LT5215B - Matricines metalproteinazes inhibuojanti kompozicija neoplazinėms ligoms gydyti - Google Patents
Matricines metalproteinazes inhibuojanti kompozicija neoplazinėms ligoms gydyti Download PDFInfo
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- LT5215B LT5215B LT2004074A LT2004074A LT5215B LT 5215 B LT5215 B LT 5215B LT 2004074 A LT2004074 A LT 2004074A LT 2004074 A LT2004074 A LT 2004074A LT 5215 B LT5215 B LT 5215B
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- matrix metalloproteinases
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- ascorbic acid
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| US8669282B2 (en) * | 2000-10-31 | 2014-03-11 | Hill's Pet Nutrition, Inc. | Companion animal compositions including lipoic acid and methods of use thereof |
| US6939860B2 (en) * | 2002-01-08 | 2005-09-06 | Matthias Rath | Composition and method for treatment of neoplastic diseases associated with elevated matrix metalloproteinase activities using catechin compounds |
| US20050079234A1 (en) * | 2003-08-27 | 2005-04-14 | Chiang Yang Chi | Compositions comprising herbs and method for immunomodulation |
| KR20050070385A (ko) * | 2003-12-30 | 2005-07-07 | (주)현덕비엔티 | 폴리페놀과, 아스코르빈산 또는 그 유도체를 함유하는항암치료 보조용 조성물 |
| US20080160099A1 (en) * | 2004-11-10 | 2008-07-03 | The Trustees Of Columbia University In The City Of New York | Methods For Treating or Preventing a Vascular Disease |
| ES2246737B1 (es) * | 2005-06-09 | 2006-12-01 | Jose Juan Rodriguez Jerez | "composicion farmaceutica que comprende lisina y usos correspondientes". |
| ES2497766T3 (es) * | 2005-12-29 | 2014-09-23 | Mitsui Norin Co., Ltd | Composiciones y procedimientos de sensibilizar a oxacilina Staphylococcus aureus resistente a meticilina |
| US20070265211A1 (en) * | 2006-05-12 | 2007-11-15 | Matthias Rath | Novel composition and method effective in inhibiting the atherogenic process |
| US20100055205A1 (en) * | 2008-08-29 | 2010-03-04 | Kristina Mains | Functional consumable compositions for promoting skin health and methods for using the same |
| EP2179722A1 (en) * | 2008-10-24 | 2010-04-28 | Heinrich-Pette-Institut für experimentelle Virologie und Immunologie | Topical formation for preventing sexual transmission of viral infection |
| ES2534245T3 (es) | 2008-11-04 | 2015-04-20 | Vymedic, Llc | Formulaciones de suplemento antiviral |
| JP4786000B2 (ja) * | 2009-10-16 | 2011-10-05 | 株式会社カネカ | 還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物 |
| EP2649994B1 (de) * | 2011-01-31 | 2017-08-30 | LUCOLAS-M.D. Ltd. | Kombinationen von aromatase inhibitoren und antioxidanzien |
| KR101829330B1 (ko) | 2011-04-13 | 2018-02-20 | (주)아모레퍼시픽 | 염증성 피부 노화 억제 물질 스크리닝 방법 |
| CN102526170B (zh) * | 2011-12-31 | 2015-04-29 | 许学志 | 抗结核杆菌的儿茶提取物组合物、其制备方法及含有它们的药物制剂和应用 |
| BE1023772B9 (fr) * | 2013-05-17 | 2017-08-02 | Valore | Composition a base d'un complexe de (+)-catechine et d'acide amine pour le traitement et la prevention du cancer |
| CN104096058A (zh) * | 2014-07-02 | 2014-10-15 | 胥玲 | 一种治疗扩张型心肌病的中药药丸 |
| BE1022579A9 (fr) * | 2014-11-10 | 2016-10-06 | Valore | Composition antimétastatique comprenant au moins un composé de type flavanol |
| IT202200013867A1 (it) * | 2022-06-30 | 2023-12-30 | Lo Li Pharma Srl | Composizione per il trattamento dell’ infezione da papilloma virus (hpv) |
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| US5962517A (en) * | 1997-01-31 | 1999-10-05 | Murad; Howard | Pharmaceutical compositions and methods for treating acne |
| US5817695A (en) * | 1997-12-24 | 1998-10-06 | Pellico; Michael A. | Nutritional product with high fat, low carbohydrate and amino acid imbalance |
| KR20020016833A (ko) | 1999-06-15 | 2002-03-06 | 뉴트리-로직스, 인크. | 발병 감소에 유용한 영양 제제, 관련 치료 방법 및 성분스크리닝 방법 |
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| US7041669B2 (en) * | 2002-02-25 | 2006-05-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-benzofused urea compounds useful in treating cytokine mediated diseases |
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2008
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Non-Patent Citations (9)
| Title |
|---|
| AHMAD N ET AL.: "Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells", J NATL CANCER INST, 1997, pages 1881 - 1886 |
| CAO Y, CAO R.: "Angiogenesis inhibited by drinking tea", NATURE, 1999, pages 381, XP000953295, DOI: doi:10.1038/18793 |
| CHEN L, LEE MJ, LI H, YANG CS.: "Absorption, distribution, elimination of tea polyphenols in rats", DRUG METAB DISPOS., 1997, pages 1045 - 1050, XP055259807 |
| CHOW H. H., CAI Y. ET AL.: "Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and Polyphenon E", CANCER EPIDEMIOL. BIOMARK. PREV., 2001, pages 53 - 58, XP002366662 |
| JANKUN J. ET AL.: "Why drinking green tea could prevent cancer", NATURE, 1997, pages 567 |
| JENNIFER RC BELL ET AL.: "(+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine1,2,3", AMERICAN SOCIETY FOR CLINICAL NUTRITION, 2000, pages 103 - 108 |
| MUKHTAR H, AHMAD N.: "Tea polyphenols: prevention of cancer and optimizing health.", AM J CLIN NUTR., 2000, pages 1698 - 1702 |
| NCI, DCPC CHEMOPREVENTION BRANCH AND AGENT DE: "Clinical development plan: Tea extracts, green tea polyphenols, epigallocatechin gallate.", J. CELL BIOCHEM, 1996, pages 236 - 257 |
| YANG C. S., CHEN L. ET AL.: "Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers", CANCER EPIDEMIOL. BIOMARK. PREV., 1998, pages 351 - 354 |
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