2022-07-04 한국전자통신연구원 마이크로 가열 장치
US11260386B2 (en) 2015-06-05 2022-03-01 The Emerther Company Component of a device, a device, and a method for purifying and testing biomolecules from biological samples
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2017180302A1 (en) 2016-04-11 2017-10-19 Apdn (B.V.I.) Inc. Method of marking cellulosic products
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
WO2018156352A1 (en) 2017-02-21 2018-08-30 Apdn (B.V.I) Inc. Nucleic acid coated submicron particles for authentication

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA596284A (en) * 1960-04-19 M. Findlay Jacquelyn Electromagnetic liquid metal pump
DE1887821U (de) * 1964-02-20 Berliner Quarz Schmelze mbH Mainz Durchlauferhitzer 8 62 B
US2698127A (en) * 1949-04-06 1954-12-28 Claude A Bowlus Hydraulic transmission unit, pump, or compressor
US2863922A (en) * 1956-10-02 1958-12-09 Hoffmann La Roche Preparation of ketene
GB823110A (en) * 1957-03-26 1959-11-04 Leslie Reginald Blake Improvements relating to electromagnetic interaction pumps
US2964532A (en) * 1957-04-17 1960-12-13 Du Pont Production of pigments
US3574485A (en) * 1958-11-28 1971-04-13 Broido Louis Method and apparatus for movement of liquids by electromagnetic means
US3108060A (en) * 1960-05-10 1963-10-22 Phillips Petroleum Co Loop reactor and process for sulfonating asphalt
US3354642A (en) * 1965-05-18 1967-11-28 Gen Motors Corp Turbomagnetic pump
US3488152A (en) * 1966-03-16 1970-01-06 United Aircraft Corp Boron production
US3518057A (en) * 1966-04-22 1970-06-30 Huron Road Hospital Method and apparatus for thrombus formation time determinations
US3411884A (en) * 1967-04-11 1968-11-19 Atomic Energy Commission Usa Process for concentrating heavy water
US3613386A (en) * 1970-03-23 1971-10-19 Air Prod & Chem Cryogenic freezer control
US3700562A (en) * 1970-08-31 1972-10-24 Technicon Instr Method and apparatus for sample analysis on a continuous flow basis
US3738815A (en) * 1970-10-09 1973-06-12 Dow Chemical Co Reactor for removing olefins from acetylenic and olefin-containing gaseous hydrocarbon mixtures
US4015943A (en) * 1972-12-15 1977-04-05 Chemische Werke Huls Aktiengesellschaft Apparatus for the esterification of terephthalic acid in the gas phase
US4113435A (en) * 1973-07-16 1978-09-12 Massachusetts Institute Of Technology Cryogenically controlled direct fluorination apparatus
US3933200A (en) * 1974-06-21 1976-01-20 Emerson Electric Co. Temperature conditioning means
FR2311764A1 (fr) * 1975-05-23 1976-12-17 Rhone Poulenc Ind Procede et appareil pour la transformation thermique de gypse
US4095952A (en) * 1976-03-16 1978-06-20 Veb Jenapharm Jena Apparatus for making (DL) pantolactone
US4181576A (en) * 1977-03-29 1980-01-01 Phillips Petroleum Company Fermentation method
US4137966A (en) * 1977-04-19 1979-02-06 The United States Of America As Represented By The Secretary Of The Navy Simulation oven
US4372918A (en) * 1978-11-15 1983-02-08 Woods Verle W Flow through pressure reaction apparatus
US4276174A (en) * 1980-03-26 1981-06-30 Union Carbide Corporation Control of sludge temperature in autothermal sludge digestion
EP0094458A1 (en) * 1982-05-17 1983-11-23 András Tejfalussy Temperature distribution regulating sample holder-adapter for forming conditions for gradient heat treatment in heat treatment ovens or furnaces
DE3421778A1 (de) * 1984-06-12 1986-01-02 Karl Dr. 7800 Freiburg Fritz Mikrowellen-erwaermungsverfahren
FR2555363B1 (fr) * 1983-11-18 1986-02-21 Cit Alcatel Machine de report de composants pour circuits hybrides
US4544025A (en) * 1984-01-17 1985-10-01 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High gradient directional solidification furnace
IE58568B1 (en) * 1984-11-15 1993-10-06 Suiker Unie Method and device for the carrying out of a microbiological or enzymatic process
US5038852A (en) * 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
CA1338457C (en) * 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
JPS63174555A (ja) * 1987-01-12 1988-07-19 Power Reactor & Nuclear Fuel Dev Corp 導電式電磁ポンプ
FI77055C (fi) * 1987-05-15 1989-01-10 Limitek Oy Vaermegradient-inkubator.
JPS6426360A (en) * 1987-07-22 1989-01-27 Hitachi Ltd Superconducting piping device
CA1293217C (en) * 1987-11-09 1991-12-17 Sooyoung Stanford Lee Controlled growth rate fermentation
FI79342C (fi) * 1987-12-23 1989-12-11 Orion Yhtymae Oy Apparat, del av en apparat och foerfarande foer maongfaldigande av nukleinsyror.
GB8807297D0 (en) * 1988-03-26 1988-04-27 Dean P D G Intelligent heating block
DE8813773U1 (it) * 1988-11-03 1989-01-05 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De
DE8814398U1 (it) * 1988-11-17 1989-02-16 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De

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NO903423L (no) 1991-02-06
CA2022564C (en) 1996-03-05
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JP3058661B2 (ja) 2000-07-04
FR2650657A1 (fr) 1991-02-08
GB8917963D0 (en) 1989-09-20
IE65524B1 (en) 1995-11-01
DK185990D0 (da) 1990-08-03
PT94899A (pt) 1992-04-30
NO903423D0 (no) 1990-08-03
SE9002566D0 (sv) 1990-08-03
GB2238005A (en) 1991-05-22
IT9021209A0 (it) 1990-08-03
AU6014890A (en) 1991-02-07
JPH0383572A (ja) 1991-04-09
FR2650657B1 (it) 1997-02-28
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IN177441B (it) 1997-01-18
IE902813A1 (en) 1991-03-27
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US5176203A (en) 1993-01-05
ES2027111A6 (es) 1992-05-16

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