LU87600A1 - Composes chimiques - Google Patents

Composes chimiques Download PDF

Info

Publication number
LU87600A1
LU87600A1 LU87600A LU87600A LU87600A1 LU 87600 A1 LU87600 A1 LU 87600A1 LU 87600 A LU87600 A LU 87600A LU 87600 A LU87600 A LU 87600A LU 87600 A1 LU87600 A1 LU 87600A1
Authority
LU
Luxembourg
Prior art keywords
fluorophenyl
formula
radical
imidazol
compound
Prior art date
Application number
LU87600A
Other languages
English (en)
French (fr)
Inventor
Nigel Stephen Watson
Chuen Chan
Barry Clive Ross
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888823191A external-priority patent/GB8823191D0/en
Priority claimed from GB888823192A external-priority patent/GB8823192D0/en
Priority claimed from GB898902847A external-priority patent/GB8902847D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of LU87600A1 publication Critical patent/LU87600A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU87600A 1988-10-03 1989-10-02 Composes chimiques LU87600A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8823191 1988-10-03
GB8823192 1988-10-03
GB888823191A GB8823191D0 (en) 1988-10-03 1988-10-03 Chemical compounds
GB888823192A GB8823192D0 (en) 1988-10-03 1988-10-03 Chemical compounds
GB8902847 1989-02-09
GB898902847A GB8902847D0 (en) 1989-02-09 1989-02-09 Chemical compounds

Publications (1)

Publication Number Publication Date
LU87600A1 true LU87600A1 (fr) 1990-05-15

Family

ID=27264106

Family Applications (1)

Application Number Title Priority Date Filing Date
LU87600A LU87600A1 (fr) 1988-10-03 1989-10-02 Composes chimiques

Country Status (19)

Country Link
US (2) US5013749A (es)
JP (1) JPH02188571A (es)
KR (1) KR900006297A (es)
AU (1) AU628862B2 (es)
BE (1) BE1003007A3 (es)
CH (1) CH680442A5 (es)
DE (1) DE3932887A1 (es)
DK (1) DK483689A (es)
ES (1) ES2019163A6 (es)
FI (1) FI894648A (es)
FR (1) FR2637183A1 (es)
GB (1) GB2223224B (es)
GR (1) GR890100634A (es)
IT (1) IT1237470B (es)
LU (1) LU87600A1 (es)
NL (1) NL8902441A (es)
NO (1) NO893909L (es)
PT (1) PT91878B (es)
SE (1) SE8903226L (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3913725A1 (de) * 1989-04-26 1990-10-31 Basf Ag 1-halogenvinyl-azole und diese enthaltende fungizide und wachstumsregulatoren
AU637408B2 (en) * 1989-10-10 1993-05-27 Glaxo Group Limited Substituted N-vinyl imidazole derivatives.
SK4112003A3 (en) * 2000-10-12 2004-01-08 Nissan Chemical Ind Ltd Preventives and remedies for complications of diabetes
US6562846B2 (en) * 2001-04-27 2003-05-13 Bristol-Myers Squibb Company Bisarylimidazolyl fatty acid amide hydrolase inhibitors
EA200601678A1 (ru) * 2004-04-16 2007-04-27 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си Новые имидазолы
US20050282883A1 (en) * 2004-04-29 2005-12-22 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20050272770A1 (en) * 2004-04-29 2005-12-08 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7163945B2 (en) * 2004-04-29 2007-01-16 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7199126B2 (en) * 2004-04-29 2007-04-03 Pharmix Corporation Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
EP1755607A2 (en) * 2004-04-29 2007-02-28 Pharmix Corporation Compositions and treatments for inhibiting kinase and/or hmg-coa reductase
US7183285B2 (en) * 2004-04-29 2007-02-27 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20060084695A1 (en) * 2004-04-29 2006-04-20 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20060111436A1 (en) * 2004-11-23 2006-05-25 John Griffin Compositions and treatments for modulating kinase and/or HMG-CoA reductase
US8372877B2 (en) 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
JPWO2012046772A1 (ja) 2010-10-06 2014-02-24 国立大学法人 東京大学 リンパ浮腫予防治療剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
AU598775B2 (en) * 1985-10-25 1990-07-05 Sandoz Ag Heterocyclic analogs of mevalonolactone
EP0244364A3 (en) * 1986-04-30 1992-04-01 Sandoz Ag Preparation of olefinic compounds
DE3800785A1 (de) * 1988-01-09 1989-07-20 Hoechst Ag Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.

Also Published As

Publication number Publication date
SE8903226D0 (sv) 1989-10-02
GR890100634A (el) 1990-11-29
GB2223224A (en) 1990-04-04
NL8902441A (nl) 1990-05-01
BE1003007A3 (fr) 1991-10-22
US5120848A (en) 1992-06-09
NO893909D0 (no) 1989-10-02
PT91878A (pt) 1990-04-30
IT8948424A0 (it) 1989-10-02
DE3932887A1 (de) 1990-04-05
ES2019163A6 (es) 1991-06-01
DK483689A (da) 1990-04-04
FI894648A0 (fi) 1989-10-02
GB8922212D0 (en) 1989-11-15
GB2223224B (en) 1992-01-08
JPH02188571A (ja) 1990-07-24
FR2637183A1 (fr) 1990-04-06
PT91878B (pt) 1995-05-31
NO893909L (no) 1990-04-04
FI894648A (fi) 1990-04-04
DK483689D0 (da) 1989-10-02
AU4243189A (en) 1990-04-05
US5013749A (en) 1991-05-07
SE8903226L (sv) 1990-04-04
IT1237470B (it) 1993-06-07
AU628862B2 (en) 1992-09-24
KR900006297A (ko) 1990-05-07
CH680442A5 (es) 1992-08-31

Similar Documents

Publication Publication Date Title
LU87600A1 (fr) Composes chimiques
JP3316661B2 (ja) 〔(ヒドロキシフェニルアミノ)カルボニル〕ピロール
BE1006343A5 (fr) Derives de l'indole.
EP2430012A1 (fr) Dérivés de 7-aza-spiro[3.5]nonane-7-carboxylates, leur prépraration et leur application en thérapeutique
EP1401432B1 (fr) Derives d'imidazoles modulant les canaux sodiques
FR2542315A1 (fr) Nouveaux composes azoliques, leur preparation et leur utilisation comme antifongiques et fongicides
JPS6136259A (ja) 新規オキシインドール‐誘導体、その製法及びこれを含有する心蔵及び循環系疾病の治療及び予防剤
LU85551A1 (fr) Nouveaux composes azoliques,leur preparation et leur utilisation comme antifongiques et fongicides
EP1546111A2 (fr) Composes derives de la 2-thiohydantoine et leur utilisation pour le traitement du diabete
FR2552759A1 (fr) Composes de la 1,2,4-triazolone et leur application pharmacologique
EP1611127A2 (fr) Derives de quinoleines-4-substituees avec une activite antimicrobienne
FR2626175A1 (fr) Composes nouveaux de 1,2-ethylenediamine et composition pharmaceutique les contenant
EP1720829B1 (fr) Derives d' heteroaryl-alkylcarbamates, leur preparation et leur application comme inhibiteurs de l'enzyme faah
JPH08823B2 (ja) 血糖低下性チアゾリジンジオンとその中間体
CA2557942C (fr) Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique
US5055484A (en) 7(1h-pyrrol-3-yl)-substituted 3,5-dihydroxyhept-6-enoic acids, 7-(1h-pyrrol-3-yl)-substituted 3,5-dihyroxyhept-anoic acids, their corresponding delta-lactones and salts, their use as medicaments and pharmaceutical products and intermediates
CA2296725C (fr) Polyhydroxybutylpyrazines, leur preparation et les medicaments les contenant
US5112819A (en) Imidazole derivatives, pharmaceutical compositions and use
EP1551821B1 (fr) Derives de 3-(cyclopenten-1-yl)-benzyl- ou 3-(cyclopenten-1-yl)-heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie
LU86443A1 (fr) Nouveaux compoes azoliques,leur preparation et leur utilisation comme antifongiques et fongicides
FR2830862A1 (fr) Derives nitroso de la diphenylamine a fonction ether ou thioether, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
WO2018042096A1 (fr) Derives de 2-quinoline-2-one en tant que modulateurs de recepteurs nmda, compositions les comprenant et utilisation de ces composes dans le traitement de maladies impliquant le systeme nerveux central
WO2003011856A1 (fr) Derives d'aminoalkylimidazole, leur preparation et leur utilisation en therapeutique
JPH06256322A (ja) 抗真菌剤