LT4042B - A hypotensive composition and a process for the preraration thereof - Google Patents
A hypotensive composition and a process for the preraration thereof Download PDFInfo
- Publication number
- LT4042B LT4042B LT95-084A LT95084A LT4042B LT 4042 B LT4042 B LT 4042B LT 95084 A LT95084 A LT 95084A LT 4042 B LT4042 B LT 4042B
- Authority
- LT
- Lithuania
- Prior art keywords
- weight
- nifedipine
- solution
- ethyl oleate
- percent
- Prior art date
Links
- 230000001077 hypotensive effect Effects 0.000 title claims description 6
- 239000000203 mixture Substances 0.000 title description 19
- 238000000034 method Methods 0.000 title description 6
- 208000001953 Hypotension Diseases 0.000 title 1
- 208000021822 hypotensive Diseases 0.000 title 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims abstract description 46
- 229960001597 nifedipine Drugs 0.000 claims abstract description 45
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 24
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims abstract description 24
- 229940093471 ethyl oleate Drugs 0.000 claims abstract description 24
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- 239000000654 additive Substances 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 4
- 239000012456 homogeneous solution Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 abstract description 8
- -1 Poly(ethylene glycol) Polymers 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 26
- 239000008194 pharmaceutical composition Substances 0.000 description 11
- 235000019441 ethanol Nutrition 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000013355 food flavoring agent Nutrition 0.000 description 4
- 210000002200 mouth mucosa Anatomy 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 206010002383 Angina Pectoris Diseases 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000004479 aerosol dispenser Substances 0.000 description 1
- OJYGBLRPYBAHRT-IPQSZEQASA-N chloralose Chemical compound O1[C@H](C(Cl)(Cl)Cl)O[C@@H]2[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]21 OJYGBLRPYBAHRT-IPQSZEQASA-N 0.000 description 1
- 229950009941 chloralose Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9402193A HU214582B (hu) | 1994-07-26 | 1994-07-26 | Porlasztható, vérnyomáscsökkentő hatású gyógyszerkészítmény és eljárás előállítására |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LT95084A LT95084A (en) | 1996-06-25 |
| LT4042B true LT4042B (en) | 1996-09-25 |
Family
ID=10985460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT95-084A LT4042B (en) | 1994-07-26 | 1995-07-20 | A hypotensive composition and a process for the preraration thereof |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPH08169829A (pl) |
| AT (1) | AT402690B (pl) |
| AU (1) | AU699386B2 (pl) |
| BE (1) | BE1011413A4 (pl) |
| CZ (1) | CZ286399B6 (pl) |
| DE (1) | DE19527140A1 (pl) |
| EE (1) | EE9500029A (pl) |
| FR (1) | FR2722988B1 (pl) |
| GB (1) | GB2291593B (pl) |
| HR (1) | HRP950374A2 (pl) |
| HU (1) | HU214582B (pl) |
| IT (1) | IT1277348B1 (pl) |
| LT (1) | LT4042B (pl) |
| LV (1) | LV11026B (pl) |
| PL (1) | PL181069B1 (pl) |
| SK (1) | SK280463B6 (pl) |
| UA (1) | UA39880C2 (pl) |
| YU (1) | YU50795A (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69738333T2 (de) * | 1997-10-01 | 2008-11-27 | Novadel Pharma Inc. | Nichtpolares Spray zur bukkalen Verabreichung |
| US20030095925A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
| US7632517B2 (en) | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
| EP2767163A1 (en) * | 2005-02-17 | 2014-08-20 | Abbott Laboratories | Transmucosal administration of drug compositions for treating and preventing disorders in animals |
| DE102006027794A1 (de) * | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Antihypertonie-Kombinationswafer |
| FR2906140B1 (fr) * | 2006-09-22 | 2008-12-05 | Philippe Perovitch | Forme galenique pour l'administration par voie trans-muqueuse de principes actifs |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3307422A1 (de) | 1983-03-03 | 1984-09-06 | Bayer Ag, 5090 Leverkusen | Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen |
| EP0190292A1 (de) | 1984-08-23 | 1986-08-13 | Kuhlemann & Co | Pharmazeutische zubereitung. |
| DE3544692A1 (de) | 1985-12-18 | 1987-06-19 | Bayer Ag | Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE71520T1 (de) * | 1986-03-10 | 1992-02-15 | Burghart Kurt | Pharmazeutische zubereitung sowie verfahren zur herstellung derselben. |
| US4863970A (en) * | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
| ES2042527T3 (es) * | 1986-11-14 | 1993-12-16 | Theratech Inc | Un metodo para preparar una composicion farmaceutica aumentadora de la penetracion para la aplicacion topica. |
| JPS63170316A (ja) * | 1986-12-30 | 1988-07-14 | Fujimoto Seiyaku Kk | ニフエジピン経皮吸収外用製剤 |
| DE3714402A1 (de) * | 1987-04-30 | 1988-11-10 | Kali Chemie Pharma Gmbh | Arzneimittelformulierung |
| GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| AT391269B (de) * | 1988-12-30 | 1990-09-10 | Burghart Kurt | Pharmazeutische zubereitung |
| US5298258A (en) * | 1989-12-28 | 1994-03-29 | Nitto Denko Corporation | Acrylic oily gel bioadhesive material and acrylic oily gel preparation |
| HU205249B (en) * | 1990-11-09 | 1992-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing suspensive aerosole composition |
-
1994
- 1994-07-26 HU HU9402193A patent/HU214582B/hu unknown
-
1995
- 1995-06-27 AU AU23269/95A patent/AU699386B2/en not_active Ceased
- 1995-06-30 HR HRP9402193A patent/HRP950374A2/hr not_active Application Discontinuation
- 1995-07-13 CZ CZ19951811A patent/CZ286399B6/cs not_active IP Right Cessation
- 1995-07-17 AT AT0121495A patent/AT402690B/de not_active IP Right Cessation
- 1995-07-17 FR FR9508598A patent/FR2722988B1/fr not_active Expired - Fee Related
- 1995-07-20 LT LT95-084A patent/LT4042B/lt not_active IP Right Cessation
- 1995-07-20 SK SK922-95A patent/SK280463B6/sk unknown
- 1995-07-21 JP JP7185275A patent/JPH08169829A/ja active Pending
- 1995-07-24 PL PL95309757A patent/PL181069B1/pl not_active IP Right Cessation
- 1995-07-24 BE BE9500646A patent/BE1011413A4/fr not_active IP Right Cessation
- 1995-07-25 GB GB9515205A patent/GB2291593B/en not_active Expired - Fee Related
- 1995-07-25 EE EE9500029A patent/EE9500029A/xx unknown
- 1995-07-25 DE DE19527140A patent/DE19527140A1/de not_active Withdrawn
- 1995-07-25 LV LVP-95-225A patent/LV11026B/en unknown
- 1995-07-25 UA UA95073513A patent/UA39880C2/uk unknown
- 1995-07-26 IT IT95MI001621A patent/IT1277348B1/it active IP Right Grant
- 1995-07-26 YU YU50795A patent/YU50795A/sh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3307422A1 (de) | 1983-03-03 | 1984-09-06 | Bayer Ag, 5090 Leverkusen | Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen |
| EP0190292A1 (de) | 1984-08-23 | 1986-08-13 | Kuhlemann & Co | Pharmazeutische zubereitung. |
| DE3544692A1 (de) | 1985-12-18 | 1987-06-19 | Bayer Ag | Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung |
Also Published As
| Publication number | Publication date |
|---|---|
| AU699386B2 (en) | 1998-12-03 |
| EE9500029A (et) | 1996-02-15 |
| GB9515205D0 (en) | 1995-09-20 |
| LV11026A (lv) | 1996-02-20 |
| HU214582B (hu) | 1998-04-28 |
| CZ181195A3 (en) | 1996-02-14 |
| JPH08169829A (ja) | 1996-07-02 |
| IT1277348B1 (it) | 1997-11-10 |
| HRP950374A2 (en) | 1997-10-31 |
| SK280463B6 (sk) | 2000-02-14 |
| GB2291593A (en) | 1996-01-31 |
| YU50795A (sh) | 1998-05-15 |
| AU2326995A (en) | 1996-02-08 |
| PL309757A1 (en) | 1996-02-05 |
| HUT75457A (en) | 1997-05-28 |
| FR2722988A1 (fr) | 1996-02-02 |
| BE1011413A4 (fr) | 1999-09-07 |
| UA39880C2 (uk) | 2001-07-16 |
| AT402690B (de) | 1997-07-25 |
| LT95084A (en) | 1996-06-25 |
| FR2722988B1 (fr) | 1999-10-08 |
| GB2291593B (en) | 1998-03-11 |
| DE19527140A1 (de) | 1996-02-01 |
| HU9402193D0 (en) | 1994-09-28 |
| ITMI951621A0 (it) | 1995-07-26 |
| CZ286399B6 (en) | 2000-04-12 |
| ATA121495A (de) | 1996-12-15 |
| ITMI951621A1 (it) | 1997-01-26 |
| SK92295A3 (en) | 1996-05-08 |
| PL181069B1 (pl) | 2001-05-31 |
| LV11026B (en) | 1996-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19990720 |