LT5382B - ENANTIOMERISKAI GRYNO MIRTAZAPINO GAVIMO BuDAS - Google Patents
ENANTIOMERISKAI GRYNO MIRTAZAPINO GAVIMO BuDAS Download PDFInfo
- Publication number
- LT5382B LT5382B LT2005107A LT2005107A LT5382B LT 5382 B LT5382 B LT 5382B LT 2005107 A LT2005107 A LT 2005107A LT 2005107 A LT2005107 A LT 2005107A LT 5382 B LT5382 B LT 5382B
- Authority
- LT
- Lithuania
- Prior art keywords
- acid
- mirtazapine
- combination
- compound
- solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03102095 | 2003-07-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LT2005107A LT2005107A (en) | 2006-06-27 |
| LT5382B true LT5382B (lt) | 2006-11-27 |
Family
ID=34042934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT2005107A LT5382B (lt) | 2003-07-10 | 2005-12-12 | ENANTIOMERISKAI GRYNO MIRTAZAPINO GAVIMO BuDAS |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US8058436B2 (es) |
| EP (1) | EP1656365B1 (es) |
| JP (1) | JP4668184B2 (es) |
| KR (1) | KR20060056315A (es) |
| CN (1) | CN100558722C (es) |
| AR (1) | AR046494A1 (es) |
| AT (1) | ATE433965T1 (es) |
| AU (1) | AU2004255874B2 (es) |
| BR (1) | BRPI0412447A (es) |
| CA (1) | CA2531165C (es) |
| CO (1) | CO5640123A2 (es) |
| CY (1) | CY1109327T1 (es) |
| DE (1) | DE602004021605D1 (es) |
| DK (1) | DK1656365T3 (es) |
| EC (1) | ECSP066271A (es) |
| ES (1) | ES2327123T3 (es) |
| HK (1) | HK1086841A1 (es) |
| HR (1) | HRP20051019A2 (es) |
| IL (1) | IL172549A0 (es) |
| IS (1) | IS2674B (es) |
| LT (1) | LT5382B (es) |
| LV (1) | LV13441B (es) |
| MX (1) | MXPA06000325A (es) |
| NO (1) | NO20056175L (es) |
| NZ (1) | NZ544360A (es) |
| PE (1) | PE20050323A1 (es) |
| PL (1) | PL1656365T3 (es) |
| PT (1) | PT1656365E (es) |
| RS (1) | RS20050972A (es) |
| RU (1) | RU2352566C2 (es) |
| SG (1) | SG144914A1 (es) |
| SI (1) | SI1656365T1 (es) |
| TW (1) | TWI335915B (es) |
| UA (1) | UA83666C2 (es) |
| WO (1) | WO2005005410A1 (es) |
| ZA (1) | ZA200600019B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5080050B2 (ja) * | 2005-09-26 | 2012-11-21 | 住友化学株式会社 | 光学活性なピペラジン化合物の製造方法 |
| CN102153620A (zh) * | 2005-09-26 | 2011-08-17 | 住友化学株式会社 | 光学活性的哌嗪化合物的制造方法 |
| TW200808804A (en) * | 2006-05-22 | 2008-02-16 | Organon Nv | Mirtazapine for the treatment of neuropathic pain |
| TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
| JP5438976B2 (ja) * | 2007-02-09 | 2014-03-12 | 株式会社カネカ | 光学活性２−アリールピペラジン誘導体の製造法 |
| JP5192707B2 (ja) * | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | ミルタザピンの製造方法 |
| MX2009010967A (es) * | 2007-04-11 | 2009-12-15 | Organon Nv | Un metodo para la preparacion de mirtazapina. |
| US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
| KR101485418B1 (ko) * | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | 고순도 미르타자핀의 제조방법 |
| JP6876003B2 (ja) | 2015-02-27 | 2021-05-26 | デクラ リミテッド | イヌ及びネコにおける、食欲の刺激、体重減少の管理、及び拒食症の処置 |
| KR102540021B1 (ko) * | 2020-12-02 | 2023-06-07 | (주)유케이케미팜 | 대량 생산에 적합한 미르타자핀의 제조방법 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4062848A (en) | 1975-04-05 | 1977-12-13 | Akzona Incorporated | Tetracyclic compounds |
| WO1999025356A1 (en) | 1997-11-14 | 1999-05-27 | Akzo Nobel N.V. | Use of mirtazapine for treating sleep apneas |
| WO2000062782A1 (en) | 1999-04-19 | 2000-10-26 | Teva Pharmaceutical Industries Ltd. | Novel synthesis and crystallization of piperazine ring-containing compounds |
| WO2001023345A1 (fr) | 1999-09-30 | 2001-04-05 | Sumika Fine Chemicals Co., Ltd. | Procede de preparation de derive piperazine |
| WO2001058453A1 (en) | 2000-02-11 | 2001-08-16 | Akzo Nobel N.V. | The use of mirtazapine for the treatment of sleep disorders |
| US6376668B1 (en) | 1999-12-13 | 2002-04-23 | Sumika Fine Chemicals Co., Ltd. | Process for preparing pyridinemethanol compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3959470A (en) * | 1972-11-28 | 1976-05-25 | Mikhail Davidovich Mashkovsky | Psychotropic medicinal preparation |
| RU2048469C1 (ru) * | 1989-10-05 | 1995-11-20 | Санкио Компани Лимитед | Способ получения азетидинового производного или его фармацевтически приемлемой соли |
| JPH11222407A (ja) * | 1997-11-14 | 1999-08-17 | Sankyo Co Ltd | 新規殺菌剤 |
| US20030069417A1 (en) * | 1999-04-19 | 2003-04-10 | Claude Singer | Novel synthesis and crystallization of piperazine ring-containing compounds |
| US6068695A (en) * | 1999-07-13 | 2000-05-30 | Bayer Corporation | Process for the continuous preparation of quinacridones |
| JP2001342188A (ja) * | 2000-03-27 | 2001-12-11 | Takeda Chem Ind Ltd | 縮合ピラゾール誘導体、その製造法および用途 |
| TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
-
2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko active IP Right Grant
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en active IP Right Grant
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh not_active Expired - Lifetime
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja not_active Expired - Lifetime
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de not_active Expired - Lifetime
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en not_active Expired - Lifetime
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en not_active Expired
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es not_active Expired - Lifetime
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
-
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-22 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
-
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
- 2006-08-17 HK HK06109133.3A patent/HK1086841A1/xx not_active IP Right Cessation
-
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
-
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4062848A (en) | 1975-04-05 | 1977-12-13 | Akzona Incorporated | Tetracyclic compounds |
| WO1999025356A1 (en) | 1997-11-14 | 1999-05-27 | Akzo Nobel N.V. | Use of mirtazapine for treating sleep apneas |
| WO2000062782A1 (en) | 1999-04-19 | 2000-10-26 | Teva Pharmaceutical Industries Ltd. | Novel synthesis and crystallization of piperazine ring-containing compounds |
| WO2001023345A1 (fr) | 1999-09-30 | 2001-04-05 | Sumika Fine Chemicals Co., Ltd. | Procede de preparation de derive piperazine |
| US6376668B1 (en) | 1999-12-13 | 2002-04-23 | Sumika Fine Chemicals Co., Ltd. | Process for preparing pyridinemethanol compounds |
| WO2001058453A1 (en) | 2000-02-11 | 2001-08-16 | Akzo Nobel N.V. | The use of mirtazapine for the treatment of sleep disorders |
Non-Patent Citations (1)
| Title |
|---|
| DE BOER TH ET AL.: "Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers.", NEUROPHARMACOLOGY, 1988, pages 399 - 408, XP023755747, DOI: doi:10.1016/0028-3908(88)90149-9 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC9A | Transfer of patents |
Owner name: N.V.ORGANON, NL Effective date: 20061220 |
|
| MM9A | Lapsed patents |
Effective date: 20120705 |