LT4491B - 1,4-dihidro-1,4-diokso-1h-naftaleno triciklinių darinių panaudojimas, naujų junginių gavimas ir jų taikymas vaistų gamyboje - Google Patents
1,4-dihidro-1,4-diokso-1h-naftaleno triciklinių darinių panaudojimas, naujų junginių gavimas ir jų taikymas vaistų gamyboje Download PDFInfo
- Publication number
- LT4491B LT4491B LT98-085A LT98085A LT4491B LT 4491 B LT4491 B LT 4491B LT 98085 A LT98085 A LT 98085A LT 4491 B LT4491 B LT 4491B
- Authority
- LT
- Lithuania
- Prior art keywords
- dihydro
- dioxo
- thiazole
- naphtho
- novel compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/30—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/24—Quinones containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/84—Naphthothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9514683A FR2742153B1 (fr) | 1995-12-12 | 1995-12-12 | Utilisation de derives tricycliques du 1,4-dihydro-1,4- dioxo-1h-naphtalene, nouveaux composes obtenus et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
LT98085A LT98085A (en) | 1998-11-25 |
LT4491B true LT4491B (lt) | 1999-04-26 |
Family
ID=9485393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT98-085A LT4491B (lt) | 1995-12-12 | 1998-06-10 | 1,4-dihidro-1,4-diokso-1h-naftaleno triciklinių darinių panaudojimas, naujų junginių gavimas ir jų taikymas vaistų gamyboje |
Country Status (26)
Country | Link |
---|---|
US (1) | US6262095B1 (hu) |
EP (1) | EP0876356B1 (hu) |
JP (1) | JP2000501724A (hu) |
KR (1) | KR19990072080A (hu) |
AP (1) | AP889A (hu) |
AR (1) | AR005054A1 (hu) |
AT (1) | ATE207907T1 (hu) |
AU (1) | AU716199B2 (hu) |
BR (1) | BR9611935A (hu) |
CA (1) | CA2240279A1 (hu) |
CZ (1) | CZ181198A3 (hu) |
DE (1) | DE69616598D1 (hu) |
EE (1) | EE9800174A (hu) |
FR (1) | FR2742153B1 (hu) |
HU (1) | HUP9901247A3 (hu) |
ID (1) | ID16081A (hu) |
IL (1) | IL124558A0 (hu) |
LT (1) | LT4491B (hu) |
LV (1) | LV12188B (hu) |
NO (1) | NO982696L (hu) |
NZ (1) | NZ323967A (hu) |
OA (1) | OA10696A (hu) |
PL (1) | PL327168A1 (hu) |
RU (1) | RU2178791C2 (hu) |
TR (1) | TR199801069T2 (hu) |
WO (1) | WO1997021684A1 (hu) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003999A (en) * | 1997-12-19 | 1999-07-12 | Advanced Research And Technology Institute, Inc. | Modulators of ryanodine receptors comprising 2-(aryl)-4,7-dioxobenzothiazoles and analogues thereof |
ATE318812T1 (de) * | 2000-12-21 | 2006-03-15 | Bristol Myers Squibb Co | Thiazolyl-inhibitoren von tyrosinkinasen der tec- familie |
TWI402261B (zh) | 2006-06-19 | 2013-07-21 | Takeda Pharmaceutical | 三環化合物及其醫藥組成物 |
WO2007149484A2 (en) | 2006-06-20 | 2007-12-27 | Dana-Farber Cancer Institute | Inhibitors of usp1 deubiquitinating enzyme complex |
WO2011137320A2 (en) | 2010-04-30 | 2011-11-03 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of usp1 deubiquitinating enzyme activity |
US9040713B2 (en) * | 2010-09-27 | 2015-05-26 | Emory University | Methods of managing blood sugar levels and compositions related thereto |
US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
RU2545091C1 (ru) * | 2014-03-18 | 2015-03-27 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | 1-R-4,9-ДИОКСО-1H-НАФТО[2,3-d][1,2,3]ТРИАЗОЛ-4-ОКСИМ-2-ОКСИДЫ И ИХ ПРОИЗВОДНЫЕ, ОБЛАДАЮЩИЕ ЦИТОТОКСИЧЕСКОЙ АКТИВНОСТЬЮ |
US10829427B2 (en) | 2015-12-18 | 2020-11-10 | The Board Of Regents Of The University Of Texas System | Naphthoquinones, pro-drugs, and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3039925A (en) | 1957-04-24 | 1962-06-19 | Bayer Ag | Compositions for the treatment of tuberculosis |
JPS61251657A (ja) | 1984-09-12 | 1986-11-08 | ユ−エスヴイ− フア−マシユ−テイカル コ−ポレ−シヨン | 抗高血圧性誘導体類 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05112533A (ja) * | 1991-05-08 | 1993-05-07 | Upjohn Co:The | イミダゾベンゾキノン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤 |
-
1995
- 1995-12-12 FR FR9514683A patent/FR2742153B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-10 EP EP96941734A patent/EP0876356B1/fr not_active Expired - Lifetime
- 1996-12-10 WO PCT/FR1996/001973 patent/WO1997021684A1/fr not_active Application Discontinuation
- 1996-12-10 US US09/043,831 patent/US6262095B1/en not_active Expired - Fee Related
- 1996-12-10 CZ CZ981811A patent/CZ181198A3/cs unknown
- 1996-12-10 IL IL12455896A patent/IL124558A0/xx unknown
- 1996-12-10 EE EE9800174A patent/EE9800174A/xx unknown
- 1996-12-10 NZ NZ323967A patent/NZ323967A/en unknown
- 1996-12-10 AT AT96941734T patent/ATE207907T1/de not_active IP Right Cessation
- 1996-12-10 HU HU9901247A patent/HUP9901247A3/hu unknown
- 1996-12-10 RU RU98113147/04A patent/RU2178791C2/ru active
- 1996-12-10 DE DE69616598T patent/DE69616598D1/de not_active Expired - Lifetime
- 1996-12-10 KR KR1019980704387A patent/KR19990072080A/ko not_active Application Discontinuation
- 1996-12-10 BR BR9611935A patent/BR9611935A/pt unknown
- 1996-12-10 AP APAP/P/1998/001275A patent/AP889A/en active
- 1996-12-10 CA CA002240279A patent/CA2240279A1/fr not_active Abandoned
- 1996-12-10 TR TR1998/01069T patent/TR199801069T2/xx unknown
- 1996-12-10 AU AU11018/97A patent/AU716199B2/en not_active Ceased
- 1996-12-10 JP JP9521799A patent/JP2000501724A/ja active Pending
- 1996-12-10 PL PL96327168A patent/PL327168A1/xx unknown
- 1996-12-12 AR ARP960105648A patent/AR005054A1/es unknown
- 1996-12-12 ID IDP963710A patent/ID16081A/id unknown
-
1998
- 1998-06-10 LT LT98-085A patent/LT4491B/lt not_active IP Right Cessation
- 1998-06-11 NO NO982696A patent/NO982696L/no not_active Application Discontinuation
- 1998-06-12 OA OA9800080A patent/OA10696A/fr unknown
- 1998-06-12 LV LVP-98-136A patent/LV12188B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3039925A (en) | 1957-04-24 | 1962-06-19 | Bayer Ag | Compositions for the treatment of tuberculosis |
JPS61251657A (ja) | 1984-09-12 | 1986-11-08 | ユ−エスヴイ− フア−マシユ−テイカル コ−ポレ−シヨン | 抗高血圧性誘導体類 |
Non-Patent Citations (2)
Title |
---|
F. I. CARROLL ANDJ. T. BLACKWELL: "Synthesis of 1H-naphth[2,3-d]imidazole-4,9-diones by acid catalyzed cyclization of 2-Acylamino-3-amino-1,4-naphthoquinone", JOURNAL OF HETEROCYCLIC CHEMISTRY, 1969, pages 909 - 916 |
JOHN R. E. HOOVER, ALLAN R. DAY: "Preparation of Some Imidazole Derivatives of 1,4-Naphthoquinone", J. AM. CHEM. SOC., 1954, pages 4148 - 4152, XP002030731, DOI: doi:10.1021/ja01645a028 |
Also Published As
Publication number | Publication date |
---|---|
BR9611935A (pt) | 1999-05-18 |
WO1997021684A1 (fr) | 1997-06-19 |
NO982696L (no) | 1998-08-11 |
JP2000501724A (ja) | 2000-02-15 |
FR2742153B1 (fr) | 1998-02-13 |
OA10696A (fr) | 2002-11-26 |
KR19990072080A (ko) | 1999-09-27 |
NO982696D0 (no) | 1998-06-11 |
AP889A (en) | 2000-11-17 |
EP0876356A1 (fr) | 1998-11-11 |
AU1101897A (en) | 1997-07-03 |
CA2240279A1 (fr) | 1997-06-19 |
EE9800174A (et) | 1998-12-15 |
LV12188A (lv) | 1998-12-20 |
AU716199B2 (en) | 2000-02-24 |
LT98085A (en) | 1998-11-25 |
PL327168A1 (en) | 1998-11-23 |
DE69616598D1 (de) | 2001-12-06 |
NZ323967A (en) | 2000-06-23 |
ID16081A (id) | 1997-09-04 |
US6262095B1 (en) | 2001-07-17 |
AR005054A1 (es) | 1999-04-07 |
FR2742153A1 (fr) | 1997-06-13 |
ATE207907T1 (de) | 2001-11-15 |
TR199801069T2 (xx) | 1998-08-21 |
HUP9901247A3 (en) | 2000-08-28 |
CZ181198A3 (cs) | 1998-09-16 |
HUP9901247A2 (hu) | 1999-08-30 |
EP0876356B1 (fr) | 2001-10-31 |
LV12188B (en) | 1999-07-20 |
IL124558A0 (en) | 1998-12-06 |
AP9801275A0 (en) | 1998-06-30 |
RU2178791C2 (ru) | 2002-01-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN112601750B (zh) | Ptpn11(shp2)抑制剂 | |
CA2935317C (en) | 1,2-naphthoquinone based derivative and method of preparing the same | |
JP6356334B2 (ja) | 新規なインデン誘導体、その調製方法、及びそれを有効成分として含有する網膜疾患を予防又は処置するための医薬組成物 | |
CN105392788B (zh) | 用作沉默调节蛋白调节剂的取代的桥连脲类似物 | |
JP6688372B2 (ja) | キヌレニン−3−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法 | |
JP2004520273A (ja) | Parpの阻害剤として用いるためのチエノ[2,3−c]イソキノリン | |
JP2015500212A (ja) | ポリ(adp−リボース)ポリメラーゼ阻害剤 | |
TW201908306A (zh) | 作為ask抑制劑的雜環化合物及其應用 | |
KR20000052738A (ko) | 1-페닐피라졸 화합물 및 그 약학적 용도 | |
JP3290664B2 (ja) | 3環性ベンゾアゼピンおよびベンゾチアゼピン誘導体 | |
AU2021208915B2 (en) | Novel pyrazole derivative | |
LT4491B (lt) | 1,4-dihidro-1,4-diokso-1h-naftaleno triciklinių darinių panaudojimas, naujų junginių gavimas ir jų taikymas vaistų gamyboje | |
CN106317057A (zh) | 具有咪唑并吡嗪类衍生物,其制备及其在医药上的应用 | |
NZ238648A (en) | Substituted benzoxazole derivatives and pharmaceutical compositions | |
EP3129102A1 (en) | Iodonium analogs as inhibitors of nadph oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof | |
CN111164087B (zh) | 有助于抑制人三叶因子3的化合物 | |
JP2000502081A (ja) | 1,4―ジヒドロ―1,4―ジオキソナフタレンのヘテロ芳香族及び三環式誘導体の利用、得られる新規化合物並びにその治療用途 | |
JP4965428B2 (ja) | セミカルバジド誘導体を含むフリーラジカル消去剤 | |
JP2000502334A (ja) | モノまたはジケトン二環式化合物の誘導体の使用、それにより得られた化合物、並びに炎症、片頭痛およびショックの治療用薬剤としてのそれらの用途 | |
WO2021200934A1 (ja) | 抗マラリア薬 | |
MXPA98004717A (es) | Utilizacion de derivados triciclicos de 1,4-dihidro-1,4-dioxo-1h-naftaleno, nuevos compuestos obtenidos y su aplicacion terapeutica | |
TWI410246B (zh) | 用於治療敗血症的八苯基異喹啉衍生物及其醫藥組成物 | |
JPH0755939B2 (ja) | 新規なベンゾチアゾリノン誘導体 | |
KR20240110273A (ko) | 새로운 인돌리진-피롤로피리미딘 하이브리드 유도체 제조방법 및 이를 포함하는 항암제 조성물 | |
WO2022228489A1 (zh) | Hpk1抑制剂及其在医药上的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM9A | Lapsed patents |
Effective date: 20021210 |